Risk Factors for Postpartum Psychosis (RIFPP)

Potential Risk Factors for Postpartum Psychosis

A range of psychological disorders occur in women in the postpartum period. These include "the blues", which occurs in the first days after birth and which is very common and self-limiting; severe psychoses often associated with mania or bipolar illness, occurring in the first weeks after birth; and mild to moderate depression, occurring weeks to months after birth. Studies have been done focused on postpartum psychosis using a retrospective investigation, which gave only a limited material on the prevalence of psychological disorders in postpartum women. The investigators hypothesized that different pathways to psychosis function as the risk factors which may be overlapped, truly independent, mediating, or moderating, in new mothers who are at high risk and/or during the early period of delivery. In addition, the investigators purposed that the temporal sequence of biological, social and demographic variables are also the potential factors contributing to the development of postpartum psychosis.

Study Overview

• Status: Completed
• Conditions: Psychosis; Postpartum Period

• Study Type: Observational
• Enrollment (Actual): 4000

Contacts and Locations

Study Locations

• China
  • Jiangsu
    • Nanjing, Jiangsu, China, 210004
      • Nanjing Maternal and Child Health Care Hospital

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 50 years (Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: Female

• Sampling Method: Probability Sample

Study Population

Parturients undergoing spontaneous or induced labor or cesarean delivery

Description

Inclusion Criteria:

• Pregnant women
• Chinese

Exclusion Criteria:

• Age < 18 years or > 50 years
• Gestational age < 32 weeks

Study Plan

How is the study designed?

Number of groups / cohorts

2

Cohorts and Interventions

Group / Cohort
1; Psychoses within the first 3 months postpartum
2; Psychoses > 3 months to 6 months postpartum

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Incidence of psychoses	3 months and 6 months postpartum

Secondary Outcome Measures

Outcome Measure	Time Frame
Antepartum economic level	One year before labor and delivery (recorded by antepartum communication)
Antepartum social status	One year before labor and delivery (recorded by antepartum communication)
Antepartum psychological level	1 day before birth
Intrapartum complications	1 day after birth
Baby characteristics	One minute, 5min, 15min after baby was born
Maternal characteristics	One day after birth
Medical caregiver characteristics	One day before and after the labor completion
Parturient family characteristics	One week before labor and delivery, recorded by investigators through patients' antepartum communication
Intrapartum medical procedures	One day after birth

Collaborators and Investigators

• Sponsor: Nanjing Medical University

Study record dates

Study Major Dates

• Study Start: February 1, 2009
• Primary Completion (Actual): August 1, 2012
• Study Completion (Actual): August 1, 2012

Study Registration Dates

• First Submitted: March 30, 2009
• First Submitted That Met QC Criteria: March 30, 2009
• First Posted (Estimate): March 31, 2009

Study Record Updates

• Last Update Posted (Estimate): January 14, 2014
• Last Update Submitted That Met QC Criteria: January 11, 2014
• Last Verified: January 1, 2014

More Information

Terms related to this study

• Keywords: Labor; Psychology; Postpartum Psychology
• Additional Relevant MeSH Terms: Schizophrenia Spectrum and Other Psychotic Disorders; Psychotic Disorders; Mental Disorders
• Other Study ID Numbers: NMU-200903-MZ003; NJFY09102M107