Does Statin Therapy Reduce Sympathoexcitation in Hypertension?
September 29, 2008 updated by: Radboud University Medical Center
A number of patients with hypertension have increased central sympathetic activity.
Statins seem to inhibit central sympathetic output.
This study assesses the effect of statins on central sympathetic activity in hypertension patients.
Study Overview
Study Type
Interventional
Enrollment (Anticipated)
13
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
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NIjmegen, Netherlands, 6500 HB
- Radboud University Medical Center Nijmegen
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Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
14 years to 66 years (Adult, Older Adult)
Accepts Healthy Volunteers
N/A
Genders Eligible for Study
All
Description
Inclusion Criteria:
- (Known) hypertension
- stable drug therapy for at least 2 months
- age 18-70 jaar
- BMI 18-35 kg/m2
- Sinusrhythm
Exclusion Criteria:
- Recent cardiovascular event <6 mnd
- Plasma Creatinin:
- female: >120 mmol/L
- male: >133 mmol/L
- use of:
- tricyclic antidepressants
- alpha-1 -and/or alpha-2 blockers
- disease of the autonomic nervous system (Parkinsons disease, Shy- Drager syndrome, etc)
- Albuminuria >300 mg/dag
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Allocation: Randomized
- Interventional Model: Crossover Assignment
- Masking: Double
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
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change in central sympathetic activity
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Secondary Outcome Measures
Outcome Measure |
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change in cholesterol levels, renin and aldosteron
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Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Investigators
- Principal Investigator: Cees J Tack, MD, PhD, Radboud University Medical Center
Publications and helpful links
The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
May 1, 2007
Study Completion (Actual)
March 1, 2008
Study Registration Dates
First Submitted
July 4, 2007
First Submitted That Met QC Criteria
July 4, 2007
First Posted (Estimate)
July 6, 2007
Study Record Updates
Last Update Posted (Estimate)
September 30, 2008
Last Update Submitted That Met QC Criteria
September 29, 2008
Last Verified
September 1, 2008
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- HTSTAT
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.