Effect of Daily Steps on Fat Metabolism

Effect of Daily Ambulatory Activity on the Responses to Acute Aerobic Exercise.

Reduced ambulatory activity has been shown to effect the response to a high fat tolerance test (HFTT) after acute exercise. This study will evaluate the effect of varying levels of daily ambulation on response to a HFTT after an acute aerobic exercise bout.

Study Overview

• Status: Completed
• Conditions: Atherosclerosis; Metabolic Syndrome
• Intervention / Treatment: Behavioral: Very Low Steps; Behavioral: Low Steps; Behavioral: Moderate Steps

• Study Type: Interventional
• Enrollment (Actual): 12
• Phase: Not Applicable

Contacts and Locations

Study Locations

• United States
  • Texas
    • Austin, Texas, United States, 78712
      • University of Texas at Austin Human Performance Laboratory

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 40 years (Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Exclusion Criteria:

• Cardiovascular problems (e.g. pre-existing heart issues, coronary artery disease, hypertension, etc.)
• Respiratory problems
• Musculoskeletal problems that prevent prolonged sitting or exercise
• Obesity
• Susceptibility to fainting
• Pregnancy

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Prevention
• Allocation: Randomized
• Interventional Model: Crossover Assignment
• Masking: None (Open Label)

Number of Arms

3

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Very Low Steps; Subjects will be asked to undergo reduced daily stepping to a level of 2,500 steps/d for 2 days. On the evening of day 2, they will be asked to run at 65% of VO2max for 1-hour.	Behavioral: Very Low Steps; Subjects will have a 2-day control period during which step count and diet will be controlled for and recreated for the other trials. Following this 2-day period, they will undergo the Very Low Stepping trial with the acute bout of exercise on day 2. Day 3 will consist of the lipid tolerance test to determine the ability of the body to clear triglycerides.
Experimental: Low Steps; Subjects will be asked to undergo reduced daily stepping to a level of 5,000 steps/d for 2 days. On the evening of day 2, they will be asked to run at 65% of VO2max for 1-hour.	Behavioral: Low Steps; Subjects will have a 2-day control period during which step count and diet will be controlled for and recreated for the other trials. Following this 2-day period, they will undergo the Low Stepping trial with the acute bout of exercise on day 2. Day 3 will consist of the lipid tolerance test to determine the ability of the body to clear triglycerides.
Experimental: Moderate Steps; Subjects will be asked to undergo reduced daily stepping to a level of 7,500 steps/d for 2 days. On the evening of day 2, they will be asked to run at 65% of VO2max for 1-hour.	Behavioral: Moderate Steps; Subjects will have a 2-day control period during which step count and diet will be controlled for and recreated for the other trials. Following this 2-day period, they will undergo the Moderate Stepping trial with the acute bout of exercise on day 2. Day 3 will consist of the lipid tolerance test to determine the ability of the body to clear triglycerides.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
6-Hour Plasma Triglyceride Area Under the Curve	Areas under the curve for triglyceride concentration will be calculated for hourly samples from a 6-hour lipid tolerance test.	6-hours

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
6-Hour Plasma Insulin Area Under the Curve	Areas under the curve for insulin concentration will be calculated for hourly samples from a 6-hour lipid tolerance test	6-hours
6-Hour Plasma Glucose Area Under the Curve	Areas under the curve for glucose concentration will be calculated for hourly samples from a 6-hour lipid tolerance test.	6-hours

Collaborators and Investigators

• Sponsor: University of Texas at Austin
• Investigators: Study Director: Edward F Coyle, Ph.D., University of Texas at Austin; Principal Investigator: Heath Burton, M.S., University of Texas at Austin

Publications and helpful links

General Publications

• Burton HM, Coyle EF. Daily Step Count and Postprandial Fat Metabolism. Med Sci Sports Exerc. 2021 Feb 1;53(2):333-340. doi: 10.1249/MSS.0000000000002486.

Study record dates

Study Major Dates

• Study Start (Actual): September 29, 2018
• Primary Completion (Actual): February 15, 2020
• Study Completion (Actual): May 31, 2020

Study Registration Dates

• First Submitted: September 25, 2018
• First Submitted That Met QC Criteria: October 3, 2018
• First Posted (Actual): October 5, 2018

Study Record Updates

• Last Update Posted (Actual): September 30, 2021
• Last Update Submitted That Met QC Criteria: September 29, 2021
• Last Verified: September 1, 2021

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Cardiovascular Diseases; Vascular Diseases; Glucose Metabolism Disorders; Metabolic Diseases; Arteriosclerosis; Arterial Occlusive Diseases; Insulin Resistance; Hyperinsulinism; Metabolic Syndrome; Atherosclerosis
• Other Study ID Numbers: 2018-08-0031

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: No

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No