Intra-abdominal adipose tissue values associated with risk of possessing elevated blood lipids and blood pressure

Abstract

Central fat distribution and more recently intra-abdominal adipose tissue (IAF) have been associated with elevated cardiovascular risk factors (CRF). Despite increased interest in use of LAF for screening for CRF, interpretation of risk found in a specific IAF is difficult since regressions for estimating CRF from IAF have not been published. The purpose of this paper is to report IAF values that are likely to be associated with elevated CRF. One hundred forty-six healthy male subjects 30-71 years were evaluated for IAF and subcutaneous fat (computed tomography scan at 4th lumbar vertebra), height, body weight, % fat, various anthropometric measures, blood cholesterol (CHOL), HDL cholesterol (HDL), systolic blood pressure (SBP), and diastolic blood pressure (DBP). Receiver-Operating-Characteristic curves (ROC) were used to develop IAF cutpoints associated with elevation of at least one established CRF criteria (CHOL=200, HDL=<35, SBP=140, DBP=90). A sensitivity/(1- specificity) curve established the value of using IAF cutpoints for detecting elevated CRF. Likelihood ratios were used to identify optimal cutpoints. Two cutpoints were identified, 131 cm2 with a relatively high Lpos ratio and 71 cm2 with a relatively low Lneg. False positives associated with 131 cm2 were 14% for one or more elevated CRF. False negatives associated with 71 cm2 were 9% for one or more elevated CRF, 4% for two or more CRF, and 0% for three or more elevated CRF. This study clearly indicates that IAF above 131 cm2 is related to elevated CRF and IAF below 71 cm2 is associated with reduced cardiovascular risk.