Serum Carotenoids and Risk of Gastrointestinal Tract Cancer: Meta-analysis of Ten Studies

February 15, 2018 updated by: Yong Zhou
Previous studies have suggested that serum carotenoids may be associated with risk of gastrointestinal tract cancer (GIT cancer), but the results were inconsistent. Thus, the investigators conducted a meta-analysis to evaluate the associations between serum carotenoids and risk of GIT cancer.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Observational

Enrollment (Actual)

40641

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • China
    • Sichuan
      • Chengdu, Sichuan, China, 610041
        • West China Hospital, Sichuan University

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Child
  • Adult
  • Older Adult

Accepts Healthy Volunteers

N/A

Genders Eligible for Study

All

Sampling Method

Probability Sample

Study Population

The study population include people from primary care clinic or community sample.

Description

Inclusion Criteria:

  • The study had both case and control groups
  • Serum carotenoids levels, relative risk (RR) or OR and corresponding 95% CI were reported
  • Patients in case group were diagnosed with GIT cancer

Exclusion Criteria:

·Animal studies

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
Jing Huang et. al, 2017
Other: serum carotenoids
In each study, the serum concentrations of carotenoids were detected by high performance liquid chromatography
Max Leenders et. al,2014
Other: serum carotenoids
In each study, the serum concentrations of carotenoids were detected by high performance liquid chromatography
Yusuke Okuyama et. al,2014
Other: serum carotenoids
In each study, the serum concentrations of carotenoids were detected by high performance liquid chromatography
GC Kabat et. al,2012
Other: serum carotenoids
In each study, the serum concentrations of carotenoids were detected by high performance liquid chromatography
Christina Persson et. al,2008
Other: serum carotenoids
In each study, the serum concentrations of carotenoids were detected by high performance liquid chromatography
M Jenab et. al,2006
Other: serum carotenoids
In each study, the serum concentrations of carotenoids were detected by high performance liquid chromatography
Kenji Wakai et. al,2005
Other: serum carotenoids
In each study, the serum concentrations of carotenoids were detected by high performance liquid chromatography
Christian C. Abnet et. al,2003
Other: serum carotenoids
In each study, the serum concentrations of carotenoids were detected by high performance liquid chromatography
N Malila et. al,2002
Other: serum carotenoids
In each study, the serum concentrations of carotenoids were detected by high performance liquid chromatography
G Pappalardo et. al,1997
Other: serum carotenoids
In each study, the serum concentrations of carotenoids were detected by high performance liquid chromatography

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Gastrointestinal Tract Cancer Incident Measure
Time Frame: Through study completion, an average of 5 years.
The gastrointestinal tract cancer incident would be recorded during the follow-up years.
Through study completion, an average of 5 years.

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Yong Zhou

Collaborators

Sichuan Provincial Science and Technology Support Project (2016SZ0047)

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

November 1, 2017

Primary Completion (Actual)

November 20, 2017

Study Completion (Actual)

December 28, 2017

Study Registration Dates

First Submitted

February 7, 2018

First Submitted That Met QC Criteria

February 7, 2018

First Posted (Actual)

February 14, 2018

Study Record Updates

Last Update Posted (Actual)

February 22, 2018

Last Update Submitted That Met QC Criteria

February 15, 2018

Last Verified

February 1, 2018

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 2759067085

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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