The Study of Infection and Cell Inflammation in Peritoneal Dialysate
November 23, 2005 updated by: National Taiwan University Hospital
A progressive decline of plasma triggering receptor expressed on myeloid cells-1 (TREM-1) concentration indicates a favorable clinical evolution during the recovery phase of sepsis.
The expression of TREM-1 in dialysate of peritoneal dialysis patients was not yet documented.
We will collect the dialysate of peritonitis in peritoenal dialysis patients and analyze the time serial change.
Study Overview
Status
Unknown
Conditions
Detailed Description
The triggering receptor expressed on myeloid cells-1 (TREM-1) is a member of the immunoglobulin superfamily, and its expression is upregulated on phagocytic cells in the presence of bacteria or fungi (1).
Several experiments by Bouchon and colleagues showed that TREM-1 mediates the acute inflammatory response to microbial products.
Human tissues infected with bacteria are infiltrated with neutrophils and macrophages that express high levels of TREM-1.
Conversely, TREM-1 is only weakly expressed in samples from patients with noninfectious inflammatory disorders.
In addition, TREM-1 is shed from the membrane of activated phagocytes and can be found in a soluble form in body fluids.
The presence of a soluble form of TREM-1 in samples of bronchoalveolar lavage fluid from mechanically ventilated patients has been shown to be a good indicator of infectious pneumonia.
During sepsis, a progressive decline of plasma sTREM-1 concentration indicates a favorable clinical evolution during the recovery phase of sepsis.
In addition, baseline sTREM-1 level may prove useful in predicting outcome of septic patients.
We will collect the dialysate of peritonitis in peritoneal dialysis patients and analyze the time serials change.
Study Type
Observational
Enrollment
100
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
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Taipei, Taiwan
- Recruiting
- National Taiwan University Hospital
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Contact:
- Vincent Wu, MD
- Phone Number: 886-2-2356-2000
- Email: walt-wu@yahoo.com.tw
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Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years to 80 years (Adult, Older Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
Inclusion Criteria:
peritoneal dialysis patients, dialysis period for more than 3 months.
Exclusion Criteria:
age younger than 18 years old, Pregnant or lactating women. (Pre-menopause women, capable of bearing children will undergo pregnancy test)
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Investigators
- Study Chair: Kwan-Dun Wu, MD, PhD, National Taiwan University
Publications and helpful links
The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.
General Publications
- Gibot S, Cravoisy A, Levy B, Bene MC, Faure G, Bollaert PE. Soluble triggering receptor expressed on myeloid cells and the diagnosis of pneumonia. N Engl J Med. 2004 Jan 29;350(5):451-8. doi: 10.1056/NEJMoa031544.
- Bouchon A, Dietrich J, Colonna M. Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes. J Immunol. 2000 May 15;164(10):4991-5. doi: 10.4049/jimmunol.164.10.4991.
- Bouchon A, Facchetti F, Weigand MA, Colonna M. TREM-1 amplifies inflammation and is a crucial mediator of septic shock. Nature. 2001 Apr 26;410(6832):1103-7. doi: 10.1038/35074114.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
June 1, 2005
Study Completion
June 1, 2009
Study Registration Dates
First Submitted
September 12, 2005
First Submitted That Met QC Criteria
September 12, 2005
First Posted (Estimate)
September 15, 2005
Study Record Updates
Last Update Posted (Estimate)
November 24, 2005
Last Update Submitted That Met QC Criteria
November 23, 2005
Last Verified
June 1, 2005
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 9461700636
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