Hyperalgesia and NMDA Receptor Antagonist

March 12, 2014 updated by: Kim Mihyun, Seoul National University Bundang Hospital
NMDA receptor is administered and postoperative remote hyperalgesia is investigated.

Study Overview

Status

Unknown

Conditions

Intervention / Treatment

Detailed Description

NMDA receptor is adminstered and postoperative tertiary hyperalgesia is investigated.

QST and pain measures for remote hyperalgesia are compared between control and magnesium or ketamine group.

Study Type

Interventional

Enrollment (Anticipated)

90

Phase

  • Not Applicable

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 85 years (ADULT, OLDER_ADULT)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Description

Inclusion Criteria:

  • ASA1-2

Exclusion Criteria:

  • contraindication to the study drugs

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: PREVENTION
  • Allocation: RANDOMIZED
  • Interventional Model: PARALLEL
  • Masking: QUADRUPLE

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
EXPERIMENTAL: magnesium
magnesium is added perioperatively to those patients undergoing staged total knee arthroplasty and other surgeries.
Drug: Magnesium Sulfate
magnesium sulfate is added to the patients
EXPERIMENTAL: ketamine
ketamine is administered to those patients undergoing stated TKA and other operations.
Drug: ketamine
ketamine is added to the patients.
PLACEBO_COMPARATOR: control
normal saline (placebo) is administered to the patients.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
pain
Time Frame: until 1 month from the end of the operation
pain (QST and pain measures )until 1 month from the end of the operation
until 1 month from the end of the operation

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Seoul National University Bundang Hospital

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

March 1, 2014

Primary Completion (ANTICIPATED)

July 1, 2014

Study Completion (ANTICIPATED)

July 1, 2014

Study Registration Dates

First Submitted

March 12, 2014

First Submitted That Met QC Criteria

March 12, 2014

First Posted (ESTIMATE)

March 14, 2014

Study Record Updates

Last Update Posted (ESTIMATE)

March 14, 2014

Last Update Submitted That Met QC Criteria

March 12, 2014

Last Verified

March 1, 2014

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • Hyperalgesia

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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