Sulindac in Preventing Breast Cancer in Women at High Risk for Breast Cancer

May 1, 2013 updated by: National Cancer Institute (NCI)

Phase IB Sulindac Study for Women at High Risk for Breast Cancer

RATIONALE: Chemoprevention is the use of certain drugs to keep cancer from forming, growing, or coming back. The use of sulindac may prevent breast cancer.

PURPOSE: This randomized phase I trial is studying the effects of sulindac, to prevent breast cancer, in women at high risk for breast cancer.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

OBJECTIVES:

Primary

  • Determine the partitioning of sulindac and its metabolites in women at high risk for breast cancer by measuring drug and metabolite levels in nipple aspirate fluid (NAF) after 6 weeks of therapy.

Secondary

  • Determine prostaglandin levels in the NAF of patients treated with this drug.
  • Determine if NAG-1 levels are induced in the NAF of patients treated with this drug.
  • Determine if C-reactive protein levels are reduced in the NAF of patients treated with this drug.
  • Determine if NAG-1 levels and/or karyometric features in ductal epithelial cells are modulated in patients treated with this drug.

OUTLINE: This is a randomized, open-label study.

Patients undergo nipple aspirate fluid (NAF) collection. Patients are then randomized to 1 of 2 treatment arms.

  • Arm I: Patients receive oral sulindac once daily.
  • Arm II: Patients receive oral sulindac twice daily. In both arms, treatment continues for 6 weeks in the absence of disease progression or unacceptable toxicity. All patients then undergo a second NAF collection.

After completion of study treatment, patients are followed at 2 weeks.

PROJECTED ACCRUAL: A total of 30 patients (15 per treatment arm) will be accrued for this study.

Study Type

Interventional

Enrollment (Anticipated)

30

Phase

  • Phase 1

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • United States
    • Arizona
      • Tucson, Arizona, United States, 85724-5024
        • Arizona Cancer Center at University of Arizona Health Sciences Center

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 65 years (Adult, Older Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

Female

Description

DISEASE CHARACTERISTICS:

  • Meets 1 of the following criteria:

    • Gail assessment score > 1.7% risk for 5 years
    • History of lobular carcinoma in situ (pathology report required)
    • History of ductal carcinoma in situ (DCIS) (pathology report required)
    • History of breast cancer in ≥ 1 first-degree relative or history of BRCA1 or BRCA2 positivity not treated with oophorectomy or mastectomy (test report required)
    • History of breast cancer in ≥ 2 second-degree relatives
    • Any family history of breast cancer diagnosed prior to age 50
    • Personal history of breast cancer (invasive or DCIS) with 1 breast intact
  • Nipple aspirate fluid production ≥ 5 microliters

  • Negative mammogram for breast cancer within the past 10 months

    • Any suspicious breast masses must be examined by a clinical professional

  • Hormone receptor status:

    • Not specified

PATIENT CHARACTERISTICS:

Sex

  • Female

Menopausal status

  • Pre- or postmenopausal

Performance status

  • Karnofsky 80-100%

Life expectancy

  • Not specified

Hematopoietic

  • WBC ≥ 3,000/mm^3
  • Absolute neutrophil count ≥ 1,500/mm^3
  • Platelet count ≥ 100,000/mm^3
  • No history of bleeding or clotting disorder

Hepatic

  • Bilirubin ≤ 2.0 mg/dL
  • AST and ALT ≤ 2.0 times upper limit of normal
  • No indication of abnormal liver function

Renal

  • Creatinine normal

Cardiovascular

  • No symptomatic congestive heart failure
  • No unstable angina pectoris
  • No cardiac arrhythmia

Gastrointestinal

  • No frequent, chronic, or moderate/severe gastric complaint
  • No upper gastrointestinal problems (e.g., symptoms of heartburn, dyspepsia, or abdominal pain) requiring prescription or nonprescription medical remedies more than once per week (on average)
  • No history of peptic ulcer or occult or gross intestinal bleeding

Other

  • Not pregnant or nursing
  • Negative pregnancy test
  • Fertile patients must use effective contraception
  • No history of allergic reaction (e.g., urticaria, asthma, rhinitis) or gastric intolerance attributed to compounds of similar chemical or biological composition to sulindac
  • No history of allergy attributed to lidocaine, EMLA® cream, or xylocaine
  • No concurrent uncontrolled illness
  • No ongoing or active infection
  • No psychiatric illness or social situation that would preclude study compliance
  • No more than 2-3 servings of alcohol per week during study participation

PRIOR CONCURRENT THERAPY:

Chemotherapy

  • More than 6 months since prior chemotherapy for breast cancer (invasive or DCIS)

Endocrine therapy

  • More than 6 months since prior hormonal therapy for breast cancer (invasive or DCIS)
  • No concurrent hormone-suppressing agents (e.g., tamoxifen or anastrozole)
  • No concurrent selective estrogen-receptor modulators
  • No concurrent aromatase inhibitors

Radiotherapy

  • More than 6 months since prior radiotherapy for breast cancer (invasive or DCIS)

Surgery

  • See Disease Characteristics
  • No prior breast duct-disrupting surgery (e.g., mastectomy) that would preclude ductoscopy

Other

  • More than 3 months since prior warfarin or other systemic anticoagulant
  • More than 4-6 weeks since prior nonsteroidal anti-inflammatory drugs
  • No concurrent phenytoin or sulfonamides
  • No concurrent warfarin or other systemic anticoagulant
  • No other concurrent nonsteroidal anti-inflammatory drugs (including low-dose aspirin)
  • No concurrent large doses of supplements, vitamins (> regular daily multivitamin) and/or herbal medicines (e.g., echinacea, ginkgo biloba, Hypericum perforatum [St. John's wort], or herbal tea)
  • No other concurrent investigational agents

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Prevention
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: None (Open Label)

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Sulindac and sulindac metabolite levels in nipple aspirate fluid (NAF) after 6 weeks of treatment

Secondary Outcome Measures

Outcome Measure
Prostaglandin (PGE2) levels in NAF before and after 6 weeks of treatment
NAG-1 induction and C-reactive protein (CRP) reduction before and after 6 weeks of treatment
Magnitude of change and dose response of PGE2, NAG-1, and CRP in NAF before and after 6 weeks of treatment

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

National Cancer Institute (NCI)

Collaborators

University of Arizona

Investigators

  • Study Chair: Patricia Thompson, PhD, University of Arizona

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

November 1, 2005

Primary Completion (Actual)

August 1, 2007

Study Completion (Actual)

January 1, 2010

Study Registration Dates

First Submitted

October 25, 2005

First Submitted That Met QC Criteria

October 25, 2005

First Posted (Estimate)

October 27, 2005

Study Record Updates

Last Update Posted (Estimate)

May 3, 2013

Last Update Submitted That Met QC Criteria

May 1, 2013

Last Verified

October 1, 2011

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • CDR0000447144
  • P30CA023074 (U.S. NIH Grant/Contract)
  • UARIZ-UAZ04-2-02
  • UARIZ-HSC-0553

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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