Energy Expenditure Responses to Acute Exercise in Older Women (Calorie Expenditure and Exercise) (CEE)

Energy Expenditure Responses to Acute Exercise in Older Women

In older, normal-weight women (60-75 yrs, BMI=18-28 kg/m2), an acute bout of higher-intensity (60% of maximum effort) aerobic exercise, in comparison to an isocaloric bout of lower-intensity (45% of maximum effort) exercise (caloric expenditure of 3.5 kcal/kg body weight for both), will result in differential:

1. decline in non-exercise activity calorie expenditure in the subsequent 48 hours after exercise;
2. increase in resting metabolic rate 48 hours after exercise;
3. increase in serum free triiodo-L-thyronine (free T3) concentrations immediately following exercise;
4. decline from pre-exercise in plasma leptin and serum free T3 concentrations 48 hours after exercise.

Study Overview

• Status: Completed
• Conditions: Aging
• Intervention / Treatment: Other: exercise

• Study Type: Interventional
• Enrollment (Actual): 26
• Phase: Not Applicable

Contacts and Locations

Study Locations

• United States
  • Missouri
    • St. Louis, Missouri, United States, 63110
      • Washington University School of Medicine

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 60 years to 75 years (Adult, Older Adult)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: Female

Description

Inclusion Criteria:

1. Women
2. Age 60-75 years
3. normal weight
4. Weight-stable (± 5%) within the previous 3 months
5. Non-smoking for last year
6. Able to provide own transportation to study visits
7. Not currently involved in any other research study
8. Willing and able to participate in all aspects of the trial including research testing
9. Willing to give informed consent to participate

Exclusion Criteria:

1. Self-reported significant cardiovascular disease
2. Other self-reported medical conditions such as diabetes, chronic or recurrent respiratory conditions, active cancer, musculoskeletal disease
3. Medications known to affect exercise performance or metabolism
4. Excess caffeine use (> 500mg/day)
5. Any self-reported contraindications to exercise
6. Clinical depression
7. Abnormal cognitive function -

Study Plan

How is the study designed?

Design Details

• Allocation: Randomized
• Interventional Model: Crossover Assignment
• Masking: None (Open Label)

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
non-exercise activity calorie expenditure	2 days after exercise sessions

Secondary Outcome Measures

Outcome Measure	Time Frame
resting metabolic rate	2 days after exercise sessions

Collaborators and Investigators

• Sponsor: Washington University School of Medicine
• Collaborators: National Institute on Aging (NIA)
• Investigators: Principal Investigator: Xuewen Wang, PhD, Washington University School of Medicine

Study record dates

Study Major Dates

• Study Start: October 1, 2009
• Primary Completion (Actual): December 1, 2011
• Study Completion (Actual): December 1, 2011

Study Registration Dates

• First Submitted: October 1, 2009
• First Submitted That Met QC Criteria: October 1, 2009
• First Posted (Estimate): October 2, 2009

Study Record Updates

• Last Update Posted (Estimate): December 6, 2011
• Last Update Submitted That Met QC Criteria: December 2, 2011
• Last Verified: December 1, 2011

More Information

Terms related to this study

• Keywords: exercise; energy expenditure; older; RMR; NEAT
• Other Study ID Numbers: 09-0864; K99AG031297 (U.S. NIH Grant/Contract)