Hormonal Regulation of Postpartum Weight and Presence of Gut Peptides in Human Milk

Role of Ghrelin and PYY in Postpartum Body Weight Regulation and Presence in Human Milk

Hormonal Regulation of Postpartum Weight and Presence of Gut Peptides in Human Milk Studies suggest that childbearing is an important contributor to the development of obesity in many women and that breastfeeding may be protective.

Ghrelin and peptide YY (PYY) are gut hormones involved in appetite regulation and energy homeostasis and are biological neuroendocrine signals that potentially affect body weight and adiposity/

Study Overview

• Status: Completed
• Conditions: Maternal Obesity Syndrome
• Intervention / Treatment: Other: cross-sectional

Detailed Description

Role of Ghrelin and PYY in Postpartum Body Weight Regulation and Presence in Human Milk.

This study evaluated whether fasting or postprandial ghrelin or PYY is different between lactating and nonlactating postpartum women matched for age, body weight, and adiposity.

Eligibility Criteria: Healthy females, 18+ years old, non-smokers, no major food allergies, first-time mom, currently pregnant or within 1 month of giving birth.

• Study Type: Interventional
• Enrollment (Actual): 44
• Phase: Not Applicable

Contacts and Locations

Study Locations

• United States
  • Wyoming
    • Laramie, Wyoming, United States, 82071
      • Nutritional and Exercise Lab University of Wyoming

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 45 years (Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: Female

Description

Inclusion Criteria:

• Healthy women (non-smokers) at least 18 years old who did not have any pregnancy complications, and gave birth to their first child within one month.
• The study is open to women who are breastfeeding or formula feeding.

Exclusion Criteria:

• Smoker,
• had twins or triples,
• had any major complication of pregnancy(example,
• gestational diabetes);
• have kidney, liver, hormonal, stomach, intestine,lung, heart or blood disease. This also includes high blood pressure;
• use prescription or over-the-counter medicine or herbal drinks or pills.
• History of depression, anxiety, disordered eating, other psychological problems, alcoholism or other substance abuse.
• Severely claustrophobic.
• Having a strong fear of needles and/or do not feel you can have blood drawn every 30 minutes from a plastic catheter.
• Are not able to or willing to fully participate in the study, and are pregnant, anemic or have a thyroid problem.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Prevention
• Allocation: Non-Randomized
• Interventional Model: Parallel Assignment
• Masking: None (Open Label)

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Other: Four weeks Postpartum Lactating; women between 18 and 45 who delivered their first child 4 weeks prior and who were currently lactating and planning to lactate for one year postpartum.	Other: cross-sectional; Monitoring two recently discovered appetite hormones called "ghrelin" and "neuropeptide YY (PYY)." This study evaluated whether fasting or postprandial ghrelin or PYY is different btween lactating and nonlactating postpartum women matched for age, body weight, and adiposity.
Other: Control Never Pregnant; women between 18 and 45 who have never been pregnant	Other: cross-sectional; Monitoring two recently discovered appetite hormones called "ghrelin" and "neuropeptide YY (PYY)." This study evaluated whether fasting or postprandial ghrelin or PYY is different btween lactating and nonlactating postpartum women matched for age, body weight, and adiposity.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
"Role of Ghrelin and PYY in Postpartum Body Weight Regulation and Presence in Human Milk"	Biomedical Research Study that will provide information on reducing maternal obesity.	5 years

Collaborators and Investigators

• Sponsor: University of Wyoming
• Investigators: Principal Investigator: Dawine E. Larson-Meyer, Phd, RD, University of Wyoming

Study record dates

Study Major Dates

• Study Start: August 1, 2009
• Primary Completion (Actual): April 1, 2014
• Study Completion (Actual): April 1, 2014

Study Registration Dates

• First Submitted: January 9, 2012
• First Submitted That Met QC Criteria: January 18, 2012
• First Posted (Estimate): January 23, 2012

Study Record Updates

• Last Update Posted (Estimate): January 9, 2015
• Last Update Submitted That Met QC Criteria: January 7, 2015
• Last Verified: January 1, 2015

More Information

Terms related to this study

• Keywords: Human milk, Ghrelin,PYY and maternal obesity.
• Additional Relevant MeSH Terms: Overnutrition; Nutrition Disorders; Overweight; Body Weight; Pregnancy Complications; Obesity; Obesity, Maternal
• Other Study ID Numbers: P20RR016474 (U.S. NIH Grant/Contract)

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No
• product manufactured in and exported from the U.S.: No