Influence of Laminoplasty and Internal Fixation on Vertebral Stability After Laminectomy

April 18, 2016 updated by: Yuntao Lu, Southern Medical University, China

Influence of Laminoplasty and Internal Fixation on Vertebral Stability After Cervical, Thoracic and Lumbar Laminectomy for Tumor Resection

The lesion located inside the spinal canal caused big trouble for clinical treatment. Traditional laminectomy will destroy the biomechanics and influent the vertebral stability, which might cause kyphosis or other deformity. So in some centers, neurosurgeries praised laminoplasty to make the intactness of posterior column. They thought the laminoplasty can maintain the vertebral stability, and meanwhile the range of motion won't change so much. However, some other scholars thought laminoplasty had no helps for stability because of the pseudarthrosis. They preferred screw and stick system for internal fixation. And we did meet several patients after laminectomy suffered with spinal deformity. So we thought it is necessary for investigating the benefit of patients from laminoplasty and internal fixation.

Study Overview

Status

Unknown

Intervention / Treatment

Detailed Description

After laminectomy for removal of the cervical, thoracic and lumbar lesions, the recruited cases were randomly divided into two groups.

  1. The cases in group of laminoplasty, the lamina and spinous process was replanted to maintain the anatomical intactness of spinal canal.
  2. On the other hand, the cases in internal fixation group, the pedicle screws were implanted, and tickets were used to complete the internal fixation.

During 3 years follow up, the vertebral deformity and the range of motion were investigated and evaluated. And in the meantime, the patient's age will also be analyzed to detect it's influence for the prognosis.

Study Type

Observational

Enrollment (Anticipated)

120

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

  • Name: Yuntao Lu, M.D., Ph.D
  • Phone Number: +8613632101002
  • Email: lllu2000@163.com

Study Contact Backup

  • Name: Yiping Mo, Bachelor
  • Phone Number: +8620-61641806

Study Locations

    • Guangdong
      • Guangzhou, Guangdong, China, 510515
        • Recruiting
        • Nan fang hospital, Southern medical university
        • Contact:
          • Chongyuan Xu, Ph.D
          • Phone Number: +8620-62787238
        • Principal Investigator:
          • Yuntao Lu, M.D., Ph.D
        • Sub-Investigator:
          • Lin Pen, M.D.
        • Sub-Investigator:
          • Hai Wang, M.D., Ph.D
        • Sub-Investigator:
          • Jin Shi, Master

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Sampling Method

Probability Sample

Study Population

  1. Adult patients (>18 years) were enrolled.
  2. The patients suffered with lesion inside the spinal canal, who underwent laminectomy to remove the lesion.
  3. The cases with pathological malignant tumors were excluded from this study.
  4. Health condition of patients (KPS) > 70.

Description

Inclusion Criteria:

- 1. Adult patients (>=18 years) were enrolled. 2. The patients suffered with lesion inside the spinal canal, who underwent laminectomy to remove the lesion.

3. Pathology proved benign lesion. 4. Health condition of patients (KPS) >= 70.

Exclusion Criteria:

  • 1. Children cases (<18 years) were excluded.
  • 2.The cases with pathological malignant tumors were excluded from this study.
  • 3. KPS of patients < 70.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Observational Models: Cohort
  • Time Perspectives: Prospective

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
Surgical perfomance (Laminoplasty)
After the lesions inside the spinal canal were surgical removed by laminectomy, the lamina and spinous process were replanted with titanium plates and screws.
Two different surgical performances
Surgical perfomance (Internal fixation)
After the lesions inside the spinal canal were surgical removed by laminectomy, the pedicle screws (Thoracic and lumbar vertebra) or lateral mass (Cervical vertebra) and sticks were used for internal fixation.
Two different surgical performances

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
Vertebral deformity
Time Frame: 3 years
3 years

Secondary Outcome Measures

Outcome Measure
Time Frame
The influence of age on the vertebral deformity
Time Frame: 3 years
3 years

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Investigators

  • Principal Investigator: Yuntao Lu, M.D., Ph.D, Nanfang neurosurgery research institution

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

January 1, 2015

Primary Completion (Anticipated)

December 1, 2018

Study Completion (Anticipated)

July 1, 2019

Study Registration Dates

First Submitted

May 4, 2015

First Submitted That Met QC Criteria

May 6, 2015

First Posted (Estimate)

May 7, 2015

Study Record Updates

Last Update Posted (Estimate)

April 19, 2016

Last Update Submitted That Met QC Criteria

April 18, 2016

Last Verified

April 1, 2016

More Information

Terms related to this study

Other Study ID Numbers

  • SMU-spine-1

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

Clinical Trials on Disorders Following Clinical Procedure

Clinical Trials on Surgical performance

Subscribe