25-Hydroxyvitamin D in the range of 20 to 100 ng/mL and incidence of kidney stones

Abstract

Objectives: Increasing 25-hydroxyvitamin D serum levels can prevent a wide range of diseases. There is a concern about increasing kidney stone risk with vitamin D supplementation. We used GrassrootsHealth data to examine the relationship between vitamin D status and kidney stone incidence.

Methods: The study included 2012 participants followed prospectively for a median of 19 months. Thirteen individuals self-reported kidney stones during the study period. Multivariate logistic regression was applied to assess the association between vitamin D status and kidney stones.

Results: We found no statistically significant association between serum 25-hydroxyvitamin D and kidney stones (P = .42). Body mass index was significantly associated with kidney stone risk (odds ratio = 3.5; 95% confidence interval = 1.1, 11.3).

Conclusions: We concluded that a serum 25-hydroxyvitamin D level of 20 to 100 nanograms per milliliter has no significant association with kidney stone incidence.

Figures

FIGURE 1—

Frequency distribution of 25(OH)D among participants who developed or did not develop kidney stones: GrassrootsHealth cohort, 2009–2012. Note. 25(OH)D = 25-hydroxyvitamin D. Line represents median 25(OH)D serum level of 50 ng/mL among those who did not develop kidney stones. We excluded an outlier of a participant who did not develop a kidney stone (397 ng/mL). A recommendation to consult with a physician was sent to the participant. The sample size was n = 2012.