Evaluation of Immune Function in Biliary Atresia Children With Prolonged Jaundice

Impaired T-Lymphocyte Proliferative Function in Biliary Atresia Children With Prolonged Jaundice


Lead Sponsor: National Taiwan University Hospital

Source National Taiwan University Hospital
Brief Summary

Null hypothesis of this study: Biliary atresia patients with cholestatic jaundice do not have systemic immunity defect.

Detailed Description

Biliary atresia patients with cholestatic jaundice were noted to have increased incidence of infectious complications. Previous animal models of bile duct ligation with acute jaundice ever demonstrated impairment of both humoral and cellular immune function. We performed the immunity study in biliary atresia patients due to the lack of comprehensive systemic immunity study in pediatric cholestatic model. Systemic humoral immunity (total serum IgG, IgA, IgM, C3 and C4), specific cellular immunity (lymphocyte classification, mitogen response, cytokines level after PHA stimulation test), and non-specific cellular immunity (absolute neutrophil count, PMN CD11b/CD18 expression level, PMN superoxide release function, and PMN phagocytosis function) were tested. Association with serum bilirubin level, nutritional status and blood biochemical values were tested to see the relation between systemic immune function and cholestatic jaundice.

Overall Status Unknown status
Start Date April 2004
Study Type Observational
Enrollment 30


Inclusion Criteria:

Biliary patients older than 1-year-old status post Kasai operation.

Exclusion Criteria:

Received liver transplantation, immunosuppresant, systemic immunoglobulin (within 6 months) and obvious infectious episode (within 2 weeks).

Gender: All

Minimum Age: 1 Year

Maximum Age: N/A

Healthy Volunteers: No

Overall Official
Last Name Role Affiliation
Mei-Hwei Chang, MD Study Chair Department of Pediatrics, Natonal Taiwan University Hospital
Overall Contact

Last Name: Jia-Feng Wu, MD

Phone: 886-2-23123456

Phone Ext.: 5451

Email: [email protected]

Facility: Status: Contact: Contact Backup: Investigator: Department of Pediatrics, National Taiwan University Hospital Yen-Hsuan Ni, MD 886-2-23123456 5451 [email protected] Jia-Feng Wu, MD Principal Investigator
Location Countries


Verification Date

June 2005

Has Expanded Access No
Condition Browse
Study Design Info

Observational Model: Defined Population

Time Perspective: Prospective

Source: ClinicalTrials.gov