Superior Mesenteric Artery Dissection

Isolated Superior Mesenteric Artery Dissection With Concomitant Vascular Aberrancy: Extremely Rare Cases and Clinical Implications

This study investigate CT images of patients with spontaneous isolated superior mesenteric artery dissection (SISMAD). The investigators also further analyze the CT morphological differences between different options, aiming to determine "alarming CT character" during initial conservative treatment.

Study Overview

• Status: Completed
• Conditions: Vascular Diseases
• Intervention / Treatment: Other

Detailed Description

57 Patients with SISMAD from Oct 2011 to Jan 2018 in investigator's hospital were included in this research. The investigators collected relevant clinical data and further investigated the CTA characters of both true lumen and false lumen. SMA angle, distance between entry site of dissection and SMA root were also measured.

• Study Type: Observational
• Enrollment (Actual): 57

Contacts and Locations

Study Locations

• China
  • Hubei
    • Wuhan, Hubei, China, 430030
      • Tongji Hospital

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Child; Adult; Older Adult
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

Between Oct. 2011 and Jan. 2018, a total of 57 consecutive patients with SISMAD were included in this study.

Description

Inclusion Criteria:

• SMA dissection

Exclusion Criteria:

• SMA dissection combined with aortic or other visceral arteries
• Trauma related SMA dissection

Study Plan

How is the study designed?

Number of groups / cohorts

2

Cohorts and Interventions

Group / Cohort
conservative treatment; Conservative treatment consisted of bowel rest, intravenous fluid therapy, nutritional support, strict blood pressure control, anticoagulation (with or without antiplatelet) and close observation
Interventional and surgical treatment

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Diameters of true lumen	Measure the diameters of patent true lumen in patients with isolated mesenteric artery dissection thrombosis in the false lumen , the distance between entry site of dissection and SMA root (P=0.133), the presence of SMA branch involving (P=0.322) have no difference in different treatment groups	up to 6 months
the distance between dissection and SMA root	Measure the distance between dissection and SMA root in patients with isolated mesenteric artery dissection	up to 6 months
the angle between SMA root and abodominal aorta	Measure the angle between SMA root and abodominal aorta in patients with isolated mesenteric artery dissection	up to 6 months

Collaborators and Investigators

• Sponsor: Tongji Hospital
• Investigators: Principal Investigator: Lei Dou, Dr., Tongji Hospital

Study record dates

Study Major Dates

• Study Start (Actual): January 10, 2018
• Primary Completion (Actual): April 10, 2018
• Study Completion (Actual): April 26, 2018

Study Registration Dates

• First Submitted: May 12, 2018
• First Submitted That Met QC Criteria: September 11, 2018
• First Posted (Actual): September 13, 2018

Study Record Updates

• Last Update Posted (Actual): September 13, 2018
• Last Update Submitted That Met QC Criteria: September 11, 2018
• Last Verified: September 1, 2018

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Cardiovascular Diseases; Aneurysm; Vascular Diseases; Aneurysm, Dissecting
• Other Study ID Numbers: TJ-207101

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No