A Randomized Controlled Trial on the Effect of Exercise on Physical, Cognitive and Affective Function in Dementia Subjects

To Study the Effect of Exercise Training in Term of Aerobic Exercise for 3 Months, on the Physical, Cognitive and Affective Function in Dementia Subjects


Lead Sponsor: Hospital Authority, Hong Kong

Source Hospital Authority, Hong Kong
Brief Summary

Studies have shown conflicting results of the effect of exercise on dementia patients.

The aim of this study is to examine the role of physical activity on the risk of cognitive impairment and dementia in older persons.

To promote the benefits of aerobic exercise on dementia patients and encourage exercise prescription in the management of dementia subjects.

Overall Status Unknown status
Start Date January 2006
Completion Date October 2007
Phase N/A
Study Type Interventional
Primary Outcome
Measure Time Frame
Physical function measurement using SF-12 every 3 months for 1 year
Affective function measurement by Cornell depression score every 3 months for 1 year
Cognitive function by MMSE and ADAS-cog every 3 months for 1 year
Secondary Outcome
Measure Time Frame
6 minutes walk, functional reach, Berg balance scale every 3 months for 1 year
Carer stress scale every 3 months for 1 year
No. of fall/restricted activity days/time spend in exercise or walking every 3 months for 1 year
Enrollment 64

Intervention Type: Procedure

Intervention Name: Aerobic exercise training



Inclusion Criteria:

- MMSE<26

- Age >60

- Community dwelling and ambulatory

- Have a caregiver that is willing to participate and escort patient to hospital for training and assessment

Exclusion Criteria:

- MMSE<10

- live in old age home

- poor mobility, unable to attend exercise training

- no carer to bring patient to attend hospital training

Gender: All

Minimum Age: 60 Years

Maximum Age: N/A

Overall Official
Last Name Role Affiliation
Doris KY Miu, Dr Principal Investigator Department of Medicine and Geriatrics, Kwong Wah Hospital
Overall Contact

Last Name: Doris KY Miu, Dr

Phone: (852) 3517 5326

Email: [email protected]

Facility: Status: Investigator: Kwong Wah Hospital Ying Fai Mak, Dr Sub-Investigator
Location Countries


Verification Date

July 2010

Has Expanded Access No
Condition Browse
Study Design Info

Allocation: Randomized

Intervention Model: Parallel Assignment

Masking: Single

Source: ClinicalTrials.gov