Effect of High Altitude Exposure, Acclimatization and Re-exposure on Lung Water Content by Ultrasound
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
Low altitude baseline measurements will be performed in Santiago de Chile, 520 m, over the course of 3 days. Participants will then travel by commercial airline (5 h flight) and by bus (3 h ride) to the Atacama large Millimeter Array (ALMA) base camp located at 2900 m near San Pedro de Atacama, northern Chile. Participants will stay there for the next 7 nights and they will be spend the days (6-8 h daily) at the telescope station at 5050 m while undergoing physiological testing. Daily transports from 2900 to 5050 m will be by car (1 h ride, one way). After the first 7 day altitude sojourn participants will return to the Santiago area (520 m) for a 7 day recovery period.
A second altitude sojourn cycle with an identical schedule as the one described above and a final low altitude stay of 3 days will follow.
Measurements on study subjects will be performed at baseline (lowland, Santiago de Chile), then at 2nd day of altitude exposure and 7th day at altitude before returning to lowland; those are repeated in the second altitude sojourn cycle. Measurements will be conducted by qualified specialists using a portable ultrasound device.
Study Type
Enrollment (Actual)
Phase
- Not Applicable
Contacts and Locations
Study Locations
-
-
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Zurich, Switzerland, 8091
- Switzerland
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-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- Born, raised and currently living <800m
- No overnight stay at altitudes > 1500m 4 weeks before the study
Exclusion Criteria:
- Previous altitude intolerance to altitude <3000m
- Pregnancy
- Health impairment, which requires regular treatment
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Prevention
- Allocation: N/A
- Interventional Model: Single Group Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
|---|---|
|
Experimental: Altitude Exposure
Acute high altitude exposure followed by 7 day acclimatization and reexposure after 7 days at low altitude
|
Altitude Exposure
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
|---|---|
|
ultrasound lung comets
Time Frame: change from lowland baseline at 520m, day 2 and first sojourn at 5050 m, day 2
|
change from lowland baseline at 520m, day 2 and first sojourn at 5050 m, day 2
|
Secondary Outcome Measures
Outcome Measure |
Time Frame |
|---|---|
|
ultrasound lung comets
Time Frame: first sojourn at 5050 m, 7; second sojourn at 5050m, day 2, 7
|
first sojourn at 5050 m, 7; second sojourn at 5050m, day 2, 7
|
Collaborators and Investigators
Sponsor
Collaborators
Study record dates
Study Major Dates
Study Start
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- REB15-2709_V5
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
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