Airway Remodeling in Chronic Obstructive Pulmonary Disease and Asthma: the Role of Matrix Metalloproteinase-9

Katarzyna Grzela, Malgorzata Litwiniuk, Wioletta Zagorska, Tomasz Grzela, Katarzyna Grzela, Malgorzata Litwiniuk, Wioletta Zagorska, Tomasz Grzela

Abstract

Chronic obstructive pulmonary disease (COPD) and asthma are both associated with airflow restriction and progressive remodeling, which affect the respiratory tract. Among various biological factors involved in the pathomechanisms of both diseases, proteolytic enzymes--matrix metalloproteinases (MMPs)--play an important role, especially MMP-9. In this review, the authors discuss the current topics of research concerning the possible role of MMP-9 in both mentioned diseases. They include the analysis of protein levels, nucleotide polymorphisms of MMP-9 gene and their possible correlation with asthma and COPD. Finally, the authors refer to the studies on MMP-9 inhibition as a new perspective for increasing the effectiveness of treatment in asthma and COPD.

Keywords: Asthma; COPD; Chronic obstructive pulmonary disease; MMP-9; Remodeling.

Figures

Fig. 1
Fig. 1
The schematic representation of airway mucosa: in a healthy individual (a), structural changes in COPD- (b), and asthma-associated remodeling (c). The detailed description is given in the text

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