Double Filtration Plasmapheresis (DFPP) and Lipid Metabolism

March 16, 2021 updated by: Jin HM, MD, Shanghai Pudong Hospital

Double Filtration Plasmapheresis (DFPP) Improves Lipid Profile and Platelet Function in Hyperlipidemia Patients

Little clinic trials showed that Double Filtration Plasmapheresis (DFPP) could improve lipid metabolism, however, whether DFPP can improve platelet function and recover Endothelial function is unknown. In this study, we try to confirm the hypothesis that DFPP can improve endothelial function in hyperlipidemia patients.

Study Overview

Status

Recruiting

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Anticipated)

30

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

  • Name: Huimin Jin, doctor
  • Phone Number: 13917232915
  • Email: hmjgli@163.com

Study Locations

  • China
    • Shanghai
      • Shanghai, Shanghai, China, 201399
        • Recruiting
        • Shanghai Pudong Hospital
        • Contact:
          • Huimin Jin, doctor

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 80 years (Adult, Older Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Description

Inclusion Criteria:

  1. hyperlipidemia

Exclusion Criteria:

  1. Severe liver and kidney dysfunction
  2. Severe cardiopulmonary insufficiency
  3. tumor
  4. pregnancy

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: N/A
  • Interventional Model: Single Group Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Other: DFPP group
self contrast (before and after DFPP)
Device: DFPP
Lipid levels,platelet function，and platelet RNA sequencing in hyperlipidemia patients before and after DFPP

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
lipid levels
Time Frame: 1 year
reduce in lipid levels
1 year

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Platelet RNA sequencing
Time Frame: 1 year
whether the RNA sequencing of platelet changed ?
1 year

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Shanghai Pudong Hospital

Investigators

  • Principal Investigator: Bo Yu, doctor, Shanghai Pudong Hospital

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

February 1, 2018

Primary Completion (Anticipated)

April 1, 2021

Study Completion (Anticipated)

April 1, 2021

Study Registration Dates

First Submitted

April 2, 2018

First Submitted That Met QC Criteria

April 2, 2018

First Posted (Actual)

April 9, 2018

Study Record Updates

Last Update Posted (Actual)

March 17, 2021

Last Update Submitted That Met QC Criteria

March 16, 2021

Last Verified

March 1, 2021

More Information

Terms related to this study

Other Study ID Numbers

  • ShanghaiPudongH2

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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