Post-discharge persistent symptoms and health-related quality of life after hospitalization for COVID-19
Eve Garrigues, Paul Janvier, Yousra Kherabi, Audrey Le Bot, Antoine Hamon, Hélène Gouze, Lucile Doucet, Sabryne Berkani, Emma Oliosi, Elise Mallart, Félix Corre, Virginie Zarrouk, Jean-Denis Moyer, Adrien Galy, Vasco Honsel, Bruno Fantin, Yann Nguyen, Eve Garrigues, Paul Janvier, Yousra Kherabi, Audrey Le Bot, Antoine Hamon, Hélène Gouze, Lucile Doucet, Sabryne Berkani, Emma Oliosi, Elise Mallart, Félix Corre, Virginie Zarrouk, Jean-Denis Moyer, Adrien Galy, Vasco Honsel, Bruno Fantin, Yann Nguyen
Abstract
Objective: To assess post-discharge persistent symptoms and health-related quality of life (HRQoL) of patients hospitalized in a COVID-19 ward unit more than 100 days after their admission.
Methods: All eligible patients were contacted by phone by trained physicians and were asked to answer to a dedicated questionnaire. Patients managed in hospital ward without needing intensive care were compared with those who were transferred in intensive care units (ICU).
Results: We included 120 patients after a mean (±SD) of 110.9 (±11.1) days following admission. The most frequently reported persistent symptoms were fatigue (55%), dyspnoea (42%), loss of memory (34%), concentration and sleep disorders (28% and 30.8%, respectively). Comparisons between ward- and ICU patients led to no statistically significant differences regarding those symptoms. In both group, EQ-5D (mobility, self-care, pain, anxiety or depression, usual activity) was altered with a slight difference in pain in the ICU group.
Conclusion: Most patients requiring hospitalization for COVID-19 still have persistent symptoms. While there were few differences between HRQoL between ward and ICU patients, our findings must be confirmed in larger cohorts, including more severe patients.
Keywords: Covid-19; Health-related quality of life; Persistent symptoms.
Conflict of interest statement
Declaration of Competing Interest None of the authors declared any competing interest in link with the present study.
Copyright © 2020. Published by Elsevier Ltd.
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References
- Nguyen Y., Corre F., Honsel V., Curac S., Zarrouk V., Fantin B. Applicability of the CURB-65 pneumonia severity score for outpatient treatment of COVID-19. J Infect. 2020;81(3):e96–e98.
- Carfì A., Bernabei R., Landi F., Gemelli Against COVID-19 Post-Acute Care Study Group Persistent Symptoms in Patients After Acute COVID-19. JAMA. 2020
- Halpin S.J., McIvor C., Whyatt G., Adams A., Harvey O., McLean L. Post-discharge symptoms and rehabilitation needs in survivors of COVID-19 infection: a cross-sectional evaluation. J Med Virol. 2020
- Herdman M., Gudex C., Lloyd A., M Janssen, Kind P., Parkin D. Development and preliminary testing of the new five-level version of EQ-5D (EQ-5D-5L) Qual Life Res Int J Qual Life Asp Treat Care Rehabil. 2011;20(10):1727–1736.
- Andrade L.F., Ludwig K., Goni J.M.R., Oppe M., de Pouvourville G. A French Value Set for the EQ-5D-5L. PharmacoEconomics. 2020;38(4):413–425.
- Turkmen D., Altunisik N., Sener S., Colak C. Evaluation of the effects of COVID-19 pandemic on hair diseases through a web-based questionnaire. Dermatol Ther. 2020:e13923.
Source: PubMed