- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00030303
Vaccine Therapy in Treating Patients With Chronic Myelogenous Leukemia
A Feasibility And Toxicity Study Of Vaccination With HSP70 For The Treatment Of Chronic Myelogenous Leukemia In Chronic Phase
RATIONALE: Vaccines made from a person's white blood cells may make the body build an immune response to kill cancer cells.
PURPOSE: Phase I trial to study the effectiveness of vaccine therapy in treating patients who have chronic myelogenous leukemia.
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
OBJECTIVES:
- Determine the feasibility of vaccination with autologous heat shock protein 70 in patients with chronic phase chronic myelogenous leukemia.
- Determine the toxicity of this vaccination in these patients.
OUTLINE: Patients undergo leukapheresis to obtain peripheral mononuclear cells (PMNCs). Heat shock protein 70 (HSP70) is derived from the autologous PMNCs. Patients receive HSP70 intradermally once weekly for 8 weeks.
Patients are followed for 2 weeks.
Study Type
Enrollment (Actual)
Phase
- Phase 1
Contacts and Locations
Study Locations
-
-
Connecticut
-
Farmington, Connecticut, United States, 06030-1601
- University of Connecticut Health Center
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
DISEASE CHARACTERISTICS:
Diagnosis of chronic phase chronic myelogenous leukemia
- Philadelphia chromosome positive
- Peripheral blast count no greater than 10%
- No molecular remission
- Less than 3 years since initial diagnosis
- No anticipation of requirement for bone marrow or stem cell transplantation for 6 months
PATIENT CHARACTERISTICS:
Age:
- 18 and over
Performance status:
- ECOG 0-1
Life expectancy:
- Not specified
Hematopoietic:
- Hemoglobin at least 10 g/dL
- Platelet count at least 20,000/mm^3
Hepatic:
- Bilirubin less than 2.0 times upper limit of normal (ULN)
- Transaminase less than 2.0 times ULN
Renal:
- Creatinine less than 2.0 mg/dL
Other:
- Not pregnant
- Negative pregnancy test
- Fertile patients must use effective contraception
- No significant active infection requiring hospitalization
- No other serious illness or significant behavioral or psychological problem that would preclude study involvement
PRIOR CONCURRENT THERAPY:
Biologic therapy:
- See Disease Characteristics
- Prior interferon alfa allowed
- No concurrent interferon alfa
Chemotherapy:
- Prior cytarabine or other cytotoxic agents allowed
- No concurrent cytarabine or other cytotoxic agents
- Concurrent hydroxyurea allowed
Endocrine therapy:
- No concurrent corticosteroid therapy
Radiotherapy:
- Not specified
Surgery:
- Not specified
Other:
- No concurrent immunosuppressive medications
- Concurrent imatinib mesylate allowed
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: N/A
- Interventional Model: Single Group Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: vaccine
recombinant 70-kD heat-shock protein
|
Collaborators and Investigators
Sponsor
Investigators
- Study Chair: Zihai Li, MD, PhD, UConn Health
Publications and helpful links
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- UCHC-01117
- CDR0000069127 (Registry Identifier: PDQ (Physician Data Query))
- UCHC-7659
- NCI-V01-1685
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
product manufactured in and exported from the U.S.
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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