Preoperative Biochemical Predictors of Outcome in Patients With Hip Fracture

Can Biochemical Tests Predict Outcome in Patients With Hip Fracture?

The objective of the study is to identify biochemical predictors of morbidity and mortality in patients suffering from hip fracture. For this purpose blood samples are collected prehospitally or in the emergency department in patients with a suspected hip fracture. During the hospital stay medical history, anesthesiological management recorded. In addition, american society of anesthesiology physiological score (ASA), revised cardiac risk index (RCRI), and POSSUM score is calculated. Morbidity and mortality is recorded " in house", after 30 days, after 4 months and after 1 year. Biochemical predictors of outcome will be evaluated with logistic regression analysis. Biochemical predictors include pro-brain natriuretic peptide, lactate, pro-calcitonin, adrenomedullin, copeptin, cystatin c. The predictive value of the potential markers will be compared to that of ASA, RCRI and POSSUM.

Study Overview

• Status: Completed
• Conditions: Hip Fracture

• Study Type: Observational
• Enrollment (Actual): 999

Contacts and Locations

Study Locations

• Sweden
  • Skane
    • Lund, Skane, Sweden, 22285
      • Skåne University Hospital, Lund

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

patients presenting with hip fracture at University Hospital Lund Sweden

Description

Inclusion Criteria:

• Patients presenting with out of hospital hip fracture at University Hospital Lund Sweden
• Informed consent
• Blood sampling within 3 hrs of first contact with healthcare

Exclusion Criteria:

• No consent can be obtained
• Non-operative management
• Followup through the Swedish National Quality for Hip fracture patients not possible
• High energy trauma

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Mortality	30 days

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Morbidity	Infectious complications Cardiovascular complications Thromboembolic complications Respiratory complications Renal complications Surgical complications	30 day

Collaborators and Investigators

• Sponsor: Region Skane
• Collaborators: Anna and Edwin Berger Foundation
• Investigators: Principal Investigator: Peter Bentzer, MD, PhD, Skåne University Hospital

Study record dates

Study Major Dates

• Study Start: January 1, 2011
• Primary Completion (Actual): August 1, 2014

Study Registration Dates

• First Submitted: January 18, 2011
• First Submitted That Met QC Criteria: January 19, 2011
• First Posted (Estimate): January 20, 2011

Study Record Updates

• Last Update Posted (Estimate): November 15, 2016
• Last Update Submitted That Met QC Criteria: November 11, 2016
• Last Verified: November 1, 2016

More Information

Terms related to this study

• Keywords: outcome; biochemical; Predictor
• Additional Relevant MeSH Terms: Wounds and Injuries; Leg Injuries; Femoral Fractures; Hip Injuries; Fractures, Bone; Hip Fractures
• Other Study ID Numbers: USILAN-2; 1837 (Region Skane ALF); 2010 (Fred Hutch/University of Washington Cancer Consortium)

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: YES
• IPD Plan Description: Upon reasonable request