Effects of Resistance-band Training and Creatine Supplementation Strategies in Healthy Older Adults

Effects of Resistance-band Training and Creatine Supplementation in Healthy Older Adults

The primary purpose is to compare the effects of creatine supplementation (bolus ingestion of 5 grams vs. 3 grams) during 16 weeks of resistance-band training on measures of body composition (i.e., whole-body lean tissue mass, total body water), arm and leg muscle thickness (growth), muscle performance (i.e., power, strength, endurance) and functional ability (i.e., walking speed, balance).

A secondary purpose of this research is to examine the effects of bolus ingestion of creatine (5 grams) compared to intermittent ingestion of creatine (2 x 2.5 grams) during 16 weeks of resistance-band training on measures of body composition (i.e., whole-body lean tissue mass, total body water), arm and leg muscle thickness (growth), muscle performance (i.e., power, strength, endurance) and functional ability (i.e., walking speed, balance).

Study Overview

• Status: Recruiting
• Conditions: Aging
• Intervention / Treatment: Dietary supplement: Creatine Bolus 5; Dietary supplement: Creatine Bolus 3; Dietary supplement: Creatine Intermittent 5; Dietary supplement: Placebo

Detailed Description

Resistance-band training is safe, conveient, easy-to-use, eliminates potential barriers to exercise participation (i.e., lack of transportation to and from commercial training facilities) and results in high exercise compliance and adherence. Further, resistance-band training results in similar improvements in muscle performance and functional ability compared to traditional resistance-type training using free-weights and machines.

Creatine is a naturally occurring nitrogen-containing compound produced in the body in the liver and brain and can also be found in food products such as red meat and seafood or through commercially available manufactured creatine products.

Evidence-based research shows that creatine supplementation, when ingested during a resistance exercise training program, improves measures of lean mass and muscle growth, muscle performance and functional ability. However, the optimal creatine supplementation protocol to achieve these benefits is unknown.

• Study Type: Interventional
• Enrollment (Estimated): 52
• Phase: Not Applicable

Contacts and Locations

• Study Contact: Name: Darren Candow; Phone Number: 306-585-4906; Email: Darren.Candow@uregina.ca

Study Locations

• Canada
  • Saskatchewan
    • Regina, Saskatchewan, Canada, S4S4H4
      • Recruiting
      • University of Regina
      • Contact: Darren G Candow, PhD; Phone Number: 3062090280; Email: Darren.Candow@uregina.ca
      • Contact: Darren G Candow, PhD

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: Yes

Description

Inclusion Criteria:

• if you are 50 years of age and older
• if you have not been performing more than 1 resistance training session per week for the past 6 weeks or more.

Exclusion Criteria:

• if you have taken creatine supplements within 30 days prior to the start of the study
• if you have pre-existing allergies to the placebo (corn-starch maltodextrin).

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Triple

Number of Arms

4

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Placebo Comparator: Placebo	Dietary supplement: Placebo; (Serving: 8 grams of placebo in the morning; Servings 2: 8 grams of placebo at least 6 hours after Serving 1).
Experimental: Creatine Bolus 5	Dietary supplement: Creatine Bolus 5; (Serving 1: 5 grams of creatine + 3 grams of placebo in the morning; Serving 2: 8 grams of placebo at least 6 hours after Serving 1).
Experimental: Creatine Bolus 3	Dietary supplement: Creatine Bolus 3; (Serving 1: 3 grams of creatine + 5 grams of placebo in the morning; Serving 2: 8 grams of placebo at least 6 hours after Serving 1).
Experimental: Creatine Intermittent 5	Dietary supplement: Creatine Intermittent 5; (Serving 1: 2.5 grams of creatine + 5.5 grams of placebo in the morning, Serving 2: 2.5 grams of creatine + 5.5 grams of placebo at least 6 hours after Serving 1).

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Whole-body lean mass (kg)	Bioelectrical impedance analysis	baseline, week 16
Muscle Hypertrophy (cm)	B-mode ultrasound	baseline, week 16
Strength (kg)	1-repetition maximum leg press and chest press	baseline, week 16
Endurance (number of repetitions to fatigue)	Leg press and chest press	baseline, week 16
Power (feet)	medicine ball throw	baseline, week 16
Balance (Centre of Pressure)	Force Plate	baseline, week 16
Gait Speed (meters)	Walking distance	baseline, week 16

Collaborators and Investigators

• Sponsor: University of Regina
• Collaborators: Iovate Health Sciences International Inc
• Investigators: Principal Investigator: Darren Candow, University of Regina

Study record dates

Study Major Dates

• Study Start (Actual): August 20, 2024
• Primary Completion (Estimated): July 30, 2025
• Study Completion (Estimated): July 30, 2025

Study Registration Dates

• First Submitted: September 16, 2024
• First Submitted That Met QC Criteria: September 18, 2024
• First Posted (Actual): September 23, 2024

Study Record Updates

• Last Update Posted (Actual): September 23, 2024
• Last Update Submitted That Met QC Criteria: September 18, 2024
• Last Verified: September 1, 2024

More Information

Terms related to this study

• Keywords: Aging; Strength; Creatine; Muscle; Resistance-Bands
• Other Study ID Numbers: 853

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No
• product manufactured in and exported from the U.S.: No