Effect of Low-level Laser Therapy (808nm) on Marker of Muscle Damage

Effect of Low-level Laser Therapy (808nm) on Marker of Muscle Damage: Randomized Double-blind Placebo-controlled Study

The study hypothesis is a decreased muscle damage induced by exercises when low-level laser therapy is applied on body muscles before exercises.

Study Overview

• Status: Completed
• Conditions: Healthy
• Intervention / Treatment: Device: Low-level laser therapy (808nm) and exercise

Detailed Description

The study assessed males submitted to exercise to induce muscle damage. Creatine kinase levels in blood was quantified in order to identify the magnitude of muscle damage.

• Study Type: Interventional
• Enrollment (Actual): 22
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Brazil
  • Rio Grande do Norte
    • Natal, Rio Grande do Norte, Brazil, 59072-970
      • Federal Univesity of Rio Grande do Norte

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 25 years to 35 years (Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: Male

Description

Inclusion Criteria:

• healthy males,
• physically active,
• aged between 25-40 years.

Exclusion Criteria:

• smoker, or
• under medicine as anti-inflammatory and/or any drug that could affect normal and physiological conditions and lesion in upper limbs.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Triple

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Active Comparator: Low-level laser therapy (LLLT) on muscle damage; Effects of low-level laser therapy (LLLT)on muscle damage	Device: Low-level laser therapy (808nm) and exercise; Use of low-level laser therapy(LLLT)or placebo-LLLT applied on biceps brachii for muscle damage recovery; Other Names: Low-level laser therapy; Laser device (808nm; 100mW; DMC®, Brazil); Muscle damage; Muscle recovery
Active Comparator: Low-level laser therapy (LLLT) placebo on muscle damage; Effects of low-level laser therapy (LLLT) placebo on muscle damage	Device: Low-level laser therapy (808nm) and exercise; Use of low-level laser therapy(LLLT)or placebo-LLLT applied on biceps brachii for muscle damage recovery; Other Names: Low-level laser therapy; Laser device (808nm; 100mW; DMC®, Brazil); Muscle damage; Muscle recovery

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Creatine Kinase analysis in blood	Evaluation of Creatine Kinase (CK) levels in blood before, immediately after and 24h, 48h and 72h after protocol of exercise to induce muscle damage	72 hours

Collaborators and Investigators

• Sponsor: Universidade Federal de Sao Carlos
• Collaborators: Universidade Federal do Rio Grande do Norte

Publications and helpful links

General Publications

• Vieira WH, Ferraresi C, Perez SE, Baldissera V, Parizotto NA. Effects of low-level laser therapy (808 nm) on isokinetic muscle performance of young women submitted to endurance training: a randomized controlled clinical trial. Lasers Med Sci. 2012 Mar;27(2):497-504. doi: 10.1007/s10103-011-0984-0. Epub 2011 Aug 26.
• Ferraresi C, de Brito Oliveira T, de Oliveira Zafalon L, de Menezes Reiff RB, Baldissera V, de Andrade Perez SE, Matheucci Junior E, Parizotto NA. Effects of low level laser therapy (808 nm) on physical strength training in humans. Lasers Med Sci. 2011 May;26(3):349-58. doi: 10.1007/s10103-010-0855-0. Epub 2010 Nov 18.

Study record dates

Study Major Dates

• Study Start: February 1, 2011
• Primary Completion (Actual): October 1, 2011
• Study Completion (Actual): June 1, 2012

Study Registration Dates

• First Submitted: March 1, 2013
• First Submitted That Met QC Criteria: March 7, 2013
• First Posted (Estimate): March 11, 2013

Study Record Updates

• Last Update Posted (Estimate): March 11, 2013
• Last Update Submitted That Met QC Criteria: March 7, 2013
• Last Verified: March 1, 2013

More Information

Terms related to this study

• Keywords: low-level laser therapy; muscle damage
• Other Study ID Numbers: CEP/UFRN 176/10