Using the Digital EEG Spectral Analysis in Assessing Neuroelectrical Processing Abnormalities in Autism

Individuals with Autism Spectrum Disorder will have abnormal DESA® results. Our objective is to use neuroelectrical measures to determine the degree of processing abnormalities in individuals with Autism. The study will survey processing patterns and will locate and evaluate the degree(s) of abnormalities for further study. The abnormal results of comprehensive neuroelectrical evaluations of individuals with Autism when compared to the normative database will provide objective, verifiable, neurophysiological information with which to form novel approaches to the disorder.

Study Overview

• Status: Withdrawn
• Conditions: Autistic Disorder; Asperger Syndrome; Autism, Early Infantile; Autism, Infantile

Detailed Description

The research method will be: gathering, analyzing and utilizing data.

We will observe research subjects through neuroelectrical instrumentation, then, compare results to retrospective information collected from research subjects and a normative database.

A qualified neurologist thoroughly familiar with electrophysiology will interpret the data, and analyze it to explore the abnormalities.

The hypothesis will be evaluated.

We will, then, utilize the results to find data-based forms of treatment for those with the disorder.

• Study Type: Observational
• Enrollment (Anticipated): 200

Contacts and Locations

Study Locations

• United States
  • California
    • Northridge, California, United States, 91326
      • Yellen & Associates, Inc.

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 5 years to 25 years (ADULT, CHILD)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

The study population includes individuals with Autism without exclusion on the basis of sex, gender, race or ethnicity. There will be 100 research subjects, with a ratio of four males to one female, and those being approximately sixty-five children and thirty-five adults.

Description

Inclusion Criteria:

• The study will include children between the ages of five and eighteen, adults from the age of nineteen to twenty-five, and those with the diagnosis of Autism and Autism Spectrum Disorders.

Exclusion Criteria:

• those with mental retardation
• those with any other neurological disorder
• those that cannot sit in a chair for one hundred and fifty minutes
• those that have been previously diagnosed with a seizure disorder
• those who are blind and/or deaf
• those who are not ambulatory
• those who cannot understand English
• those that are not a resident of Los Angeles County

Study Plan

How is the study designed?

Number of groups / cohorts

2

Cohorts and Interventions

Group / Cohort
1; Year one
2; Year two

Collaborators and Investigators

• Sponsor: Yellen & Associates, Inc.
• Investigators: Principal Investigator: Andrew G Yellen, PhD, President, Yellen & Associates, Inc.; Study Chair: Thomas Schweller, MD, Neurologist

Study record dates

Study Major Dates

• Study Start: January 1, 2010
• Primary Completion (ANTICIPATED): January 1, 2011
• Study Completion (ANTICIPATED): December 1, 2012

Study Registration Dates

• First Submitted: June 5, 2008
• First Submitted That Met QC Criteria: June 6, 2008
• First Posted (ESTIMATE): June 9, 2008

Study Record Updates

• Last Update Posted (ESTIMATE): October 2, 2009
• Last Update Submitted That Met QC Criteria: October 1, 2009
• Last Verified: October 1, 2009

More Information

Terms related to this study

• Keywords: Electroencephalography; Brain Mapping; Evoked Potentials; Evoked Potentials, Visual; Evoked Potentials, Auditory
• Additional Relevant MeSH Terms: Mental Disorders; Neurodevelopmental Disorders; Child Development Disorders, Pervasive; Autism Spectrum Disorder; Autistic Disorder; Asperger Syndrome
• Other Study ID Numbers: PA-06-278