Immunotherapy With Nivolumab and Ipilimumab Followed by Nivolumab or Nivolumab With Cabozantinib for Patients With Advanced Kidney Cancer, The PDIGREE Study
May 28, 2026 updated by: National Cancer Institute (NCI)
PD-Inhibitor (Nivolumab) and Ipilimumab Followed by Nivolumab Vs. VEGF TKI Cabozantinib With Nivolumab: A Phase III Trial in Metastatic Untreated REnal Cell CancEr [PDIGREE]
This phase III trial compares the usual treatment (treatment with ipilimumab and nivolumab followed by nivolumab alone) to treatment with ipilimumab and nivolumab, followed by nivolumab with cabozantinib in patients with untreated renal cell carcinoma that has spread to other parts of the body.
The addition of cabozantinib to the usual treatment may make it work better.
Immunotherapy with monoclonal antibodies, such as nivolumab and ipilimumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread.
Cabozantinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.
It is not yet known how well the combination of cabozantinib and nivolumab after initial treatment with ipilimumab and nivolumab works in treating patients with renal cell cancer that has spread to other parts of the body.
Study Overview
Status
Active, not recruiting
Conditions
- Clear Cell Renal Cell Carcinoma
- Stage III Renal Cell Cancer AJCC v8
- Stage IV Renal Cell Cancer AJCC v8
- Metastatic Malignant Neoplasm in the Bone
- Metastatic Malignant Neoplasm in the Lymph Nodes
- Metastatic Malignant Neoplasm in the Viscera
- Sarcomatoid Renal Cell Carcinoma
- Rhabdoid Tumor of the Kidney
- Metastatic Malignant Neoplasm in the Soft Tissue
Detailed Description
PRIMARY OBJECTIVE:
I. To compare the overall survival (OS) in patients with metastatic renal cell cancer (RCC) treated with ipilimumab-nivolumab followed by either nivolumab versus cabozantinib-nivolumab.
SECONDARY OBJECTIVES:
I. To determine progression free survival (PFS) of patients treated with nivolumab versus nivolumab-cabozantinib.
II. To evaluate the 12-month complete response rate in patients treated with ipilimumab-nivolumab followed by cabozantinib-nivolumab versus ipilimumab-nivolumab followed by nivolumab (patients who have complete response [CR] and relapse before 12 months will not be counted as a CR at 12-months).
III. To evaluate the rates of discontinuing therapy at 1 year. IV. To compare objective response rates (ORR, assessed by Response Evaluation Criteria in Solid Tumors [RECIST] 1.1 and Immune Response Evaluation Criteria in Solid Tumors [iRECIST] criteria) for patients treated with ipilimumab-nivolumab followed by cabozantinib-nivolumab versus ipilimumab-nivolumab followed by nivolumab.
V. To document the adverse event profile of ipilimumab-nivolumab followed by cabozantinib-nivolumab.
BIOMARKER OBJECTIVES:
I. To evaluate biomarkers associated with exceptional responses in both arms (exceptional responses defined as CRs with treatment discontinuation at 12 months or 24 months).
II. To evaluate whether baseline IL-6 is predictive of outcome in patients treated with cabozantinib-containing regimen.
QUALITY OF LIFE (QOL) OBJECTIVES:
I. To compare health-related quality of life at 18 months post-registration as assessed by the Functional Assessment of Cancer Therapy (FACT)-Kidney Symptom Index 19 (FKSI-19) between patients randomized to nivolumab (nivo) versus (vs) cabozantinib (cabo)/nivo.
II. To compare health-related quality of life as assessed by the FKSI-19 between patients randomized to nivo vs cabo/nivo at other time points.
III. To compare patient-reported fatigue using Patient-Reported Outcomes Measurement Information System (PROMIS)-Fatigue between patients randomized to nivo vs cabo/nivo.
IV. To compare quality-adjusted survival (overall survival x utility score assessed by EuroQol five-dimensional questionnaire [EQ5D-5L]) between patients randomized to nivo vs cabo/nivo.
OUTLINE:
INDUCTION: Patients receive nivolumab intravenously (IV) over 30 minutes and ipilimumab IV over 30 minutes on day 1. Treatment repeats every 21 days for up to 4 cycles in the absence of disease progression or unacceptable toxicity.
TREATMENT:
Patients with unconfirmed but clinical progression of disease (iuPD) with clinical instability receive cabozantinib orally (PO) daily on days 1-28. Treatment repeats every 28 days until further disease progression or unacceptable toxicity.
Patients with unconfirmed CR (iCR) receive nivolumab IV between 30-60 minutes on day 1. Treatment repeats every 28 days in the absence of disease progression or unacceptable toxicity.
Patients with non-CR/non-PD or iuPD with clinical stability are randomized to 1 of 2 arms.
ARM A: Patients receive nivolumab IV between 30-60 minutes on day 1. Treatment repeats every 28 days in the absence of disease progression or unacceptable toxicity.
ARM B: Patients receive nivolumab IV between 30-60 minutes on day 1 and cabozantinib PO daily on days 1-28. Treatment repeats every 28 days in the absence of disease progression or unacceptable toxicity.
Patients undergo computed tomography (CT) scan, magnetic resonance imaging (MRI) and blood and urine sample collection, and may also undergo a bone scan as clinically indicated throughout the study.
Study Type
Interventional
Enrollment (Estimated)
1175
Phase
- Phase 3
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
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San Juan, Puerto Rico, 00902
- Pan American Center for Oncology Trials LLC
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Alabama
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Mobile, Alabama, United States, 36688
- University of South Alabama Mitchell Cancer Institute
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Alaska
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Anchorage, Alaska, United States, 98508
- Anchorage Associates in Radiation Medicine
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Anchorage, Alaska, United States, 99508
- Alaska Breast Care and Surgery LLC
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Anchorage, Alaska, United States, 99508
- Alaska Oncology and Hematology LLC
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Anchorage, Alaska, United States, 99508
- Alaska Women's Cancer Care
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Anchorage, Alaska, United States, 99508
- Anchorage Oncology Centre
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Anchorage, Alaska, United States, 99508
- Katmai Oncology Group
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Anchorage, Alaska, United States, 99508
- Providence Alaska Medical Center
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Anchorage, Alaska, United States, 99504
- Anchorage Radiation Therapy Center
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Fairbanks, Alaska, United States, 99701
- Fairbanks Memorial Hospital
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Arizona
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Kingman, Arizona, United States, 86401
- Kingman Regional Medical Center
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Phoenix, Arizona, United States, 85004
- Cancer Center at Saint Joseph's
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Arkansas
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Fayetteville, Arkansas, United States, 72703
- Highlands Oncology Group - Fayetteville
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Fort Smith, Arkansas, United States, 72903
- Mercy Hospital Fort Smith
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Hot Springs, Arkansas, United States, 71913
- CHI Saint Vincent Cancer Center Hot Springs
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Rogers, Arkansas, United States, 72758
- Highlands Oncology Group - Rogers
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Springdale, Arkansas, United States, 72762
- Highlands Oncology Group
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California
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Anaheim, California, United States, 92806
- Kaiser Permanente-Anaheim
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Arroyo Grande, California, United States, 93420
- PCR Oncology
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Arroyo Grande, California, United States, 93420
- Mission Hope Medical Oncology - Arroyo Grande
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Baldwin Park, California, United States, 91706
- Kaiser Permanente-Baldwin Park
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Bellflower, California, United States, 90706
- Kaiser Permanente-Bellflower
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Burbank, California, United States, 91505
- Providence Saint Joseph Medical Center/Disney Family Cancer Center
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Clovis, California, United States, 93611
- Community Cancer Institute
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Clovis, California, United States, 93611
- University Oncology Associates
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Fontana, California, United States, 92335
- Kaiser Permanente-Fontana
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Harbor City, California, United States, 90710
- Kaiser Permanente South Bay
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Irvine, California, United States, 92618
- Kaiser Permanente-Irvine
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La Jolla, California, United States, 92093
- UC San Diego Moores Cancer Center
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Los Angeles, California, United States, 90027
- Kaiser Permanente Los Angeles Medical Center
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Los Angeles, California, United States, 90034
- Kaiser Permanente West Los Angeles
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Ontario, California, United States, 91761
- Kaiser Permanente-Ontario
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Panorama City, California, United States, 91402
- Kaiser Permanente - Panorama City
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Riverside, California, United States, 92505
- Kaiser Permanente-Riverside
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Sacramento, California, United States, 95817
- University of California Davis Comprehensive Cancer Center
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San Diego, California, United States, 92120
- Kaiser Permanente-San Diego Zion
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San Diego, California, United States, 92134
- Naval Medical Center -San Diego
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San Diego, California, United States, 92108
- Kaiser Permanente-San Diego Mission
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San Diego, California, United States, 92123
- Sharp Memorial Hospital
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San Francisco, California, United States, 94158
- UCSF Medical Center-Mission Bay
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San Luis Obispo, California, United States, 93401
- Pacific Central Coast Health Center-San Luis Obispo
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San Marcos, California, United States, 92078
- Kaiser Permanente-San Marcos
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Santa Maria, California, United States, 93444
- Mission Hope Medical Oncology - Santa Maria
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Woodland Hills, California, United States, 91367
- Kaiser Permanente-Woodland Hills
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Colorado
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Aurora, Colorado, United States, 80012
- Rocky Mountain Cancer Centers-Aurora
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Aurora, Colorado, United States, 80012
- The Medical Center of Aurora
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Aurora, Colorado, United States, 80045
- UCHealth University of Colorado Hospital
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Boulder, Colorado, United States, 80303
- Boulder Community Foothills Hospital
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Boulder, Colorado, United States, 80304
- Rocky Mountain Cancer Centers-Boulder
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Centennial, Colorado, United States, 80112
- Rocky Mountain Cancer Centers - Centennial
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Colorado Springs, Colorado, United States, 80907
- Penrose-Saint Francis Healthcare
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Colorado Springs, Colorado, United States, 80909
- UCHealth Memorial Hospital Central
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Colorado Springs, Colorado, United States, 80907
- Rocky Mountain Cancer Centers-Penrose
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Colorado Springs, Colorado, United States, 80920
- Memorial Hospital North
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Denver, Colorado, United States, 80205
- Kaiser Permanente-Franklin
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Denver, Colorado, United States, 80218
- Presbyterian - Saint Lukes Medical Center - Health One
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Denver, Colorado, United States, 80220
- Rose Medical Center
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Denver, Colorado, United States, 80218
- Rocky Mountain Cancer Centers-Midtown
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Denver, Colorado, United States, 80220
- Rocky Mountain Cancer Centers-Rose
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Denver, Colorado, United States, 80218
- Colorado Blood Cancer Institute
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Denver, Colorado, United States, 80204
- Cancer Center of Colorado at Sloan's Lake
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Denver, Colorado, United States, 80209
- The Women's Imaging Center
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Denver, Colorado, United States, 80206
- National Jewish Health-Main Campus
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Denver, Colorado, United States, 80220
- Western Surgical Care
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Denver, Colorado, United States, 80206
- UCHealth - Cherry Creek
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Denver, Colorado, United States, 80218
- Saint Joseph Hospital - Cancer Centers of Colorado
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Denver, Colorado, United States, 80210
- AdventHealth Porter
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Durango, Colorado, United States, 81301
- Mercy Medical Center
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Durango, Colorado, United States, 81301
- CommonSpirit Cancer Center Mercy
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Englewood, Colorado, United States, 80113
- Mountain Blue Cancer Care Center - Swedish
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Englewood, Colorado, United States, 80113
- Swedish Medical Center
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Englewood, Colorado, United States, 80113
- Rocky Mountain Cancer Centers - Swedish
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Englewood, Colorado, United States, 80113
- The Melanoma and Skin Cancer Institute
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Fort Collins, Colorado, United States, 80524
- Poudre Valley Hospital
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Fort Collins, Colorado, United States, 80528
- Cancer Care and Hematology-Fort Collins
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Golden, Colorado, United States, 80401
- National Jewish Health-Western Hematology Oncology
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Grand Junction, Colorado, United States, 81501
- Saint Mary's Hospital and Regional Medical Center
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Greeley, Colorado, United States, 80631
- UCHealth Greeley Hospital
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Greeley, Colorado, United States, 80631
- Banner North Colorado Medical Center
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Highlands Ranch, Colorado, United States, 80129
- UCHealth Highlands Ranch Hospital
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Lafayette, Colorado, United States, 80026
- Kaiser Permanente-Rock Creek
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Lafayette, Colorado, United States, 80026
- Good Samaritan Hospital - Cancer Centers of Colorado
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Lakewood, Colorado, United States, 80228
- Rocky Mountain Cancer Centers-Lakewood
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Lakewood, Colorado, United States, 80228
- CommonSpirit Saint Anthony Hospital Cancer Center
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Littleton, Colorado, United States, 80120
- Rocky Mountain Cancer Centers-Littleton
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Littleton, Colorado, United States, 80122
- AdventHealth Littleton
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Lone Tree, Colorado, United States, 80124
- Kaiser Permanente-Lone Tree
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Lone Tree, Colorado, United States, 80124
- Sky Ridge Medical Center
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Lone Tree, Colorado, United States, 80124
- Rocky Mountain Cancer Centers-Sky Ridge
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Lone Tree, Colorado, United States, 80124
- UCHealth Lone Tree Health Center
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Longmont, Colorado, United States, 80501
- Longmont United Hospital
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Longmont, Colorado, United States, 80501
- Rocky Mountain Cancer Centers-Longmont
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Loveland, Colorado, United States, 80538
- Medical Center of the Rockies
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Loveland, Colorado, United States, 80539
- Banner North Colorado Medical Center - Loveland Campus
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Parker, Colorado, United States, 80138
- AdventHealth Parker
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Pueblo, Colorado, United States, 81004
- Saint Mary Corwin Medical Center
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Thornton, Colorado, United States, 80260
- Rocky Mountain Cancer Centers-Thornton
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Thornton, Colorado, United States, 80260
- National Jewish Health-Northern Hematology Oncology
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Wheat Ridge, Colorado, United States, 80401
- Intermountain Health Lutheran Hospital
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Connecticut
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Stamford, Connecticut, United States, 06904
- Stamford Hospital/Bennett Cancer Center
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Delaware
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Lewes, Delaware, United States, 19958
- Beebe Medical Center
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Millville, Delaware, United States, 19967
- Beebe South Coastal Health Campus
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Newark, Delaware, United States, 19713
- Helen F Graham Cancer Center
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Newark, Delaware, United States, 19713
- Delaware Clinical and Laboratory Physicians PA
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Newark, Delaware, United States, 19713
- Medical Oncology Hematology Consultants PA
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Newark, Delaware, United States, 19718
- Christiana Care Health System-Christiana Hospital
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Rehoboth Beach, Delaware, United States, 19971
- Beebe Health Campus
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Seaford, Delaware, United States, 19973
- TidalHealth Nanticoke / Allen Cancer Center
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Wilmington, Delaware, United States, 19801
- Christiana Care Health System-Wilmington Hospital
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District of Columbia
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Washington D.C., District of Columbia, United States, 20037
- George Washington University Medical Center
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Washington D.C., District of Columbia, United States, 20010
- Medstar Washington Hospital Center
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Washington D.C., District of Columbia, United States, 20007
- MedStar Georgetown University Hospital
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Florida
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Coral Gables, Florida, United States, 33146
- UM Sylvester Comprehensive Cancer Center at Coral Gables
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Deerfield Beach, Florida, United States, 33442
- UM Sylvester Comprehensive Cancer Center at Deerfield Beach
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Fort Lauderdale, Florida, United States, 33308
- Holy Cross Hospital
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Gainesville, Florida, United States, 32610
- UF Health Cancer Institute - Gainesville
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Miami, Florida, United States, 33136
- University of Miami Miller School of Medicine-Sylvester Cancer Center
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Miami, Florida, United States, 33176
- UM Sylvester Comprehensive Cancer Center at Kendall
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Orlando, Florida, United States, 32806
- Orlando Health Cancer Institute
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Plantation, Florida, United States, 33324
- UM Sylvester Comprehensive Cancer Center at Plantation
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Georgia
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Atlanta, Georgia, United States, 30342
- Northside Hospital
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Duluth, Georgia, United States, 30096
- Northside Hospital - Duluth
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Lawrenceville, Georgia, United States, 30046
- Northside Hospital - Gwinnett
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Savannah, Georgia, United States, 31405
- Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
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Snellville, Georgia, United States, 30078
- Suburban Hematology Oncology Associates - Snellville
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Hawaii
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Honolulu, Hawaii, United States, 96813
- Queen's Medical Center
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Honolulu, Hawaii, United States, 96817
- The Cancer Center of Hawaii-Liliha
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Honolulu, Hawaii, United States, 96813
- Hawaii Cancer Care Inc - Waterfront Plaza
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Honolulu, Hawaii, United States, 96813
- Queen's Cancer Cenrer - POB I
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Honolulu, Hawaii, United States, 96813
- Straub Clinic and Hospital
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Honolulu, Hawaii, United States, 96813
- University of Hawaii Cancer Center
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Honolulu, Hawaii, United States, 96817
- Queen's Cancer Center - Kuakini
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Honolulu, Hawaii, United States, 96826
- Kapiolani Medical Center for Women and Children
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Honolulu, Hawaii, United States, 96813
- Island Urology
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Lihue, Hawaii, United States, 96766
- Wilcox Memorial Hospital and Kauai Medical Clinic
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‘Aiea, Hawaii, United States, 96701
- Hawaii Cancer Care - Westridge
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‘Aiea, Hawaii, United States, 96701
- Pali Momi Medical Center
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‘Aiea, Hawaii, United States, 96701
- Queen's Cancer Center - Pearlridge
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‘Aiea, Hawaii, United States, 96701
- The Cancer Center of Hawaii-Pali Momi
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Idaho
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Boise, Idaho, United States, 83706
- Saint Alphonsus Cancer Care Center-Boise
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Boise, Idaho, United States, 83712
- Saint Luke's Cancer Institute - Boise
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Caldwell, Idaho, United States, 83605
- Saint Alphonsus Cancer Care Center-Caldwell
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Coeur d'Alene, Idaho, United States, 83814
- Kootenai Health - Coeur d'Alene
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Emmett, Idaho, United States, 83617
- Walter Knox Memorial Hospital
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Fruitland, Idaho, United States, 83619
- Saint Luke's Cancer Institute - Fruitland
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Meridian, Idaho, United States, 83642
- Idaho Urologic Institute-Meridian
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Meridian, Idaho, United States, 83642
- Saint Luke's Cancer Institute - Meridian
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Nampa, Idaho, United States, 83687
- Saint Alphonsus Cancer Care Center-Nampa
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Nampa, Idaho, United States, 83687
- Saint Luke's Cancer Institute - Nampa
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Post Falls, Idaho, United States, 83854
- Kootenai Clinic Cancer Services - Post Falls
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Sandpoint, Idaho, United States, 83864
- Kootenai Clinic Cancer Services - Sandpoint
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Twin Falls, Idaho, United States, 83301
- Saint Luke's Cancer Institute - Twin Falls
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Illinois
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Alton, Illinois, United States, 62002
- OSF Saint Anthony's Health Center
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Aurora, Illinois, United States, 60504
- Rush-Copley Medical Center
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Bloomington, Illinois, United States, 61704
- Illinois CancerCare-Bloomington
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Burr Ridge, Illinois, United States, 60527
- Loyola Center for Health at Burr Ridge
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Canton, Illinois, United States, 61520
- Illinois CancerCare-Canton
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Carbondale, Illinois, United States, 62902
- Memorial Hospital of Carbondale
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Carterville, Illinois, United States, 62918
- SIH Cancer Institute
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Carthage, Illinois, United States, 62321
- Illinois CancerCare-Carthage
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Centralia, Illinois, United States, 62801
- Centralia Oncology Clinic
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Chicago, Illinois, United States, 60611
- Northwestern University
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Chicago, Illinois, United States, 60637
- University of Chicago Comprehensive Cancer Center
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Chicago, Illinois, United States, 60612
- John H Stroger Jr Hospital of Cook County
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Chicago, Illinois, United States, 60612
- Rush MD Anderson Cancer Center
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Danville, Illinois, United States, 61832
- Carle at The Riverfront
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DeKalb, Illinois, United States, 60115
- Northwestern Medicine Cancer Center Kishwaukee
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Decatur, Illinois, United States, 62526
- Decatur Memorial Hospital
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Decatur, Illinois, United States, 62526
- Cancer Care Specialists of Illinois - Decatur
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Dixon, Illinois, United States, 61021
- Illinois CancerCare-Dixon
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Effingham, Illinois, United States, 62401
- Crossroads Cancer Center
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Effingham, Illinois, United States, 62401
- Carle Physician Group-Effingham
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Elmhurst, Illinois, United States, 60126
- Elmhurst Memorial Hospital
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Eureka, Illinois, United States, 61530
- Illinois CancerCare-Eureka
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Galesburg, Illinois, United States, 61401
- Western Illinois Cancer Treatment Center
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Galesburg, Illinois, United States, 61401
- Illinois CancerCare-Galesburg
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Geneva, Illinois, United States, 60134
- Northwestern Medicine Cancer Center Delnor
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Harvey, Illinois, United States, 60426
- Ingalls Memorial Hospital
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Homer Glen, Illinois, United States, 60491
- Loyola Medicine Homer Glen
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Joliet, Illinois, United States, 60435
- Duly Health and Care Joliet
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Kewanee, Illinois, United States, 61443
- Illinois CancerCare-Kewanee Clinic
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Lake Forest, Illinois, United States, 60045
- Northwestern Medicine Lake Forest Hospital
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Macomb, Illinois, United States, 61455
- Illinois CancerCare-Macomb
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Mattoon, Illinois, United States, 61938
- Carle Physician Group-Mattoon/Charleston
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Maywood, Illinois, United States, 60153
- Loyola University Medical Center
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Melrose Park, Illinois, United States, 60160
- Marjorie Weinberg Cancer Center at Loyola-Gottlieb
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Mount Vernon, Illinois, United States, 62864
- SSM Health Good Samaritan
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Naperville, Illinois, United States, 60540
- Edward Hospital/Cancer Center
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New Lenox, Illinois, United States, 60451
- UC Comprehensive Cancer Center at Silver Cross
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O'Fallon, Illinois, United States, 62269
- Cancer Care Center of O'Fallon
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Orland Park, Illinois, United States, 60462
- University of Chicago Medicine-Orland Park
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Orland Park, Illinois, United States, 60462
- Northwestern Medicine Orland Park
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Ottawa, Illinois, United States, 61350
- Illinois CancerCare-Ottawa Clinic
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Pekin, Illinois, United States, 61554
- Illinois CancerCare-Pekin
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Peoria, Illinois, United States, 61636
- Methodist Medical Center of Illinois
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Peoria, Illinois, United States, 61615
- Illinois CancerCare-Peoria
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Peru, Illinois, United States, 61354
- Illinois CancerCare-Peru
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Peru, Illinois, United States, 61354
- Valley Radiation Oncology
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Plainfield, Illinois, United States, 60585
- Edward Hospital/Cancer Center?Plainfield
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Princeton, Illinois, United States, 61356
- Illinois CancerCare-Princeton
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Rockford, Illinois, United States, 61114
- UW Health Carbone Cancer Center Rockford
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Shiloh, Illinois, United States, 62269
- Memorial Hospital East
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Springfield, Illinois, United States, 62702
- Southern Illinois University School of Medicine
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Springfield, Illinois, United States, 62702
- Springfield Clinic
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Springfield, Illinois, United States, 62781
- Springfield Memorial Hospital
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Swansea, Illinois, United States, 62226
- Southwest Illinois Health Services LLP
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Urbana, Illinois, United States, 61801
- Carle Cancer Center
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Urbana, Illinois, United States, 61801
- The Carle Foundation Hospital
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Warrenville, Illinois, United States, 60555
- Northwestern Medicine Cancer Center Warrenville
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Washington, Illinois, United States, 61571
- Illinois CancerCare - Washington
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Yorkville, Illinois, United States, 60560
- Rush-Copley Healthcare Center
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Indiana
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Indianapolis, Indiana, United States, 46237
- Franciscan Health Indianapolis
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Indianapolis, Indiana, United States, 46202
- Indiana University/Melvin and Bren Simon Cancer Center
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Indianapolis, Indiana, United States, 46202
- Sidney and Lois Eskenazi Hospital
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Michigan City, Indiana, United States, 46360
- Woodland Cancer Care Center
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Mooresville, Indiana, United States, 46158
- Franciscan Health Mooresville
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Richmond, Indiana, United States, 47374
- Reid Health
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Iowa
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Ames, Iowa, United States, 50010
- Mary Greeley Medical Center
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Ames, Iowa, United States, 50010
- McFarland Clinic - Ames
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Ankeny, Iowa, United States, 50023
- UI Health Care Mission Cancer and Blood - Ankeny Clinic
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Boone, Iowa, United States, 50036
- McFarland Clinic - Boone
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Carroll, Iowa, United States, 51401
- Saint Anthony Regional Hospital
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Clive, Iowa, United States, 50325
- Mercy Cancer Center-West Lakes
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Clive, Iowa, United States, 50325
- UI Health Care Mission Cancer and Blood - West Des Moines Clinic
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Council Bluffs, Iowa, United States, 51503
- Alegent Health Mercy Hospital
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Creston, Iowa, United States, 50801
- Greater Regional Medical Center
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Des Moines, Iowa, United States, 50309
- Iowa Methodist Medical Center
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Des Moines, Iowa, United States, 50314
- Mercy Medical Center - Des Moines
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Des Moines, Iowa, United States, 50314
- Broadlawns Medical Center
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Des Moines, Iowa, United States, 50316
- Iowa Lutheran Hospital
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Des Moines, Iowa, United States, 50309
- UI Health Care Mission Cancer and Blood - Des Moines Clinic
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Des Moines, Iowa, United States, 50314
- UI Health Care Mission Cancer and Blood - Laurel Clinic
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Fort Dodge, Iowa, United States, 50501
- McFarland Clinic - Trinity Cancer Center
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Fort Dodge, Iowa, United States, 50501
- UI Healthcare Mission Cancer and Blood - Fort Dodge
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Jefferson, Iowa, United States, 50129
- McFarland Clinic - Jefferson
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Marshalltown, Iowa, United States, 50158
- McFarland Clinic - Marshalltown
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Sioux City, Iowa, United States, 51101
- Siouxland Regional Cancer Center
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West Des Moines, Iowa, United States, 50266-7700
- Methodist West Hospital
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West Des Moines, Iowa, United States, 50266
- Mercy Medical Center-West Lakes
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Kansas
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Fairway, Kansas, United States, 66205
- University of Kansas Clinical Research Center
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Garden City, Kansas, United States, 67846
- Central Care Cancer Center - Garden City
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Great Bend, Kansas, United States, 67530
- Central Care Cancer Center - Great Bend
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Hays, Kansas, United States, 67601
- HaysMed
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Lawrence, Kansas, United States, 66044
- Lawrence Memorial Hospital
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Lenexa, Kansas, United States, 66219
- Kansas Institute of Medicine Cancer and Blood Center
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Lenexa, Kansas, United States, 66219
- Minimally Invasive Surgery Hospital
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Olathe, Kansas, United States, 66061
- The University of Kansas Cancer Center - Olathe
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Overland Park, Kansas, United States, 66210
- University of Kansas Cancer Center-Overland Park
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Overland Park, Kansas, United States, 66209
- Menorah Medical Center
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Parsons, Kansas, United States, 67357
- Cancer Center of Kansas - Parsons
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Pittsburg, Kansas, United States, 66762
- Freeman Physician Group of Pittsburg
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Pittsburg, Kansas, United States, 66762
- Mercy Hospital Pittsburg
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Salina, Kansas, United States, 67401
- Salina Regional Health Center
-
Topeka, Kansas, United States, 66606
- University of Kansas Health System Saint Francis Campus
-
Westwood, Kansas, United States, 66205
- University of Kansas Hospital-Westwood Cancer Center
-
Wichita, Kansas, United States, 67214
- Ascension Via Christi Hospitals Wichita
-
Wichita, Kansas, United States, 67208
- Cancer Center of Kansas-Wichita Medical Arts Tower
-
Wichita, Kansas, United States, 67214
- Cancer Center of Kansas - Wichita
-
-
Kentucky
-
Bardstown, Kentucky, United States, 40004
- Flaget Memorial Hospital
-
Corbin, Kentucky, United States, 40701
- Commonwealth Cancer Center-Corbin
-
Lexington, Kentucky, United States, 40536
- University of Kentucky/Markey Cancer Center
-
Lexington, Kentucky, United States, 40504
- Saint Joseph Radiation Oncology Resource Center
-
Lexington, Kentucky, United States, 40509
- Saint Joseph Hospital East
-
London, Kentucky, United States, 40741
- Saint Joseph London
-
Louisville, Kentucky, United States, 40202
- Jewish Hospital
-
Louisville, Kentucky, United States, 40245
- UofL Health Medical Center Northeast
-
Louisville, Kentucky, United States, 40207
- Baptist Health Louisville
-
Louisville, Kentucky, United States, 40215
- Saints Mary and Elizabeth Hospital
-
Shepherdsville, Kentucky, United States, 40165
- Jewish Hospital Medical Center South
-
-
Louisiana
-
Baton Rouge, Louisiana, United States, 70805
- LSU Health Baton Rouge-North Clinic
-
Baton Rouge, Louisiana, United States, 70809
- Louisiana Hematology Oncology Associates LLC
-
Baton Rouge, Louisiana, United States, 70809
- Mary Bird Perkins Cancer Center
-
Baton Rouge, Louisiana, United States, 70836
- Ochsner High Grove
-
Baton Rouge, Louisiana, United States, 70809
- Hematology/Oncology Clinic PLLC
-
Baton Rouge, Louisiana, United States, 70808
- Our Lady of The Lake
-
Baton Rouge, Louisiana, United States, 70808
- Our Lady of the Lake Physician Group
-
Covington, Louisiana, United States, 70433
- Northshore Oncology Associates-Covington
-
Covington, Louisiana, United States, 70433
- Ochsner Hematology Oncology North Shore - Covington (West Region)
-
Houma, Louisiana, United States, 70360
- Terrebonne General Medical Center
-
Houma, Louisiana, United States, 70360
- Oncology Center of The South Incorporated
-
Metairie, Louisiana, United States, 70006
- East Jefferson General Hospital
-
Metairie, Louisiana, United States, 70006
- LSU Healthcare Network / Metairie Multi-Specialty Clinic
-
Monroe, Louisiana, United States, 71202
- Ochsner LSU Health Monroe Medical Center
-
New Orleans, Louisiana, United States, 70112
- Tulane University School of Medicine
-
New Orleans, Louisiana, United States, 70121
- Ochsner Medical Center Jefferson
-
New Orleans, Louisiana, United States, 70112
- University Medical Center New Orleans
-
New Orleans, Louisiana, United States, 70112
- Louisiana State University Health Science Center
-
New Orleans, Louisiana, United States, 70115
- Touro Infirmary
-
Shreveport, Louisiana, United States, 71103
- LSU Health Sciences Center at Shreveport
-
-
Maine
-
Augusta, Maine, United States, 04330
- Harold Alfond Center for Cancer Care
-
Belfast, Maine, United States, 04915
- MaineHealth Waldo Hospital
-
Biddeford, Maine, United States, 04005
- MaineHealth Maine Medical Center - Biddeford
-
Brewer, Maine, United States, 04412
- Lafayette Family Cancer Center-EMMC
-
Norway, Maine, United States, 04268
- MaineHealth Stephens Hospital
-
Rockport, Maine, United States, 04856
- Penobscot Bay Medical Center
-
Sanford, Maine, United States, 04073
- MaineHealth Cancer Care and IV Therapy - Sanford
-
South Portland, Maine, United States, 04106
- MaineHealth Cancer Care and IV Therapy - South Portland
-
-
Maryland
-
Baltimore, Maryland, United States, 21204
- Greater Baltimore Medical Center
-
-
Massachusetts
-
Boston, Massachusetts, United States, 02215
- Dana-Farber Cancer Institute
-
Newton, Massachusetts, United States, 02467
- Dana-Farber Cancer Institute - Chestnut Hill
-
Springfield, Massachusetts, United States, 01104
- Mercy Medical Center
-
-
Michigan
-
Adrian, Michigan, United States, 49221
- Hickman Cancer Center
-
Ann Arbor, Michigan, United States, 48106
- Trinity Health Saint Joseph Mercy Hospital Ann Arbor
-
Battle Creek, Michigan, United States, 49017
- Bronson Battle Creek
-
Brighton, Michigan, United States, 48114
- Trinity Health IHA Medical Group Hematology Oncology - Brighton
-
Brighton, Michigan, United States, 48114
- Trinity Health Medical Center - Brighton
-
Brownstown, Michigan, United States, 48183
- Henry Ford Cancer Institute-Downriver
-
Canton, Michigan, United States, 48188
- Trinity Health IHA Medical Group Hematology Oncology - Canton
-
Canton, Michigan, United States, 48188
- Trinity Health Medical Center - Canton
-
Caro, Michigan, United States, 48723
- Caro Cancer Center
-
Chelsea, Michigan, United States, 48118
- Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
-
Chelsea, Michigan, United States, 48118
- Chelsea Hospital
-
Clarkston, Michigan, United States, 48346
- Hematology Oncology Consultants-Clarkston
-
Clarkston, Michigan, United States, 48346
- Newland Medical Associates-Clarkston
-
Clinton Township, Michigan, United States, 48038
- Henry Ford Macomb Hospital-Clinton Township
-
Dearborn, Michigan, United States, 48126
- Henry Ford Medical Center-Fairlane
-
Detroit, Michigan, United States, 48202
- Henry Ford Hospital
-
Detroit, Michigan, United States, 48236
- Henry Ford Health Saint John Hospital
-
East China Township, Michigan, United States, 48054
- Henry Ford River District Hospital
-
Escanaba, Michigan, United States, 49829
- OSF Saint Francis Hospital and Medical Group
-
Flint, Michigan, United States, 48503
- Hurley Medical Center
-
Flint, Michigan, United States, 48503
- Genesee Hematology Oncology PC
-
Flint, Michigan, United States, 48503
- Genesys Hurley Cancer Institute
-
Flint, Michigan, United States, 48503
- Cancer Hematology Centers - Flint
-
Grand Rapids, Michigan, United States, 49503
- Trinity Health Grand Rapids Hospital
-
Grand Rapids, Michigan, United States, 49503
- Corewell Health Grand Rapids Hospitals - Butterworth Hospital
-
Grand Rapids, Michigan, United States, 49503
- Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital
-
Grosse Pointe Woods, Michigan, United States, 48236
- Henry Ford Saint John Hospital - Academic
-
Grosse Pointe Woods, Michigan, United States, 48236
- Henry Ford Saint John Hospital - Breast
-
Grosse Pointe Woods, Michigan, United States, 48236
- Henry Ford Saint John Hospital - Van Elslander
-
Jackson, Michigan, United States, 49201
- Allegiance Health
-
Kalamazoo, Michigan, United States, 49007
- West Michigan Cancer Center
-
Kalamazoo, Michigan, United States, 49007
- Bronson Methodist Hospital
-
Kalamazoo, Michigan, United States, 49009
- Beacon Kalamazoo Cancer Center
-
Kalamazoo, Michigan, United States, 49048
- Beacon Kalamazoo
-
Lansing, Michigan, United States, 48912
- University of Michigan Health - Sparrow Lansing
-
Livonia, Michigan, United States, 48154
- Trinity Health Saint Mary Mercy Livonia Hospital
-
Livonia, Michigan, United States, 48154
- Hope Cancer Clinic
-
Macomb, Michigan, United States, 48044
- Henry Ford Warren Hospital - Breast Macomb
-
Macomb, Michigan, United States, 48044
- Henry Ford Saint John Hospital - Macomb Medical
-
Marlette, Michigan, United States, 48453
- Saint Mary's Oncology/Hematology Associates of Marlette
-
Monroe, Michigan, United States, 48162
- Toledo Clinic Cancer Centers-Monroe
-
Muskegon, Michigan, United States, 49444
- Trinity Health Muskegon Hospital
-
Niles, Michigan, United States, 49120
- Corewell Health Lakeland Hospitals - Niles Hospital
-
Norton Shores, Michigan, United States, 49444
- Cancer and Hematology Centers of Western Michigan - Norton Shores
-
Novi, Michigan, United States, 48377
- Henry Ford Medical Center-Columbus
-
Novi, Michigan, United States, 48374
- Henry Ford Health Providence Novi Hospital
-
Pontiac, Michigan, United States, 48341
- Hope Cancer Center
-
Pontiac, Michigan, United States, 48341
- Newland Medical Associates-Pontiac
-
Pontiac, Michigan, United States, 48341
- Trinity Health Saint Joseph Mercy Oakland Hospital
-
Pontiac, Michigan, United States, 48341
- Michigan Healthcare Professionals Pontiac
-
Port Huron, Michigan, United States, 48060
- Lake Huron Medical Center
-
Port Huron, Michigan, United States, 48060
- Huron Medical Center PC
-
Reed City, Michigan, United States, 49677
- Corewell Health Reed City Hospital
-
Rochester Hills, Michigan, United States, 48309
- Henry Ford Rochester Hospital
-
Saginaw, Michigan, United States, 48604
- Oncology Hematology Associates of Saginaw Valley PC
-
Saginaw, Michigan, United States, 48601
- MyMichigan Medical Center Saginaw
-
Saint Joseph, Michigan, United States, 49085
- Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center
-
Saint Joseph, Michigan, United States, 49085
- Corewell Health Lakeland Hospitals - Saint Joseph Hospital
-
Shelby, Michigan, United States, 48315
- Henry Ford Macomb Health Center - Shelby Township
-
Southfield, Michigan, United States, 48075
- Henry Ford Health Providence Southfield Hospital
-
Sterling Heights, Michigan, United States, 48312
- Bhadresh Nayak MD PC-Sterling Heights
-
Tawas City, Michigan, United States, 48764
- MyMichigan Medical Center Tawas
-
Traverse City, Michigan, United States, 49684
- Munson Medical Center
-
Warren, Michigan, United States, 48088
- Advanced Breast Care Center PLLC
-
Warren, Michigan, United States, 48093
- Macomb Hematology Oncology PC
-
Warren, Michigan, United States, 48093
- Henry Ford Madison Heights Hospital - Breast
-
Warren, Michigan, United States, 48093
- Henry Ford Health Warren Hospital
-
Warren, Michigan, United States, 48093
- Henry Ford Warren Hospital - GLCMS
-
West Bloomfield, Michigan, United States, 48322
- Henry Ford West Bloomfield Hospital
-
West Branch, Michigan, United States, 48661
- Saint Mary's Oncology/Hematology Associates of West Branch
-
Wyoming, Michigan, United States, 49519
- University of Michigan Health - West
-
Ypsilanti, Michigan, United States, 48197
- Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
-
Ypsilanti, Michigan, United States, 48106
- Huron Gastroenterology PC
-
-
Minnesota
-
Aitkin, Minnesota, United States, 56431
- Riverwood Healthcare Center
-
Bemidji, Minnesota, United States, 56601
- Sanford Joe Lueken Cancer Center
-
Brainerd, Minnesota, United States, 56401
- Essentia Health Saint Joseph's Medical Center
-
Burnsville, Minnesota, United States, 55337
- Fairview Ridges Hospital
-
Burnsville, Minnesota, United States, 55337
- Minnesota Oncology - Burnsville
-
Cambridge, Minnesota, United States, 55008
- Cambridge Medical Center
-
Coon Rapids, Minnesota, United States, 55433
- Mercy Hospital
-
Deer River, Minnesota, United States, 56636
- Essentia Health - Deer River Clinic
-
Detroit Lakes, Minnesota, United States, 56501
- Essentia Health Saint Mary's - Detroit Lakes Clinic
-
Duluth, Minnesota, United States, 55805
- Essentia Health Cancer Center
-
Duluth, Minnesota, United States, 55805
- Essentia Health Saint Mary's Medical Center
-
Duluth, Minnesota, United States, 55805
- Miller-Dwan Hospital
-
Edina, Minnesota, United States, 55435
- Fairview Southdale Hospital
-
Fergus Falls, Minnesota, United States, 56537
- Lake Region Healthcare Corporation-Cancer Care
-
Fosston, Minnesota, United States, 56542
- Essentia Health - Fosston
-
Fridley, Minnesota, United States, 55432
- Unity Hospital
-
Hibbing, Minnesota, United States, 55746
- Essentia Health Hibbing Clinic
-
Maple Grove, Minnesota, United States, 55369
- Fairview Clinics and Surgery Center Maple Grove
-
Maplewood, Minnesota, United States, 55109
- Saint John's Hospital - Healtheast
-
Maplewood, Minnesota, United States, 55109
- Minnesota Oncology Hematology PA-Maplewood
-
Minneapolis, Minnesota, United States, 55415
- Hennepin County Medical Center
-
Minneapolis, Minnesota, United States, 55407
- Abbott-Northwestern Hospital
-
Minneapolis, Minnesota, United States, 55454
- Health Partners Inc
-
Minneapolis, Minnesota, United States, 55417
- Minneapolis VA Medical Center
-
Monticello, Minnesota, United States, 55362
- Monticello Cancer Center
-
New Ulm, Minnesota, United States, 56073
- New Ulm Medical Center
-
Park Rapids, Minnesota, United States, 56470
- Essentia Health - Park Rapids
-
Princeton, Minnesota, United States, 55371
- Fairview Northland Medical Center
-
Robbinsdale, Minnesota, United States, 55422
- North Memorial Medical Health Center
-
Saint Cloud, Minnesota, United States, 56303
- Coborn Cancer Center at Saint Cloud Hospital
-
Saint Louis Park, Minnesota, United States, 55416
- Park Nicollet Clinic - Saint Louis Park
-
Saint Paul, Minnesota, United States, 55101
- Regions Hospital
-
Saint Paul, Minnesota, United States, 55102
- United Hospital
-
Sandstone, Minnesota, United States, 55072
- Essentia Health Sandstone
-
Shakopee, Minnesota, United States, 55379
- Saint Francis Regional Medical Center
-
Stillwater, Minnesota, United States, 55082
- Lakeview Hospital
-
Thief River Falls, Minnesota, United States, 56701
- Sanford Thief River Falls Medical Center
-
Virginia, Minnesota, United States, 55792
- Essentia Health Virginia Clinic
-
Waconia, Minnesota, United States, 55387
- Ridgeview Medical Center
-
Willmar, Minnesota, United States, 56201
- Rice Memorial Hospital
-
Woodbury, Minnesota, United States, 55125
- Minnesota Oncology Hematology PA-Woodbury
-
Worthington, Minnesota, United States, 56187
- Sanford Cancer Center Worthington
-
Wyoming, Minnesota, United States, 55092
- Fairview Lakes Medical Center
-
-
Mississippi
-
Columbus, Mississippi, United States, 39705
- Baptist Memorial Hospital and Cancer Center-Golden Triangle
-
Grenada, Mississippi, United States, 38901
- Baptist Cancer Center-Grenada
-
Gulfport, Mississippi, United States, 39502
- Gulfport Memorial Hospital
-
Jackson, Mississippi, United States, 39216
- University of Mississippi Medical Center
-
New Albany, Mississippi, United States, 38652
- Baptist Memorial Hospital and Cancer Center-Union County
-
Oxford, Mississippi, United States, 38655
- Baptist Memorial Hospital and Cancer Center-Oxford
-
Southhaven, Mississippi, United States, 38671
- Baptist Memorial Hospital and Cancer Center-Desoto
-
-
Missouri
-
Ballwin, Missouri, United States, 63011
- Mercy Oncology and Hematology - Clayton-Clarkson
-
Bolivar, Missouri, United States, 65613
- Central Care Cancer Center - Bolivar
-
Bonne Terre, Missouri, United States, 63628
- Parkland Health Center-Bonne Terre
-
Branson, Missouri, United States, 65616
- Cox Cancer Center Branson
-
Cape Girardeau, Missouri, United States, 63703
- Saint Francis Medical Center
-
Cape Girardeau, Missouri, United States, 63703
- Mercy Cancer Center - Cape Girardeau
-
Chesterfield, Missouri, United States, 63017
- Saint Luke's Hospital
-
City of Saint Peters, Missouri, United States, 63376
- Siteman Cancer Center at Saint Peters Hospital
-
Columbia, Missouri, United States, 65212
- MU Health - University Hospital/Ellis Fischel Cancer Center
-
Creve Coeur, Missouri, United States, 63141
- Siteman Cancer Center at West County Hospital
-
Farmington, Missouri, United States, 63640
- Parkland Health Center - Farmington
-
Independence, Missouri, United States, 64057
- Centerpoint Medical Center LLC
-
Jefferson City, Missouri, United States, 65109
- MU Health Care Goldschmidt Cancer Center
-
Joplin, Missouri, United States, 64804
- Freeman Health System
-
Joplin, Missouri, United States, 64804
- Mercy Hospital Joplin
-
Kansas City, Missouri, United States, 64154
- University of Kansas Cancer Center - North
-
Kansas City, Missouri, United States, 64132
- Research Medical Center
-
Kansas City, Missouri, United States, 64108
- University Health Truman Medical Center
-
Lee's Summit, Missouri, United States, 64064
- University of Kansas Cancer Center - Lee's Summit
-
North Kansas City, Missouri, United States, 64116
- University of Kansas Cancer Center at North Kansas City Hospital
-
Rolla, Missouri, United States, 65401
- Mercy Clinic-Rolla-Cancer and Hematology
-
Rolla, Missouri, United States, 65401
- Phelps Health Delbert Day Cancer Institute
-
Saint Joseph, Missouri, United States, 64506
- Heartland Regional Medical Center
-
Sainte Genevieve, Missouri, United States, 63670
- Sainte Genevieve County Memorial Hospital
-
Springfield, Missouri, United States, 65807
- CoxHealth South Hospital
-
Springfield, Missouri, United States, 65804
- Mercy Hospital Springfield
-
St Louis, Missouri, United States, 63110
- Washington University School of Medicine
-
St Louis, Missouri, United States, 63129
- Siteman Cancer Center-South County
-
St Louis, Missouri, United States, 63136
- Siteman Cancer Center at Christian Hospital
-
St Louis, Missouri, United States, 63131
- Missouri Baptist Medical Center
-
St Louis, Missouri, United States, 63109
- Mercy Infusion Center - Chippewa
-
St Louis, Missouri, United States, 63141
- Mercy Hospital Saint Louis
-
St Louis, Missouri, United States, 63128
- Mercy Hospital South
-
Sullivan, Missouri, United States, 63080
- Missouri Baptist Sullivan Hospital
-
Sunset Hills, Missouri, United States, 63127
- BJC Outpatient Center at Sunset Hills
-
Washington, Missouri, United States, 63090
- Mercy Hospital Washington
-
-
Montana
-
Anaconda, Montana, United States, 59711
- Community Hospital of Anaconda
-
Billings, Montana, United States, 59101
- Billings Clinic Cancer Center
-
Billings, Montana, United States, 59101
- Saint Vincent Healthcare
-
Billings, Montana, United States, 59102
- Saint Vincent Frontier Cancer Center
-
Bozeman, Montana, United States, 59715
- Bozeman Health Deaconess Hospital
-
Butte, Montana, United States, 59701
- Saint James Community Hospital and Cancer Treatment Center
-
Great Falls, Montana, United States, 59405
- Great Falls Clinic
-
Great Falls, Montana, United States, 59405
- Benefis Sletten Cancer Institute
-
Helena, Montana, United States, 59601
- Saint Peter's Community Hospital
-
Kalispell, Montana, United States, 59901
- Logan Health Medical Center
-
Missoula, Montana, United States, 59802
- Saint Patrick Hospital - Community Hospital
-
Missoula, Montana, United States, 59804
- Community Medical Center
-
-
Nebraska
-
Bellevue, Nebraska, United States, 68123
- Nebraska Medicine-Bellevue
-
Grand Island, Nebraska, United States, 68803
- Nebraska Cancer Specialists/Oncology Hematology West PC
-
Kearney, Nebraska, United States, 68847
- CHI Health Good Samaritan
-
Lincoln, Nebraska, United States, 68510
- Saint Elizabeth Regional Medical Center
-
Lincoln, Nebraska, United States, 68516
- Cancer Partners of Nebraska
-
Omaha, Nebraska, United States, 68114
- Nebraska Methodist Hospital
-
Omaha, Nebraska, United States, 68198
- University of Nebraska Medical Center
-
Omaha, Nebraska, United States, 68124
- Alegent Health Bergan Mercy Medical Center
-
Omaha, Nebraska, United States, 68118
- Nebraska Medicine-Village Pointe
-
Omaha, Nebraska, United States, 68122
- Alegent Health Immanuel Medical Center
-
Omaha, Nebraska, United States, 68130
- Alegent Health Lakeside Hospital
-
Omaha, Nebraska, United States, 68131
- Creighton University Medical Center
-
Omaha, Nebraska, United States, 68114
- Oncology Associates PC
-
Omaha, Nebraska, United States, 68114
- Nebraska Cancer Specialists/Oncology Hematology West PC - MECC
-
Papillion, Nebraska, United States, 68046
- Midlands Community Hospital
-
-
Nevada
-
Carson City, Nevada, United States, 89703
- Carson Tahoe Regional Medical Center
-
Henderson, Nevada, United States, 89052
- Comprehensive Cancer Centers of Nevada - Henderson
-
Henderson, Nevada, United States, 89052
- Cancer and Blood Specialists-Henderson
-
Henderson, Nevada, United States, 89052
- Las Vegas Cancer Center-Henderson
-
Henderson, Nevada, United States, 89074
- Comprehensive Cancer Centers of Nevada-Southeast Henderson
-
Henderson, Nevada, United States, 89052
- Comprehensive Cancer Centers of Nevada-Horizon Ridge
-
Henderson, Nevada, United States, 89074
- Las Vegas Urology - Green Valley
-
Henderson, Nevada, United States, 89074
- Las Vegas Urology - Pebble
-
Henderson, Nevada, United States, 89074
- Urology Specialists of Nevada - Green Valley
-
Henderson, Nevada, United States, 89074
- Oncology Las Vegas - Henderson
-
Las Vegas, Nevada, United States, 89144
- Summerlin Hospital Medical Center
-
Las Vegas, Nevada, United States, 89109
- Sunrise Hospital and Medical Center
-
Las Vegas, Nevada, United States, 89102
- OptumCare Cancer Care at Charleston
-
Las Vegas, Nevada, United States, 89106
- Radiation Oncology Centers of Nevada Central
-
Las Vegas, Nevada, United States, 89119
- Radiation Oncology Centers of Nevada Southeast
-
Las Vegas, Nevada, United States, 89128
- Comprehensive Cancer Centers of Nevada - Northwest
-
Las Vegas, Nevada, United States, 89128
- OptumCare Cancer Care at MountainView
-
Las Vegas, Nevada, United States, 89135
- Alliance for Childhood Diseases/Cure 4 the Kids Foundation
-
Las Vegas, Nevada, United States, 89144
- Comprehensive Cancer Centers of Nevada - Town Center
-
Las Vegas, Nevada, United States, 89144
- Comprehensive Cancer Centers of Nevada-Summerlin
-
Las Vegas, Nevada, United States, 89148
- Comprehensive Cancer Centers of Nevada
-
Las Vegas, Nevada, United States, 89169
- Comprehensive Cancer Centers of Nevada - Central Valley
-
Las Vegas, Nevada, United States, 89102
- University Medical Center of Southern Nevada
-
Las Vegas, Nevada, United States, 89106
- Cancer and Blood Specialists-Shadow
-
Las Vegas, Nevada, United States, 89109
- HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway
-
Las Vegas, Nevada, United States, 89113
- HealthCare Partners Medical Group Oncology/Hematology-San Martin
-
Las Vegas, Nevada, United States, 89128
- Cancer and Blood Specialists-Tenaya
-
Las Vegas, Nevada, United States, 89128
- HealthCare Partners Medical Group Oncology/Hematology-Tenaya
-
Las Vegas, Nevada, United States, 89148-2405
- Las Vegas Cancer Center-Medical Center
-
Las Vegas, Nevada, United States, 89149
- HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills
-
Las Vegas, Nevada, United States, 89128
- Ann M Wierman MD LTD
-
Las Vegas, Nevada, United States, 89074
- Las Vegas Urology - Pecos
-
Las Vegas, Nevada, United States, 89102
- Desert West Surgery
-
Las Vegas, Nevada, United States, 89103
- Hope Cancer Care of Nevada
-
Las Vegas, Nevada, United States, 89106
- Urology Specialists of Nevada - Central
-
Las Vegas, Nevada, United States, 89113
- Las Vegas Prostate Cancer Center
-
Las Vegas, Nevada, United States, 89113
- Las Vegas Urology - Sunset
-
Las Vegas, Nevada, United States, 89128
- Las Vegas Urology - Cathedral Rock
-
Las Vegas, Nevada, United States, 89128
- Las Vegas Urology - Smoke Ranch
-
Las Vegas, Nevada, United States, 89128
- Urology Specialists of Nevada - Northwest
-
Las Vegas, Nevada, United States, 89169
- University Cancer Center
-
Las Vegas, Nevada, United States, 89113
- Urology Specialists of Nevada - Southwest
-
Las Vegas, Nevada, United States, 89128
- Oncology Las Vegas - Tenaya
-
Las Vegas, Nevada, United States, 89183
- OptumCare Cancer Care at Fort Apache
-
Pahrump, Nevada, United States, 89048
- Hope Cancer Care of Nevada-Pahrump
-
Reno, Nevada, United States, 89502
- Renown Regional Medical Center
-
Reno, Nevada, United States, 89503
- Saint Mary's Regional Medical Center
-
Reno, Nevada, United States, 89509
- Radiation Oncology Associates
-
-
New Hampshire
-
Concord, New Hampshire, United States, 03301
- New Hampshire Oncology Hematology PA-Concord
-
Manchester, New Hampshire, United States, 03103
- Solinsky Center for Cancer Care
-
Manchester, New Hampshire, United States, 03103
- Elliot Hospital
-
-
New Jersey
-
Brick, New Jersey, United States, 08724
- Ocean University Medical Center
-
Cape May Court House, New Jersey, United States, 08210
- AtlantiCare Health Park-Cape May Court House
-
Egg Harbor, New Jersey, United States, 08234
- AtlantiCare Surgery Center
-
Hackensack, New Jersey, United States, 07601
- Hackensack University Medical Center
-
Livingston, New Jersey, United States, 07039
- Saint Barnabas Medical Center
-
Manahawkin, New Jersey, United States, 08050
- Southern Ocean County Medical Center
-
Mullica Hill, New Jersey, United States, 08062
- Inspira Medical Center Mullica Hill
-
Neptune City, New Jersey, United States, 07753
- Jersey Shore Medical Center
-
New Brunswick, New Jersey, United States, 08903
- Rutgers Cancer Institute of New Jersey
-
Red Bank, New Jersey, United States, 07701
- Riverview Medical Center/Booker Cancer Center
-
-
New Mexico
-
Albuquerque, New Mexico, United States, 87106
- University of New Mexico Cancer Center
-
-
New York
-
Auburn, New York, United States, 13021
- Hematology Oncology Associates of Central New York-Auburn
-
Camillus, New York, United States, 13031
- Hematology Oncology Associates of CNY at Camillus
-
Cooperstown, New York, United States, 13326
- Mary Imogene Bassett Hospital
-
East Syracuse, New York, United States, 13057
- Hematology Oncology Associates of Central New York-East Syracuse
-
Glens Falls, New York, United States, 12801
- Glens Falls Hospital
-
Lake Success, New York, United States, 11042
- Northwell Health/Center for Advanced Medicine
-
New York, New York, United States, 10065
- NYP/Weill Cornell Medical Center
-
Rochester, New York, United States, 14642
- University of Rochester
-
Stony Brook, New York, United States, 11794
- Stony Brook University Medical Center
-
The Bronx, New York, United States, 10461
- Montefiore Medical Center-Einstein Campus
-
The Bronx, New York, United States, 10467
- Montefiore Medical Center - Moses Campus
-
The Bronx, New York, United States, 10461
- Montefiore Medical Center-Weiler Hospital
-
-
North Carolina
-
Asheville, North Carolina, United States, 28803
- AdventHealth Infusion Center Asheville
-
Chapel Hill, North Carolina, United States, 27599
- UNC Lineberger Comprehensive Cancer Center
-
Charlotte, North Carolina, United States, 28204
- Novant Health Presbyterian Medical Center
-
Clemmons, North Carolina, United States, 27012
- Wake Forest University at Clemmons
-
Clinton, North Carolina, United States, 28328
- Southeastern Medical Oncology Center-Clinton
-
Clyde, North Carolina, United States, 28721
- AdventHealth Infusion Center Haywood
-
Durham, North Carolina, United States, 27710
- Duke University Medical Center
-
Durham, North Carolina, United States, 27705
- Durham VA Medical Center
-
Goldsboro, North Carolina, United States, 27534
- Southeastern Medical Oncology Center-Goldsboro
-
Greenville, North Carolina, United States, 27834
- ECU Health Medical Center
-
Hendersonville, North Carolina, United States, 28791
- Margaret R Pardee Memorial Hospital
-
Hendersonville, North Carolina, United States, 28792
- AdventHealth Hendersonville
-
Huntersville, North Carolina, United States, 28078
- Novant Health Cancer Institute - Huntersville
-
Huntersville, North Carolina, United States, 28078
- Novant Health Presbyterian Medical Center Huntersville
-
Jacksonville, North Carolina, United States, 28546
- Southeastern Medical Oncology Center-Jacksonville
-
Kenansville, North Carolina, United States, 28349
- ECU Health Oncology Kenansville
-
Kernersville, North Carolina, United States, 27284
- Novant Health Cancer Institute - Kernersville
-
Kinston, North Carolina, United States, 28501
- ECU Health Oncology Kinston
-
Matthews, North Carolina, United States, 28105
- Novant Health Cancer Institute - Matthews
-
Mooresville, North Carolina, United States, 28117
- Novant Health Cancer Institute - Mooresville
-
Mount Airy, North Carolina, United States, 27030
- Novant Health Cancer Institute - Mount Airy
-
North Wilkesboro, North Carolina, United States, 28659
- Novant Health Cancer Institute - Wilkesboro
-
Richlands, North Carolina, United States, 28574
- ECU Health Oncology Richlands
-
Statesville, North Carolina, United States, 28625
- Novant Health Cancer Institute - Statesville
-
Statesville, North Carolina, United States, 28677
- Wake Forest Baptist Health - Hematology Oncology - Statesville
-
Thomasville, North Carolina, United States, 27360
- Novant Health Cancer Institute - Thomasville
-
Weaverville, North Carolina, United States, 28787
- AdventHealth Infusion Center Weaverville
-
Wilkesboro, North Carolina, United States, 28659
- Wake Forest Baptist Health - Wilkes Medical Center
-
Winston-Salem, North Carolina, United States, 27157
- Wake Forest University Health Sciences
-
Winston-Salem, North Carolina, United States, 27103
- Novant Health Forsyth Medical Center
-
-
North Dakota
-
Bismarck, North Dakota, United States, 58501
- Sanford Bismarck Medical Center
-
Fargo, North Dakota, United States, 58122
- Sanford Roger Maris Cancer Center
-
Fargo, North Dakota, United States, 58103
- Essentia Health Cancer Center-South University Clinic
-
Fargo, North Dakota, United States, 58122
- Sanford Broadway Medical Center
-
Fargo, North Dakota, United States, 58103
- Sanford South University Medical Center
-
Fargo, North Dakota, United States, 58103
- Southpointe-Sanford Medical Center Fargo
-
Fargo, North Dakota, United States, 58104
- Sanford Medical Center Fargo
-
Grand Forks, North Dakota, United States, 58201
- Altru Cancer Center
-
Jamestown, North Dakota, United States, 58401
- Essentia Health - Jamestown Clinic
-
Minot, North Dakota, United States, 58701
- Trinity Cancer Care Center
-
-
Ohio
-
Beavercreek, Ohio, United States, 45431
- Indu and Raj Soin Medical Center
-
Belpre, Ohio, United States, 45714
- Strecker Cancer Center-Belpre
-
Boardman, Ohio, United States, 44512
- Saint Elizabeth Boardman Hospital
-
Centerville, Ohio, United States, 45459
- Miami Valley Hospital South
-
Centerville, Ohio, United States, 45459
- Dayton Physicians LLC-Miami Valley South
-
Chillicothe, Ohio, United States, 45601
- Adena Regional Medical Center
-
Cincinnati, Ohio, United States, 45219
- University of Cincinnati Cancer Center-UC Medical Center
-
Cincinnati, Ohio, United States, 45220
- Good Samaritan Hospital - Cincinnati
-
Cincinnati, Ohio, United States, 45242
- Bethesda North Hospital
-
Cincinnati, Ohio, United States, 45236
- Oncology Hematology Care Inc-Kenwood
-
Cincinnati, Ohio, United States, 45247
- TriHealth Cancer Institute-Westside
-
Cincinnati, Ohio, United States, 45255
- TriHealth Cancer Institute-Anderson
-
Cleveland, Ohio, United States, 44109
- MetroHealth Medical Center
-
Columbus, Ohio, United States, 43214
- Riverside Methodist Hospital
-
Columbus, Ohio, United States, 43210
- Ohio State University Comprehensive Cancer Center
-
Columbus, Ohio, United States, 43219
- The Mark H Zangmeister Center
-
Columbus, Ohio, United States, 43214
- Columbus Oncology and Hematology Associates Inc
-
Columbus, Ohio, United States, 43228
- Doctors Hospital
-
Columbus, Ohio, United States, 43213
- Mount Carmel East Hospital
-
Columbus, Ohio, United States, 43215
- Grant Medical Center
-
Columbus, Ohio, United States, 43222
- Mount Carmel Health Center West
-
Dayton, Ohio, United States, 45406
- Good Samaritan Hospital - Dayton
-
Dayton, Ohio, United States, 45409
- Miami Valley Hospital
-
Dayton, Ohio, United States, 45415
- Miami Valley Hospital North
-
Dayton, Ohio, United States, 45415
- Dayton Physician LLC - Englewood
-
Dayton, Ohio, United States, 45409
- Premier Blood and Cancer Center
-
Delaware, Ohio, United States, 43015
- Delaware Health Center-Grady Cancer Center
-
Delaware, Ohio, United States, 43015
- Grady Memorial Hospital
-
Dublin, Ohio, United States, 43016
- Dublin Methodist Hospital
-
Dublin, Ohio, United States, 43016
- Columbus Oncology and Hematology Associates
-
Findlay, Ohio, United States, 45840
- Blanchard Valley Hospital
-
Findlay, Ohio, United States, 45840
- Armes Family Cancer Center
-
Findlay, Ohio, United States, 45840
- Orion Cancer Care
-
Franklin, Ohio, United States, 45005-1066
- Atrium Medical Center-Middletown Regional Hospital
-
Franklin, Ohio, United States, 45005
- Dayton Physicians LLC-Atrium
-
Gahanna, Ohio, United States, 43230
- Central Ohio Breast and Endocrine Surgery
-
Greenville, Ohio, United States, 45331
- Wayne Hospital
-
Greenville, Ohio, United States, 45331
- Dayton Physicians LLC-Wayne
-
Greenville, Ohio, United States, 45331
- Miami Valley Cancer Care and Infusion
-
Grove City, Ohio, United States, 43123
- Mount Carmel Grove City Hospital
-
Kettering, Ohio, United States, 45429
- Kettering Medical Center
-
Kettering, Ohio, United States, 45409
- Greater Dayton Cancer Center
-
Kettering, Ohio, United States, 45420
- First Dayton Cancer Care
-
Lancaster, Ohio, United States, 43130
- Fairfield Medical Center
-
Lima, Ohio, United States, 45801
- Saint Rita's Medical Center
-
Mansfield, Ohio, United States, 44903
- OhioHealth Mansfield Hospital
-
Marietta, Ohio, United States, 45750
- Marietta Memorial Hospital
-
Marion, Ohio, United States, 43302
- OhioHealth Marion General Hospital
-
Marysville, Ohio, United States, 43040
- Memorial Hospital
-
Mount Vernon, Ohio, United States, 43050
- Knox Community Hospital
-
Newark, Ohio, United States, 43055
- Licking Memorial Hospital
-
Newark, Ohio, United States, 43055
- Newark Radiation Oncology
-
Perrysburg, Ohio, United States, 43551
- Mercy Health - Perrysburg Hospital
-
Portsmouth, Ohio, United States, 45662
- Southern Ohio Medical Center
-
Springfield, Ohio, United States, 45504
- Springfield Regional Cancer Center
-
Springfield, Ohio, United States, 45504
- Springfield Regional Medical Center
-
Toledo, Ohio, United States, 43623
- Mercy Health - Saint Anne Hospital
-
Toledo, Ohio, United States, 43623
- Toledo Clinic Cancer Centers-Toledo
-
Toledo, Ohio, United States, 43608
- Mercy Health - Saint Vincent Hospital
-
Troy, Ohio, United States, 45373
- Upper Valley Medical Center
-
Troy, Ohio, United States, 45373
- Dayton Physicians LLC - Troy
-
Warren, Ohio, United States, 44484
- Saint Joseph Warren Hospital
-
West Chester, Ohio, United States, 45069
- University of Cincinnati Cancer Center-West Chester
-
Westerville, Ohio, United States, 43081
- Saint Ann's Hospital
-
Youngstown, Ohio, United States, 44501
- Saint Elizabeth Youngstown Hospital
-
Zanesville, Ohio, United States, 43701
- Genesis Healthcare System Cancer Care Center
-
-
Oklahoma
-
Lawton, Oklahoma, United States, 73505
- Cancer Centers of Southwest Oklahoma Research
-
Oklahoma City, Oklahoma, United States, 73104
- University of Oklahoma Health Sciences Center
-
Oklahoma City, Oklahoma, United States, 73120
- Mercy Hospital Oklahoma City
-
Tulsa, Oklahoma, United States, 74146
- Oklahoma Cancer Specialists and Research Institute-Tulsa
-
-
Oregon
-
Baker City, Oregon, United States, 97814
- Saint Alphonsus Cancer Care Center-Baker City
-
Bend, Oregon, United States, 97701
- Saint Charles Health System
-
Clackamas, Oregon, United States, 97015
- Clackamas Radiation Oncology Center
-
Clackamas, Oregon, United States, 97015
- Providence Cancer Institute Clackamas Clinic
-
Coos Bay, Oregon, United States, 97420
- Bay Area Hospital
-
Gresham, Oregon, United States, 97030
- Legacy Mount Hood Medical Center
-
Newberg, Oregon, United States, 97132
- Providence Newberg Medical Center
-
Ontario, Oregon, United States, 97914
- Saint Alphonsus Cancer Care Center-Ontario
-
Oregon City, Oregon, United States, 97045
- Providence Willamette Falls Medical Center
-
Portland, Oregon, United States, 97239
- Oregon Health and Science University
-
Portland, Oregon, United States, 97210
- Legacy Good Samaritan Hospital and Medical Center
-
Portland, Oregon, United States, 97213
- Providence Portland Medical Center
-
Portland, Oregon, United States, 97225
- Providence Saint Vincent Medical Center
-
Redmond, Oregon, United States, 97756
- Saint Charles Health System-Redmond
-
Tualatin, Oregon, United States, 97062
- Legacy Meridian Park Hospital
-
-
Pennsylvania
-
Allentown, Pennsylvania, United States, 18103
- Lehigh Valley Hospital-Cedar Crest
-
Bethlehem, Pennsylvania, United States, 18017
- Lehigh Valley Hospital - Muhlenberg
-
Bryn Mawr, Pennsylvania, United States, 19010
- Bryn Mawr Hospital
-
Chadds Ford, Pennsylvania, United States, 19317
- Christiana Care Health System-Concord Health Center
-
Collegeville, Pennsylvania, United States, 19426
- Main Line Health Center-Collegeville
-
Danville, Pennsylvania, United States, 17822
- Geisinger Medical Center
-
East Stroudsburg, Pennsylvania, United States, 18301
- Pocono Medical Center
-
Exton, Pennsylvania, United States, 19341
- Main Line Health Center-Exton
-
Hazleton, Pennsylvania, United States, 18201
- Geisinger Medical Center-Cancer Center Hazleton
-
Hazleton, Pennsylvania, United States, 18201
- Lehigh Valley Hospital-Hazleton
-
Hershey, Pennsylvania, United States, 17033-0850
- Penn State Milton S Hershey Medical Center
-
Lewisburg, Pennsylvania, United States, 17837
- Geisinger Medical Oncology-Lewisburg
-
Lewistown, Pennsylvania, United States, 17044
- Lewistown Hospital
-
Media, Pennsylvania, United States, 19063
- Riddle Memorial Hospital
-
Newtown Square, Pennsylvania, United States, 19073
- Bryn Mawr Health Center
-
Paoli, Pennsylvania, United States, 19301
- Paoli Memorial Hospital
-
Philadelphia, Pennsylvania, United States, 19107
- Thomas Jefferson University Hospital
-
Philadelphia, Pennsylvania, United States, 19148
- Jefferson Methodist Hospital
-
Pottsville, Pennsylvania, United States, 17901
- Geisinger Cancer Services-Pottsville
-
Sayre, Pennsylvania, United States, 18840
- Guthrie Medical Group PC-Robert Packer Hospital
-
Scranton, Pennsylvania, United States, 18510
- Community Medical Center
-
Selinsgrove, Pennsylvania, United States, 17870
- Geisinger Medical Oncology-Selinsgrove
-
State College, Pennsylvania, United States, 16801
- Geisinger Medical Group
-
Wilkes-Barre, Pennsylvania, United States, 18711
- Geisinger Wyoming Valley/Henry Cancer Center
-
Wynnewood, Pennsylvania, United States, 19096
- Lankenau Medical Center
-
-
South Carolina
-
Boiling Springs, South Carolina, United States, 29316
- Prisma Health Cancer Institute - Spartanburg
-
Charleston, South Carolina, United States, 29425
- Medical University of South Carolina
-
Easley, South Carolina, United States, 29640
- Prisma Health Cancer Institute - Easley
-
Gaffney, South Carolina, United States, 29341
- Gibbs Cancer Center-Gaffney
-
Greenville, South Carolina, United States, 29605
- Prisma Health Cancer Institute - Faris
-
Greenville, South Carolina, United States, 29607
- Saint Francis Cancer Center
-
Greenville, South Carolina, United States, 29615
- Prisma Health Cancer Institute - Eastside
-
Greenville, South Carolina, United States, 29605
- Prisma Health Cancer Institute - Butternut
-
Greenville, South Carolina, United States, 29601
- Saint Francis Hospital
-
Greenville, South Carolina, United States, 29605
- Prisma Health Greenville Memorial Hospital
-
Greer, South Carolina, United States, 29650
- Prisma Health Cancer Institute - Greer
-
Greer, South Carolina, United States, 29651
- Gibbs Cancer Center-Pelham
-
Seneca, South Carolina, United States, 29672
- Prisma Health Cancer Institute - Seneca
-
Spartanburg, South Carolina, United States, 29303
- Spartanburg Medical Center
-
Spartanburg, South Carolina, United States, 29307
- Spartanburg Medical Center - Mary Black Campus
-
Spartanburg, South Carolina, United States, 29303
- North Grove Medical Park
-
Union, South Carolina, United States, 29379
- SMC Center for Hematology Oncology Union
-
-
South Dakota
-
Aberdeen, South Dakota, United States, 57401
- Avera Cancer Institute-Aberdeen
-
Rapid City, South Dakota, United States, 57701
- Rapid City Regional Hospital
-
Sioux Falls, South Dakota, United States, 57105
- Avera Cancer Institute
-
Sioux Falls, South Dakota, United States, 57117-5134
- Sanford USD Medical Center - Sioux Falls
-
Sioux Falls, South Dakota, United States, 57104
- Sanford Cancer Center Oncology Clinic
-
-
Tennessee
-
Alcoa, Tennessee, United States, 37701
- University Cancer Specialists - Alcoa
-
Bristol, Tennessee, United States, 37620
- Bristol Regional Medical Center
-
Collierville, Tennessee, United States, 38017
- Baptist Memorial Hospital and Cancer Center-Collierville
-
Cookeville, Tennessee, United States, 38501
- Cookeville Regional Medical Center
-
Kingsport, Tennessee, United States, 37660
- Ballad Health Cancer Care - Kingsport
-
Kingsport, Tennessee, United States, 37660
- Wellmont Holston Valley Hospital and Medical Center
-
Knoxville, Tennessee, United States, 37920
- University of Tennessee - Knoxville
-
Memphis, Tennessee, United States, 38120
- Baptist Memorial Hospital and Cancer Center-Memphis
-
-
Texas
-
Austin, Texas, United States, 78701
- Dell Seton Medical Center at The University of Texas
-
Bryan, Texas, United States, 77802
- Saint Joseph Regional Cancer Center
-
Dallas, Texas, United States, 75235
- Parkland Memorial Hospital
-
Dallas, Texas, United States, 75390
- UT Southwestern/Simmons Cancer Center-Dallas
-
Dallas, Texas, United States, 75237
- UT Southwestern Simmons Cancer Center - RedBird
-
Fort Worth, Texas, United States, 76104
- UT Southwestern/Simmons Cancer Center-Fort Worth
-
Galveston, Texas, United States, 77555-0565
- University of Texas Medical Branch
-
Houston, Texas, United States, 77030
- Memorial Hermann Texas Medical Center
-
Laredo, Texas, United States, 78041
- Doctor's Hospital of Laredo
-
Richardson, Texas, United States, 75080
- UT Southwestern Clinical Center at Richardson/Plano
-
-
Utah
-
American Fork, Utah, United States, 84003
- American Fork Hospital / Huntsman Intermountain Cancer Center
-
Cedar City, Utah, United States, 84720
- Sandra L Maxwell Cancer Center
-
Logan, Utah, United States, 84321
- Logan Regional Hospital
-
Murray, Utah, United States, 84107
- Intermountain Medical Center
-
Ogden, Utah, United States, 84403
- McKay-Dee Hospital Center
-
Provo, Utah, United States, 84604
- Utah Valley Regional Medical Center
-
Riverton, Utah, United States, 84065
- Riverton Hospital
-
Salt Lake City, Utah, United States, 84106
- Utah Cancer Specialists-Salt Lake City
-
Salt Lake City, Utah, United States, 84143
- LDS Hospital
-
St. George, Utah, United States, 84770
- Saint George Regional Medical Center
-
-
Vermont
-
Berlin Corners, Vermont, United States, 05602
- Central Vermont Medical Center/National Life Cancer Treatment
-
Burlington, Vermont, United States, 05401
- University of Vermont Medical Center
-
Burlington, Vermont, United States, 05405
- University of Vermont and State Agricultural College
-
-
Virginia
-
Bristol, Virginia, United States, 24201
- Ballad Health Cancer Care - Bristol
-
Fishersville, Virginia, United States, 22939
- Augusta Health Center for Cancer and Blood Disorders
-
Lynchburg, Virginia, United States, 24501
- Centra Alan B Pearson Regional Cancer Center
-
Mechanicsville, Virginia, United States, 23116
- Bon Secours Memorial Regional Medical Center
-
Midlothian, Virginia, United States, 23114
- Bon Secours Saint Francis Medical Center
-
Midlothian, Virginia, United States, 23113
- Bon Secours Westchester Emergency Center
-
Norfolk, Virginia, United States, 23505
- Bon Secours DePaul Medical Center
-
Norton, Virginia, United States, 24273
- Ballad Health Cancer Care - Norton
-
Portsmouth, Virginia, United States, 23707
- Bon Secours Maryview Medical Center
-
Richmond, Virginia, United States, 23226
- Bon Secours Saint Mary's Hospital
-
Richmond, Virginia, United States, 23230
- Bon Secours Cancer Institute at Reynolds Crossing
-
Richmond, Virginia, United States, 23298
- VCU Massey Comprehensive Cancer Center
-
South Hill, Virginia, United States, 23970
- VCU Community Memorial Health Center
-
Suffolk, Virginia, United States, 23435
- Bon Secours Health Center at Harbour View
-
-
Washington
-
Aberdeen, Washington, United States, 98520
- Providence Regional Cancer System-Aberdeen
-
Auburn, Washington, United States, 98001
- MultiCare Auburn Medical Center
-
Bellevue, Washington, United States, 98004
- Overlake Medical Center
-
Bellingham, Washington, United States, 98225
- PeaceHealth Saint Joseph Medical Center
-
Burien, Washington, United States, 98166
- Highline Medical Center-Main Campus
-
Centralia, Washington, United States, 98531
- Providence Regional Cancer System-Centralia
-
Edmonds, Washington, United States, 98026
- Swedish Cancer Institute-Edmonds
-
Enumclaw, Washington, United States, 98022
- Saint Elizabeth Hospital
-
Everett, Washington, United States, 98201
- Providence Regional Cancer Partnership
-
Federal Way, Washington, United States, 98003
- Saint Francis Hospital
-
Gig Harbor, Washington, United States, 98335
- MultiCare Gig Harbor Medical Park
-
Issaquah, Washington, United States, 98029
- Swedish Cancer Institute-Issaquah
-
Kennewick, Washington, United States, 99336
- Kadlec Clinic Hematology and Oncology
-
Lacey, Washington, United States, 98503
- Providence Regional Cancer System-Lacey
-
Lakewood, Washington, United States, 98499
- Saint Clare Hospital
-
Longview, Washington, United States, 98632
- PeaceHealth Saint John Medical Center
-
Port Townsend, Washington, United States, 98368
- Jefferson Healthcare
-
Poulsbo, Washington, United States, 98370
- Harrison HealthPartners Hematology and Oncology-Poulsbo
-
Puyallup, Washington, United States, 98372
- MultiCare Good Samaritan Hospital
-
Renton, Washington, United States, 98055
- Valley Medical Center
-
Seattle, Washington, United States, 98107
- Swedish Medical Center-Ballard Campus
-
Seattle, Washington, United States, 98122
- Swedish Medical Center-First Hill
-
Seattle, Washington, United States, 98104
- Pacific Gynecology Specialists
-
Seattle, Washington, United States, 98122-5711
- Swedish Medical Center-Cherry Hill
-
Sedro-Woolley, Washington, United States, 98284
- PeaceHealth United General Medical Center
-
Shelton, Washington, United States, 98584
- Providence Regional Cancer System-Shelton
-
Silverdale, Washington, United States, 98383
- Saint Joseph Medical Center Hematology and Oncology - Silverdale
-
Spokane, Washington, United States, 99204
- MultiCare Deaconess Cancer and Blood Specialty Center - Downtown
-
Spokane, Washington, United States, 99218
- MultiCare Deaconess Cancer and Blood Specialty Center - North
-
Spokane Valley, Washington, United States, 99216
- MultiCare Deaconess Cancer and Blood Specialty Center - Valley
-
Tacoma, Washington, United States, 98405
- Mary Bridge Children's Hospital and Health Center
-
Tacoma, Washington, United States, 98405
- Northwest Medical Specialties PLLC
-
Tacoma, Washington, United States, 98405
- MultiCare Tacoma General Hospital
-
Tacoma, Washington, United States, 98405
- Franciscan Research Center-Northwest Medical Plaza
-
Vancouver, Washington, United States, 98686
- Legacy Salmon Creek Hospital
-
Vancouver, Washington, United States, 98664
- PeaceHealth Southwest Medical Center
-
Vancouver, Washington, United States, 98684
- Legacy Cancer Institute Medical Oncology and Day Treatment
-
Walla Walla, Washington, United States, 99362
- Providence Saint Mary Regional Cancer Center
-
Yakima, Washington, United States, 98902
- North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
-
Yelm, Washington, United States, 98597
- Providence Regional Cancer System-Yelm
-
-
West Virginia
-
Bridgeport, West Virginia, United States, 26330
- United Hospital Center
-
Charleston, West Virginia, United States, 25304
- West Virginia University Charleston Division
-
Huntington, West Virginia, United States, 25701
- Edwards Comprehensive Cancer Center
-
Martinsburg, West Virginia, United States, 25401
- WVUH-Berkely Medical Center
-
Morgantown, West Virginia, United States, 26506
- West Virginia University Healthcare
-
Parkersburg, West Virginia, United States, 26101
- Camden Clark Medical Center
-
-
Wisconsin
-
Antigo, Wisconsin, United States, 54409
- Langlade Hospital and Cancer Center
-
Appleton, Wisconsin, United States, 54911
- ThedaCare Regional Cancer Center
-
Ashland, Wisconsin, United States, 54806
- Duluth Clinic Ashland
-
Ashland, Wisconsin, United States, 54806
- Northwest Wisconsin Cancer Center
-
Eau Claire, Wisconsin, United States, 54701
- Marshfield Medical Center-EC Cancer Center
-
Eau Claire, Wisconsin, United States, 54701
- HSHS Sacred Heart Hospital
-
Green Bay, Wisconsin, United States, 54301
- Saint Vincent Hospital Cancer Center Green Bay
-
Green Bay, Wisconsin, United States, 54303
- Saint Vincent Hospital Cancer Center at Saint Mary's
-
Green Bay, Wisconsin, United States, 54301
- Bellin Memorial Hospital
-
Madison, Wisconsin, United States, 53792
- University of Wisconsin Carbone Cancer Center - University Hospital
-
Madison, Wisconsin, United States, 53715
- SSM Health Dean Medical Group - South Madison Campus
-
Manitowoc, Wisconsin, United States, 54221
- Holy Family Memorial Hospital
-
Marshfield, Wisconsin, United States, 54449
- Marshfield Medical Center-Marshfield
-
Medford, Wisconsin, United States, 54451
- Aspirus Medford Hospital
-
Menomonee Falls, Wisconsin, United States, 53051
- Froedtert Menomonee Falls Hospital
-
Milwaukee, Wisconsin, United States, 53226
- Medical College of Wisconsin
-
Minocqua, Wisconsin, United States, 54548
- Marshfield Medical Center - Minocqua
-
Mukwonago, Wisconsin, United States, 53149
- ProHealth D N Greenwald Center
-
New Richmond, Wisconsin, United States, 54017
- Cancer Center of Western Wisconsin
-
Oconomowoc, Wisconsin, United States, 53066
- ProHealth Oconomowoc Memorial Hospital
-
Oconto Falls, Wisconsin, United States, 54154
- Saint Vincent Hospital Cancer Center at Oconto Falls
-
Rhinelander, Wisconsin, United States, 54501
- Aspirus Cancer Care - James Beck Cancer Center
-
Rice Lake, Wisconsin, United States, 54868
- Marshfield Medical Center-Rice Lake
-
Sheboygan, Wisconsin, United States, 53081
- HSHS Saint Nicholas Hospital
-
Stevens Point, Wisconsin, United States, 54482
- Marshfield Medical Center-River Region at Stevens Point
-
Stevens Point, Wisconsin, United States, 54481
- Aspirus Cancer Care - Stevens Point
-
Sturgeon Bay, Wisconsin, United States, 54235-1495
- Saint Vincent Hospital Cancer Center at Sturgeon Bay
-
Waukesha, Wisconsin, United States, 53188
- UW Cancer Center at ProHealth Care
-
Waukesha, Wisconsin, United States, 53188
- ProHealth Waukesha Memorial Hospital
-
Wausau, Wisconsin, United States, 54401
- Aspirus Regional Cancer Center
-
West Bend, Wisconsin, United States, 53095
- Froedtert West Bend Hospital/Kraemer Cancer Center
-
Weston, Wisconsin, United States, 54476
- Marshfield Medical Center - Weston
-
Wisconsin Rapids, Wisconsin, United States, 54494
- Aspirus Cancer Care - Wisconsin Rapids
-
-
Wyoming
-
Cheyenne, Wyoming, United States, 82001
- Cheyenne Regional Medical Center-West
-
Cody, Wyoming, United States, 82414
- Billings Clinic-Cody
-
Sheridan, Wyoming, United States, 82801
- Welch Cancer Center
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years and older (Adult, Older Adult)
Accepts Healthy Volunteers
No
Description
Inclusion Criteria:
- STEP I REGISTRATION CRITERIA
- Histologically documented renal cell carcinoma with clear cell component, including patients who have sarcomatoid or rhabdoid features
- Any metastatic disease, including visceral, lymph node, other soft tissue and bone, measurable per RECIST 1.1
- Measurable disease as defined in the protocol
- Must be intermediate or poor risk patient per International Metastatic Renal Cell Carcinoma Database (IMDC) criteria (1 or more of the following): Karnofsky performance status [KPS] < 80, < 1 year from diagnosis [including initial nephrectomy] to systemic treatment for metastatic disease, hemoglobin less than lower limit of normal [LLN], corrected calcium concentration greater than upper limit of normal [ULN], absolute neutrophil count greater than ULN, platelet count > ULN)
- Central nervous system (CNS) disease permitted, if stable and not otherwise causing symptoms or needing active treatment
- Karnofsky performance status >= 70%
- No prior treatment with PD-1, PD-L1, or CTLA-4 targeting agents (including but not limited to nivolumab, pembrolizumab, pidilizumab, durvalumab, atezolizumab, tremelimumab, and ipilimumab), or any other drug or antibody specifically targeting T-cell co-stimulation or checkpoint pathways. The only exception is for prior treatment with nivolumab or other PD-1/PD-L1/CTLA-4 targeting therapy on pre- or post-operative trials, as long as > 1 year since completion of systemic therapy
- No prior previous systemic therapy for renal cell carcinoma (prior HD IL-2 [>28 days]. Prior adjuvant sunitinib >180 days since completion and prior immunotherapy as above are allowed).
- No systemic cancer therapy less than 28 days prior to registration; no radiation therapy less than 14 days prior to registration. There must be a complete recovery and no ongoing complications from radiotherapy
- Not pregnant and not nursing, because this study involves an agent that has known genotoxic, mutagenic and teratogenic effects. Therefore, for women of childbearing potential only, a negative serum or urine pregnancy test done =< 14 days prior to registration is required
- Age >= 18 years
None of the following:
- Active autoimmune disease requiring ongoing therapy
- Ongoing acute toxicity > grade 2 from previous treatment
- History of severe allergic, anaphylactic or other hypersensitivity reactions to chimeric or humanized antibodies
- Active hepatitis B/C, or active tuberculosis (purified protein derivative [PPD] response without active tuberculosis [TB] is allowed)
- HIV-infected patients with detectable viral load within 6 months prior to registration. Patients on effective anti-retroviral therapy with undetectable viral load within 6 months prior to registration are eligible
- Concurrent use of immunosuppressive medication including prednisone above 10 mg daily
- Uncontrolled adrenal insufficiency
- Uncontrolled hypertension (systolic blood pressure [BP] > 150mmHg or diastolic BP > 90mmHg)
- Major surgery less than 28 days prior to registration
- Any serious non-healing wound, ulcer, or bone fracture within 28 days prior to registration
- Any arterial thrombotic events within 180 days prior to registration
- Clinically significant hematuria, hematemesis, or hemoptysis within 12 weeks prior to registration
- Cavitating pulmonary lesions or known endotracheal or endobronchial disease manifestations
- Lesions encasing or invading any major blood vessels (this does not include tumor thrombus extending into/through renal vein/inferior vena cava [IVC]). Patients with tumor thrombus extending into/through renal vein are considered eligible
- Moderate of severe hepatic impairment (child-Pugh B or C)
- Any history of untreated pulmonary embolism or deep venous thrombosis (DVT) in the 180 days prior to registration. (Any asymptomatic, treated pulmonary embolism or asymptomatic, treated deep venous thrombosis > 30 days prior to registration allowed)
- Corrected QT interval calculated by the Fridericia formula (QTcF) > 500 ms
- Unstable cardiac arrhythmia within 6 months prior to registration
- Any gastrointestinal (GI) bleeding =< 180 days, hemoptysis, or other signs of pulmonary hemorrhage =< 90 days prior to registration
- History of abdominal fistula, gastrointestinal perforation, intra-abdominal abscess, bowel obstruction, or gastric outlet obstruction within 180 days prior to registration
- Active peptic ulcer disease, inflammatory bowel disease, or malabsorption syndrome within 28 days prior to registration
- Untreated hypothyroidism (treated hypothyroidism on thyroid replacement therapy is allowed. Abnormal thyroid-stimulating hormone [TSH] is acceptable with normal T3/free T4 if treated on thyroid replacement therapy)
- Evidence of pancreatitis, history of organ transplant, or history of congenital QT syndrome
- Active treatment with coumarin agents (e.g., warfarin), direct thrombin inhibitors (e.g., dabigatran), direct Xa inhibitor betrixaban or platelet inhibitors (e.g., clopidogrel) within 5 days of registration Allowed anticoagulants include: prophylactic use of low-dose aspirin for cardio-protection (per local applicable guidelines) and low-dose low molecular weight heparins (LMWH), therapeutic doses of LMWH or anticoagulation with direct factor Xa inhibitors rivaroxaban, edoxaban, apixaban. Allowed also in patients with known brain metastases who are on a stable dose of the anticoagulant for at least 1 week prior to registration without clinically significant hemorrhagic complications from the anticoagulation regimen or the tumor
- Significant cardiac ischemia events (ST elevation myocardial infarction [STEMI] or non-ST-elevation myocardial infarction [NSTEMI]) within 6 months or active New York (NY) Heart Association class 3-4 heart failure symptoms
- Absolute neutrophil count (ANC) >= 1,500/mm^3
- Platelet count >= 100,000/mm^3
- Hemoglobin >= 8 g/dL
- Calculated (Calc.) creatinine clearance >= 30 mL/min
- Urine protein =< 1+ or urine protein to creatinine (UPC) ratio < 1
- Total bilirubin =< 1.5 x upper limit of normal (ULN) (except for patients with known or likely Gilbert's syndrome, for whom total bilirubin up to 3 mg/dL is allowed with direct bilirubin =< 20% total bilirubin)
- Aspartate aminotransferase/alanine aminotransferase (AST/ALT) =< 2.5 x upper limit of normal (ULN) or < 5 x ULN if hepatic metastases present
- STEP 2 REGISTRATION ELIGIBILITY CRITERIA
- Successful completion of at least 1 cycle of ipilimumab/nivolumab
- Resolution of any treatment-related adverse events to grade 1 or less per dose modification section (this criteria does not include any adverse events [AEs] not attributable to treatment which are present due to disease), with prednisone-equivalent dosing at 10 mg daily or less. Exceptions for this criteria include patients receiving replacement hormone treatments (such as levothyroxine for treatment-related hypothyroidism or glucocorticoid replacement for adrenal insufficiency). Please contact study chair if further discussion is needed
- No more than 80 days from last dose of ipilimumab/nivolumab
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
|---|---|
|
Active Comparator: Arm A (nivolumab)
INDUCTION: Patients receive nivolumab IV over 30 minutes and ipilimumab IV over 30 minutes on day 1. Treatment repeats every 21 days for up to 4 cycles in the absence of disease progression or unacceptable toxicity. TREATMENT: Patients with iuPD with clinical instability receive cabozantinib PO daily on days 1-28. Treatment repeats every 28 days until further disease progression or unacceptable toxicity Patients with iCR receive nivolumab IV over 30 minutes on day 1. Treatment repeats every 28 days in the absence of disease progression or unacceptable toxicity. Patients with non-CR/non-PD with clinical stability receive nivolumab IV over 30 minutes on day 1. Treatment repeats every 28 days in the absence of disease progression or unacceptable toxicity. Patients undergo CT scan, MRI and blood and urine sample collection, and may also undergo a bone scan as clinically indicated throughout the study. |
Given IV
Other Names:
Ancillary studies
Other Names:
Ancillary studies
Undergo MRI
Other Names:
Given IV
Other Names:
Undergo CT scan
Other Names:
Undergo blood and urine sample collection
Other Names:
Undergo bone scan
Other Names:
|
|
Experimental: Arm B (nivolumab, cabozantinib)
INDUCTION: Patients receive nivolumab IV over 30 minutes and ipilimumab IV over 30 minutes on day 1. Treatment repeats every 21 days for up to 4 cycles in the absence of disease progression or unacceptable toxicity. TREATMENT: Patients with iuPD with clinical instability receive cabozantinib PO daily on days 1-28. Treatment repeats every 28 days until further disease progression or unacceptable toxicity. Patients with iCR receive nivolumab IV over 30 minutes on day 1. Treatment repeats every 28 days in the absence of disease progression or unacceptable toxicity. Patients with non-CR/non-PD rwith clinical stability eceive nivolumab IV over 30 minutes on day 1 and cabozantinib PO daily on days 1-28. Treatment repeats every 28 days in the absence of disease progression or unacceptable toxicity. Patients undergo CT scan, MRI and blood and urine sample collection, and may also undergo a bone scan as clinically indicated throughout the study. |
Given IV
Other Names:
Ancillary studies
Other Names:
Ancillary studies
Undergo MRI
Other Names:
Given IV
Other Names:
Given PO
Undergo CT scan
Other Names:
Undergo blood and urine sample collection
Other Names:
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
|---|---|---|
|
Overall survival (OS)
Time Frame: From registration to date of death from any cause for non-randomized patients, from time of randomization until death from any cause for randomized patients, assessed up to 5 years
|
OS of patients who achieve complete response (CR) and progressive disease (PD) from ipilimumab-nivolumab induction phase will be summarized.
The stratified log-rank statistic will be the primary analysis to compare the hypothesis on OS with the stratification factors (presence of bone metastases and IMDC risk criteria).
The Kaplan-Meier product-limit estimator will be used to estimate the OS.
A stratified proportional hazards model will be used to generate estimates for the OS hazard ratio.
For the randomized patients, OS will be calculated and compared from the time of randomization until the time of an OS event or time of last-follow-up, whatever occurs first.
For the patients who were initially CR or PD, OS will be measured from the time of study registration.
A comparison of OS will be made across the patient groups (randomized patients, patients initially CR, and patients initially PD).
|
From registration to date of death from any cause for non-randomized patients, from time of randomization until death from any cause for randomized patients, assessed up to 5 years
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
|---|---|---|
|
Progression-free survival (PFS)
Time Frame: From date of registration to date of progression (or disease recurrence) or death due to any cause, whichever occurs first, assessed up to 5 years
|
Progression will be defined using the Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 criteria.
PFS of patients who achieve CR and PD from ipilimumab-nivolumab induction phase will be summarized (secondary analysis).
The Kaplan-Meier product-limit estimator will be used to estimate the PFS distribution.
A stratified proportional hazards model will be used to generate estimates for the PFS hazard ratio.
For the randomized patients, PFS will be calculated and compared from the time of randomization until the time of a PFS event or time of last-follow-up, whatever occurs first.
For the patients who were initially CR or PD, PFS will be measured from the time of study registration.
A comparison of PFS will be made across the patient groups (randomized patients, patients initially CR, and patients initially PD).
For this comparison, PFS will be measured from time of study registration all the patients, regardless of whether they were randomized or not.
|
From date of registration to date of progression (or disease recurrence) or death due to any cause, whichever occurs first, assessed up to 5 years
|
|
Complete response (CR) (randomized patients)
Time Frame: At 12 months from date of randomization
|
Patients who had a CR prior to 12 months but have experienced a disease recurrence prior to 12 months, will not be considered to be a CR at 12 months.
The Cochran-Mantel-Haenszel test will be used to compare the two arms on the proportion of patients who have a 12-month CR adjusting on the stratification factors.
|
At 12 months from date of randomization
|
|
Objective response
Time Frame: Up to 5 years
|
Defined as the best response observed that has been confirmed by a scan performed 4 or more weeks after the observation of the initial response.
The objective response will be confirmed using RECIST 1.1.
In addition, objective responses will also be confirmed using Immune Response Evaluation Criteria in Solid Tumors (iRECIST).
|
Up to 5 years
|
|
Proportion of patients who discontinue protocol-directed treatment prior to 1 year from date of study registration
Time Frame: Up to 5 years
|
Patients who stop their protocol directed treatment for any reason prior to one year from study registration will be considered to have discontinued their treatment.
The Cochran-Mantel-Haenszel test will also be used to compare the proportion of patients who discontinue their treatment prior to one-year after study registration.
|
Up to 5 years
|
|
Incidence of adverse events
Time Frame: Up to 5 years
|
Assessed with National Cancer Institute Common Terminology Criteria for Adverse Events version 5.0.
A Fisher's exact test will be used to compare the two treatment arms on the proportion of patient with a grade 3 or higher adverse event.
|
Up to 5 years
|
Other Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
|---|---|---|
|
Estimates of OS by sex
Time Frame: From registration to date of death from any cause for non-randomized patients, from time of randomization until death from any cause for randomized patients, assessed up to 5 years
|
Estimates of OS and the corresponding 95% confidence intervals (CIs) by sex will be provided (with an understanding that sometimes the CI or estimate will not be computable because of scant data).
|
From registration to date of death from any cause for non-randomized patients, from time of randomization until death from any cause for randomized patients, assessed up to 5 years
|
|
Estimates of OS by race
Time Frame: From registration to date of death from any cause for non-randomized patients, from time of randomization until death from any cause for randomized patients, assessed up to 5 years
|
Estimates of OS and the corresponding 95% CIs by race will be provided (with an understanding that sometimes the CI or estimate will not be computable because of scant data).
|
From registration to date of death from any cause for non-randomized patients, from time of randomization until death from any cause for randomized patients, assessed up to 5 years
|
|
Estimates of OS by ethnicity
Time Frame: From registration to date of death from any cause for non-randomized patients, from time of randomization until death from any cause for randomized patients, assessed up to 5 years
|
Estimates of OS and the corresponding 95% CIs by ethnicity will be provided (with an understanding that sometimes the CI or estimate will not be computable because of scant data).
|
From registration to date of death from any cause for non-randomized patients, from time of randomization until death from any cause for randomized patients, assessed up to 5 years
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Investigators
- Principal Investigator: Tian Zhang, Alliance for Clinical Trials in Oncology
Publications and helpful links
The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.
General Publications
- Yang Y, Psutka SP, Parikh AB, Li M, Collier K, Miah A, Mori SV, Hinkley M, Tykodi SS, Hall E, Thompson JA, Yin M. Combining immune checkpoint inhibition plus tyrosine kinase inhibition as first and subsequent treatments for metastatic renal cell carcinoma. Cancer Med. 2022 Aug;11(16):3106-3114. doi: 10.1002/cam4.4679. Epub 2022 Mar 18.
- Labriola MK, George DJ. Setting a new standard for long-term survival in metastatic kidney cancer. Cancer. 2022 Jun 1;128(11):2058-2060. doi: 10.1002/cncr.34177. Epub 2022 Apr 5. No abstract available.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
June 7, 2019
Primary Completion (Estimated)
January 25, 2028
Study Completion (Estimated)
January 25, 2028
Study Registration Dates
First Submitted
January 3, 2019
First Submitted That Met QC Criteria
January 3, 2019
First Posted (Actual)
January 4, 2019
Study Record Updates
Last Update Posted (Actual)
May 29, 2026
Last Update Submitted That Met QC Criteria
May 28, 2026
Last Verified
February 1, 2026
More Information
Terms related to this study
Additional Relevant MeSH Terms
- Urogenital Diseases
- Pathologic Processes
- Urogenital Neoplasms
- Neoplasms by Site
- Neoplasms
- Male Urogenital Diseases
- Kidney Diseases
- Urologic Diseases
- Female Urogenital Diseases
- Female Urogenital Diseases and Pregnancy Complications
- Neoplasms by Histologic Type
- Neoplasms, Glandular and Epithelial
- Adenocarcinoma
- Neoplastic Processes
- Urologic Neoplasms
- Carcinoma
- Kidney Neoplasms
- Neoplasm Metastasis
- Pathological Conditions, Signs and Symptoms
- Carcinoma, Renal Cell
- Lymphatic Metastasis
- Amino Acids, Peptides, and Proteins
- Proteins
- Investigative Techniques
- Clinical Laboratory Techniques
- Diagnostic Techniques and Procedures
- Diagnosis
- Biological Factors
- Antibodies, Monoclonal, Humanized
- Antibodies, Monoclonal
- Antibodies
- Immunoglobulins
- Immunoproteins
- Blood Proteins
- Serum Globulins
- Globulins
- Chemistry Techniques, Analytical
- Spectrum Analysis
- Receptors, Cell Surface
- Membrane Proteins
- Antigens
- Antigens, Surface
- Biomarkers
- Receptors, Immunologic
- Antigens, Differentiation, T-Lymphocyte
- Antigens, Differentiation
- Immune Checkpoint Proteins
- Costimulatory and Inhibitory T-Cell Receptors
- Nivolumab
- Ipilimumab
- Specimen Handling
- Magnetic Resonance Spectroscopy
- cabozantinib
- CTLA-4 Antigen
Other Study ID Numbers
- NCI-2018-03694 (Registry Identifier: CTRP (Clinical Trial Reporting Program))
- U10CA180821 (U.S. NIH Grant/Contract)
- A031704 (Other Identifier: CTEP)
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
YES
IPD Plan Description
NCI is committed to sharing data in accordance with NIH policy.
For more details on how clinical trial data is shared, access the link to the NIH data sharing policy page
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Yes
Studies a U.S. FDA-regulated device product
No
product manufactured in and exported from the U.S.
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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