Oxytocin's Effect on Social Pain Empathy

February 6, 2018 updated by: Keith Kendrick, University of Electronic Science and Technology of China

Oxytocinergic Modulation of Perceived Social Exclusion

The aim of the present experiment is to examine oxytocin's behavioral and neural effects on social pain empathy

Study Overview

Status

Unknown

Conditions

Intervention / Treatment

Detailed Description

In the current study, the investigators plan to examine whether oxytocin modulates behavior and neural activity during observing another person being excluded in an online ball-tossing game (a modified cyberball paradigm).

Study Type

Interventional

Enrollment (Anticipated)

60

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • China
    • Sichuan
      • Chendu, Sichuan, China, 611731
        • Recruiting
        • School of Life science and Technology, University of Electronic Science and Technology of China
        • Contact:

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 30 years (Adult)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

Male

Description

Inclusion Criteria:

  • healthy participants without past or current psychiatric or neurological disorders

Exclusion Criteria:

  • history of head injury
  • medical or psychiatric illness
  • smoking or drinking 24 hours before experiment

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Basic Science
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Double

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: oxytocin group
male participants with oxytocin treatment
Drug: oxytocin treatment
intranasal administration of oxytocin
Placebo Comparator: placebo group
male participants with placebo treatment
Drug: placebo treatment
intranasal administration of placebo

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Neural activity changes associated with oxytocin administration
Time Frame: 45-60 minutes after drug administration
fMRI-assessed brain activity during observing other being socially excluded
45-60 minutes after drug administration

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Behavioral changes associated with oxytocin administration: ball-tossing
Time Frame: 45-60 minutes after drug administration
Number of tosses to the other players (the excluder, new player, or previously excluded player)
45-60 minutes after drug administration

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

University of Electronic Science and Technology of China

Investigators

  • Principal Investigator: Keith Kendrick, Dr., School of Life science and Technology, University of Electronic Science and Technology of China

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

January 10, 2017

Primary Completion (Anticipated)

October 30, 2018

Study Completion (Anticipated)

October 30, 2018

Study Registration Dates

First Submitted

April 17, 2017

First Submitted That Met QC Criteria

April 17, 2017

First Posted (Actual)

April 20, 2017

Study Record Updates

Last Update Posted (Actual)

February 7, 2018

Last Update Submitted That Met QC Criteria

February 6, 2018

Last Verified

February 1, 2018

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • UESTC-neuSCAN-33

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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