Physical Activity, Insulin Resistance and Function of Fat Tissue in the Offspring of Patients With Type 2 Diabetes
April 19, 2007 updated by: NHS Greater Glasgow and Clyde
Physical Activity, Insulin Resistance and Adipose Tissue Gene Expression in the Offspring of Patients With Type 2 Diabetes
Offspring of patients with type 2 diabetes have increased risk of developing diabetes and are typically more insulin resistant than their peers with no diabetes family history.
We have recently demonstrated that, in contrast to their sedentary counterparts, physically active offspring are not insulin resistant.
In the proposed controlled clinical study, we will examine the effects of a moderate exercise programme on insulin resistance, and other metabolic risk factors, in sedentary offspring and matched control subjects.
We hypothesise that offspring will exhibit an augmented response to exercise, thereby normalising their predisposition to an adverse metabolic profile.
We will also investigate expression of adipokines and other genes in adipose tissue to determine whether these contribute to the increased insulin resistance observed in offspring and whether they are influenced by exercise.
The results will help to determine the efficacy of exercise in normalising metabolism in offspring and will help elucidate the mechanisms involved.
Study Overview
Status
Completed
Conditions
Intervention / Treatment
Study Type
Interventional
Enrollment
80
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
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Glasgow, United Kingdom, G12 8QQ
- University of Glasgow
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Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
20 years to 45 years (Adult)
Accepts Healthy Volunteers
Yes
Genders Eligible for Study
Female
Description
Inclusion Criteria:
- 2 subject groups - 'control' and 'offspring'
- Offspring - at least 1 parent diagnosed with type 2 diabetes before age 65
- Controls - no history of type 2 diabetes in 1st or 2nd degree relatives
- In generally good health
- Non-smoker
- Fasting glucose < 7 mmol/l
- Blood pressure <160/90 mm Hg
- No established CHD (e.g. MI, stroke, CABG, PCTA)
Exclusion Criteria:
- Established CHD (e.g. MI, stroke, CABG, PCTA)
- diabetes
- smoking
- hypertension (BP > 160/90 mmHg)
- pregnancy
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Factorial Assignment
- Masking: None (Open Label)
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
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Insulin resistance at 8 weeks
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Risk markers for cardiovascular disease/diabetes at 8 weeks
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Adipose tissue gene expression at 8 weeks
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Secondary Outcome Measures
Outcome Measure |
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Fitness at 8 weeks
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Body composition/adiposity at 8 weeks
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Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Collaborators
Investigators
- Principal Investigator: Jason MR Gill, BSc MSc PhD, University of Glasgow
Publications and helpful links
The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.
General Publications
- Higgins S, Gill JM, Janilionyte R, Caslake MJ, Malkova D. Physical activity, dietary intake and metabolic risk factors in non-diabetic daughters of patients with type II diabetes. Prev Med. 2005 Feb;40(2):145-51. doi: 10.1016/j.ypmed.2004.05.004.
- Barwell ND, Malkova D, Moran CN, Cleland SJ, Packard CJ, Zammit VA, Gill JM. Exercise training has greater effects on insulin sensitivity in daughters of patients with type 2 diabetes than in women with no family history of diabetes. Diabetologia. 2008 Oct;51(10):1912-9. doi: 10.1007/s00125-008-1097-6. Epub 2008 Jul 29.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
September 1, 2004
Study Completion (Actual)
February 1, 2007
Study Registration Dates
First Submitted
December 21, 2005
First Submitted That Met QC Criteria
December 21, 2005
First Posted (Estimate)
December 22, 2005
Study Record Updates
Last Update Posted (Estimate)
April 20, 2007
Last Update Submitted That Met QC Criteria
April 19, 2007
Last Verified
April 1, 2007
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 03BI004
- BHF Project Grant PG/03/145
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