The Effects of Short-time High-intensity Interval Training on Tissue Glucose and Fat Metabolism in Healthy Subjects and Patients With Type 2 Diabetes (HITPET)

The objectives of this study are to investigate the effects of short-time high-intensity interval training on tissue glucose and fat metabolism in healthy lean subjects and type 2 diabetic patients using modern and noninvasive imaging methods positron emission tomography (PET), magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS).

Study Overview

• Status: Unknown
• Conditions: Type 2 Diabetes Mellitus; Healthy Volunteers
• Intervention / Treatment: Behavioral: HIT exercise intervention; Behavioral: Aerobic exercise intervention

• Study Type: Interventional
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Finland
  • Turku, Finland, 20521
    • Recruiting
    • Turku PET Centre
    • Contact: Jarna C Hannukainen, PhD; Phone Number: +358-2-3131878; Email: jarna.hannukainen@tyks.fi
    • Principal Investigator: Jarna C Hannukainen, PhD
    • Sub-Investigator: Kari K Kalliokoski, PhD
    • Sub-Investigator: Joonas J Eskelinen, BM
    • Sub-Investigator: Anna Savolainen, BM
    • Sub-Investigator: Ilkka Heinonen, PhD
    • Sub-Investigator: Kirsi A Virtanen, PhD
    • Sub-Investigator: Jukka Kemppainen, PhD
    • Sub-Investigator: Juhani Knuuti, Professor
    • Sub-Investigator: Pirjo Nuutila, Professor
    • Sub-Investigator: Jussi Pärkkä, MD
    • Sub-Investigator: Virva Lepomäki, MSc
    • Sub-Investigator: Riitta Parkkola, MD, PhD

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 40 years to 55 years (Adult)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: Male

Description

Inclusion Criteria:

The healthy patients

1. Age 40-55
2. BMI 18.5-30
3. Fasting plasma glucose less than 6.1 mmol/l
4. Normal glucose tolerance test (OGTT)

The type 2 diabetic patients:

1. Age-, sex-, and BMI-matched with the study subjects in the phase 1
2. In a good treatment balance
3. Glycated haemoglobin (HbA1c) less than 7.5 mmol/l
4. Two hours glucose value in oral glucose tolerance test (OGTT) less than 10.0 mmol/l

Exclusion Criteria:

The healthy patients

1. Blood pressure > 140/90 mmHg
2. Any chronic disease
3. Any chronic medical defect or injury which hinder/interfere everyday life
4. History of anorexia nervosa or bulimia
5. History of rest or exercise-induced asthma
6. Previous use of anabolic steroids, additives or any other substrates
7. Smoking of tobacco, taking of snuffs, or use of narcotics.
8. Significant use of alcohol
9. Any other condition that in the opinion of the investigator could create a hazard to the subject safety, endanger the study procedures or interfere with the interpretation of study results
10. Presence of any ferromagnetic objects that would make MR imaging contraindicated
11. Current or history of regular and systematic exercise training
12. VO2max >40 ml/min/kg

The type 2 diabetic patients:

1. Any other chronic disease than diabetes
2. Blood pressure > 140/90 mmHg
3. Any chronic medical defect or injury which hinder/interfere everyday life
4. History of anorexia nervosa or bulimia
5. History of rest or exercise-induced asthma
6. Smoking of tobacco, taking of snuffs, or use of narcotics.
7. Any other condition that in the opinion of the investigator could create a hazard to the subject safety, endanger the study procedures or interfere with the interpretation of study results
8. Presence of any ferromagnetic objects that would make MRI imaging contraindicated
9. Current or history of regular and systematic exercise training
10. VO2max >40 ml/ min/kg

Study Plan

How is the study designed?

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: HIT training	Behavioral: HIT exercise intervention
Active Comparator: Aerobic exercise training	Behavioral: Aerobic exercise intervention

Collaborators and Investigators

• Sponsor: Turku University Hospital
• Collaborators: University of Turku; University of Helsinki; Academy of Finland; European Foundation for the Study of Diabetes; Verve Research, Oulu, Finland; Ministry of Education and Culture, Finland; Orion Farmos Research Foundation; Turku PET Centre

Publications and helpful links

General Publications

• Ojala R, Motiani KK, Ivaska KK, Arponen M, Eskelinen JJ, Virtanen KA, Loyttyniemi E, Heiskanen MA, U-Din M, Nuutila P, Kalliokoski KK, Hannukainen JC. Bone Marrow Metabolism Is Impaired in Insulin Resistance and Improves After Exercise Training. J Clin Endocrinol Metab. 2020 Dec 1;105(12):e4290-303. doi: 10.1210/clinem/dgaa516.
• Motiani KK, Collado MC, Eskelinen JJ, Virtanen KA, Loyttyniemi E, Salminen S, Nuutila P, Kalliokoski KK, Hannukainen JC. Exercise Training Modulates Gut Microbiota Profile and Improves Endotoxemia. Med Sci Sports Exerc. 2020 Jan;52(1):94-104. doi: 10.1249/MSS.0000000000002112.
• Heiskanen MA, Motiani KK, Mari A, Saunavaara V, Eskelinen JJ, Virtanen KA, Koivumaki M, Loyttyniemi E, Nuutila P, Kalliokoski KK, Hannukainen JC. Exercise training decreases pancreatic fat content and improves beta cell function regardless of baseline glucose tolerance: a randomised controlled trial. Diabetologia. 2018 Aug;61(8):1817-1828. doi: 10.1007/s00125-018-4627-x. Epub 2018 May 2.

Study record dates

Study Registration Dates

• First Submitted: April 28, 2011
• First Submitted That Met QC Criteria: April 28, 2011
• First Posted (Estimate): April 29, 2011

Study Record Updates

• Last Update Posted (Estimate): April 29, 2011
• Last Update Submitted That Met QC Criteria: April 28, 2011
• Last Verified: April 1, 2011

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Glucose Metabolism Disorders; Metabolic Diseases; Endocrine System Diseases; Diabetes Mellitus; Diabetes Mellitus, Type 2
• Other Study ID Numbers: 95/180/2010