The Effect of Experimental Knee Pain During Strengthening Exercises on Muscle Strength Gain

May 3, 2011 updated by: Frederiksberg University Hospital
The purpose of this study is to evaluate the effects of experimental knee pain on the muscle strength gain after 8 weeks of strengthening exercises for the quadriceps. It is hypothesized that experimental knee pain will reduce the muscle strength gain following strengthening exercises in healthy volunteers.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Actual)

36

Phase

  • Not Applicable

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

20 years to 35 years (Adult)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

All

Description

Inclusion Criteria:

  • aged between 20 to 35 years
  • healthy
  • untrained (non-regular exercise participation [i.e. < 1 day/week])

Exclusion Criteria:

  • symptomatic musculoskeletal diseases
  • history of traumatic injuries to muscles, tendons or joints of the lower extremity
  • knee joint pain within a month prior to enrollment

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Basic Science
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Experimental Knee Pain
Experimental knee pain induced by injections of 1 ml hypertonic saline in to the infrapatellar fat pad
Other: Experimental knee pain
Injection of 1 ml hypertonic saline (5.8%) into the infrapatellar fat pad
Active Comparator: Control
non-painful injections of isotonic saline into the infrapatellar fatpad.
Other: Non-painful control injections
Injection of isotonic saline into the infrapatellar fat pad

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
Isokinetic knee muscle strength
Time Frame: At baseline and after 8 weeks of exercise
At baseline and after 8 weeks of exercise

Secondary Outcome Measures

Outcome Measure
Time Frame
One-leg chair rise
Time Frame: At baseline and after 8 weeks of exercise
At baseline and after 8 weeks of exercise

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Frederiksberg University Hospital

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

February 1, 2010

Primary Completion (Actual)

August 1, 2010

Study Completion (Actual)

August 1, 2010

Study Registration Dates

First Submitted

May 2, 2011

First Submitted That Met QC Criteria

May 3, 2011

First Posted (Estimate)

May 4, 2011

Study Record Updates

Last Update Posted (Estimate)

May 4, 2011

Last Update Submitted That Met QC Criteria

May 3, 2011

Last Verified

February 1, 2010

More Information

Terms related to this study

Other Study ID Numbers

  • 072.07

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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