Behavioral Deficits at 18-22 Months of Age Are Associated with Early Cerebellar Injury and Cognitive and Language Performance in Children Born Extremely Preterm
Andrea F Duncan, Carla M Bann, Allison Dempsey, Myriam Peralta-Carcelen, Susan Hintz, Eunice Kennedy Shriver National Institute of Child Health and Development Neonatal Research Network, Alan H Jobe, Michael S Caplan, Abbot R Laptook, Betty R Vohr, William Oh, Angelita M Hensman, Barbara Alksninis, Dawn Andrews, Kristen Angela, Susan Barnett, Bill Cashore, Melinda Caskey, Kim Francis, Dan Gingras, Katharine Johnson, Theresa M Leach, Bonnie E Stephens, Victoria E Watson, Michele C Walsh, Avroy A Fanaroff, Nancy S Newman, Deanne E Wilson-Costello, Bonnie S Siner, Arlene Zadell, Julie DiFiore, Monika Bhola, Harriet G Friedman, Gulgun Yalcinkaya, Dorothy Bulas, Ronald N Goldberg, C Michael Cotten, Ricki F Goldstein, Patricia Ashley, Kathy J Auten, Kimberley A Fisher, Katherine A Foy, Sharon F Freedman, Kathryn E Gustafson, Melody B Lohmeyer, William F Malcolm, David K Wallace, David P Carlton, Barbara J Stoll, Ira Adams-Chapman, Susie Buchter, Anthony J Piazza, Sheena Carter, Sobha Fritz, Ellen C Hale, Amy K Hutchinson, Maureen Mulligan LaRossa, Rosemary D Higgins, Stephanie Wilson Archer, Gregory M Sokol, Brenda B Poindexter, Anna M Dusick, James A Lemons, Leslie D Wilson, Faithe Hamer, Ann B Cook, Dianne E Herron, Carolyn Lytle, Heike M Minnich, Mary Anne Berberich, Carol J Blaisdell, Dorothy B Gail, James P Kiley, Abhik Das, Marie G Gantz, Jamie E Newman, Helen Cheng, Betty K Hastings, Elizabeth M McClure, Jeanette O'Donnell Auman, Carolyn Petrie Huitema, W Kenneth Poole, James W Pickett 2nd, Dennis Wallace, Lisa A Wrage, Kristin M Zaterka-Baxter, Krisa P Van Meurs, David K Stevenson, M Bethany Ball, Patrick D Barnes, Barbara Bentley, Elizabeth F Bruno, Maria Elena DeAnda, Anne M DeBattista, Jean G Kohn, Melinda S Proud, Renee P Pyle, Hali E Weiss, Ivan D Frantz 3rd, John M Fiascone, Elisabeth C McGowan, Anne Furey, Brenda L MacKinnon, Ellen Nylen, Ana Brussa, Cecelia Sibley, Waldemar A Carlo, Namasivayam Ambalavanan, Monica V Collins, Shirley S Cosby, Vivien A Phillips, Kirstin J Bailey, Fred J Biasini, Maria Hopkins, Kristen C Johnston, Kathleen G Nelson, Cryshelle S Patterson, Richard V Rector, Leslie Rodriguez, Amanda Soong, Sally Whitley, Sheree York, Neil N Finer, Maynard R Rasmussen, Paul R Wozniak, Yvonne E Vaucher, Wade Rich, Kathy Arnell, Rene Barbieri-Welge, Ayala Ben-Tall, Renee Bridge, Clarence Demetrio, Martha G Fuller, Elaine Ito, Meghan Lukasik, Deborah Pontillo, Donna Posin, Cheryl Runyan, James Wilkes, Paul Zlotnik, Edward F Bell, John A Widness, Michael J Acarregui, Jonathan M Klein, Tarah T Colaizy, Karen J Johnson, Diane L Eastman, Shahnaz Duara, Charles R Bauer, Ruth Everett-Thomas, Maria Calejo, Alexis N Diaz, Silvia M Frade Eguaras, Andrea Garcia, Kasey Hamlin-Smith, Michelle Harwood Berkowits, Sylvia Hiriart-Fajardo, Elaine O Mathews, Helina Pierre, Arielle Riguard, Alexandra Stroerger, Kristi L Watterberg, Robin K Ohls, Janell Fuller, Julie Rohr, Conra Backstrom Lacy, Jean Lowe, Rebecca Montman, Sandra Brown, Nirupama Laroia, Dale L Phelps, Gary J Myers, Gary D Markowitz, Linda J Reubens, Diane Hust, Lisa Augostino, Julie Babish Johnson, Erica Burnell, Harris Gelbard, Rosemary L Jensen, Emily Kushner, Joan Merzbach, Jonathan Mink, Carlos Torres, David Wang, Kelley Yost, Pablo J Sánchez, Charles R Rosenfeld, Walid A Salhab, Roy J Heyne, Sally S Adams, James Allen, Laura Grau, Alicia Guzman, Gaynelle Hensley, Elizabeth T Heyne, Jackie F Hickman, Melissa H Leps, Linda A Madden, Melissa Martin, Nancy A Miller, Janet S Morgan, Araceli Solis, Lizette E Torres, Catherine Twell Boatman, Diana M Vasil, Kathleen A Kennedy, Jon E Tyson, Patricia W Evans, Esther G Akpa, Nora I Alaniz, Beverly Foley Harris, Charles Green, Margarita Jiminez, Anna E Lis, Sarah Martin, Georgia E McDavid, Brenda H Morris, Margaret L Poundstone, Stacy Reddoch, Saba Siddiki, Patti L Pierce Tate, Sharon L Wright, Bradley A Yoder, Roger G Faix, Shawna Baker, Karie Bird, Anna E Bullwinkle, Jill Burnett, Laura Cole, Karen A Osborne, Cynthia Spencer, R Edison Steele, Michael Steffen, Kimberlee Weaver-Lewis, T Michael O'Shea, Robert G Dillard, Lisa K Washburn, Nancy J Peters, Barbara G Jackson, Korinne Chiu, Deborah Evans Allred, Donald J Goldstein, Raquel Halfond, Carroll Peterson, Ellen L Waldrep, Cherrie D Welch, Melissa Whalen Morris, Gail Wiley Hounshell, Seetha Shankaran, Beena G Sood, Thomas L Slovis, Athina Pappas, Rebecca Bara, Elizabeth Billian, Laura A Goldston, Mary Johnson, Andrea F Duncan, Carla M Bann, Allison Dempsey, Myriam Peralta-Carcelen, Susan Hintz, Eunice Kennedy Shriver National Institute of Child Health and Development Neonatal Research Network, Alan H Jobe, Michael S Caplan, Abbot R Laptook, Betty R Vohr, William Oh, Angelita M Hensman, Barbara Alksninis, Dawn Andrews, Kristen Angela, Susan Barnett, Bill Cashore, Melinda Caskey, Kim Francis, Dan Gingras, Katharine Johnson, Theresa M Leach, Bonnie E Stephens, Victoria E Watson, Michele C Walsh, Avroy A Fanaroff, Nancy S Newman, Deanne E Wilson-Costello, Bonnie S Siner, Arlene Zadell, Julie DiFiore, Monika Bhola, Harriet G Friedman, Gulgun Yalcinkaya, Dorothy Bulas, Ronald N Goldberg, C Michael Cotten, Ricki F Goldstein, Patricia Ashley, Kathy J Auten, Kimberley A Fisher, Katherine A Foy, Sharon F Freedman, Kathryn E Gustafson, Melody B Lohmeyer, William F Malcolm, David K Wallace, David P Carlton, Barbara J Stoll, Ira Adams-Chapman, Susie Buchter, Anthony J Piazza, Sheena Carter, Sobha Fritz, Ellen C Hale, Amy K Hutchinson, Maureen Mulligan LaRossa, Rosemary D Higgins, Stephanie Wilson Archer, Gregory M Sokol, Brenda B Poindexter, Anna M Dusick, James A Lemons, Leslie D Wilson, Faithe Hamer, Ann B Cook, Dianne E Herron, Carolyn Lytle, Heike M Minnich, Mary Anne Berberich, Carol J Blaisdell, Dorothy B Gail, James P Kiley, Abhik Das, Marie G Gantz, Jamie E Newman, Helen Cheng, Betty K Hastings, Elizabeth M McClure, Jeanette O'Donnell Auman, Carolyn Petrie Huitema, W Kenneth Poole, James W Pickett 2nd, Dennis Wallace, Lisa A Wrage, Kristin M Zaterka-Baxter, Krisa P Van Meurs, David K Stevenson, M Bethany Ball, Patrick D Barnes, Barbara Bentley, Elizabeth F Bruno, Maria Elena DeAnda, Anne M DeBattista, Jean G Kohn, Melinda S Proud, Renee P Pyle, Hali E Weiss, Ivan D Frantz 3rd, John M Fiascone, Elisabeth C McGowan, Anne Furey, Brenda L MacKinnon, Ellen Nylen, Ana Brussa, Cecelia Sibley, Waldemar A Carlo, Namasivayam Ambalavanan, Monica V Collins, Shirley S Cosby, Vivien A Phillips, Kirstin J Bailey, Fred J Biasini, Maria Hopkins, Kristen C Johnston, Kathleen G Nelson, Cryshelle S Patterson, Richard V Rector, Leslie Rodriguez, Amanda Soong, Sally Whitley, Sheree York, Neil N Finer, Maynard R Rasmussen, Paul R Wozniak, Yvonne E Vaucher, Wade Rich, Kathy Arnell, Rene Barbieri-Welge, Ayala Ben-Tall, Renee Bridge, Clarence Demetrio, Martha G Fuller, Elaine Ito, Meghan Lukasik, Deborah Pontillo, Donna Posin, Cheryl Runyan, James Wilkes, Paul Zlotnik, Edward F Bell, John A Widness, Michael J Acarregui, Jonathan M Klein, Tarah T Colaizy, Karen J Johnson, Diane L Eastman, Shahnaz Duara, Charles R Bauer, Ruth Everett-Thomas, Maria Calejo, Alexis N Diaz, Silvia M Frade Eguaras, Andrea Garcia, Kasey Hamlin-Smith, Michelle Harwood Berkowits, Sylvia Hiriart-Fajardo, Elaine O Mathews, Helina Pierre, Arielle Riguard, Alexandra Stroerger, Kristi L Watterberg, Robin K Ohls, Janell Fuller, Julie Rohr, Conra Backstrom Lacy, Jean Lowe, Rebecca Montman, Sandra Brown, Nirupama Laroia, Dale L Phelps, Gary J Myers, Gary D Markowitz, Linda J Reubens, Diane Hust, Lisa Augostino, Julie Babish Johnson, Erica Burnell, Harris Gelbard, Rosemary L Jensen, Emily Kushner, Joan Merzbach, Jonathan Mink, Carlos Torres, David Wang, Kelley Yost, Pablo J Sánchez, Charles R Rosenfeld, Walid A Salhab, Roy J Heyne, Sally S Adams, James Allen, Laura Grau, Alicia Guzman, Gaynelle Hensley, Elizabeth T Heyne, Jackie F Hickman, Melissa H Leps, Linda A Madden, Melissa Martin, Nancy A Miller, Janet S Morgan, Araceli Solis, Lizette E Torres, Catherine Twell Boatman, Diana M Vasil, Kathleen A Kennedy, Jon E Tyson, Patricia W Evans, Esther G Akpa, Nora I Alaniz, Beverly Foley Harris, Charles Green, Margarita Jiminez, Anna E Lis, Sarah Martin, Georgia E McDavid, Brenda H Morris, Margaret L Poundstone, Stacy Reddoch, Saba Siddiki, Patti L Pierce Tate, Sharon L Wright, Bradley A Yoder, Roger G Faix, Shawna Baker, Karie Bird, Anna E Bullwinkle, Jill Burnett, Laura Cole, Karen A Osborne, Cynthia Spencer, R Edison Steele, Michael Steffen, Kimberlee Weaver-Lewis, T Michael O'Shea, Robert G Dillard, Lisa K Washburn, Nancy J Peters, Barbara G Jackson, Korinne Chiu, Deborah Evans Allred, Donald J Goldstein, Raquel Halfond, Carroll Peterson, Ellen L Waldrep, Cherrie D Welch, Melissa Whalen Morris, Gail Wiley Hounshell, Seetha Shankaran, Beena G Sood, Thomas L Slovis, Athina Pappas, Rebecca Bara, Elizabeth Billian, Laura A Goldston, Mary Johnson
Abstract
Objective: To investigate associations in toddlers born extremely preterm (<28 weeks) between neonatal neuroimaging and 18- to 22-month developmental and behavioral outcomes.
Study design: Cohort analysis from the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network Surfactant Positive Airway Pressure and Pulse Oximetry Trial Neuroimaging and Neurodevelopmental Outcomes Study of infants born extremely preterm. Subjects underwent cranial ultrasonography and near-term magnetic resonance imaging (MRI). At 18-22 months of corrected age, the assessment included the Brief Infant Toddler Social Emotional Assessment (BITSEA) Problem and Competence Scale scores and the Bayley Scales of Infant Development, Third Edition (Bayley-III). The BITSEA Problem Scale assesses dysregulation; the Competence Scale assesses social-emotional competence. We examined associations of Problem and Competence scores and positive screen rates with cranial ultrasonography and near-term MRI. Mean BITSEA and Bayley-III scores were compared using ANOVA and positive screen rates with the χ2 test. We computed correlations between BITSEA and Bayley-III scores.
Results: Of the 397 children, positive BITSEA screens were found in 34% for the Problem score and 26% for the Competence score. Presence of lesions on near-term MRI that included cerebellar lesions were significantly associated with lower BITSEA Competence but not with Problem scores; Competence scores were inversely related to the presence/significance of lesions. Positive screens on Competence scores and on both Competence and Problem scores were significantly associated with Bayley-III cognitive and language scores <85 (P < .001).
Conclusions: Social-emotional competence contributes to deficits in cognitive and language development. Presence of injury on near-term MRI that includes cerebellar lesions is associated with later social-emotional competence and may be a useful predictor to guide early assessment and intervention.
Trial registration: ClinicalTrials.gov: NCT00063063 and NCT00233324.
Keywords: behavior; extremely preterm; neuroimaging.
Copyright © 2018 Elsevier Inc. All rights reserved.
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Source: PubMed