Effects of Betaine Supplementation on Strength and Muscle Creatine Content

January 12, 2012 updated by: Bruno Gualano, University of Sao Paulo

Effects of Betaine Supplementation Combined or Not With Creatine Supplementation on Muscle Creatine Content and Strength

It has been suggested that betaine supplementation may improve muscle strength by increasing muscle creatine content. However, there is no data supporting this assumption. The investigators speculate that betaine supplementation could enhance intramuscular creatine content, which would result in strength improvements.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Actual)

40

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Brazil
      • Sao Paulo, Brazil, 05508-030
        • University of Sao Paulo

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

16 years to 28 years (Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

Male

Description

Inclusion Criteria:

  • physically inactive
  • non-obese

Exclusion Criteria:

  • skeletal muscle disturbance
  • cardiovascular disturbance
  • use of dietary supplements

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Double

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: creatine
will receive creatine monohydrate (20g/d) throughout 10 days
Dietary supplement: creatine
20g/d throughout 10 days
Experimental: betaine
will receive betaine (2g/d) throughout 10 days
Dietary supplement: betaine
2g/d throughout 10 days
Placebo Comparator: placebo (dextrose)
will receive dextrose(20g/d)throughout 10 days.
Dietary supplement: dextrose
dextrose (placebo), 20 g/d throughout 10 days
Active Comparator: creatine plus betaine
will receive creatine (20g/d) plus betaine (2g/d) throughout 10 days
Dietary supplement: creatine plus betaine
creatine (20g/d) plus betaine (2g/d) throughout 10 days

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
strength
Time Frame: after 10 days
after 10 days

Secondary Outcome Measures

Outcome Measure
Time Frame
intramuscular creatine content
Time Frame: after 10 days
after 10 days

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

University of Sao Paulo

Investigators

  • Study Director: Bruno Gualano, PhD, University of Sao Paulo

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

October 1, 2010

Primary Completion (Actual)

July 1, 2011

Study Completion (Actual)

July 1, 2011

Study Registration Dates

First Submitted

October 1, 2010

First Submitted That Met QC Criteria

October 1, 2010

First Posted (Estimate)

October 4, 2010

Study Record Updates

Last Update Posted (Estimate)

January 16, 2012

Last Update Submitted That Met QC Criteria

January 12, 2012

Last Verified

January 1, 2012

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • betaine supplementation

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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