Effects of Aerobic Exercise Detraining (E-Mechanic_Fol)

March 21, 2016 updated by: John Apolzan, Pennington Biomedical Research Center

Effects of Aerobic Exercise Detraining on Energy Balance in Overweight Persons

The proposed study seeks to better understand the role of body weight, energy expenditure, and energy intake as mechanisms of body weight gain during detraining following aerobic exercise. It is hypothesized that participants in the higher dose exercise group will have greater body weight gain compared to the lower exercise dose and control group from wk 24 to wk 76 follow-up.

Study Overview

Status

Completed

Conditions

Detailed Description

Eligibility criteria include having successfully completed the main E-Mechanic study, be willing to archive blood samples and not being currently enrolled in another study that may effect body, energy intake or energy expenditure. The investigators will measure body weight, waist/hip circumference, blood pressure, body composition, physical activity, questionnaire about appetite/food intake and physical fitness.

Study Type

Observational

Enrollment (Actual)

25

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • United States
    • Louisiana
      • Baton Rouge, Louisiana, United States, 70808
        • Pennington Biomedical Research Center

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 67 years (Adult, Older Adult)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

All

Sampling Method

Non-Probability Sample

Study Population

Participants that successfully enrolled and completed the E-Mechanic study and are not past 88 weeks study randomization.

Description

Inclusion Criteria:

  • Completed the E-Mechanic study
  • Be willing to archive blood samples
  • Not participating in a study that would alter body weight, energy intake, or energy expenditure.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Healthy Living
non exercise healthy living control group
General Health
Exercise Group (8 KKW) One exercise group will obtain 8KKW (kcal/kg/week) over 3-4 sessions per week, which will result in each session lasting approximately 30 minutes. We will recruit 1 year post study intervention.
Weight Loss
Exercise Group (20 KKW) Exercise group will obtain 20 KKW, perform in 4-5 sessions per week for approximately 50-70 minutes per session. We will recruit 1 year post study intervention.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Body Weight
Time Frame: Week 64 - 88 post study randomization
Fasting body weight
Week 64 - 88 post study randomization

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Energy Expenditure
Time Frame: Week 64 - 90 since study randomization
Energy expenditure is calculated with the Sensewear Armband.
Week 64 - 90 since study randomization
Energy Intake
Time Frame: Week 64 - 90 post study randomization
Energy expenditure is calculated with the Sensewear Armband and furthermore, energy intake is calculated by adjusting TDEE for change in body weight following the methods used in doubly labeled water adjustment.
Week 64 - 90 post study randomization

Other Outcome Measures

Outcome Measure
Measure Description
Time Frame
Circumferences
Time Frame: Week 64-88 post study randomization
Waist and hip circumferences
Week 64-88 post study randomization
Blood Pressure
Time Frame: Week 64-88 post study randomization
Week 64-88 post study randomization
Body Composition
Time Frame: Week 64 - 88 post study randomization
Whole Body Scan GE iDXA (Dual energy x-ray absorptiometry)
Week 64 - 88 post study randomization
Triglycerides
Time Frame: Week 64 - 88 post study randomization
Week 64 - 88 post study randomization
Cholesterol
Time Frame: Week 64 - 88 post study randomization
Total, HDL, and LDL cholesterol
Week 64 - 88 post study randomization

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Pennington Biomedical Research Center

Investigators

  • Principal Investigator: John W Apolzan, PhD, PBRC

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

September 1, 2014

Primary Completion (Actual)

March 1, 2016

Study Completion (Actual)

March 1, 2016

Study Registration Dates

First Submitted

June 4, 2014

First Submitted That Met QC Criteria

June 5, 2014

First Posted (Estimate)

June 6, 2014

Study Record Updates

Last Update Posted (Estimate)

March 22, 2016

Last Update Submitted That Met QC Criteria

March 21, 2016

Last Verified

March 1, 2016

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • PBRC 2014-028

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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