Arm and Leg Cycling Exercise After Stroke

Adjunct Locomotor Training to Improve Walking Ability After Stroke

It has been found that arm and leg cycling is similar to walking in terms of the muscle activation patterns and joint ranges of motion. In addition, arm and leg cycling and walking activate similar neural pathways. Another advantage of arm and leg cycling is that it involves coordination of all four limbs in a rhythmic movement. This may be particularly beneficial given previous findings that arm movement contributes to the activation of leg muscles during walking in humans. This is achieved with interconnected neural pathways that link the arms to the legs. These neural interlimb connections remain intact in stroke victims, such that maximizing the contribution of the arms to the legs may increase coordination for walking. Thus, the objectives of this research are to determine if arm and leg cycling can be used to increase the strength of interlimb connections and if this helps to improve walking ability in a post-stroke population. It is hypothesized that arm and leg cycling will transfer to improvements in walking in a post stroke population.

Study Overview

• Status: Unknown
• Conditions: Stroke
• Intervention / Treatment: Behavioral: Arm and Leg Cycling Exercise Program

Detailed Description

For those who have suffered a stroke, damage to the brain can result in a decreased ability to walk, thus decreasing quality of life in a significant way. Traditionally, body weight supported treadmill training has been used for walking rehabilitation; however, this therapy requires specialized technicians, equipment, and facilities. Arm and leg cycle ergometers, a device commonly found in a gym, could provide an inexpensive and readily accessible means for walking rehabilitation.

• Study Type: Interventional
• Enrollment (Anticipated): 20
• Phase: Not Applicable

Contacts and Locations

• Study Contact: Name: Taryn Klarner, M.Sc.; Phone Number: (250) 472-5487; Email: rnl@uvic.ca

Study Locations

• Canada
  • British Columbia
    • Victoria, British Columbia, Canada, V8W 3N4
      • Recruiting
      • Rehabilitation Neuroscience Laboratory
      • Contact: Marj Wilder, B.Sc.; Email: mwilder@uvic.ca
      • Principal Investigator: E Paul Zehr, PhD

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Child; Adult; Older Adult
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• stroke
• lives within the Victoria, Vancouver Island, and Vancouver mainland communities

Exclusion Criteria:

• inability to stand for 5 minutes unassisted

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: N/A
• Interventional Model: Single Group Assignment
• Masking: None (Open Label)

Number of Arms

1

Arms and Interventions

Participant Group / Arm

Intervention / Treatment

Experimental: Arm and Leg Cycling Exercise Program; Multiple baseline test sessions will be used for the same participant to establish a meaningful baseline thus confirming consistency of all outcome measures prior to the intervention.

Behavioral: Arm and Leg Cycling Exercise Program; Participants will perform arm and leg cycling training three times a week, with 30 minutes of aggregate exercise time per session. To evaluate the physiological cost of exercise, heart rate and a rating of perceived exertion will be collected. The progressive element of this training will include increasing the resistance of the ergometer over the six weeks in order to maintain the same relative exercise stress.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Change in Treadmill Walking Characteristics	Treadmill walking characteristics will be gauged via a customized analysis of muscle activity patterns and lower limb joint kinematics. Walking frequency, symmetry, and timing will also be analyzed	Baseline, immediately post-intervention (average of 4 days following last exercise session)

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Interlimb Connections	To assess the strength of inter-limb coupling, simultaneous electrical stimulation will be applied to (5x1.0ms trains at 300Hz) the cutaneous nerves in the hand (superficial radial) and foot (superficial peroneal). The reflex responses recorded in all four limbs will be evaluated at different phases of the walking cycle.	Baseline, immediately post-intervention (average of 4 days following the last exercise session)
Fugl-Meyer Assessment	The Fugl-Meyer Assessment is a stroke-specific, performance-based impairment index. It is designed to assess motor functioning, balance, sensation and joint functioning in patients with post-stroke hemiplegia.	Baseline, immediately post-intervention (average of 4 days following the last exercise session)
Brunnstrom recovery stages	The Brunnstrom Approach emphasises the synergic pattern of movement which develops during recovery from hemiplegia.	Baseline, immediately post-intervention (average of 4 days following the last exercise session)
Timed up and go test	The Timed Up and Go test is a simple test used to assess a person's mobility and requires both static and dynamic balance. It uses the time that a person takes to rise from a chair, walk three metres, turn around, walk back to the chair, and sit down. During the test, the person is expected to wear their regular footwear and use any mobility aids that they would normally require.	Baseline, immediately post-intervention (average of 4 days following the last exercise session)
10 meter walk test	The 10 meter walk test is a timed test to evaluate walking speed	Baseline, immediately post-intervention (average of 4 days following the last exercise session)
Six minute walk test	The six-minute walk test (6MWT) measures the distance an individual is able to walk over a total of six minutes on a hard, flat surface. The goal is for the individual to walk as far as possible in six minutes. The individual is allowed to self-pace and rest as needed as they traverse back and forth along a marked walkway.	Baseline, immediately post-intervention (average of 4 days following last exercise session)

Collaborators and Investigators

• Sponsor: University of Victoria
• Collaborators: Heart and Stroke Foundation of Canada; Canadian Stroke Network
• Investigators: Principal Investigator: E. Paul Zehr, PhD, University of Victoria

Study record dates

Study Major Dates

• Study Start: July 1, 2011
• Primary Completion (Anticipated): December 1, 2014
• Study Completion (Anticipated): March 1, 2015

Study Registration Dates

• First Submitted: August 28, 2014
• First Submitted That Met QC Criteria: September 2, 2014
• First Posted (Estimate): September 5, 2014

Study Record Updates

• Last Update Posted (Estimate): September 5, 2014
• Last Update Submitted That Met QC Criteria: September 2, 2014
• Last Verified: September 1, 2014

More Information

Terms related to this study

• Keywords: stroke; rehabilitation; walking; interlimb connections
• Additional Relevant MeSH Terms: Cardiovascular Diseases; Vascular Diseases; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Stroke
• Other Study ID Numbers: 07-480-04d