Understanding Local Determinants of Cardiovascular Disease and Diabetes

Understanding Local Determinants of Cardiovascular Disease and Diabetes to Inform Novel Interventional Strategies

Cross-sectional survey of all adults residing in two defined geographical regions in urban Lilongwe and rural Karonga District. Participants were interviewed, had anthropometric measures taken, and had fasting blood specimens taken.

Study Overview

• Status: Completed
• Conditions: Hypertension; Diabetes; Overweight and Obesity
• Intervention / Treatment: Other: No intervention

• Study Type: Observational
• Enrollment (Actual): 28891

Contacts and Locations

Study Locations

• Malawi
  • Lilongwe, Malawi
    • MEIRU

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (ADULT, OLDER_ADULT)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: All

• Sampling Method: Probability Sample

Study Population

All adults within 2 defined geographical areas - one in urban Lilongwe, one in rural Karonga District

Description

Inclusion Criteria:

• all adults over 18 self-identifying as normally resident in the pre-defined geographical areas

Exclusion Criteria:

• None

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
What is the true burden of hypertension, diabetes, and hyperlipidaemia?	Prevalence of hypertension (BP <140/90 or self-report of antihypertensive use), diabetes (fasting blood glucose >7.0 or self-report history of diabetes), and hyperlipidaemia	By end of 2018

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
What is the prevalence of known risk factors - notably smoking, obesity, physical inactivity, alcohol, salt, and saturated fat intake?	Description of prevalence of known risk factors of hypertension, diabetes, and hyperlipidaemia. Dietary salt intake is estimated both by how long a defined quantity of salt is reported to last in a household on average, and from spot urine sodium specimens.	By end of 2020
Is infection, notably HIV infection or its therapy, associated with increased risk of NCDs?	Description of HIV infection and its therapy in relationship to hypertension, diabetes and hyperlipidaemia	By end of 2020

Collaborators and Investigators

• Sponsor: Malawi Epidemiology and Intervention Research Unit

Publications and helpful links

General Publications

• Prynn JE, Banda L, Amberbir A, Price AJ, Kayuni N, Jaffar S, Crampin AC, Smeeth L, Nyirenda M. Dietary sodium intake in urban and rural Malawi, and directions for future interventions. Am J Clin Nutr. 2018 Sep 1;108(3):587-593. doi: 10.1093/ajcn/nqy125.

Study record dates

Study Major Dates

• Study Start (ACTUAL): May 1, 2013
• Primary Completion (ACTUAL): February 1, 2015
• Study Completion (ACTUAL): February 1, 2015

Study Registration Dates

• First Submitted: January 30, 2018
• First Submitted That Met QC Criteria: January 30, 2018
• First Posted (ACTUAL): February 5, 2018

Study Record Updates

• Last Update Posted (ACTUAL): April 17, 2018
• Last Update Submitted That Met QC Criteria: April 13, 2018
• Last Verified: April 1, 2018

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Glucose Metabolism Disorders; Metabolic Diseases; Endocrine System Diseases; Body Weight; Cardiovascular Diseases; Diabetes Mellitus; Overweight
• Other Study ID Numbers: NCD

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: UNDECIDED

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No