- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03037216
Investigation of Exercise Training-Induced Myokines and Adipolkines in Humans
August 19, 2020 updated by: Joslin Diabetes Center
The purpose of this study is to find out whether exercise training leads to changes in the blood that are produced by exercised muscles and if these changes produce new hormones that affect the body's regulation of sugar and body weight.
Study Overview
Study Type
Interventional
Enrollment (Actual)
10
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
Massachusetts
-
Boston, Massachusetts, United States, 02215
- Joslin Diabetes Center
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
16 years to 48 years (Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
Inclusion Criteria:
- Age between 18-35. Body mass index (BMI) must be ≥18.5 and ≤27 kg/m2. HbA1c values ≤5.7%
Exclusion Criteria:
- Age <18 and >50
- HbA1c ≥ 5.7%; heart or lung disease
- acute systemic infection accompanied by fever, body aches, or swollen lymph glands
- BMI > 27 kg/m2
- current dieting or weight loss efforts
- current pregnancy or breastfeeding
- known history of HIV/AIDS; cancer
- biochemical evidence of renal or hepatic dysfunction; renal or liver disease demyelinating diseases such as multiple sclerosis or amyotrophic lateral sclerosis
- recent blood donation
- clinical history of stroke
- hypertension (systolic > 140 mmHg or diastolic > 90 mmHg)
- type 1 or 2 diabetes; inability to exercise at 50% of predicted heart rate (HR) reserve at baseline
- Participants taking beta-blockers Participants who screen positive for The American Heart Association's contraindications to exercise testing
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Basic Science
- Allocation: N/A
- Interventional Model: Single Group Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Experimental Exercise-Training Intervention
Subjects will undergo a 10-week aerobic exercise protocol.
|
10 Week aerobic exercise training
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Changes in circulating proteins in the blood.
Time Frame: Baseline vs. Post 10 Week Training.
|
Baseline vs. Post 10 Week Training.
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Collaborators
Investigators
- Principal Investigator: Laurie J Goodyear, PhD, Joslin Diabetes Center
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
December 15, 2016
Primary Completion (Actual)
December 1, 2019
Study Completion (Actual)
February 1, 2020
Study Registration Dates
First Submitted
January 26, 2017
First Submitted That Met QC Criteria
January 27, 2017
First Posted (Estimate)
January 31, 2017
Study Record Updates
Last Update Posted (Actual)
August 20, 2020
Last Update Submitted That Met QC Criteria
August 19, 2020
Last Verified
August 1, 2020
More Information
Terms related to this study
Keywords
Other Study ID Numbers
- 2016-34
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
No
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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