- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00137709
Hormone Profiles in Adults With Newly Diagnosed Epilepsy
Hormone Profiles in Adults Treated With Valproate vs. Lamotrigine Monotherapy for Newly Diagnosed Epilepsy: A Prospective Randomised Study
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
Sodium valproate is an established antiepileptic drug used against a broad range of seizure types. Lamotrigine, a newer antiepileptic drug available since late 1980s, has a similar range of action and is approved as first-line treatment for epilepsy in the United States and many European countries as well as in Hong Kong. Recently, concern has been raised over the association between valproate treatment and polycystic ovarian syndrome, a condition characterised by multiple cysts in the ovaries in women and a range of hormonal and metabolic disturbances. Cross-sectional studies from Finland suggest that up to 40% of women treated with valproate have polycystic ovaries. Lamotrigine substitution for valproate has been reported to normalise these parameters in some patients. Elevated serum insulin and androgen levels have also been reported in over 50% of male patients taking valproate for epilepsy. However, such high incidence of hormonal abnormalities associated with valproate treatment has not been reproduced in studies conducted in other western populations. No similar studies in Chinese patients have been reported. In addition, these cross-sectional studies suffer from many potential confounding factors, such as previous treatment with other antiepileptic drugs, variation in duration of treatment, thus limiting the ability to establish a causal relationship.
This phase IV study aims to examine whether valproate treatment is associated with hormonal abnormalities in Chinese epilepsy patients. Newly diagnosed patients will be randomised to receive valproate or lamotrigine and their hormonal profiles measured prospectively for 12 months.
Study Type
Enrollment (Anticipated)
Phase
- Phase 4
Contacts and Locations
Study Contact
- Name: Patrick Kwan, FHKAM
- Phone Number: 852-2632-2211
- Email: patrickkwan@cuhk.edu.hk
Study Contact Backup
- Name: Evelyn Yu, MSc
- Phone Number: 852-2632-3856
- Email: evelyn.yu@cuhk.edu.hk
Study Locations
-
-
-
Kowloon, Hong Kong
- Recruiting
- United Christian Hospital
-
Contact:
- Ping Wing Ng, FHKAM
-
Principal Investigator:
- Ping Wing Ng, FHKAM
-
Shatin, Hong Kong
- Recruiting
- Prince of Wales Hospital
-
Contact:
- Patrick Kwan, FHKAM
- Phone Number: 852-2632-2211
- Email: patrickkwan@cuhk.edu.hk
-
Contact:
- Evelyn Yu, MSc
- Phone Number: 852-2632-3856
- Email: evelyn.yu@cuhk.edu.hk
-
Principal Investigator:
- Patrick Kwan, FHKAM
-
Sub-Investigator:
- Howan Leung, MRCP
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- Patients aged between 15 and 55
- Ethnically Chinese
- Newly diagnosed epilepsy requiring antiepileptic drug treatment; or patients previously treated with antiepileptic drugs but have withdrawn from medication for at least 1 year, and now require resumption of antiepileptic drug therapy due to seizure relapse.
Exclusion Criteria:
- Post-menopausal women.
- Pregnant women.
- Women who have undergone oophorectomy.
- Women taking or have taken oral contraceptive pills in the previous 3 months.
- Women diagnosed with or suspected to have polycystic ovarian syndrome.
- Subjects with diabetes mellitus.
- Subjects receiving hormone replacement or glucocorticoids.
- Subjects receiving long-term warfarin.
- Subjects suffering from significant systemic diseases, or illnesses that interfere with pituitary-gonadal functions.
- Subjects with a progressive or degenerative neurological disorder.
- Subjects who are unable to take their medication reliably.
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: None (Open Label)
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Fasting insulin/glucose ratio
Time Frame: 12 months
|
12 months
|
Secondary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Number of subjects with above normal upper limit(s) of: insulin level
Time Frame: 12 months
|
12 months
|
testosterone
Time Frame: 12 months
|
12 months
|
low-density lipoprotein (LDL) cholesterol
Time Frame: 12 months
|
12 months
|
luteinizing hormone (LH)/follicle stimulating hormone (FSH) ratio
Time Frame: 12 months
|
12 months
|
dehydroepiandrosterone (DHEA)
Time Frame: 12 months
|
12 months
|
Collaborators and Investigators
Sponsor
Investigators
- Principal Investigator: Patrick Kwan, FHKAM, Chinese University of Hong Kong
Study record dates
Study Major Dates
Study Start
Study Completion (Anticipated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
- Brain Diseases
- Central Nervous System Diseases
- Nervous System Diseases
- Epilepsy
- Physiological Effects of Drugs
- Neurotransmitter Agents
- Molecular Mechanisms of Pharmacological Action
- Central Nervous System Depressants
- Enzyme Inhibitors
- Antipsychotic Agents
- Tranquilizing Agents
- Psychotropic Drugs
- Membrane Transport Modulators
- GABA Agents
- Anticonvulsants
- Sodium Channel Blockers
- Antimanic Agents
- Calcium-Regulating Hormones and Agents
- Calcium Channel Blockers
- Lamotrigine
- Valproic Acid
Other Study ID Numbers
- CRE-2004.399
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Epilepsy
-
NaviFUS CorporationTaipei Veterans General Hospital, TaiwanCompletedDrug Resistant Epilepsy | Epilepsy, Drug Resistant | Intractable Epilepsy | Refractory Epilepsy | Drug Refractory Epilepsy | Epilepsy, Drug Refractory | Epilepsy, Intractable | Medication Resistant EpilepsyTaiwan
-
Great Ormond Street Hospital for Children NHS Foundation...Active, not recruitingEpilepsies, Partial | Intractable Epilepsy | Focal Epilepsy | Refractory Epilepsy | Epilepsy Intractable | Epilepsy in Children | Epilepsy, FocalUnited Kingdom
-
University of British ColumbiaTerminatedJuvenile Myoclonic Epilepsy | Childhood Absence Epilepsy | Juvenile Absence EpilepsyCanada
-
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen UniversityRecruiting
-
Neuroelectrics CorporationRecruitingEpilepsy | Seizures | Refractory Epilepsy | Epilepsy, Tonic-Clonic | Epilepsy in Children | Seizures, Focal | Focal SeizureSpain, United States, France, Belgium
-
Oslo University HospitalCompletedEpilepsy | Generalized Epilepsy | Focal EpilepsyNorway
-
UCB Pharma SACompletedEpilepsy, Tonic-clonicPoland, Sweden, Hungary, Czechia
-
UCB PharmaCompletedEpilepsy, Tonic-clonic
-
University Hospital, LilleUnknownFocal Epilepsy | Epilepsy IntractableFrance
-
Xuanwu Hospital, BeijingPeking University; Beijing Tiantan Hospital; Qilu Hospital of Shandong University and other collaboratorsNot yet recruitingEpilepsy, Drug ResistantChina
Clinical Trials on Sodium valproate
-
University of BirminghamActive, not recruitingWolfram SyndromeFrance, United Kingdom, Poland, Spain
-
Xijing HospitalUnknownTraumatic Brain InjuryChina
-
All India Institute of Medical Sciences, New DelhiUnknownChronic Lymphocytic LeukemiaIndia
-
University of VirginiaTerminatedGlioblastomaUnited States
-
Postgraduate Institute of Dental Sciences RohtakUnknownAlveolar Bone LossIndia
-
Ewha Womans UniversityWithdrawnBipolar DepressionKorea, Republic of
-
National Institute on Alcohol Abuse and Alcoholism...University of PittsburghCompleted
-
University of North Carolina, Chapel HillRecruitingStroke | Brain Ischemia | Brain Injuries, Traumatic | Heart Arrest | Intracranial Hemorrhages | Brain Hypoxia | Coma | Hypoxia-Ischemia, Brain | Persistent Vegetative State | Brain Injuries, AcuteUnited States
-
Boston Children's HospitalUniversity of LouisvilleWithdrawn
-
Ewha Womans University Mokdong HospitalWithdrawnDepression, BipolarKorea, Republic of