The Current Perspectives of Stem Cell Therapy in Orthopedic Surgery

Serkan Akpancar, Oner Tatar, Hasan Turgut, Faruk Akyildiz, Safak Ekinci, Serkan Akpancar, Oner Tatar, Hasan Turgut, Faruk Akyildiz, Safak Ekinci

Abstract

Context: Musculoskeletal injuries may be painful, troublesome, life limiting and also one of the global health problems. There has been considerable amount of interest during the past two decades to stem cells and tissue engineering techniques in orthopedic surgery, especially to manage special and compulsive injuries within the musculoskeletal system.

Evidence acquisition: The aim of this study was to present a literature review regarding the most recent progress in stem cell procedures and current indications in orthopedics clinical care practice. The Medline and PubMed library databases were searched for the articles related with stem cell procedures in the field of orthopedic surgery and additionally the reference list of each article was also included to provide a comprehensive evaluation.

Results: Various sources of stem cells have been studied for orthopedics clinical care practice. Stem cell therapy has successfully used for major orthopedic procedures in terms of bone-joint injuries (fractures-bone defects, nonunion, and spinal injuries), osteoarthritis-cartilage defects, ligament-tendon injuries, femoral head osteonecrosis and osteogenesis imperfecta. Stem cells have also used in bone tissue engineering in combining with the scaffolds and provided faster and better healing of tissues.

Conclusions: Large amounts of preclinical studies have been made of stem cells and there is an increasing interest to perform these studies within the human population but preclinical studies are insufficient; therefore, much more and efficient studies should be conducted to evaluate the efficacy and safety of stem cells.

Keywords: Adipose Derived Stem Cells; Bone Marrow Derived Stem Cells; Mesenchymal Stem Cells; Orthopedic Surgery; Stem Cells.

Conflict of interest statement

Conflict of Interests:The authors declare that there is no conflict of interests regarding the publication of this paper.

Figures

Figure 1.. Types of Stem Cells According…
Figure 1.. Types of Stem Cells According to Differentiating Potential
Figure 2.. Mesenchymal Stem Cell Sources and…
Figure 2.. Mesenchymal Stem Cell Sources and the Most Preferred Conditions in Orthopedic Surgery

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