Intranasal Desmopressin vs IV Ketorolac in Renal Colic Pain Control

October 18, 2016 updated by: Kambiz Nasiri, Shahid Beheshti University of Medical Sciences

Comparison of Intranasal Desmopressin vs IV Ketorolac in Renal Colic Patients

The aim of this study is the comparison of efficacy of intravenous ketorolac and intranasal desmopressin in renal colic patients pain control.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

40 renal colic patients have been divided into 2 groups randomly, one group has been received 30mg intravenous Ketorolac and 4 puffs nasal Normal Saline while other has been received 40 micrograms nasal Desmopressin and 1cc intravenous Normal Saline. Pain Score before drug administration,also 10, 30 and 60 minutes after drug administration has been measured bye Visual Analogue Scale ( VAS ).

Study Type

Interventional

Enrollment (Actual)

40

Phase

  • Not Applicable

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

16 years to 50 years (ADULT, CHILD)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Description

Inclusion Criteria:

  • renal colic patients

Exclusion Criteria:

  • history of hypertension and cardiac disease
  • pregnant patients
  • use of analgesic within 4 hours before intervention

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: TREATMENT
  • Allocation: RANDOMIZED
  • Interventional Model: PARALLEL
  • Masking: TRIPLE

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
EXPERIMENTAL: Ketorolac
30mg ketorolac administrated intravenous and 4 puffs nasal Normal Saline.
Drug: Ketorolac
30mg intravenous Ketorolac.
Other Names:
  • Toradol
Drug: Normal Saline
1cc intravenous Normal Saline.
Other Names:
  • NaCl
Drug: Normal Saline
4 puffs nasal Normal Saline.
Other Names:
  • NaCl
ACTIVE_COMPARATOR: Desmopressin
40 microgram nasal desmopressin administrated and 1cc Normal Saline intravenous
Drug: Normal Saline
1cc intravenous Normal Saline.
Other Names:
  • NaCl
Drug: Normal Saline
4 puffs nasal Normal Saline.
Other Names:
  • NaCl
Drug: Desmopressin
40 micrograms Nasal Desmopressin.
Other Names:
  • Ddavp

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
Pain score
Time Frame: Pain score change from baseline pain score before intervention 10, 30 and 60 minutes after intervention
Pain score change from baseline pain score before intervention 10, 30 and 60 minutes after intervention

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Shahid Beheshti University of Medical Sciences

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

January 1, 2015

Primary Completion (ACTUAL)

February 1, 2016

Study Completion (ACTUAL)

April 1, 2016

Study Registration Dates

First Submitted

October 12, 2016

First Submitted That Met QC Criteria

October 18, 2016

First Posted (ESTIMATE)

October 19, 2016

Study Record Updates

Last Update Posted (ESTIMATE)

October 19, 2016

Last Update Submitted That Met QC Criteria

October 18, 2016

Last Verified

October 1, 2016

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 688

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

UNDECIDED

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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