In vitro fertilization and pregnancy rates: the influence of sperm motility and morphology on IVF outcome
E T Donnelly, S E Lewis, J A McNally, W Thompson, E T Donnelly, S E Lewis, J A McNally, W Thompson
Abstract
Objective: To determine the relationship between sperm motility and sperm morphology parameters and IVF and pregnancy rates.
Design: Pre- and postpreparation analysis of semen samples from infertile couples undergoing IVF-ET.
Setting: Andrology Laboratory, Royal Maternity Hospital, Belfast, Northern Ireland.
Patient(s): One hundred fifty couples undergoing IVF-ET treatment at the Regional Fertility Centre.
Intervention(s): None.
Main outcome measure(s): The ability of human sperm to achieve IVF and pregnancy was investigated in relation to motility parameters (assessed with computer-aided sperm analysis [Integrated Visual Optical System] and percent normal morphology (determined with the strict criteria).
Result(s): Significant differences were observed in motility parameters and percent normal morphology in samples that achieved > or =50% fertilization compared with < or =50% fertilization and between samples that achieved a pregnancy compared with those that did not. Significant positive correlations were observed between percent progressive motility, the velocity of sperm movement, and morphology parameters and both IVF and pregnancy.
Conclusion(s): Both sperm motility parameters and percent normal morphology are significant factors in predicting fertilization and pregnancy rates in IVF.
Source: PubMed