- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01023997
Central Corneal Thickness in Glaucoma
May 9, 2014 updated by: AGP Konstas, Aristotle University Of Thessaloniki
Central Corneal Thickness in Patients With Exfoliation Syndrome, Exfoliative Glaucoma, Exfoliative Glaucoma, Primary Open-angle Glaucoma and Ocular Hypertension
The purpose of this study is to compare the central corneal thickness measurement in patients with exfoliation syndrome, exfoliative glaucoma, primary open-angle glaucoma, ocular hypertension and normal controls and to evaluate the value of corneal thickness in the diagnosis and management of glaucoma.
Study Overview
Status
Completed
Conditions
Detailed Description
To compare the central corneal thickness measurement in patients with exfoliation, primary open-angle glaucoma, ocular hypertension and normal controls and to evaluate the value of corneal thickness in the diagnosis and management of glaucoma.
Prospective study in progress.
Randomly selected patients undergo a comprehensive ophthalmic exam which includes 2 separate pachymetry measurements in 2 different examinations at the same time of the day (10:00 am) with 3 different pachymeters.
The values obtained are correlated with a number of other glaucoma parameters.
A thinner cornea may represent a specific attribute and an additional risk factor for patients with exfoliation.
Evaluation of corneal thickness is an important exam in the management of patients with exfoliation.
Study Type
Observational
Enrollment (Actual)
700
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
-
Thessaloniki, Greece, 546 36
- Glaucoma Unit, 1st University Department of Ophthalmology
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
25 years to 89 years (Adult, Older Adult)
Accepts Healthy Volunteers
Yes
Genders Eligible for Study
All
Sampling Method
Probability Sample
Study Population
individuals with and without exfoliation
Description
Inclusion Criteria:
- Exfoliation material on pupil
- Intraocular pressure below 21 mm Hg without glaucomatous damage
- Intraocular pressure above 21 mm Hg without glaucomatous damage
- Raised intraocular pressure with glaucomatous damage
Exclusion Criteria:
- Corneal disorders
- History of trauma
- Evidence of corneal abnormality that may influence IOP
- Contact lens use
- Corneal surgery
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
---|
normal controls
|
primary open-angle glaucoma
|
ocular hypertension patients
|
Exfoliation patients
patients with exfoliation syndrome or exfoliative glaucoma
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
central corneal thickness
Time Frame: Morning measurement (10:00-11:00)
|
Morning measurement (10:00-11:00)
|
Secondary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Visual field, scanning laser polarimetry
Time Frame: 10:00-11:00
|
10:00-11:00
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Investigators
- Study Director: Kostantinos Kaltsos, MD, PhD, 1st University Dept of Ophthalmology
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
January 1, 2008
Primary Completion (Actual)
January 1, 2013
Study Completion (Actual)
January 1, 2013
Study Registration Dates
First Submitted
December 1, 2009
First Submitted That Met QC Criteria
December 1, 2009
First Posted (Estimate)
December 2, 2009
Study Record Updates
Last Update Posted (Estimate)
May 12, 2014
Last Update Submitted That Met QC Criteria
May 9, 2014
Last Verified
May 1, 2014
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- A3502
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Exfoliation Syndrome
-
AurolabUnknown
-
University of Occupational and Environmental HealthUnknownCataract With Exfoliation SyndromeJapan
-
St. Erik Eye HospitalTerminatedGlaucoma, Open-Angle | Pseudo Exfoliation SyndromeSweden
-
St. Erik Eye HospitalCompletedOcular Hypertension | Glaucoma | Open Angle Glaucoma | Pseudo Exfoliation SyndromeSweden
-
Helsinki University Central HospitalRecruitingCataract | Exfoliation GlaucomaFinland
-
St. Erik Eye HospitalRecruitingPseudo Exfoliation Syndrome | Glaucoma Open-Angle PrimarySweden
-
Assiut UniversityRecruitingPseudoexfoliation SyndromeEgypt
-
General Hospital Sveti DuhCompletedPseudoexfoliation SyndromeCroatia
-
Aristotle University Of ThessalonikiCompleted