The Changes of CD4+T Lymphocyte Subsets in Septic Patients

The Role of CD4+T Lymphocyte Subsets in Cell Immunity in Patients With Sepsis

The purpose of this study is to explore the value of CD4+T lymphocyte subsets in cell immunity in the patients with sepsis.There are immunoparalysis in septic patients,the important player is the change of CD4+T lymphocyte,this immunoparalysis state contribute to the illness progress and outcome. Comprehend the change regularity of septic patients' cell immunity can guide fiter and correcter treatment.

Study Overview

• Status: Unknown
• Conditions: Sepsis; SIRS(Systemic Inflammatory Response Syndrome)

• Study Type: Observational

Contacts and Locations

Study Locations

• China
  • Beijing
    • Beijing, Beijing, China, 100853
      • Chinese PLA General hospital

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

All subjects were selected from among inpatients who were hospitalized between March 2010 and March 2011 in the Respiratory ICU, Surgical ICU, and Emergency ICU, Chinese People's Liberation Army (CPLA) General Hospital.

Description

Inclusion Criteria:

• Male and female aged 18 years old and over;
• Fulfilled at least two criteria of systemic inflammatory response syndrome (a) core temperature higher than 38 °C or lower than 36 °C (b)respiratory rate above 20/min, or PCO2 below 32 mmHg (c) pulse rate above 90/min, and (d) white blood cell count greater than 12,000/μl or lower than < 4,000/μl or less than 10% of bands.
• Clinically suspected infection;

Exclusion Criteria:

• were under 18 years of age;
• were refused by the patients or his/her familiality;
• were suffering from acquired immunodeficiency syndrome,virlhepatitis,autoimmune diseases and hematology;
• use medicine which can affect immune system,such as Glucocorticoid and Immunosuppressant
• died within 24h after being taken into the ICU, or refused to get involved in the study, or gave up treatment during the period of observation

Study Plan

How is the study designed?

Number of groups / cohorts

3

Cohorts and Interventions

Group / Cohort
SIRS; (1) temperature > 38oC or < 36oC; (2) pulse rate > 90 beats/min; (3) ventilation rate > 20 breaths/min or hyperventilation with a partial pressure of arterial carbon dioxide (PaCO2) < 32 mmHg; (4) white blood cell (WBC) count >1 2,000μL-1 or < 4000 μL-1 , or > 10% immature cells.
sepsis; SIRS + infection
Normal; not SIRS and have no infection

Collaborators and Investigators

• Sponsor: Chinese PLA General Hospital
• Investigators: Study Director: Xie Li Xin, Doctor, Department of Respiratory Diseases, Chinese PLA General Hospital

Study record dates

Study Major Dates

• Study Start: August 1, 2011
• Primary Completion (Anticipated): March 1, 2012
• Study Completion (Anticipated): March 1, 2012

Study Registration Dates

• First Submitted: December 16, 2011
• First Submitted That Met QC Criteria: December 16, 2011
• First Posted (Estimate): December 19, 2011

Study Record Updates

• Last Update Posted (Estimate): December 19, 2011
• Last Update Submitted That Met QC Criteria: December 16, 2011
• Last Verified: July 1, 2011

More Information

Terms related to this study

• Keywords: sepsis; immunoparalysis; CD4+T lymphocyte subsets
• Additional Relevant MeSH Terms: Pathologic Processes; Infections; Inflammation; Shock; Sepsis; Systemic Inflammatory Response Syndrome
• Other Study ID Numbers: 20111013-008