- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00798564
Exercise Induced Asthma and Airway Reactivity in Athletes
Explorative Study "Exercise Induced Asthma and Airway Reactivity in Athletes"
Study Overview
Status
Conditions
Detailed Description
By non-invasive tools the investigators wish to characterize type of airway reaction to various provocative stimuli in athletes doing two different sort activities, Tennis or swimming. As controls are being used sedentary age-matched controls from the same region, exposed to the same school environment. Thus we wish to:
- explore the prevalence of positive mannitol reactivity among swimmers and tennis player and how this relates to symptoms, disease history and to a sport specific exercise provocation test.
- compare the results from sport specific testing with a standardized eucapnic hyperventilation test (EHV)
- compare the overall reactivity to mannitol or EHV among swimmers and tennis players compared to aged matched controls.
- explore the role by CC16 in airway reactivity to different provocative stimuli and to see whether there is a difference between different sport activities, different test protocols and between athletes and controls.
- explore evidence of eicosanoid related inflammatory reaction in athletes and controls in relation to different provocative stimuli
The study population consists of 100 elite swimmers, 100 elite tennis players and 100 non-elite, eged matched controls. In the latter group, 30 are aged matched non-atopic non-asthmatic controls.
Study Type
Enrollment (Actual)
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Sampling Method
Study Population
Description
Inclusion Criteria:
- Subjects aged 16-19 from Skåne.
- All should approve attendance in the study by signing an informed consent. Igf they are aged under 18, parents should also sign.
- Three groups are included
- Elite aspiring swimmers with an average training intensity of at least hours per week the last year.
Exclusion Criteria:
Study Plan
How is the study designed?
Design Details
Collaborators and Investigators
Sponsor
Collaborators
Investigators
- Principal Investigator: Leif H Bjermer, MD, PhD, Lund University
Study record dates
Study Major Dates
Study Start
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 34797
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