Natriuretic Peptides - Predictors of In-hospital and Long-term Major Adverse Cardiac Events After Emergency Surgery?

Prospective Study to Evaluate the Predictive Value of Brain Natriuretic Peptides for Adverse Long-term Cardiac Outcome

The investigators hypothesize that the level of perioperative natriuretic peptides is associated with in-hospital and long term major adverse cardiac events.

Study Overview

• Status: Completed
• Conditions: Surgery

Detailed Description

The purpose of the study is to measure levels of brain natriuretic peptides before and after urgent non-cardiac surgery and to evaluate their predictive value for adverse long-term outcome.

• Study Type: Observational
• Enrollment (Actual): 297

Contacts and Locations

Study Locations

• Austria
  • Graz, Austria, 8036
    • Department of Anesthesia and Intensive Care Medicine

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 50 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

Consecutive patients undergoing emergency non-cardiac surgery

Description

Inclusion criteria:

• Emergency surgery:

  1. Vascular
  2. Intra-abdominal

  3. Orthopedic

     Exclusion Criteria:

• Patients unable to provide informed consent
• Thoracic surgery
• Trauma surgery

Study Plan

How is the study designed?

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort
No treatment; Consecutive patients undergoing emergency surgery

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Occurence of Adverse Cardiac Events	Occurence of major adverse cardiac events (composite of nonfatal myocardial infarction, acute heart failure or death). Non-fatal Myocardial infarction was defined as a typical increase and decrease of troponin together with evidence of myocardial ischemia with at least one of the following: symptoms of ischemia, ECG changes indicative of ischemia or new Q waves, or imaging evidence of new regional wall motion abnormality. Acute heart failure was defined as clinical signs and symptoms of heart failure with echocardiographic evidence of cardiac dysfunction and clinical response to treatment directed towards heart failure.	postoperatively (index surgery) until a median follow-up of 34 months

Other Outcome Measures

Outcome Measure	Measure Description	Time Frame
NT-ProBNP Preoperative	NT-ProBNP was measured 0-24 hours before induction of anesthesia	0-24 hours before induction of anesthesia
Association Between Preoperative NT-ProBNP and Occurence of Adverse Cardiac Events	Evaluation of the association between preoperative NT-ProBNP and occurence of adverse cardiac events	postoperatively (index surgery) until a median follow-up of 34 months

Collaborators and Investigators

• Sponsor: Medical University of Graz
• Investigators: Principal Investigator: Elisabeth Mahla, M.D., Department of Anesthesiology and Intensive Care Medicine, Medical University of Graz

Study record dates

Study Major Dates

• Study Start: February 1, 2008
• Primary Completion (Actual): January 1, 2014
• Study Completion (Actual): February 1, 2014

Study Registration Dates

• First Submitted: July 18, 2009
• First Submitted That Met QC Criteria: July 20, 2009
• First Posted (Estimate): July 21, 2009

Study Record Updates

• Last Update Posted (Estimate): June 29, 2015
• Last Update Submitted That Met QC Criteria: June 9, 2015
• Last Verified: June 1, 2015

More Information

Terms related to this study

• Keywords: natriuretic peptides; emergency non-cardiac surgery
• Other Study ID Numbers: 19-077 ex 07/08