Genetics and Mechanisms of Rheumatoid Arthritis (RASGENAS)

February 7, 2013 updated by: Stefan Zorad, Slovak Academy of Sciences

Rheumatoid Arthritis Susceptibility Genes in Austrian and Slovak Population

The study is aimed at revealing genetic background in rheumatoid arthritis (RA). For that purpose samples of DNA will be collected from 500 RA patients and similar number of controls from whole Slovakia. Variations in several genes associated with RA will be evaluated. The second aim is to assess functional changes in immune cells from selected patients and their evaluation together with genetic background. The project has observational character without any intention to change the treatment of RA patients.

Study Overview

Status

Completed

Conditions

Study Type

Observational

Enrollment (Actual)

790

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Slovakia
      • Bratislava, Slovakia, 83101
        • Slovak Academy of Sciences, Center for Molecular Medicine

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

All

Sampling Method

Probability Sample

Study Population

Patients with rheumatoid arthritis and healthy controls from Slovakia and Austria

Description

Inclusion Criteria:

  • rheumatoid arthritis or healthy

Exclusion Criteria:

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Healthy controls
Healthy control subjects
Rheumatoid Arthritis
Patients with rheumatoid arthritis

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Genetic association
Time Frame: 1 day
Association of selected single nucleotide polymorphisms with rheumatoid arthritis.
1 day

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Peripheral blood mononuclear cells reactivity
Time Frame: 1 day
Reactivity and functional changes of peripheral blood mononuclear cells obtained from patients with rheumatoid arthritis in comparison to healthy controls.
1 day

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Slovak Academy of Sciences

Investigators

  • Study Chair: Richard Imrich, Slovak Academy of Sciences, Center for Molecular Medicine

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

October 1, 2009

Primary Completion (Actual)

June 1, 2012

Study Completion (Actual)

December 1, 2012

Study Registration Dates

First Submitted

February 3, 2013

First Submitted That Met QC Criteria

February 7, 2013

First Posted (Estimate)

February 11, 2013

Study Record Updates

Last Update Posted (Estimate)

February 11, 2013

Last Update Submitted That Met QC Criteria

February 7, 2013

Last Verified

February 1, 2013

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • RASGENAS
  • ATMOS N00024 (Other Grant/Funding Number: Cross Border Cooperation Slovakia - Austria 2007 - 2013)

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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