Immunterapi med Nivolumab och Ipilimumab följt av Nivolumab eller Nivolumab med Cabozantinib för patienter med avancerad njurcancer, PDIGREE-studien
23 oktober 2026 uppdaterad av: National Cancer Institute (NCI)
PD-hämmare (Nivolumab) och Ipilimumab följt av Nivolumab vs. VEGF TKI Cabozantinib med Nivolumab: En fas III-studie i metastaserad obehandlad njurcellscancer [PDIGREE]
This phase III trial compares the usual treatment (treatment with ipilimumab and nivolumab followed by nivolumab alone) to treatment with ipilimumab and nivolumab, followed by nivolumab with cabozantinib in patients with untreated renal cell carcinoma that has spread to other parts of the body. The addition of cabozantinib to the usual treatment may make it work better. Immunotherapy with monoclonal antibodies, such as nivolumab and ipilimumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Cabozantinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. It is not yet known how well the combination of cabozantinib and nivolumab after initial treatment with ipilimumab and nivolumab works in treating patients with renal cell cancer that has spread to other parts of the body.
Studieöversikt
Status
Aktiv, inte rekryterande
Betingelser
- Clear Cell Renal Cell Carcinom
- Steg III njurcellscancer AJCC v8
- Steg IV njurcellscancer AJCC v8
- Metastatisk malign neoplasm i benet
- Metastatisk malign neoplasm i lymfkörtlarna
- Metastatisk malign neoplasma i inälvorna
- Sarkomatoid njurcellscancer
- Rhabdoid tumör i njuren
- Metastaserande malign neoplasma i mjukvävnaden
Detaljerad beskrivning
PRIMARY OBJECTIVE:
I. To compare the overall survival (OS) in patients with metastatic renal cell cancer (RCC) treated with ipilimumab-nivolumab followed by either nivolumab versus cabozantinib-nivolumab.
SECONDARY OBJECTIVES:
I. To determine progression free survival (PFS) of patients treated with nivolumab versus nivolumab-cabozantinib.
II. To evaluate the 12-month complete response rate in patients treated with ipilimumab-nivolumab followed by cabozantinib-nivolumab versus ipilimumab-nivolumab followed by nivolumab (patients who have complete response [CR] and relapse before 12 months will not be counted as a CR at 12-months).
III. To evaluate the rates of discontinuing therapy at 1 year. IV. To compare objective response rates (ORR, assessed by Response Evaluation Criteria in Solid Tumors [RECIST] 1.1 and Immune Response Evaluation Criteria in Solid Tumors [iRECIST] criteria) for patients treated with ipilimumab-nivolumab followed by cabozantinib-nivolumab versus ipilimumab-nivolumab followed by nivolumab.
V. To document the adverse event profile of ipilimumab-nivolumab followed by cabozantinib-nivolumab.
BIOMARKER OBJECTIVES:
I. To evaluate biomarkers associated with exceptional responses in both arms (exceptional responses defined as CRs with treatment discontinuation at 12 months or 24 months).
II. To evaluate whether baseline IL-6 is predictive of outcome in patients treated with cabozantinib-containing regimen.
QUALITY OF LIFE (QOL) OBJECTIVES:
I. To compare health-related quality of life at 18 months post-registration as assessed by the Functional Assessment of Cancer Therapy (FACT)-Kidney Symptom Index 19 (FKSI-19) between patients randomized to nivolumab (nivo) versus (vs) cabozantinib (cabo)/nivo.
II. To compare health-related quality of life as assessed by the FKSI-19 between patients randomized to nivo vs cabo/nivo at other time points.
III. To compare patient-reported fatigue using Patient-Reported Outcomes Measurement Information System (PROMIS)-Fatigue between patients randomized to nivo vs cabo/nivo.
IV. To compare quality-adjusted survival (overall survival x utility score assessed by EuroQol five-dimensional questionnaire [EQ5D-5L]) between patients randomized to nivo vs cabo/nivo.
OUTLINE:
INDUCTION: Patients receive nivolumab intravenously (IV) over 30 minutes and ipilimumab IV over 30 minutes on day 1. Treatment repeats every 21 days for up to 4 cycles in the absence of disease progression or unacceptable toxicity.
TREATMENT:
Patients with unconfirmed but clinical progression of disease (iuPD) with clinical instability receive cabozantinib orally (PO) daily on days 1-28. Treatment repeats every 28 days until further disease progression or unacceptable toxicity.
Patients with unconfirmed CR (iCR) receive nivolumab IV between 30-60 minutes on day 1. Treatment repeats every 28 days in the absence of disease progression or unacceptable toxicity.
Patients with non-CR/non-PD or iuPD with clinical stability are randomized to 1 of 2 arms.
ARM A: Patients receive nivolumab IV between 30-60 minutes on day 1. Treatment repeats every 28 days in the absence of disease progression or unacceptable toxicity.
ARM B: Patients receive nivolumab IV between 30-60 minutes on day 1 and cabozantinib PO daily on days 1-28. Treatment repeats every 28 days in the absence of disease progression or unacceptable toxicity.
Patients undergo computed tomography (CT) scan, magnetic resonance imaging (MRI) and blood and urine sample collection, and may also undergo a bone scan as clinically indicated throughout the study.
Studietyp
Interventionell
Inskrivning (Beräknad)
1175
Fas
- Fas 3
Kontakter och platser
Det här avsnittet innehåller kontaktuppgifter för dem som genomför studien och information om var denna studie genomförs.
Studieorter
-
-
Alabama
-
Mobile, Alabama, Förenta staterna, 36688
- University of South Alabama Mitchell Cancer Institute
-
-
Alaska
-
Anchorage, Alaska, Förenta staterna, 98508
- Anchorage Associates in Radiation Medicine
-
Anchorage, Alaska, Förenta staterna, 99508
- Alaska Breast Care and Surgery LLC
-
Anchorage, Alaska, Förenta staterna, 99508
- Alaska Oncology and Hematology LLC
-
Anchorage, Alaska, Förenta staterna, 99508
- Alaska Women's Cancer Care
-
Anchorage, Alaska, Förenta staterna, 99508
- Anchorage Oncology Centre
-
Anchorage, Alaska, Förenta staterna, 99508
- Katmai Oncology Group
-
Anchorage, Alaska, Förenta staterna, 99508
- Providence Alaska Medical Center
-
Anchorage, Alaska, Förenta staterna, 99504
- Anchorage Radiation Therapy Center
-
Fairbanks, Alaska, Förenta staterna, 99701
- Fairbanks Memorial Hospital
-
-
Arizona
-
Kingman, Arizona, Förenta staterna, 86401
- Kingman Regional Medical Center
-
Phoenix, Arizona, Förenta staterna, 85004
- Cancer Center at Saint Joseph's
-
-
Arkansas
-
Fayetteville, Arkansas, Förenta staterna, 72703
- Highlands Oncology Group - Fayetteville
-
Fort Smith, Arkansas, Förenta staterna, 72903
- Mercy Hospital Fort Smith
-
Hot Springs, Arkansas, Förenta staterna, 71913
- CHI Saint Vincent Cancer Center Hot Springs
-
Rogers, Arkansas, Förenta staterna, 72758
- Highlands Oncology Group - Rogers
-
Springdale, Arkansas, Förenta staterna, 72762
- Highlands Oncology Group
-
-
California
-
Anaheim, California, Förenta staterna, 92806
- Kaiser Permanente-Anaheim
-
Arroyo Grande, California, Förenta staterna, 93420
- PCR Oncology
-
Arroyo Grande, California, Förenta staterna, 93420
- Mission Hope Medical Oncology - Arroyo Grande
-
Baldwin Park, California, Förenta staterna, 91706
- Kaiser Permanente-Baldwin Park
-
Bellflower, California, Förenta staterna, 90706
- Kaiser Permanente-Bellflower
-
Burbank, California, Förenta staterna, 91505
- Providence Saint Joseph Medical Center/Disney Family Cancer Center
-
Clovis, California, Förenta staterna, 93611
- Community Cancer Institute
-
Clovis, California, Förenta staterna, 93611
- University Oncology Associates
-
Fontana, California, Förenta staterna, 92335
- Kaiser Permanente-Fontana
-
Harbor City, California, Förenta staterna, 90710
- Kaiser Permanente South Bay
-
Irvine, California, Förenta staterna, 92618
- Kaiser Permanente-Irvine
-
La Jolla, California, Förenta staterna, 92093
- UC San Diego Moores Cancer Center
-
Los Angeles, California, Förenta staterna, 90027
- Kaiser Permanente Los Angeles Medical Center
-
Los Angeles, California, Förenta staterna, 90034
- Kaiser Permanente West Los Angeles
-
Ontario, California, Förenta staterna, 91761
- Kaiser Permanente-Ontario
-
Panorama City, California, Förenta staterna, 91402
- Kaiser Permanente - Panorama City
-
Riverside, California, Förenta staterna, 92505
- Kaiser Permanente-Riverside
-
Sacramento, California, Förenta staterna, 95817
- University of California Davis Comprehensive Cancer Center
-
San Diego, California, Förenta staterna, 92120
- Kaiser Permanente-San Diego Zion
-
San Diego, California, Förenta staterna, 92134
- Naval Medical Center -San Diego
-
San Diego, California, Förenta staterna, 92123
- Sharp Memorial Hospital
-
San Diego, California, Förenta staterna, 92108
- Kaiser Permanente-Rio San Diego
-
San Francisco, California, Förenta staterna, 94158
- UCSF Medical Center-Mission Bay
-
San Luis Obispo, California, Förenta staterna, 93401
- Pacific Central Coast Health Center-San Luis Obispo
-
San Marcos, California, Förenta staterna, 92078
- Kaiser Permanente-San Marcos
-
Santa Maria, California, Förenta staterna, 93444
- Mission Hope Medical Oncology - Santa Maria
-
Woodland Hills, California, Förenta staterna, 91367
- Kaiser Permanente-Woodland Hills
-
-
Colorado
-
Aurora, Colorado, Förenta staterna, 80012
- Rocky Mountain Cancer Centers-Aurora
-
Aurora, Colorado, Förenta staterna, 80012
- The Medical Center of Aurora
-
Aurora, Colorado, Förenta staterna, 80045
- UCHealth University of Colorado Hospital
-
Boulder, Colorado, Förenta staterna, 80303
- Boulder Community Foothills Hospital
-
Boulder, Colorado, Förenta staterna, 80304
- Rocky Mountain Cancer Centers-Boulder
-
Centennial, Colorado, Förenta staterna, 80112
- Rocky Mountain Cancer Centers - Centennial
-
Colorado Springs, Colorado, Förenta staterna, 80907
- Penrose-Saint Francis Healthcare
-
Colorado Springs, Colorado, Förenta staterna, 80909
- UCHealth Memorial Hospital Central
-
Colorado Springs, Colorado, Förenta staterna, 80907
- Rocky Mountain Cancer Centers-Penrose
-
Colorado Springs, Colorado, Förenta staterna, 80920
- Memorial Hospital North
-
Denver, Colorado, Förenta staterna, 80205
- Kaiser Permanente-Franklin
-
Denver, Colorado, Förenta staterna, 80218
- Presbyterian - Saint Lukes Medical Center - Health One
-
Denver, Colorado, Förenta staterna, 80220
- Rose Medical Center
-
Denver, Colorado, Förenta staterna, 80218
- Rocky Mountain Cancer Centers-Midtown
-
Denver, Colorado, Förenta staterna, 80220
- Rocky Mountain Cancer Centers-Rose
-
Denver, Colorado, Förenta staterna, 80218
- Colorado Blood Cancer Institute
-
Denver, Colorado, Förenta staterna, 80204
- Cancer Center of Colorado at Sloan's Lake
-
Denver, Colorado, Förenta staterna, 80209
- The Women's Imaging Center
-
Denver, Colorado, Förenta staterna, 80206
- National Jewish Health-Main Campus
-
Denver, Colorado, Förenta staterna, 80220
- Western Surgical Care
-
Denver, Colorado, Förenta staterna, 80206
- UCHealth - Cherry Creek
-
Denver, Colorado, Förenta staterna, 80218
- Saint Joseph Hospital - Cancer Centers of Colorado
-
Denver, Colorado, Förenta staterna, 80210
- AdventHealth Porter
-
Durango, Colorado, Förenta staterna, 81301
- Mercy Medical Center
-
Durango, Colorado, Förenta staterna, 81301
- CommonSpirit Cancer Center Mercy
-
Englewood, Colorado, Förenta staterna, 80113
- Mountain Blue Cancer Care Center - Swedish
-
Englewood, Colorado, Förenta staterna, 80113
- Swedish Medical Center
-
Englewood, Colorado, Förenta staterna, 80113
- Rocky Mountain Cancer Centers - Swedish
-
Englewood, Colorado, Förenta staterna, 80113
- The Melanoma and Skin Cancer Institute
-
Fort Collins, Colorado, Förenta staterna, 80524
- Poudre Valley Hospital
-
Fort Collins, Colorado, Förenta staterna, 80528
- Cancer Care and Hematology-Fort Collins
-
Golden, Colorado, Förenta staterna, 80401
- National Jewish Health-Western Hematology Oncology
-
Grand Junction, Colorado, Förenta staterna, 81501
- Saint Mary's Hospital and Regional Medical Center
-
Greeley, Colorado, Förenta staterna, 80631
- UCHealth Greeley Hospital
-
Greeley, Colorado, Förenta staterna, 80631
- Banner North Colorado Medical Center
-
Highlands Ranch, Colorado, Förenta staterna, 80129
- UCHealth Highlands Ranch Hospital
-
Lafayette, Colorado, Förenta staterna, 80026
- Kaiser Permanente-Rock Creek
-
Lafayette, Colorado, Förenta staterna, 80026
- Good Samaritan Hospital - Cancer Centers of Colorado
-
Lakewood, Colorado, Förenta staterna, 80228
- Rocky Mountain Cancer Centers-Lakewood
-
Lakewood, Colorado, Förenta staterna, 80228
- CommonSpirit Saint Anthony Hospital Cancer Center
-
Littleton, Colorado, Förenta staterna, 80120
- Rocky Mountain Cancer Centers-Littleton
-
Littleton, Colorado, Förenta staterna, 80122
- AdventHealth Littleton
-
Lone Tree, Colorado, Förenta staterna, 80124
- Kaiser Permanente-Lone Tree
-
Lone Tree, Colorado, Förenta staterna, 80124
- Sky Ridge Medical Center
-
Lone Tree, Colorado, Förenta staterna, 80124
- Rocky Mountain Cancer Centers-Sky Ridge
-
Lone Tree, Colorado, Förenta staterna, 80124
- UCHealth Lone Tree Health Center
-
Longmont, Colorado, Förenta staterna, 80501
- Longmont United Hospital
-
Longmont, Colorado, Förenta staterna, 80501
- Rocky Mountain Cancer Centers-Longmont
-
Loveland, Colorado, Förenta staterna, 80538
- Medical Center of the Rockies
-
Loveland, Colorado, Förenta staterna, 80539
- Banner North Colorado Medical Center - Loveland Campus
-
Parker, Colorado, Förenta staterna, 80138
- AdventHealth Parker
-
Pueblo, Colorado, Förenta staterna, 81004
- Saint Mary Corwin Medical Center
-
Thornton, Colorado, Förenta staterna, 80260
- Rocky Mountain Cancer Centers-Thornton
-
Thornton, Colorado, Förenta staterna, 80260
- National Jewish Health-Northern Hematology Oncology
-
Wheat Ridge, Colorado, Förenta staterna, 80401
- Intermountain Health Lutheran Hospital
-
-
Connecticut
-
Stamford, Connecticut, Förenta staterna, 06904
- Stamford Hospital/Bennett Cancer Center
-
-
Delaware
-
Lewes, Delaware, Förenta staterna, 19958
- Beebe Medical Center
-
Millville, Delaware, Förenta staterna, 19967
- Beebe South Coastal Health Campus
-
Newark, Delaware, Förenta staterna, 19713
- Helen F Graham Cancer Center
-
Newark, Delaware, Förenta staterna, 19713
- Delaware Clinical and Laboratory Physicians PA
-
Newark, Delaware, Förenta staterna, 19713
- Medical Oncology Hematology Consultants PA
-
Newark, Delaware, Förenta staterna, 19718
- Christiana Care Health System-Christiana Hospital
-
Rehoboth Beach, Delaware, Förenta staterna, 19971
- Beebe Health Campus
-
Seaford, Delaware, Förenta staterna, 19973
- TidalHealth Nanticoke / Allen Cancer Center
-
Wilmington, Delaware, Förenta staterna, 19801
- Christiana Care Health System-Wilmington Hospital
-
-
District of Columbia
-
Washington D.C., District of Columbia, Förenta staterna, 20037
- George Washington University Medical Center
-
Washington D.C., District of Columbia, Förenta staterna, 20010
- MedStar Washington Hospital Center
-
Washington D.C., District of Columbia, Förenta staterna, 20007
- MedStar Georgetown University Hospital
-
-
Florida
-
Coral Gables, Florida, Förenta staterna, 33146
- UM Sylvester Comprehensive Cancer Center at Coral Gables
-
Deerfield Beach, Florida, Förenta staterna, 33442
- UM Sylvester Comprehensive Cancer Center at Deerfield Beach
-
Fort Lauderdale, Florida, Förenta staterna, 33308
- Holy Cross Hospital
-
Gainesville, Florida, Förenta staterna, 32610
- UF Health Cancer Institute - Gainesville
-
Miami, Florida, Förenta staterna, 33136
- University of Miami Miller School of Medicine-Sylvester Cancer Center
-
Miami, Florida, Förenta staterna, 33176
- UM Sylvester Comprehensive Cancer Center at Kendall
-
Orlando, Florida, Förenta staterna, 32806
- Orlando Health Cancer Institute
-
Plantation, Florida, Förenta staterna, 33324
- UM Sylvester Comprehensive Cancer Center at Plantation
-
-
Georgia
-
Atlanta, Georgia, Förenta staterna, 30342
- Northside Hospital
-
Duluth, Georgia, Förenta staterna, 30096
- Northside Hospital - Duluth
-
Lawrenceville, Georgia, Förenta staterna, 30046
- Northside Hospital - Gwinnett
-
Savannah, Georgia, Förenta staterna, 31405
- Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
-
Snellville, Georgia, Förenta staterna, 30078
- Suburban Hematology Oncology Associates - Snellville
-
-
Hawaii
-
Honolulu, Hawaii, Förenta staterna, 96813
- Queen's Medical Center
-
Honolulu, Hawaii, Förenta staterna, 96817
- The Cancer Center of Hawaii-Liliha
-
Honolulu, Hawaii, Förenta staterna, 96813
- Hawaii Cancer Care Inc - Waterfront Plaza
-
Honolulu, Hawaii, Förenta staterna, 96813
- Queen's Cancer Cenrer - POB I
-
Honolulu, Hawaii, Förenta staterna, 96813
- Straub Clinic and Hospital
-
Honolulu, Hawaii, Förenta staterna, 96813
- University of Hawaii Cancer Center
-
Honolulu, Hawaii, Förenta staterna, 96817
- Queen's Cancer Center - Kuakini
-
Honolulu, Hawaii, Förenta staterna, 96826
- Kapiolani Medical Center for Women and Children
-
Honolulu, Hawaii, Förenta staterna, 96813
- Island Urology
-
Lihue, Hawaii, Förenta staterna, 96766
- Wilcox Memorial Hospital and Kauai Medical Clinic
-
‘Aiea, Hawaii, Förenta staterna, 96701
- Hawaii Cancer Care - Westridge
-
‘Aiea, Hawaii, Förenta staterna, 96701
- Pali Momi Medical Center
-
‘Aiea, Hawaii, Förenta staterna, 96701
- Queen's Cancer Center - Pearlridge
-
‘Aiea, Hawaii, Förenta staterna, 96701
- The Cancer Center of Hawaii-Pali Momi
-
-
Idaho
-
Boise, Idaho, Förenta staterna, 83706
- Saint Alphonsus Cancer Care Center-Boise
-
Boise, Idaho, Förenta staterna, 83712
- Saint Luke's Cancer Institute - Boise
-
Caldwell, Idaho, Förenta staterna, 83605
- Saint Alphonsus Cancer Care Center-Caldwell
-
Coeur d'Alene, Idaho, Förenta staterna, 83814
- Kootenai Health - Coeur d'Alene
-
Emmett, Idaho, Förenta staterna, 83617
- Walter Knox Memorial Hospital
-
Fruitland, Idaho, Förenta staterna, 83619
- Saint Luke's Cancer Institute - Fruitland
-
Meridian, Idaho, Förenta staterna, 83642
- Idaho Urologic Institute-Meridian
-
Meridian, Idaho, Förenta staterna, 83642
- Saint Luke's Cancer Institute - Meridian
-
Nampa, Idaho, Förenta staterna, 83687
- Saint Alphonsus Cancer Care Center-Nampa
-
Nampa, Idaho, Förenta staterna, 83687
- Saint Luke's Cancer Institute - Nampa
-
Post Falls, Idaho, Förenta staterna, 83854
- Kootenai Clinic Cancer Services - Post Falls
-
Sandpoint, Idaho, Förenta staterna, 83864
- Kootenai Clinic Cancer Services - Sandpoint
-
Twin Falls, Idaho, Förenta staterna, 83301
- Saint Luke's Cancer Institute - Twin Falls
-
-
Illinois
-
Alton, Illinois, Förenta staterna, 62002
- OSF Saint Anthony's Health Center
-
Aurora, Illinois, Förenta staterna, 60504
- Rush-Copley Medical Center
-
Bloomington, Illinois, Förenta staterna, 61704
- Illinois CancerCare-Bloomington
-
Burr Ridge, Illinois, Förenta staterna, 60527
- Loyola Center for Health at Burr Ridge
-
Canton, Illinois, Förenta staterna, 61520
- Illinois CancerCare-Canton
-
Carbondale, Illinois, Förenta staterna, 62902
- Memorial Hospital of Carbondale
-
Carterville, Illinois, Förenta staterna, 62918
- SIH Cancer Institute
-
Carthage, Illinois, Förenta staterna, 62321
- Illinois CancerCare-Carthage
-
Centralia, Illinois, Förenta staterna, 62801
- Centralia Oncology Clinic
-
Chicago, Illinois, Förenta staterna, 60611
- Northwestern University
-
Chicago, Illinois, Förenta staterna, 60637
- University of Chicago Comprehensive Cancer Center
-
Chicago, Illinois, Förenta staterna, 60612
- John H Stroger Jr Hospital of Cook County
-
Chicago, Illinois, Förenta staterna, 60612
- Rush MD Anderson Cancer Center
-
Danville, Illinois, Förenta staterna, 61832
- Carle at The Riverfront
-
DeKalb, Illinois, Förenta staterna, 60115
- Northwestern Medicine Cancer Center Kishwaukee
-
Decatur, Illinois, Förenta staterna, 62526
- Decatur Memorial Hospital
-
Decatur, Illinois, Förenta staterna, 62526
- Cancer Care Specialists of Illinois - Decatur
-
Dixon, Illinois, Förenta staterna, 61021
- Illinois CancerCare-Dixon
-
Effingham, Illinois, Förenta staterna, 62401
- Crossroads Cancer Center
-
Effingham, Illinois, Förenta staterna, 62401
- Carle Physician Group-Effingham
-
Elmhurst, Illinois, Förenta staterna, 60126
- Elmhurst Memorial Hospital
-
Eureka, Illinois, Förenta staterna, 61530
- Illinois CancerCare-Eureka
-
Galesburg, Illinois, Förenta staterna, 61401
- Western Illinois Cancer Treatment Center
-
Galesburg, Illinois, Förenta staterna, 61401
- Illinois CancerCare-Galesburg
-
Geneva, Illinois, Förenta staterna, 60134
- Northwestern Medicine Cancer Center Delnor
-
Harvey, Illinois, Förenta staterna, 60426
- Ingalls Memorial Hospital
-
Homer Glen, Illinois, Förenta staterna, 60491
- Loyola Medicine Homer Glen
-
Joliet, Illinois, Förenta staterna, 60435
- Duly Health and Care Joliet
-
Kewanee, Illinois, Förenta staterna, 61443
- Illinois CancerCare-Kewanee Clinic
-
Lake Forest, Illinois, Förenta staterna, 60045
- Northwestern Medicine Lake Forest Hospital
-
Macomb, Illinois, Förenta staterna, 61455
- Illinois CancerCare-Macomb
-
Mattoon, Illinois, Förenta staterna, 61938
- Carle Physician Group-Mattoon/Charleston
-
Maywood, Illinois, Förenta staterna, 60153
- Loyola University Medical Center
-
Melrose Park, Illinois, Förenta staterna, 60160
- Marjorie Weinberg Cancer Center at Loyola-Gottlieb
-
Mount Vernon, Illinois, Förenta staterna, 62864
- SSM Health Good Samaritan
-
Naperville, Illinois, Förenta staterna, 60540
- Edward Hospital/Cancer Center
-
New Lenox, Illinois, Förenta staterna, 60451
- UC Comprehensive Cancer Center at Silver Cross
-
O'Fallon, Illinois, Förenta staterna, 62269
- Cancer Care Center of O'Fallon
-
Orland Park, Illinois, Förenta staterna, 60462
- University of Chicago Medicine-Orland Park
-
Orland Park, Illinois, Förenta staterna, 60462
- Northwestern Medicine Orland Park
-
Ottawa, Illinois, Förenta staterna, 61350
- Illinois CancerCare-Ottawa Clinic
-
Pekin, Illinois, Förenta staterna, 61554
- Illinois CancerCare-Pekin
-
Peoria, Illinois, Förenta staterna, 61636
- Methodist Medical Center of Illinois
-
Peoria, Illinois, Förenta staterna, 61615
- Illinois CancerCare-Peoria
-
Peru, Illinois, Förenta staterna, 61354
- Illinois CancerCare-Peru
-
Peru, Illinois, Förenta staterna, 61354
- Valley Radiation Oncology
-
Plainfield, Illinois, Förenta staterna, 60585
- Edward Hospital/Cancer Center?Plainfield
-
Princeton, Illinois, Förenta staterna, 61356
- Illinois CancerCare-Princeton
-
Rockford, Illinois, Förenta staterna, 61114
- UW Health Carbone Cancer Center Rockford
-
Shiloh, Illinois, Förenta staterna, 62269
- Memorial Hospital East
-
Springfield, Illinois, Förenta staterna, 62702
- Southern Illinois University School of Medicine
-
Springfield, Illinois, Förenta staterna, 62702
- Springfield Clinic
-
Springfield, Illinois, Förenta staterna, 62781
- Springfield Memorial Hospital
-
Swansea, Illinois, Förenta staterna, 62226
- Southwest Illinois Health Services LLP
-
Urbana, Illinois, Förenta staterna, 61801
- Carle Cancer Center
-
Urbana, Illinois, Förenta staterna, 61801
- The Carle Foundation Hospital
-
Warrenville, Illinois, Förenta staterna, 60555
- Northwestern Medicine Cancer Center Warrenville
-
Washington, Illinois, Förenta staterna, 61571
- Illinois CancerCare - Washington
-
Yorkville, Illinois, Förenta staterna, 60560
- Rush-Copley Healthcare Center
-
-
Indiana
-
Indianapolis, Indiana, Förenta staterna, 46237
- Franciscan Health Indianapolis
-
Indianapolis, Indiana, Förenta staterna, 46202
- Indiana University/Melvin and Bren Simon Cancer Center
-
Indianapolis, Indiana, Förenta staterna, 46202
- Sidney and Lois Eskenazi Hospital
-
Michigan City, Indiana, Förenta staterna, 46360
- Woodland Cancer Care Center
-
Mooresville, Indiana, Förenta staterna, 46158
- Franciscan Health Mooresville
-
Richmond, Indiana, Förenta staterna, 47374
- Reid Health
-
-
Iowa
-
Ames, Iowa, Förenta staterna, 50010
- Mary Greeley Medical Center
-
Ames, Iowa, Förenta staterna, 50010
- McFarland Clinic - Ames
-
Ankeny, Iowa, Förenta staterna, 50023
- UI Health Care Mission Cancer and Blood - Ankeny Clinic
-
Boone, Iowa, Förenta staterna, 50036
- McFarland Clinic - Boone
-
Carroll, Iowa, Förenta staterna, 51401
- Saint Anthony Regional Hospital
-
Clive, Iowa, Förenta staterna, 50325
- Mercy Cancer Center-West Lakes
-
Clive, Iowa, Förenta staterna, 50325
- UI Health Care Mission Cancer and Blood - West Des Moines Clinic
-
Council Bluffs, Iowa, Förenta staterna, 51503
- Alegent Health Mercy Hospital
-
Creston, Iowa, Förenta staterna, 50801
- Greater Regional Medical Center
-
Des Moines, Iowa, Förenta staterna, 50309
- Iowa Methodist Medical Center
-
Des Moines, Iowa, Förenta staterna, 50314
- Mercy Medical Center - Des Moines
-
Des Moines, Iowa, Förenta staterna, 50314
- Broadlawns Medical Center
-
Des Moines, Iowa, Förenta staterna, 50316
- Iowa Lutheran Hospital
-
Des Moines, Iowa, Förenta staterna, 50309
- UI Health Care Mission Cancer and Blood - Des Moines Clinic
-
Des Moines, Iowa, Förenta staterna, 50314
- UI Health Care Mission Cancer and Blood - Laurel Clinic
-
Fort Dodge, Iowa, Förenta staterna, 50501
- McFarland Clinic - Trinity Cancer Center
-
Fort Dodge, Iowa, Förenta staterna, 50501
- UI Healthcare Mission Cancer and Blood - Fort Dodge
-
Jefferson, Iowa, Förenta staterna, 50129
- McFarland Clinic - Jefferson
-
Marshalltown, Iowa, Förenta staterna, 50158
- McFarland Clinic - Marshalltown
-
Sioux City, Iowa, Förenta staterna, 51101
- Siouxland Regional Cancer Center
-
West Des Moines, Iowa, Förenta staterna, 50266-7700
- Methodist West Hospital
-
West Des Moines, Iowa, Förenta staterna, 50266
- Mercy Medical Center-West Lakes
-
-
Kansas
-
Fairway, Kansas, Förenta staterna, 66205
- University of Kansas Clinical Research Center
-
Garden City, Kansas, Förenta staterna, 67846
- Central Care Cancer Center - Garden City
-
Great Bend, Kansas, Förenta staterna, 67530
- Central Care Cancer Center - Great Bend
-
Hays, Kansas, Förenta staterna, 67601
- HaysMed
-
Lawrence, Kansas, Förenta staterna, 66044
- Lawrence Memorial Hospital
-
Lenexa, Kansas, Förenta staterna, 66219
- Kansas Institute of Medicine Cancer and Blood Center
-
Lenexa, Kansas, Förenta staterna, 66219
- Minimally Invasive Surgery Hospital
-
Olathe, Kansas, Förenta staterna, 66061
- The University of Kansas Cancer Center - Olathe
-
Overland Park, Kansas, Förenta staterna, 66210
- University of Kansas Cancer Center-Overland Park
-
Overland Park, Kansas, Förenta staterna, 66209
- Menorah Medical Center
-
Parsons, Kansas, Förenta staterna, 67357
- Cancer Center of Kansas - Parsons
-
Pittsburg, Kansas, Förenta staterna, 66762
- Freeman Physician Group of Pittsburg
-
Pittsburg, Kansas, Förenta staterna, 66762
- Mercy Hospital Pittsburg
-
Salina, Kansas, Förenta staterna, 67401
- Salina Regional Health Center
-
Topeka, Kansas, Förenta staterna, 66606
- University of Kansas Health System Saint Francis Campus
-
Westwood, Kansas, Förenta staterna, 66205
- University of Kansas Hospital-Westwood Cancer Center
-
Wichita, Kansas, Förenta staterna, 67214
- Ascension Via Christi Hospitals Wichita
-
Wichita, Kansas, Förenta staterna, 67208
- Cancer Center of Kansas-Wichita Medical Arts Tower
-
Wichita, Kansas, Förenta staterna, 67214
- Cancer Center of Kansas - Wichita
-
-
Kentucky
-
Bardstown, Kentucky, Förenta staterna, 40004
- CommonSpirit Saint Joseph Hospital - Bardstown
-
Corbin, Kentucky, Förenta staterna, 40701
- Commonwealth Cancer Center-Corbin
-
Lexington, Kentucky, Förenta staterna, 40536
- University of Kentucky/Markey Cancer Center
-
Lexington, Kentucky, Förenta staterna, 40504
- Saint Joseph Radiation Oncology Resource Center
-
Lexington, Kentucky, Förenta staterna, 40509
- CommonSpirit Saint Joseph Medical Center - East Lexington
-
London, Kentucky, Förenta staterna, 40741
- CommonSpirit Saint Joseph Hospital London
-
Louisville, Kentucky, Förenta staterna, 40202
- Jewish Hospital
-
Louisville, Kentucky, Förenta staterna, 40245
- UofL Health Medical Center Northeast
-
Louisville, Kentucky, Förenta staterna, 40207
- Baptist Health Louisville
-
Louisville, Kentucky, Förenta staterna, 40215
- Saints Mary and Elizabeth Hospital
-
Shepherdsville, Kentucky, Förenta staterna, 40165
- Jewish Hospital Medical Center South
-
-
Louisiana
-
Baton Rouge, Louisiana, Förenta staterna, 70805
- LSU Health Baton Rouge-North Clinic
-
Baton Rouge, Louisiana, Förenta staterna, 70809
- Louisiana Hematology Oncology Associates LLC
-
Baton Rouge, Louisiana, Förenta staterna, 70809
- Mary Bird Perkins Cancer Center
-
Baton Rouge, Louisiana, Förenta staterna, 70836
- Ochsner High Grove
-
Baton Rouge, Louisiana, Förenta staterna, 70809
- Hematology/Oncology Clinic PLLC
-
Baton Rouge, Louisiana, Förenta staterna, 70808
- Our Lady of The Lake
-
Baton Rouge, Louisiana, Förenta staterna, 70808
- Our Lady of the Lake Physician Group
-
Covington, Louisiana, Förenta staterna, 70433
- Northshore Oncology Associates-Covington
-
Covington, Louisiana, Förenta staterna, 70433
- Ochsner Hematology Oncology North Shore - Covington (West Region)
-
Houma, Louisiana, Förenta staterna, 70360
- Terrebonne General Medical Center
-
Houma, Louisiana, Förenta staterna, 70360
- Oncology Center of The South Incorporated
-
Metairie, Louisiana, Förenta staterna, 70006
- East Jefferson General Hospital
-
Metairie, Louisiana, Förenta staterna, 70006
- LSU Healthcare Network / Metairie Multi-Specialty Clinic
-
Monroe, Louisiana, Förenta staterna, 71202
- Ochsner LSU Health Monroe Medical Center
-
New Orleans, Louisiana, Förenta staterna, 70112
- Tulane University School of Medicine
-
New Orleans, Louisiana, Förenta staterna, 70121
- Ochsner Medical Center Jefferson
-
New Orleans, Louisiana, Förenta staterna, 70112
- University Medical Center New Orleans
-
New Orleans, Louisiana, Förenta staterna, 70112
- Louisiana State University Health Science Center
-
New Orleans, Louisiana, Förenta staterna, 70115
- Touro Infirmary
-
Shreveport, Louisiana, Förenta staterna, 71103
- LSU Health Sciences Center at Shreveport
-
-
Maine
-
Augusta, Maine, Förenta staterna, 04330
- Harold Alfond Center for Cancer Care
-
Belfast, Maine, Förenta staterna, 04915
- MaineHealth Waldo Hospital
-
Biddeford, Maine, Förenta staterna, 04005
- MaineHealth Maine Medical Center - Biddeford
-
Brewer, Maine, Förenta staterna, 04412
- Lafayette Family Cancer Center-EMMC
-
Norway, Maine, Förenta staterna, 04268
- MaineHealth Stephens Hospital
-
Rockport, Maine, Förenta staterna, 04856
- Penobscot Bay Medical Center
-
Sanford, Maine, Förenta staterna, 04073
- MaineHealth Cancer Care and IV Therapy - Sanford
-
South Portland, Maine, Förenta staterna, 04106
- MaineHealth Cancer Care and IV Therapy - South Portland
-
-
Maryland
-
Baltimore, Maryland, Förenta staterna, 21204
- Greater Baltimore Medical Center
-
-
Massachusetts
-
Boston, Massachusetts, Förenta staterna, 02215
- Dana-Farber Cancer Institute
-
Newton, Massachusetts, Förenta staterna, 02467
- Dana-Farber Cancer Institute - Chestnut Hill
-
Springfield, Massachusetts, Förenta staterna, 01104
- Mercy Medical Center
-
-
Michigan
-
Adrian, Michigan, Förenta staterna, 49221
- Hickman Cancer Center
-
Ann Arbor, Michigan, Förenta staterna, 48106
- Trinity Health Saint Joseph Mercy Hospital Ann Arbor
-
Battle Creek, Michigan, Förenta staterna, 49017
- Bronson Battle Creek
-
Brighton, Michigan, Förenta staterna, 48114
- Trinity Health IHA Medical Group Hematology Oncology - Brighton
-
Brighton, Michigan, Förenta staterna, 48114
- Trinity Health Medical Center - Brighton
-
Brownstown, Michigan, Förenta staterna, 48183
- Henry Ford Cancer Institute-Downriver
-
Canton, Michigan, Förenta staterna, 48188
- Trinity Health IHA Medical Group Hematology Oncology - Canton
-
Canton, Michigan, Förenta staterna, 48188
- Trinity Health Medical Center - Canton
-
Caro, Michigan, Förenta staterna, 48723
- Caro Cancer Center
-
Chelsea, Michigan, Förenta staterna, 48118
- Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
-
Chelsea, Michigan, Förenta staterna, 48118
- Chelsea Hospital
-
Clarkston, Michigan, Förenta staterna, 48346
- Hematology Oncology Consultants-Clarkston
-
Clarkston, Michigan, Förenta staterna, 48346
- Newland Medical Associates-Clarkston
-
Clinton Township, Michigan, Förenta staterna, 48038
- Henry Ford Macomb Hospital-Clinton Township
-
Dearborn, Michigan, Förenta staterna, 48126
- Henry Ford Medical Center-Fairlane
-
Detroit, Michigan, Förenta staterna, 48202
- Henry Ford Hospital
-
Detroit, Michigan, Förenta staterna, 48236
- Henry Ford Health Saint John Hospital
-
East China Township, Michigan, Förenta staterna, 48054
- Henry Ford River District Hospital
-
Escanaba, Michigan, Förenta staterna, 49829
- OSF Saint Francis Hospital and Medical Group
-
Flint, Michigan, Förenta staterna, 48503
- Hurley Medical Center
-
Flint, Michigan, Förenta staterna, 48503
- Genesee Hematology Oncology PC
-
Flint, Michigan, Förenta staterna, 48503
- Genesys Hurley Cancer Institute
-
Flint, Michigan, Förenta staterna, 48503
- Cancer Hematology Centers - Flint
-
Grand Rapids, Michigan, Förenta staterna, 49503
- Trinity Health Grand Rapids Hospital
-
Grand Rapids, Michigan, Förenta staterna, 49503
- Corewell Health Grand Rapids Hospitals - Butterworth Hospital
-
Grand Rapids, Michigan, Förenta staterna, 49503
- Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital
-
Grosse Pointe Woods, Michigan, Förenta staterna, 48236
- Henry Ford Saint John Hospital - Academic
-
Grosse Pointe Woods, Michigan, Förenta staterna, 48236
- Henry Ford Saint John Hospital - Breast
-
Grosse Pointe Woods, Michigan, Förenta staterna, 48236
- Henry Ford Saint John Hospital - Van Elslander
-
Jackson, Michigan, Förenta staterna, 49201
- Allegiance Health
-
Kalamazoo, Michigan, Förenta staterna, 49007
- West Michigan Cancer Center
-
Kalamazoo, Michigan, Förenta staterna, 49007
- Bronson Methodist Hospital
-
Kalamazoo, Michigan, Förenta staterna, 49009
- Beacon Kalamazoo Cancer Center
-
Kalamazoo, Michigan, Förenta staterna, 49048
- Beacon Kalamazoo
-
Lansing, Michigan, Förenta staterna, 48912
- University of Michigan Health - Sparrow Lansing
-
Livonia, Michigan, Förenta staterna, 48154
- Trinity Health Saint Mary Mercy Livonia Hospital
-
Livonia, Michigan, Förenta staterna, 48154
- Hope Cancer Clinic
-
Macomb, Michigan, Förenta staterna, 48044
- Henry Ford Warren Hospital - Breast Macomb
-
Macomb, Michigan, Förenta staterna, 48044
- Henry Ford Saint John Hospital - Macomb Medical
-
Marlette, Michigan, Förenta staterna, 48453
- Saint Mary's Oncology/Hematology Associates of Marlette
-
Monroe, Michigan, Förenta staterna, 48162
- Toledo Clinic Cancer Centers-Monroe
-
Muskegon, Michigan, Förenta staterna, 49444
- Trinity Health Muskegon Hospital
-
Niles, Michigan, Förenta staterna, 49120
- Corewell Health Lakeland Hospitals - Niles Hospital
-
Norton Shores, Michigan, Förenta staterna, 49444
- Cancer and Hematology Centers of Western Michigan - Norton Shores
-
Novi, Michigan, Förenta staterna, 48377
- Henry Ford Medical Center-Columbus
-
Novi, Michigan, Förenta staterna, 48374
- Henry Ford Health Providence Novi Hospital
-
Pontiac, Michigan, Förenta staterna, 48341
- Hope Cancer Center
-
Pontiac, Michigan, Förenta staterna, 48341
- Trinity Health Saint Joseph Mercy Oakland Hospital
-
Pontiac, Michigan, Förenta staterna, 48341
- Michigan Healthcare Professionals Pontiac
-
Pontiac, Michigan, Förenta staterna, 48341
- Trinity Health IHA Medical Group-Alice Gustafson Center
-
Port Huron, Michigan, Förenta staterna, 48060
- Lake Huron Medical Center
-
Port Huron, Michigan, Förenta staterna, 48060
- Huron Medical Center PC
-
Reed City, Michigan, Förenta staterna, 49677
- Corewell Health Reed City Hospital
-
Rochester Hills, Michigan, Förenta staterna, 48309
- Henry Ford Rochester Hospital
-
Saginaw, Michigan, Förenta staterna, 48604
- Oncology Hematology Associates of Saginaw Valley PC
-
Saginaw, Michigan, Förenta staterna, 48601
- MyMichigan Medical Center Saginaw
-
Saint Joseph, Michigan, Förenta staterna, 49085
- Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center
-
Saint Joseph, Michigan, Förenta staterna, 49085
- Corewell Health Lakeland Hospitals - Saint Joseph Hospital
-
Shelby, Michigan, Förenta staterna, 48315
- Henry Ford Macomb Health Center - Shelby Township
-
Southfield, Michigan, Förenta staterna, 48075
- Henry Ford Health Providence Southfield Hospital
-
Sterling Heights, Michigan, Förenta staterna, 48312
- Bhadresh Nayak MD PC-Sterling Heights
-
Tawas City, Michigan, Förenta staterna, 48764
- MyMichigan Medical Center Tawas
-
Traverse City, Michigan, Förenta staterna, 49684
- Munson Medical Center
-
Warren, Michigan, Förenta staterna, 48088
- Advanced Breast Care Center PLLC
-
Warren, Michigan, Förenta staterna, 48093
- Macomb Hematology Oncology PC
-
Warren, Michigan, Förenta staterna, 48093
- Henry Ford Madison Heights Hospital - Breast
-
Warren, Michigan, Förenta staterna, 48093
- Henry Ford Health Warren Hospital
-
Warren, Michigan, Förenta staterna, 48093
- Henry Ford Warren Hospital - GLCMS
-
West Bloomfield, Michigan, Förenta staterna, 48322
- Henry Ford West Bloomfield Hospital
-
West Branch, Michigan, Förenta staterna, 48661
- Saint Mary's Oncology/Hematology Associates of West Branch
-
Wyoming, Michigan, Förenta staterna, 49519
- University of Michigan Health - West
-
Ypsilanti, Michigan, Förenta staterna, 48197
- Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
-
Ypsilanti, Michigan, Förenta staterna, 48106
- Huron Gastroenterology PC
-
-
Minnesota
-
Aitkin, Minnesota, Förenta staterna, 56431
- Riverwood Healthcare Center
-
Bemidji, Minnesota, Förenta staterna, 56601
- Sanford Joe Lueken Cancer Center
-
Brainerd, Minnesota, Förenta staterna, 56401
- Essentia Health Saint Joseph's Medical Center
-
Burnsville, Minnesota, Förenta staterna, 55337
- Fairview Ridges Hospital
-
Burnsville, Minnesota, Förenta staterna, 55337
- Minnesota Oncology - Burnsville
-
Cambridge, Minnesota, Förenta staterna, 55008
- Cambridge Medical Center
-
Coon Rapids, Minnesota, Förenta staterna, 55433
- Mercy Hospital
-
Deer River, Minnesota, Förenta staterna, 56636
- Essentia Health - Deer River Clinic
-
Detroit Lakes, Minnesota, Förenta staterna, 56501
- Essentia Health Saint Mary's - Detroit Lakes Clinic
-
Duluth, Minnesota, Förenta staterna, 55805
- Essentia Health Cancer Center
-
Duluth, Minnesota, Förenta staterna, 55805
- Essentia Health Saint Mary's Medical Center
-
Duluth, Minnesota, Förenta staterna, 55805
- Miller-Dwan Hospital
-
Edina, Minnesota, Förenta staterna, 55435
- Fairview Southdale Hospital
-
Fergus Falls, Minnesota, Förenta staterna, 56537
- Lake Region Healthcare Corporation-Cancer Care
-
Fosston, Minnesota, Förenta staterna, 56542
- Essentia Health - Fosston
-
Fridley, Minnesota, Förenta staterna, 55432
- Unity Hospital
-
Hibbing, Minnesota, Förenta staterna, 55746
- Essentia Health Hibbing Clinic
-
Maple Grove, Minnesota, Förenta staterna, 55369
- Fairview Clinics and Surgery Center Maple Grove
-
Maplewood, Minnesota, Förenta staterna, 55109
- Saint John's Hospital - Healtheast
-
Maplewood, Minnesota, Förenta staterna, 55109
- Minnesota Oncology Hematology PA-Maplewood
-
Minneapolis, Minnesota, Förenta staterna, 55415
- Hennepin County Medical Center
-
Minneapolis, Minnesota, Förenta staterna, 55407
- Abbott-Northwestern Hospital
-
Minneapolis, Minnesota, Förenta staterna, 55454
- Health Partners Inc
-
Minneapolis, Minnesota, Förenta staterna, 55417
- Minneapolis VA Medical Center
-
Monticello, Minnesota, Förenta staterna, 55362
- Monticello Cancer Center
-
New Ulm, Minnesota, Förenta staterna, 56073
- New Ulm Medical Center
-
Park Rapids, Minnesota, Förenta staterna, 56470
- Essentia Health - Park Rapids
-
Princeton, Minnesota, Förenta staterna, 55371
- Fairview Northland Medical Center
-
Robbinsdale, Minnesota, Förenta staterna, 55422
- North Memorial Medical Health Center
-
Saint Cloud, Minnesota, Förenta staterna, 56303
- Coborn Cancer Center at Saint Cloud Hospital
-
Saint Louis Park, Minnesota, Förenta staterna, 55416
- Park Nicollet Clinic - Saint Louis Park
-
Saint Paul, Minnesota, Förenta staterna, 55101
- Regions Hospital
-
Saint Paul, Minnesota, Förenta staterna, 55102
- United Hospital
-
Sandstone, Minnesota, Förenta staterna, 55072
- Essentia Health Sandstone
-
Shakopee, Minnesota, Förenta staterna, 55379
- Saint Francis Regional Medical Center
-
Stillwater, Minnesota, Förenta staterna, 55082
- Lakeview Hospital
-
Thief River Falls, Minnesota, Förenta staterna, 56701
- Sanford Thief River Falls Medical Center
-
Virginia, Minnesota, Förenta staterna, 55792
- Essentia Health Virginia Clinic
-
Waconia, Minnesota, Förenta staterna, 55387
- Ridgeview Medical Center
-
Willmar, Minnesota, Förenta staterna, 56201
- Rice Memorial Hospital
-
Woodbury, Minnesota, Förenta staterna, 55125
- Minnesota Oncology Hematology PA-Woodbury
-
Worthington, Minnesota, Förenta staterna, 56187
- Sanford Cancer Center Worthington
-
Wyoming, Minnesota, Förenta staterna, 55092
- Fairview Lakes Medical Center
-
-
Mississippi
-
Columbus, Mississippi, Förenta staterna, 39705
- Baptist Memorial Hospital and Cancer Center-Golden Triangle
-
Grenada, Mississippi, Förenta staterna, 38901
- Baptist Cancer Center-Grenada
-
Gulfport, Mississippi, Förenta staterna, 39502
- Gulfport Memorial Hospital
-
Jackson, Mississippi, Förenta staterna, 39216
- University of Mississippi Medical Center
-
New Albany, Mississippi, Förenta staterna, 38652
- Baptist Memorial Hospital and Cancer Center-Union County
-
Oxford, Mississippi, Förenta staterna, 38655
- Baptist Memorial Hospital and Cancer Center-Oxford
-
Southhaven, Mississippi, Förenta staterna, 38671
- Baptist Memorial Hospital and Cancer Center-Desoto
-
-
Missouri
-
Ballwin, Missouri, Förenta staterna, 63011
- Mercy Oncology and Hematology - Clayton-Clarkson
-
Bolivar, Missouri, Förenta staterna, 65613
- Central Care Cancer Center - Bolivar
-
Bonne Terre, Missouri, Förenta staterna, 63628
- Parkland Health Center-Bonne Terre
-
Branson, Missouri, Förenta staterna, 65616
- Cox Cancer Center Branson
-
Cape Girardeau, Missouri, Förenta staterna, 63703
- Saint Francis Medical Center
-
Cape Girardeau, Missouri, Förenta staterna, 63703
- Mercy Cancer Center - Cape Girardeau
-
Chesterfield, Missouri, Förenta staterna, 63017
- Saint Luke's Hospital
-
City of Saint Peters, Missouri, Förenta staterna, 63376
- Siteman Cancer Center at Saint Peters Hospital
-
Columbia, Missouri, Förenta staterna, 65212
- MU Health - University Hospital/Ellis Fischel Cancer Center
-
Creve Coeur, Missouri, Förenta staterna, 63141
- Siteman Cancer Center at West County Hospital
-
Farmington, Missouri, Förenta staterna, 63640
- Parkland Health Center - Farmington
-
Independence, Missouri, Förenta staterna, 64057
- Centerpoint Medical Center LLC
-
Jefferson City, Missouri, Förenta staterna, 65109
- MU Health Care Goldschmidt Cancer Center
-
Joplin, Missouri, Förenta staterna, 64804
- Freeman Health System
-
Joplin, Missouri, Förenta staterna, 64804
- Mercy Hospital Joplin
-
Kansas City, Missouri, Förenta staterna, 64154
- University of Kansas Cancer Center - North
-
Kansas City, Missouri, Förenta staterna, 64132
- Research Medical Center
-
Kansas City, Missouri, Förenta staterna, 64108
- University Health Truman Medical Center
-
Lee's Summit, Missouri, Förenta staterna, 64064
- University of Kansas Cancer Center - Lee's Summit
-
North Kansas City, Missouri, Förenta staterna, 64116
- University of Kansas Cancer Center at North Kansas City Hospital
-
Rolla, Missouri, Förenta staterna, 65401
- Mercy Clinic-Rolla-Cancer and Hematology
-
Rolla, Missouri, Förenta staterna, 65401
- Phelps Health Delbert Day Cancer Institute
-
Saint Joseph, Missouri, Förenta staterna, 64506
- Heartland Regional Medical Center
-
Sainte Genevieve, Missouri, Förenta staterna, 63670
- Sainte Genevieve County Memorial Hospital
-
Springfield, Missouri, Förenta staterna, 65807
- CoxHealth South Hospital
-
Springfield, Missouri, Förenta staterna, 65804
- Mercy Hospital Springfield
-
St Louis, Missouri, Förenta staterna, 63110
- Washington University School of Medicine
-
St Louis, Missouri, Förenta staterna, 63129
- Siteman Cancer Center-South County
-
St Louis, Missouri, Förenta staterna, 63136
- Siteman Cancer Center at Christian Hospital
-
St Louis, Missouri, Förenta staterna, 63131
- Missouri Baptist Medical Center
-
St Louis, Missouri, Förenta staterna, 63109
- Mercy Infusion Center - Chippewa
-
St Louis, Missouri, Förenta staterna, 63141
- Mercy Hospital Saint Louis
-
St Louis, Missouri, Förenta staterna, 63128
- Mercy Hospital South
-
Sullivan, Missouri, Förenta staterna, 63080
- Missouri Baptist Sullivan Hospital
-
Washington, Missouri, Förenta staterna, 63090
- Mercy Hospital Washington
-
-
Montana
-
Anaconda, Montana, Förenta staterna, 59711
- Community Hospital of Anaconda
-
Billings, Montana, Förenta staterna, 59101
- Billings Clinic Cancer Center
-
Billings, Montana, Förenta staterna, 59101
- Saint Vincent Healthcare
-
Billings, Montana, Förenta staterna, 59102
- Saint Vincent Frontier Cancer Center
-
Bozeman, Montana, Förenta staterna, 59715
- Bozeman Health Deaconess Hospital
-
Butte, Montana, Förenta staterna, 59701
- Saint James Community Hospital and Cancer Treatment Center
-
Great Falls, Montana, Förenta staterna, 59405
- Great Falls Clinic
-
Great Falls, Montana, Förenta staterna, 59405
- Benefis Sletten Cancer Institute
-
Helena, Montana, Förenta staterna, 59601
- Saint Peter's Community Hospital
-
Kalispell, Montana, Förenta staterna, 59901
- Logan Health Medical Center
-
Missoula, Montana, Förenta staterna, 59802
- Saint Patrick Hospital - Community Hospital
-
Missoula, Montana, Förenta staterna, 59804
- Community Medical Center
-
-
Nebraska
-
Bellevue, Nebraska, Förenta staterna, 68123
- Nebraska Medicine-Bellevue
-
Grand Island, Nebraska, Förenta staterna, 68803
- Nebraska Cancer Specialists/Oncology Hematology West PC
-
Kearney, Nebraska, Förenta staterna, 68847
- CHI Health Good Samaritan
-
Lincoln, Nebraska, Förenta staterna, 68510
- Saint Elizabeth Regional Medical Center
-
Lincoln, Nebraska, Förenta staterna, 68516
- Cancer Partners of Nebraska
-
Omaha, Nebraska, Förenta staterna, 68114
- Nebraska Methodist Hospital
-
Omaha, Nebraska, Förenta staterna, 68198
- University of Nebraska Medical Center
-
Omaha, Nebraska, Förenta staterna, 68124
- Alegent Health Bergan Mercy Medical Center
-
Omaha, Nebraska, Förenta staterna, 68118
- Nebraska Medicine-Village Pointe
-
Omaha, Nebraska, Förenta staterna, 68122
- Alegent Health Immanuel Medical Center
-
Omaha, Nebraska, Förenta staterna, 68130
- Alegent Health Lakeside Hospital
-
Omaha, Nebraska, Förenta staterna, 68114
- Oncology Associates PC
-
Omaha, Nebraska, Förenta staterna, 68114
- Nebraska Cancer Specialists/Oncology Hematology West PC - MECC
-
Papillion, Nebraska, Förenta staterna, 68046
- Midlands Community Hospital
-
-
Nevada
-
Carson City, Nevada, Förenta staterna, 89703
- Carson Tahoe Regional Medical Center
-
Henderson, Nevada, Förenta staterna, 89052
- Comprehensive Cancer Centers of Nevada - Henderson
-
Henderson, Nevada, Förenta staterna, 89052
- Cancer and Blood Specialists-Henderson
-
Henderson, Nevada, Förenta staterna, 89052
- Las Vegas Cancer Center-Henderson
-
Henderson, Nevada, Förenta staterna, 89074
- Comprehensive Cancer Centers of Nevada-Southeast Henderson
-
Henderson, Nevada, Förenta staterna, 89052
- Comprehensive Cancer Centers of Nevada-Horizon Ridge
-
Henderson, Nevada, Förenta staterna, 89074
- Las Vegas Urology - Green Valley
-
Henderson, Nevada, Förenta staterna, 89074
- Las Vegas Urology - Pebble
-
Henderson, Nevada, Förenta staterna, 89074
- Urology Specialists of Nevada - Green Valley
-
Henderson, Nevada, Förenta staterna, 89074
- Oncology Las Vegas - Henderson
-
Las Vegas, Nevada, Förenta staterna, 89144
- Summerlin Hospital Medical Center
-
Las Vegas, Nevada, Förenta staterna, 89109
- Sunrise Hospital and Medical Center
-
Las Vegas, Nevada, Förenta staterna, 89102
- OptumCare Cancer Care at Charleston
-
Las Vegas, Nevada, Förenta staterna, 89106
- Radiation Oncology Centers of Nevada Central
-
Las Vegas, Nevada, Förenta staterna, 89119
- Radiation Oncology Centers of Nevada Southeast
-
Las Vegas, Nevada, Förenta staterna, 89128
- Comprehensive Cancer Centers of Nevada - Northwest
-
Las Vegas, Nevada, Förenta staterna, 89128
- OptumCare Cancer Care at MountainView
-
Las Vegas, Nevada, Förenta staterna, 89135
- Alliance for Childhood Diseases/Cure 4 the Kids Foundation
-
Las Vegas, Nevada, Förenta staterna, 89144
- Comprehensive Cancer Centers of Nevada - Town Center
-
Las Vegas, Nevada, Förenta staterna, 89144
- Comprehensive Cancer Centers of Nevada-Summerlin
-
Las Vegas, Nevada, Förenta staterna, 89148
- Comprehensive Cancer Centers of Nevada
-
Las Vegas, Nevada, Förenta staterna, 89169
- Comprehensive Cancer Centers of Nevada - Central Valley
-
Las Vegas, Nevada, Förenta staterna, 89102
- University Medical Center of Southern Nevada
-
Las Vegas, Nevada, Förenta staterna, 89106
- Cancer and Blood Specialists-Shadow
-
Las Vegas, Nevada, Förenta staterna, 89109
- HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway
-
Las Vegas, Nevada, Förenta staterna, 89113
- HealthCare Partners Medical Group Oncology/Hematology-San Martin
-
Las Vegas, Nevada, Förenta staterna, 89128
- Cancer and Blood Specialists-Tenaya
-
Las Vegas, Nevada, Förenta staterna, 89128
- HealthCare Partners Medical Group Oncology/Hematology-Tenaya
-
Las Vegas, Nevada, Förenta staterna, 89148-2405
- Las Vegas Cancer Center-Medical Center
-
Las Vegas, Nevada, Förenta staterna, 89149
- HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills
-
Las Vegas, Nevada, Förenta staterna, 89128
- Ann M Wierman MD LTD
-
Las Vegas, Nevada, Förenta staterna, 89074
- Las Vegas Urology - Pecos
-
Las Vegas, Nevada, Förenta staterna, 89102
- Desert West Surgery
-
Las Vegas, Nevada, Förenta staterna, 89103
- Hope Cancer Care of Nevada
-
Las Vegas, Nevada, Förenta staterna, 89106
- Urology Specialists of Nevada - Central
-
Las Vegas, Nevada, Förenta staterna, 89113
- Las Vegas Prostate Cancer Center
-
Las Vegas, Nevada, Förenta staterna, 89113
- Las Vegas Urology - Sunset
-
Las Vegas, Nevada, Förenta staterna, 89128
- Las Vegas Urology - Cathedral Rock
-
Las Vegas, Nevada, Förenta staterna, 89128
- Las Vegas Urology - Smoke Ranch
-
Las Vegas, Nevada, Förenta staterna, 89128
- Urology Specialists of Nevada - Northwest
-
Las Vegas, Nevada, Förenta staterna, 89169
- University Cancer Center
-
Las Vegas, Nevada, Förenta staterna, 89113
- Urology Specialists of Nevada - Southwest
-
Las Vegas, Nevada, Förenta staterna, 89128
- Oncology Las Vegas - Tenaya
-
Las Vegas, Nevada, Förenta staterna, 89183
- OptumCare Cancer Care at Fort Apache
-
Pahrump, Nevada, Förenta staterna, 89048
- Hope Cancer Care of Nevada-Pahrump
-
Reno, Nevada, Förenta staterna, 89502
- Renown Regional Medical Center
-
Reno, Nevada, Förenta staterna, 89503
- Saint Mary's Regional Medical Center
-
Reno, Nevada, Förenta staterna, 89509
- Radiation Oncology Associates
-
-
New Hampshire
-
Concord, New Hampshire, Förenta staterna, 03301
- New Hampshire Oncology Hematology PA-Concord
-
Manchester, New Hampshire, Förenta staterna, 03103
- Solinsky Center for Cancer Care
-
Manchester, New Hampshire, Förenta staterna, 03103
- Elliot Hospital
-
-
New Jersey
-
Brick, New Jersey, Förenta staterna, 08724
- Ocean University Medical Center
-
Cape May Court House, New Jersey, Förenta staterna, 08210
- AtlantiCare Health Park-Cape May Court House
-
Egg Harbor, New Jersey, Förenta staterna, 08234
- AtlantiCare Surgery Center
-
Hackensack, New Jersey, Förenta staterna, 07601
- Hackensack University Medical Center
-
Livingston, New Jersey, Förenta staterna, 07039
- Cooperman Barnabas Medical Center
-
Manahawkin, New Jersey, Förenta staterna, 08050
- Southern Ocean County Medical Center
-
Mullica Hill, New Jersey, Förenta staterna, 08062
- Inspira Medical Center Mullica Hill
-
Neptune City, New Jersey, Förenta staterna, 07753
- Jersey Shore Medical Center
-
New Brunswick, New Jersey, Förenta staterna, 08903
- Rutgers Cancer Institute of New Jersey
-
Red Bank, New Jersey, Förenta staterna, 07701
- Riverview Medical Center/Booker Cancer Center
-
-
New Mexico
-
Albuquerque, New Mexico, Förenta staterna, 87106
- University of New Mexico Cancer Center
-
-
New York
-
Auburn, New York, Förenta staterna, 13021
- Hematology Oncology Associates of Central New York-Auburn
-
Camillus, New York, Förenta staterna, 13031
- Hematology Oncology Associates of CNY at Camillus
-
Cooperstown, New York, Förenta staterna, 13326
- Mary Imogene Bassett Hospital
-
East Syracuse, New York, Förenta staterna, 13057
- Hematology Oncology Associates of Central New York-East Syracuse
-
Glens Falls, New York, Förenta staterna, 12801
- Glens Falls Hospital
-
Lake Success, New York, Förenta staterna, 11042
- Northwell Health/Center for Advanced Medicine
-
New York, New York, Förenta staterna, 10065
- NYP/Weill Cornell Medical Center
-
Rochester, New York, Förenta staterna, 14642
- University of Rochester
-
Stony Brook, New York, Förenta staterna, 11794
- Stony Brook University Medical Center
-
The Bronx, New York, Förenta staterna, 10461
- Montefiore Medical Center-Einstein Campus
-
The Bronx, New York, Förenta staterna, 10467
- Montefiore Medical Center - Moses Campus
-
The Bronx, New York, Förenta staterna, 10461
- Montefiore Medical Center-Weiler Hospital
-
-
North Carolina
-
Asheville, North Carolina, Förenta staterna, 28803
- AdventHealth Infusion Center Asheville
-
Chapel Hill, North Carolina, Förenta staterna, 27599
- UNC Lineberger Comprehensive Cancer Center
-
Charlotte, North Carolina, Förenta staterna, 28204
- Novant Health Presbyterian Medical Center
-
Clemmons, North Carolina, Förenta staterna, 27012
- Wake Forest University at Clemmons
-
Clinton, North Carolina, Förenta staterna, 28328
- Southeastern Medical Oncology Center-Clinton
-
Clyde, North Carolina, Förenta staterna, 28721
- AdventHealth Infusion Center Haywood
-
Durham, North Carolina, Förenta staterna, 27710
- Duke University Medical Center
-
Durham, North Carolina, Förenta staterna, 27705
- Durham VA Medical Center
-
Goldsboro, North Carolina, Förenta staterna, 27534
- Southeastern Medical Oncology Center-Goldsboro
-
Greenville, North Carolina, Förenta staterna, 27834
- ECU Health Medical Center
-
Hendersonville, North Carolina, Förenta staterna, 28791
- Margaret R Pardee Memorial Hospital
-
Hendersonville, North Carolina, Förenta staterna, 28792
- AdventHealth Hendersonville
-
Huntersville, North Carolina, Förenta staterna, 28078
- Novant Health Cancer Institute - Huntersville
-
Huntersville, North Carolina, Förenta staterna, 28078
- Novant Health Presbyterian Medical Center Huntersville
-
Jacksonville, North Carolina, Förenta staterna, 28546
- Southeastern Medical Oncology Center-Jacksonville
-
Kenansville, North Carolina, Förenta staterna, 28349
- ECU Health Oncology Kenansville
-
Kernersville, North Carolina, Förenta staterna, 27284
- Novant Health Cancer Institute - Kernersville
-
Kinston, North Carolina, Förenta staterna, 28501
- ECU Health Oncology Kinston
-
Matthews, North Carolina, Förenta staterna, 28105
- Novant Health Cancer Institute - Matthews
-
Mooresville, North Carolina, Förenta staterna, 28117
- Novant Health Cancer Institute - Mooresville
-
Mount Airy, North Carolina, Förenta staterna, 27030
- Novant Health Cancer Institute - Mount Airy
-
North Wilkesboro, North Carolina, Förenta staterna, 28659
- Novant Health Cancer Institute - Wilkesboro
-
Richlands, North Carolina, Förenta staterna, 28574
- ECU Health Oncology Richlands
-
Statesville, North Carolina, Förenta staterna, 28625
- Novant Health Cancer Institute - Statesville
-
Statesville, North Carolina, Förenta staterna, 28677
- Wake Forest Baptist Health - Hematology Oncology - Statesville
-
Thomasville, North Carolina, Förenta staterna, 27360
- Novant Health Cancer Institute - Thomasville
-
Weaverville, North Carolina, Förenta staterna, 28787
- AdventHealth Infusion Center Weaverville
-
Wilkesboro, North Carolina, Förenta staterna, 28659
- Wake Forest Baptist Health - Wilkes Medical Center
-
Winston-Salem, North Carolina, Förenta staterna, 27157
- Wake Forest University Health Sciences
-
Winston-Salem, North Carolina, Förenta staterna, 27103
- Novant Health Forsyth Medical Center
-
-
North Dakota
-
Bismarck, North Dakota, Förenta staterna, 58501
- Sanford Bismarck Medical Center
-
Fargo, North Dakota, Förenta staterna, 58122
- Sanford Roger Maris Cancer Center
-
Fargo, North Dakota, Förenta staterna, 58103
- Essentia Health Cancer Center-South University Clinic
-
Fargo, North Dakota, Förenta staterna, 58122
- Sanford Broadway Medical Center
-
Fargo, North Dakota, Förenta staterna, 58103
- Sanford South University Medical Center
-
Fargo, North Dakota, Förenta staterna, 58103
- Southpointe-Sanford Medical Center Fargo
-
Fargo, North Dakota, Förenta staterna, 58104
- Sanford Medical Center Fargo
-
Grand Forks, North Dakota, Förenta staterna, 58201
- Altru Cancer Center
-
Jamestown, North Dakota, Förenta staterna, 58401
- Essentia Health - Jamestown Clinic
-
Minot, North Dakota, Förenta staterna, 58701
- Trinity Cancer Care Center
-
-
Ohio
-
Beavercreek, Ohio, Förenta staterna, 45431
- Indu and Raj Soin Medical Center
-
Belpre, Ohio, Förenta staterna, 45714
- Strecker Cancer Center-Belpre
-
Boardman, Ohio, Förenta staterna, 44512
- Saint Elizabeth Boardman Hospital
-
Centerville, Ohio, Förenta staterna, 45459
- Miami Valley Hospital South
-
Centerville, Ohio, Förenta staterna, 45459
- Dayton Physicians LLC-Miami Valley South
-
Chillicothe, Ohio, Förenta staterna, 45601
- Adena Regional Medical Center
-
Cincinnati, Ohio, Förenta staterna, 45219
- University of Cincinnati Cancer Center-UC Medical Center
-
Cincinnati, Ohio, Förenta staterna, 45220
- Good Samaritan Hospital - Cincinnati
-
Cincinnati, Ohio, Förenta staterna, 45242
- Bethesda North Hospital
-
Cincinnati, Ohio, Förenta staterna, 45236
- Oncology Hematology Care Inc-Kenwood
-
Cincinnati, Ohio, Förenta staterna, 45247
- TriHealth Cancer Institute-Westside
-
Cincinnati, Ohio, Förenta staterna, 45255
- TriHealth Cancer Institute-Anderson
-
Cleveland, Ohio, Förenta staterna, 44109
- MetroHealth Medical Center
-
Columbus, Ohio, Förenta staterna, 43214
- Riverside Methodist Hospital
-
Columbus, Ohio, Förenta staterna, 43210
- Ohio State University Comprehensive Cancer Center
-
Columbus, Ohio, Förenta staterna, 43219
- The Mark H Zangmeister Center
-
Columbus, Ohio, Förenta staterna, 43214
- Columbus Oncology and Hematology Associates Inc
-
Columbus, Ohio, Förenta staterna, 43228
- Doctors Hospital
-
Columbus, Ohio, Förenta staterna, 43213
- Mount Carmel East Hospital
-
Columbus, Ohio, Förenta staterna, 43215
- Grant Medical Center
-
Columbus, Ohio, Förenta staterna, 43222
- Mount Carmel Health Center West
-
Dayton, Ohio, Förenta staterna, 45406
- Good Samaritan Hospital - Dayton
-
Dayton, Ohio, Förenta staterna, 45409
- Miami Valley Hospital
-
Dayton, Ohio, Förenta staterna, 45415
- Miami Valley Hospital North
-
Dayton, Ohio, Förenta staterna, 45415
- Dayton Physician LLC - Englewood
-
Dayton, Ohio, Förenta staterna, 45409
- Premier Blood and Cancer Center
-
Delaware, Ohio, Förenta staterna, 43015
- Delaware Health Center-Grady Cancer Center
-
Delaware, Ohio, Förenta staterna, 43015
- Grady Memorial Hospital
-
Dublin, Ohio, Förenta staterna, 43016
- Dublin Methodist Hospital
-
Dublin, Ohio, Förenta staterna, 43016
- Columbus Oncology and Hematology Associates
-
Findlay, Ohio, Förenta staterna, 45840
- Blanchard Valley Hospital
-
Findlay, Ohio, Förenta staterna, 45840
- Armes Family Cancer Center
-
Findlay, Ohio, Förenta staterna, 45840
- Orion Cancer Care
-
Franklin, Ohio, Förenta staterna, 45005-1066
- Atrium Medical Center-Middletown Regional Hospital
-
Franklin, Ohio, Förenta staterna, 45005
- Dayton Physicians LLC-Atrium
-
Gahanna, Ohio, Förenta staterna, 43230
- Central Ohio Breast and Endocrine Surgery
-
Greenville, Ohio, Förenta staterna, 45331
- Wayne Hospital
-
Greenville, Ohio, Förenta staterna, 45331
- Dayton Physicians LLC-Wayne
-
Greenville, Ohio, Förenta staterna, 45331
- Miami Valley Cancer Care and Infusion
-
Grove City, Ohio, Förenta staterna, 43123
- Mount Carmel Grove City Hospital
-
Kettering, Ohio, Förenta staterna, 45429
- Kettering Medical Center
-
Kettering, Ohio, Förenta staterna, 45409
- Greater Dayton Cancer Center
-
Kettering, Ohio, Förenta staterna, 45420
- First Dayton Cancer Care
-
Lancaster, Ohio, Förenta staterna, 43130
- Fairfield Medical Center
-
Lima, Ohio, Förenta staterna, 45801
- Saint Rita's Medical Center
-
Mansfield, Ohio, Förenta staterna, 44903
- OhioHealth Mansfield Hospital
-
Marietta, Ohio, Förenta staterna, 45750
- Marietta Memorial Hospital
-
Marion, Ohio, Förenta staterna, 43302
- OhioHealth Marion General Hospital
-
Marysville, Ohio, Förenta staterna, 43040
- Memorial Hospital
-
Mount Vernon, Ohio, Förenta staterna, 43050
- Knox Community Hospital
-
Newark, Ohio, Förenta staterna, 43055
- Licking Memorial Hospital
-
Newark, Ohio, Förenta staterna, 43055
- Newark Radiation Oncology
-
Perrysburg, Ohio, Förenta staterna, 43551
- Mercy Health - Perrysburg Hospital
-
Portsmouth, Ohio, Förenta staterna, 45662
- Southern Ohio Medical Center
-
Springfield, Ohio, Förenta staterna, 45504
- Springfield Regional Cancer Center
-
Springfield, Ohio, Förenta staterna, 45504
- Springfield Regional Medical Center
-
Toledo, Ohio, Förenta staterna, 43623
- Mercy Health - Saint Anne Hospital
-
Toledo, Ohio, Förenta staterna, 43623
- Toledo Clinic Cancer Centers-Toledo
-
Toledo, Ohio, Förenta staterna, 43608
- Mercy Health - Saint Vincent Hospital
-
Troy, Ohio, Förenta staterna, 45373
- Upper Valley Medical Center
-
Troy, Ohio, Förenta staterna, 45373
- Dayton Physicians LLC - Troy
-
Warren, Ohio, Förenta staterna, 44484
- Saint Joseph Warren Hospital
-
West Chester, Ohio, Förenta staterna, 45069
- University of Cincinnati Cancer Center-West Chester
-
Westerville, Ohio, Förenta staterna, 43081
- Saint Ann's Hospital
-
Youngstown, Ohio, Förenta staterna, 44501
- Saint Elizabeth Youngstown Hospital
-
Zanesville, Ohio, Förenta staterna, 43701
- Genesis Healthcare System Cancer Care Center
-
-
Oklahoma
-
Lawton, Oklahoma, Förenta staterna, 73505
- Cancer Centers of Southwest Oklahoma Research
-
Oklahoma City, Oklahoma, Förenta staterna, 73104
- University of Oklahoma Health Sciences Center
-
Oklahoma City, Oklahoma, Förenta staterna, 73120
- Mercy Hospital Oklahoma City
-
Tulsa, Oklahoma, Förenta staterna, 74146
- Oklahoma Cancer Specialists and Research Institute-Tulsa
-
-
Oregon
-
Baker City, Oregon, Förenta staterna, 97814
- Saint Alphonsus Cancer Care Center-Baker City
-
Bend, Oregon, Förenta staterna, 97701
- Saint Charles Health System
-
Clackamas, Oregon, Förenta staterna, 97015
- Clackamas Radiation Oncology Center
-
Clackamas, Oregon, Förenta staterna, 97015
- Providence Cancer Institute Clackamas Clinic
-
Coos Bay, Oregon, Förenta staterna, 97420
- Bay Area Hospital
-
Gresham, Oregon, Förenta staterna, 97030
- Legacy Mount Hood Medical Center
-
Newberg, Oregon, Förenta staterna, 97132
- Providence Newberg Medical Center
-
Ontario, Oregon, Förenta staterna, 97914
- Saint Alphonsus Cancer Care Center-Ontario
-
Oregon City, Oregon, Förenta staterna, 97045
- Providence Willamette Falls Medical Center
-
Portland, Oregon, Förenta staterna, 97239
- Oregon Health and Science University
-
Portland, Oregon, Förenta staterna, 97210
- Legacy Good Samaritan Hospital and Medical Center
-
Portland, Oregon, Förenta staterna, 97213
- Providence Portland Medical Center
-
Portland, Oregon, Förenta staterna, 97225
- Providence Saint Vincent Medical Center
-
Redmond, Oregon, Förenta staterna, 97756
- Saint Charles Health System-Redmond
-
Tualatin, Oregon, Förenta staterna, 97062
- Legacy Meridian Park Hospital
-
-
Pennsylvania
-
Allentown, Pennsylvania, Förenta staterna, 18103
- Lehigh Valley Hospital-Cedar Crest
-
Bethlehem, Pennsylvania, Förenta staterna, 18017
- Lehigh Valley Hospital - Muhlenberg
-
Bryn Mawr, Pennsylvania, Förenta staterna, 19010
- Bryn Mawr Hospital
-
Chadds Ford, Pennsylvania, Förenta staterna, 19317
- Christiana Care Health System-Concord Health Center
-
Collegeville, Pennsylvania, Förenta staterna, 19426
- Main Line Health Center-Collegeville
-
Danville, Pennsylvania, Förenta staterna, 17822
- Geisinger Medical Center
-
East Stroudsburg, Pennsylvania, Förenta staterna, 18301
- Pocono Medical Center
-
Exton, Pennsylvania, Förenta staterna, 19341
- Main Line Health Center-Exton
-
Hazleton, Pennsylvania, Förenta staterna, 18201
- Geisinger Medical Center-Cancer Center Hazleton
-
Hazleton, Pennsylvania, Förenta staterna, 18201
- Lehigh Valley Hospital-Hazleton
-
Hershey, Pennsylvania, Förenta staterna, 17033-0850
- Penn State Milton S Hershey Medical Center
-
Lewisburg, Pennsylvania, Förenta staterna, 17837
- Geisinger Medical Oncology-Lewisburg
-
Lewistown, Pennsylvania, Förenta staterna, 17044
- Lewistown Hospital
-
Media, Pennsylvania, Förenta staterna, 19063
- Riddle Memorial Hospital
-
Newtown Square, Pennsylvania, Förenta staterna, 19073
- Bryn Mawr Health Center
-
Paoli, Pennsylvania, Förenta staterna, 19301
- Paoli Memorial Hospital
-
Philadelphia, Pennsylvania, Förenta staterna, 19107
- Thomas Jefferson University Hospital
-
Philadelphia, Pennsylvania, Förenta staterna, 19148
- Jefferson Methodist Hospital
-
Pottsville, Pennsylvania, Förenta staterna, 17901
- Geisinger Cancer Services-Pottsville
-
Sayre, Pennsylvania, Förenta staterna, 18840
- Guthrie Medical Group PC-Robert Packer Hospital
-
Scranton, Pennsylvania, Förenta staterna, 18510
- Community Medical Center
-
Selinsgrove, Pennsylvania, Förenta staterna, 17870
- Geisinger Medical Oncology-Selinsgrove
-
State College, Pennsylvania, Förenta staterna, 16801
- Geisinger Medical Group
-
Wilkes-Barre, Pennsylvania, Förenta staterna, 18711
- Geisinger Wyoming Valley/Henry Cancer Center
-
Wynnewood, Pennsylvania, Förenta staterna, 19096
- Lankenau Medical Center
-
-
South Carolina
-
Boiling Springs, South Carolina, Förenta staterna, 29316
- Prisma Health Cancer Institute - Spartanburg
-
Charleston, South Carolina, Förenta staterna, 29425
- Medical University of South Carolina
-
Easley, South Carolina, Förenta staterna, 29640
- Prisma Health Cancer Institute - Easley
-
Gaffney, South Carolina, Förenta staterna, 29341
- Gibbs Cancer Center-Gaffney
-
Greenville, South Carolina, Förenta staterna, 29605
- Prisma Health Cancer Institute - Faris
-
Greenville, South Carolina, Förenta staterna, 29607
- Saint Francis Cancer Center
-
Greenville, South Carolina, Förenta staterna, 29615
- Prisma Health Cancer Institute - Eastside
-
Greenville, South Carolina, Förenta staterna, 29605
- Prisma Health Cancer Institute - Butternut
-
Greenville, South Carolina, Förenta staterna, 29601
- Saint Francis Hospital
-
Greenville, South Carolina, Förenta staterna, 29605
- Prisma Health Greenville Memorial Hospital
-
Greer, South Carolina, Förenta staterna, 29650
- Prisma Health Cancer Institute - Greer
-
Greer, South Carolina, Förenta staterna, 29651
- Gibbs Cancer Center-Pelham
-
Seneca, South Carolina, Förenta staterna, 29672
- Prisma Health Cancer Institute - Seneca
-
Spartanburg, South Carolina, Förenta staterna, 29303
- Spartanburg Medical Center
-
Spartanburg, South Carolina, Förenta staterna, 29307
- Spartanburg Medical Center - Mary Black Campus
-
Spartanburg, South Carolina, Förenta staterna, 29303
- North Grove Medical Park
-
Union, South Carolina, Förenta staterna, 29379
- SMC Center for Hematology Oncology Union
-
-
South Dakota
-
Aberdeen, South Dakota, Förenta staterna, 57401
- Avera Cancer Institute-Aberdeen
-
Rapid City, South Dakota, Förenta staterna, 57701
- Rapid City Regional Hospital
-
Sioux Falls, South Dakota, Förenta staterna, 57105
- Avera Cancer Institute
-
Sioux Falls, South Dakota, Förenta staterna, 57117-5134
- Sanford USD Medical Center - Sioux Falls
-
Sioux Falls, South Dakota, Förenta staterna, 57104
- Sanford Cancer Center Oncology Clinic
-
-
Tennessee
-
Alcoa, Tennessee, Förenta staterna, 37701
- University Cancer Specialists - Alcoa
-
Bristol, Tennessee, Förenta staterna, 37620
- Bristol Regional Medical Center
-
Collierville, Tennessee, Förenta staterna, 38017
- Baptist Memorial Hospital and Cancer Center-Collierville
-
Cookeville, Tennessee, Förenta staterna, 38501
- Cookeville Regional Medical Center
-
Kingsport, Tennessee, Förenta staterna, 37660
- Ballad Health Cancer Care - Kingsport
-
Kingsport, Tennessee, Förenta staterna, 37660
- Wellmont Holston Valley Hospital and Medical Center
-
Knoxville, Tennessee, Förenta staterna, 37920
- University of Tennessee - Knoxville
-
Memphis, Tennessee, Förenta staterna, 38120
- Baptist Memorial Hospital and Cancer Center-Memphis
-
-
Texas
-
Austin, Texas, Förenta staterna, 78701
- Dell Seton Medical Center at The University of Texas
-
Bryan, Texas, Förenta staterna, 77802
- Saint Joseph Regional Cancer Center
-
Dallas, Texas, Förenta staterna, 75235
- Parkland Memorial Hospital
-
Dallas, Texas, Förenta staterna, 75390
- UT Southwestern/Simmons Cancer Center-Dallas
-
Dallas, Texas, Förenta staterna, 75237
- UT Southwestern Simmons Cancer Center - RedBird
-
Fort Worth, Texas, Förenta staterna, 76104
- UT Southwestern/Simmons Cancer Center-Fort Worth
-
Galveston, Texas, Förenta staterna, 77555-0565
- University of Texas Medical Branch
-
Houston, Texas, Förenta staterna, 77030
- Memorial Hermann Texas Medical Center
-
Laredo, Texas, Förenta staterna, 78041
- Doctor's Hospital of Laredo
-
Richardson, Texas, Förenta staterna, 75080
- UT Southwestern Clinical Center at Richardson/Plano
-
-
Utah
-
American Fork, Utah, Förenta staterna, 84003
- American Fork Hospital / Huntsman Intermountain Cancer Center
-
Cedar City, Utah, Förenta staterna, 84720
- Sandra L Maxwell Cancer Center
-
Logan, Utah, Förenta staterna, 84321
- Logan Regional Hospital
-
Murray, Utah, Förenta staterna, 84107
- Intermountain Medical Center
-
Ogden, Utah, Förenta staterna, 84403
- McKay-Dee Hospital Center
-
Provo, Utah, Förenta staterna, 84604
- Utah Valley Regional Medical Center
-
Riverton, Utah, Förenta staterna, 84065
- Riverton Hospital
-
Salt Lake City, Utah, Förenta staterna, 84106
- Utah Cancer Specialists-Salt Lake City
-
Salt Lake City, Utah, Förenta staterna, 84143
- LDS Hospital
-
St. George, Utah, Förenta staterna, 84770
- Saint George Regional Medical Center
-
-
Vermont
-
Berlin Corners, Vermont, Förenta staterna, 05602
- Central Vermont Medical Center/National Life Cancer Treatment
-
Burlington, Vermont, Förenta staterna, 05401
- University of Vermont Medical Center
-
Burlington, Vermont, Förenta staterna, 05405
- University of Vermont and State Agricultural College
-
-
Virginia
-
Bristol, Virginia, Förenta staterna, 24201
- Ballad Health Cancer Care - Bristol
-
Fishersville, Virginia, Förenta staterna, 22939
- Augusta Health Center for Cancer and Blood Disorders
-
Lynchburg, Virginia, Förenta staterna, 24501
- Centra Alan B Pearson Regional Cancer Center
-
Mechanicsville, Virginia, Förenta staterna, 23116
- Bon Secours Memorial Regional Medical Center
-
Midlothian, Virginia, Förenta staterna, 23114
- Bon Secours Saint Francis Medical Center
-
Midlothian, Virginia, Förenta staterna, 23113
- Bon Secours Westchester Emergency Center
-
Norfolk, Virginia, Förenta staterna, 23505
- Bon Secours DePaul Medical Center
-
Norton, Virginia, Förenta staterna, 24273
- Ballad Health Cancer Care - Norton
-
Portsmouth, Virginia, Förenta staterna, 23707
- Bon Secours Maryview Medical Center
-
Richmond, Virginia, Förenta staterna, 23226
- Bon Secours Saint Mary's Hospital
-
Richmond, Virginia, Förenta staterna, 23230
- Bon Secours Cancer Institute at Reynolds Crossing
-
Richmond, Virginia, Förenta staterna, 23298
- VCU Massey Comprehensive Cancer Center
-
South Hill, Virginia, Förenta staterna, 23970
- VCU Community Memorial Health Center
-
Suffolk, Virginia, Förenta staterna, 23435
- Bon Secours Health Center at Harbour View
-
-
Washington
-
Aberdeen, Washington, Förenta staterna, 98520
- Providence Regional Cancer System-Aberdeen
-
Auburn, Washington, Förenta staterna, 98001
- MultiCare Auburn Medical Center
-
Bellevue, Washington, Förenta staterna, 98004
- Overlake Medical Center
-
Bellingham, Washington, Förenta staterna, 98225
- PeaceHealth Saint Joseph Medical Center
-
Burien, Washington, Förenta staterna, 98166
- Saint Anne Hospital
-
Centralia, Washington, Förenta staterna, 98531
- Providence Regional Cancer System-Centralia
-
Edmonds, Washington, Förenta staterna, 98026
- Swedish Cancer Institute-Edmonds
-
Enumclaw, Washington, Förenta staterna, 98022
- Saint Elizabeth Hospital
-
Everett, Washington, Förenta staterna, 98201
- Providence Regional Cancer Partnership
-
Federal Way, Washington, Förenta staterna, 98003
- Saint Francis Hospital
-
Gig Harbor, Washington, Förenta staterna, 98335
- MultiCare Gig Harbor Medical Park
-
Issaquah, Washington, Förenta staterna, 98029
- Swedish Cancer Institute-Issaquah
-
Kennewick, Washington, Förenta staterna, 99336
- Kadlec Clinic Hematology and Oncology
-
Lacey, Washington, Förenta staterna, 98503
- Providence Regional Cancer System-Lacey
-
Lakewood, Washington, Förenta staterna, 98499
- Saint Clare Hospital
-
Longview, Washington, Förenta staterna, 98632
- PeaceHealth Saint John Medical Center
-
Port Townsend, Washington, Förenta staterna, 98368
- Jefferson Healthcare
-
Poulsbo, Washington, Förenta staterna, 98370
- Harrison HealthPartners Hematology and Oncology-Poulsbo
-
Puyallup, Washington, Förenta staterna, 98372
- MultiCare Good Samaritan Hospital
-
Renton, Washington, Förenta staterna, 98055
- Valley Medical Center
-
Seattle, Washington, Förenta staterna, 98107
- Swedish Medical Center-Ballard Campus
-
Seattle, Washington, Förenta staterna, 98122
- Swedish Medical Center-First Hill
-
Seattle, Washington, Förenta staterna, 98104
- Pacific Gynecology Specialists
-
Seattle, Washington, Förenta staterna, 98122-5711
- Swedish Medical Center-Cherry Hill
-
Sedro-Woolley, Washington, Förenta staterna, 98284
- PeaceHealth United General Medical Center
-
Shelton, Washington, Förenta staterna, 98584
- Providence Regional Cancer System-Shelton
-
Silverdale, Washington, Förenta staterna, 98383
- Saint Joseph Medical Center Hematology and Oncology - Silverdale
-
Spokane, Washington, Förenta staterna, 99204
- MultiCare Deaconess Cancer and Blood Specialty Center - Downtown
-
Spokane, Washington, Förenta staterna, 99218
- MultiCare Deaconess Cancer and Blood Specialty Center - North
-
Spokane Valley, Washington, Förenta staterna, 99216
- MultiCare Deaconess Cancer and Blood Specialty Center - Valley
-
Tacoma, Washington, Förenta staterna, 98405
- Mary Bridge Children's Hospital and Health Center
-
Tacoma, Washington, Förenta staterna, 98405
- Northwest Medical Specialties PLLC
-
Tacoma, Washington, Förenta staterna, 98405
- MultiCare Tacoma General Hospital
-
Tacoma, Washington, Förenta staterna, 98405
- Franciscan Research Center-Northwest Medical Plaza
-
Vancouver, Washington, Förenta staterna, 98686
- Legacy Salmon Creek Hospital
-
Vancouver, Washington, Förenta staterna, 98664
- PeaceHealth Southwest Medical Center
-
Vancouver, Washington, Förenta staterna, 98684
- Legacy Cancer Institute Medical Oncology and Day Treatment
-
Walla Walla, Washington, Förenta staterna, 99362
- Providence Saint Mary Regional Cancer Center
-
Yakima, Washington, Förenta staterna, 98902
- North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
-
Yelm, Washington, Förenta staterna, 98597
- Providence Regional Cancer System-Yelm
-
-
West Virginia
-
Bridgeport, West Virginia, Förenta staterna, 26330
- United Hospital Center
-
Charleston, West Virginia, Förenta staterna, 25304
- Vandalia Health/CAMC Institute for Academic Medicine
-
Huntington, West Virginia, Förenta staterna, 25701
- Edwards Comprehensive Cancer Center
-
Martinsburg, West Virginia, Förenta staterna, 25401
- WVUH-Berkely Medical Center
-
Morgantown, West Virginia, Förenta staterna, 26506
- West Virginia University Healthcare
-
Parkersburg, West Virginia, Förenta staterna, 26101
- Camden Clark Medical Center
-
-
Wisconsin
-
Antigo, Wisconsin, Förenta staterna, 54409
- Aspirus Cancer Care-Antigo-Volm Cancer Center
-
Appleton, Wisconsin, Förenta staterna, 54911
- ThedaCare Regional Cancer Center
-
Ashland, Wisconsin, Förenta staterna, 54806
- Duluth Clinic Ashland
-
Ashland, Wisconsin, Förenta staterna, 54806
- Northwest Wisconsin Cancer Center
-
Eau Claire, Wisconsin, Förenta staterna, 54701
- Marshfield Medical Center-EC Cancer Center
-
Eau Claire, Wisconsin, Förenta staterna, 54701
- HSHS Sacred Heart Hospital
-
Green Bay, Wisconsin, Förenta staterna, 54301
- Saint Vincent Hospital Cancer Center Green Bay
-
Green Bay, Wisconsin, Förenta staterna, 54303
- Saint Vincent Hospital Cancer Center at Saint Mary's
-
Green Bay, Wisconsin, Förenta staterna, 54301
- Bellin Memorial Hospital
-
Madison, Wisconsin, Förenta staterna, 53792
- University of Wisconsin Carbone Cancer Center - University Hospital
-
Madison, Wisconsin, Förenta staterna, 53715
- SSM Health Dean Medical Group - South Madison Campus
-
Manitowoc, Wisconsin, Förenta staterna, 54221
- Holy Family Memorial Hospital
-
Marshfield, Wisconsin, Förenta staterna, 54449
- Marshfield Medical Center-Marshfield
-
Medford, Wisconsin, Förenta staterna, 54451
- Aspirus Medford Hospital
-
Menomonee Falls, Wisconsin, Förenta staterna, 53051
- Froedtert Menomonee Falls Hospital
-
Milwaukee, Wisconsin, Förenta staterna, 53226
- Medical College of Wisconsin
-
Minocqua, Wisconsin, Förenta staterna, 54548
- Marshfield Medical Center - Minocqua
-
Mukwonago, Wisconsin, Förenta staterna, 53149
- ProHealth D N Greenwald Center
-
New Richmond, Wisconsin, Förenta staterna, 54017
- Cancer Center of Western Wisconsin
-
Oconomowoc, Wisconsin, Förenta staterna, 53066
- ProHealth Oconomowoc Memorial Hospital
-
Oconto Falls, Wisconsin, Förenta staterna, 54154
- Saint Vincent Hospital Cancer Center at Oconto Falls
-
Rhinelander, Wisconsin, Förenta staterna, 54501
- Aspirus Cancer Care-Rhinelander-James Beck Cancer Center
-
Rice Lake, Wisconsin, Förenta staterna, 54868
- Marshfield Medical Center-Rice Lake
-
Sheboygan, Wisconsin, Förenta staterna, 53081
- HSHS Saint Nicholas Hospital
-
Stevens Point, Wisconsin, Förenta staterna, 54482
- Marshfield Medical Center-River Region at Stevens Point
-
Stevens Point, Wisconsin, Förenta staterna, 54481
- Aspirus Cancer Care - Stevens Point
-
Sturgeon Bay, Wisconsin, Förenta staterna, 54235-1495
- Saint Vincent Hospital Cancer Center at Sturgeon Bay
-
Waukesha, Wisconsin, Förenta staterna, 53188
- UW Cancer Center at ProHealth Care
-
Waukesha, Wisconsin, Förenta staterna, 53188
- ProHealth Waukesha Memorial Hospital
-
Wausau, Wisconsin, Förenta staterna, 54401
- Aspirus Cancer Care-Wausau
-
West Bend, Wisconsin, Förenta staterna, 53095
- Froedtert West Bend Hospital/Kraemer Cancer Center
-
Weston, Wisconsin, Förenta staterna, 54476
- Marshfield Medical Center - Weston
-
Wisconsin Rapids, Wisconsin, Förenta staterna, 54494
- Aspirus Cancer Care - Wisconsin Rapids
-
-
Wyoming
-
Cheyenne, Wyoming, Förenta staterna, 82001
- Cheyenne Regional Medical Center-West
-
Cody, Wyoming, Förenta staterna, 82414
- Billings Clinic-Cody
-
Sheridan, Wyoming, Förenta staterna, 82801
- Welch Cancer Center
-
-
-
-
-
San Juan, Puerto Rico, 00902
- Pan American Center for Oncology Trials LLC
-
-
Deltagandekriterier
Forskare letar efter personer som passar en viss beskrivning, så kallade behörighetskriterier. Några exempel på dessa kriterier är en persons allmänna hälsotillstånd eller tidigare behandlingar.
Urvalskriterier
Åldrar som är berättigade till studier
18 år och äldre (Vuxen, Äldre vuxen)
Tar emot friska volontärer
Nej
Kön som är behöriga för studier
Allt
Beskrivning
Inclusion Criteria:
-
STEP I REGISTRATION CRITERIA
-
Histologically documented renal cell carcinoma with clear cell component, including patients who have sarcomatoid or rhabdoid features
-
Any metastatic disease, including visceral, lymph node, other soft tissue and bone, measurable per RECIST 1.1
-
Measurable disease as defined in the protocol
-
Must be intermediate or poor risk patient per International Metastatic Renal Cell Carcinoma Database (IMDC) criteria (1 or more of the following): Karnofsky performance status [KPS] < 80, < 1 year from diagnosis [including initial nephrectomy] to systemic treatment for metastatic disease, hemoglobin less than lower limit of normal [LLN], corrected calcium concentration greater than upper limit of normal [ULN], absolute neutrophil count greater than ULN, platelet count > ULN)
-
Central nervous system (CNS) disease permitted, if stable and not otherwise causing symptoms or needing active treatment
-
Karnofsky performance status >= 70%
-
No prior treatment with PD-1, PD-L1, or CTLA-4 targeting agents (including but not limited to nivolumab, pembrolizumab, pidilizumab, durvalumab, atezolizumab, tremelimumab, and ipilimumab), or any other drug or antibody specifically targeting T-cell co-stimulation or checkpoint pathways. The only exception is for prior treatment with nivolumab or other PD-1/PD-L1/CTLA-4 targeting therapy on pre- or post-operative trials, as long as > 1 year since completion of systemic therapy
-
No prior previous systemic therapy for renal cell carcinoma (prior HD IL-2 [>28 days]. Prior adjuvant sunitinib >180 days since completion and prior immunotherapy as above are allowed).
-
No systemic cancer therapy less than 28 days prior to registration; no radiation therapy less than 14 days prior to registration. There must be a complete recovery and no ongoing complications from radiotherapy
-
Not pregnant and not nursing, because this study involves an agent that has known genotoxic, mutagenic and teratogenic effects. Therefore, for women of childbearing potential only, a negative serum or urine pregnancy test done =< 14 days prior to registration is required
-
Age >= 18 years
-
None of the following:
- Active autoimmune disease requiring ongoing therapy
- Ongoing acute toxicity > grade 2 from previous treatment
- History of severe allergic, anaphylactic or other hypersensitivity reactions to chimeric or humanized antibodies
- Active hepatitis B/C, or active tuberculosis (purified protein derivative [PPD] response without active tuberculosis [TB] is allowed)
- HIV-infected patients with detectable viral load within 6 months prior to registration. Patients on effective anti-retroviral therapy with undetectable viral load within 6 months prior to registration are eligible
- Concurrent use of immunosuppressive medication including prednisone above 10 mg daily
- Uncontrolled adrenal insufficiency
- Uncontrolled hypertension (systolic blood pressure [BP] > 150mmHg or diastolic BP > 90mmHg)
- Major surgery less than 28 days prior to registration
- Any serious non-healing wound, ulcer, or bone fracture within 28 days prior to registration
- Any arterial thrombotic events within 180 days prior to registration
- Clinically significant hematuria, hematemesis, or hemoptysis within 12 weeks prior to registration
- Cavitating pulmonary lesions or known endotracheal or endobronchial disease manifestations
- Lesions encasing or invading any major blood vessels (this does not include tumor thrombus extending into/through renal vein/inferior vena cava [IVC]). Patients with tumor thrombus extending into/through renal vein are considered eligible
- Moderate of severe hepatic impairment (child-Pugh B or C)
- Any history of untreated pulmonary embolism or deep venous thrombosis (DVT) in the 180 days prior to registration. (Any asymptomatic, treated pulmonary embolism or asymptomatic, treated deep venous thrombosis > 30 days prior to registration allowed)
- Corrected QT interval calculated by the Fridericia formula (QTcF) > 500 ms
- Unstable cardiac arrhythmia within 6 months prior to registration
- Any gastrointestinal (GI) bleeding =< 180 days, hemoptysis, or other signs of pulmonary hemorrhage =< 90 days prior to registration
- History of abdominal fistula, gastrointestinal perforation, intra-abdominal abscess, bowel obstruction, or gastric outlet obstruction within 180 days prior to registration
- Active peptic ulcer disease, inflammatory bowel disease, or malabsorption syndrome within 28 days prior to registration
- Untreated hypothyroidism (treated hypothyroidism on thyroid replacement therapy is allowed. Abnormal thyroid-stimulating hormone [TSH] is acceptable with normal T3/free T4 if treated on thyroid replacement therapy)
- Evidence of pancreatitis, history of organ transplant, or history of congenital QT syndrome
- Active treatment with coumarin agents (e.g., warfarin), direct thrombin inhibitors (e.g., dabigatran), direct Xa inhibitor betrixaban or platelet inhibitors (e.g., clopidogrel) within 5 days of registration Allowed anticoagulants include: prophylactic use of low-dose aspirin for cardio-protection (per local applicable guidelines) and low-dose low molecular weight heparins (LMWH), therapeutic doses of LMWH or anticoagulation with direct factor Xa inhibitors rivaroxaban, edoxaban, apixaban. Allowed also in patients with known brain metastases who are on a stable dose of the anticoagulant for at least 1 week prior to registration without clinically significant hemorrhagic complications from the anticoagulation regimen or the tumor
- Significant cardiac ischemia events (ST elevation myocardial infarction [STEMI] or non-ST-elevation myocardial infarction [NSTEMI]) within 6 months or active New York (NY) Heart Association class 3-4 heart failure symptoms
-
Absolute neutrophil count (ANC) >= 1,500/mm^3
-
Platelet count >= 100,000/mm^3
-
Hemoglobin >= 8 g/dL
-
Calculated (Calc.) creatinine clearance >= 30 mL/min
-
Urine protein =< 1+ or urine protein to creatinine (UPC) ratio < 1
-
Total bilirubin =< 1.5 x upper limit of normal (ULN) (except for patients with known or likely Gilbert's syndrome, for whom total bilirubin up to 3 mg/dL is allowed with direct bilirubin =< 20% total bilirubin)
-
Aspartate aminotransferase/alanine aminotransferase (AST/ALT) =< 2.5 x upper limit of normal (ULN) or < 5 x ULN if hepatic metastases present
-
STEP 2 REGISTRATION ELIGIBILITY CRITERIA
-
Successful completion of at least 1 cycle of ipilimumab/nivolumab
-
Resolution of any treatment-related adverse events to grade 1 or less per dose modification section (this criteria does not include any adverse events [AEs] not attributable to treatment which are present due to disease), with prednisone-equivalent dosing at 10 mg daily or less. Exceptions for this criteria include patients receiving replacement hormone treatments (such as levothyroxine for treatment-related hypothyroidism or glucocorticoid replacement for adrenal insufficiency). Please contact study chair if further discussion is needed
-
No more than 80 days from last dose of ipilimumab/nivolumab
Studieplan
Det här avsnittet ger detaljer om studieplanen, inklusive hur studien är utformad och vad studien mäter.
Hur är studien utformad?
Designdetaljer
- Primärt syfte: Behandling
- Tilldelning: Randomiserad
- Interventionsmodell: Parallellt uppdrag
- Maskning: Ingen (Open Label)
Vapen och interventioner
Deltagargrupp / Arm |
Intervention / Behandling |
|---|---|
|
Aktiv komparator: Arm A (nivolumab)
INDUCTION: Patients receive nivolumab IV over 30 minutes and ipilimumab IV over 30 minutes on day 1. Treatment repeats every 21 days for up to 4 cycles in the absence of disease progression or unacceptable toxicity. TREATMENT: Patients with iuPD with clinical instability receive cabozantinib PO daily on days 1-28. Treatment repeats every 28 days until further disease progression or unacceptable toxicity Patients with iCR receive nivolumab IV over 30 minutes on day 1. Treatment repeats every 28 days in the absence of disease progression or unacceptable toxicity. Patients with non-CR/non-PD with clinical stability receive nivolumab IV over 30 minutes on day 1. Treatment repeats every 28 days in the absence of disease progression or unacceptable toxicity. Patients undergo CT scan, MRI and blood and urine sample collection, and may also undergo a bone scan as clinically indicated throughout the study. |
Ancillary studies
Andra namn:
Given IV
Andra namn:
Undergo MRI
Andra namn:
Ancillary studies Given IV
Andra namn:
Undergo CT scan
Andra namn:
Undergo bone scan
Andra namn:
Undergo blood and urine sample collection
Andra namn:
|
|
Experimentell: Arm B (nivolumab, cabozantinib)
INDUCTION: Patients receive nivolumab IV over 30 minutes and ipilimumab IV over 30 minutes on day 1. Treatment repeats every 21 days for up to 4 cycles in the absence of disease progression or unacceptable toxicity. TREATMENT: Patients with iuPD with clinical instability receive cabozantinib PO daily on days 1-28. Treatment repeats every 28 days until further disease progression or unacceptable toxicity. Patients with iCR receive nivolumab IV over 30 minutes on day 1. Treatment repeats every 28 days in the absence of disease progression or unacceptable toxicity. Patients with non-CR/non-PD rwith clinical stability eceive nivolumab IV over 30 minutes on day 1 and cabozantinib PO daily on days 1-28. Treatment repeats every 28 days in the absence of disease progression or unacceptable toxicity. Patients undergo CT scan, MRI and blood and urine sample collection, and may also undergo a bone scan as clinically indicated throughout the study. |
Ancillary studies
Andra namn:
Given IV
Andra namn:
Undergo MRI
Andra namn:
Ancillary studies Given IV
Andra namn:
Undergo CT scan
Andra namn:
Undergo blood and urine sample collection
Andra namn:
Given PO |
Vad mäter studien?
Primära resultatmått
Resultatmått |
Åtgärdsbeskrivning |
Tidsram |
|---|---|---|
|
Overall survival (OS)
Tidsram: From registration to date of death from any cause for non-randomized patients, from time of randomization until death from any cause for randomized patients, assessed up to 5 years
|
OS of patients who achieve complete response (CR) and progressive disease (PD) from ipilimumab-nivolumab induction phase will be summarized. The stratified log-rank statistic will be the primary analysis to compare the hypothesis on OS with the stratification factors (presence of bone metastases and IMDC risk criteria). The Kaplan-Meier product-limit estimator will be used to estimate the OS. A stratified proportional hazards model will be used to generate estimates for the OS hazard ratio. For the randomized patients, OS will be calculated and compared from the time of randomization until the time of an OS event or time of last-follow-up, whatever occurs first. For the patients who were initially CR or PD, OS will be measured from the time of study registration. A comparison of OS will be made across the patient groups (randomized patients, patients initially CR, and patients initially PD). |
From registration to date of death from any cause for non-randomized patients, from time of randomization until death from any cause for randomized patients, assessed up to 5 years
|
Sekundära resultatmått
Resultatmått |
Åtgärdsbeskrivning |
Tidsram |
|---|---|---|
|
Progression-free survival (PFS)
Tidsram: From date of registration to date of progression (or disease recurrence) or death due to any cause, whichever occurs first, assessed up to 5 years
|
Progression will be defined using the Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 criteria. PFS of patients who achieve CR and PD from ipilimumab-nivolumab induction phase will be summarized (secondary analysis). The Kaplan-Meier product-limit estimator will be used to estimate the PFS distribution. A stratified proportional hazards model will be used to generate estimates for the PFS hazard ratio. For the randomized patients, PFS will be calculated and compared from the time of randomization until the time of a PFS event or time of last-follow-up, whatever occurs first. For the patients who were initially CR or PD, PFS will be measured from the time of study registration. A comparison of PFS will be made across the patient groups (randomized patients, patients initially CR, and patients initially PD). For this comparison, PFS will be measured from time of study registration all the patients, regardless of whether they were randomized or not. |
From date of registration to date of progression (or disease recurrence) or death due to any cause, whichever occurs first, assessed up to 5 years
|
|
Complete response (CR) (randomized patients)
Tidsram: At 12 months from date of randomization
|
Patients who had a CR prior to 12 months but have experienced a disease recurrence prior to 12 months, will not be considered to be a CR at 12 months. The Cochran-Mantel-Haenszel test will be used to compare the two arms on the proportion of patients who have a 12-month CR adjusting on the stratification factors. |
At 12 months from date of randomization
|
|
Objective response
Tidsram: Up to 5 years
|
Defined as the best response observed that has been confirmed by a scan performed 4 or more weeks after the observation of the initial response. The objective response will be confirmed using RECIST 1.1. In addition, objective responses will also be confirmed using Immune Response Evaluation Criteria in Solid Tumors (iRECIST). |
Up to 5 years
|
|
Proportion of patients who discontinue protocol-directed treatment prior to 1 year from date of study registration
Tidsram: Up to 5 years
|
Patients who stop their protocol directed treatment for any reason prior to one year from study registration will be considered to have discontinued their treatment. The Cochran-Mantel-Haenszel test will also be used to compare the proportion of patients who discontinue their treatment prior to one-year after study registration. |
Up to 5 years
|
|
Incidence of adverse events
Tidsram: Up to 5 years
|
Assessed with National Cancer Institute Common Terminology Criteria for Adverse Events version 5.0. A Fisher's exact test will be used to compare the two treatment arms on the proportion of patient with a grade 3 or higher adverse event. |
Up to 5 years
|
Andra resultatmått
Resultatmått |
Åtgärdsbeskrivning |
Tidsram |
|---|---|---|
|
Estimates of OS by sex
Tidsram: From registration to date of death from any cause for non-randomized patients, from time of randomization until death from any cause for randomized patients, assessed up to 5 years
|
Estimates of OS and the corresponding 95% confidence intervals (CIs) by sex will be provided (with an understanding that sometimes the CI or estimate will not be computable because of scant data). |
From registration to date of death from any cause for non-randomized patients, from time of randomization until death from any cause for randomized patients, assessed up to 5 years
|
|
Estimates of OS by race
Tidsram: From registration to date of death from any cause for non-randomized patients, from time of randomization until death from any cause for randomized patients, assessed up to 5 years
|
Estimates of OS and the corresponding 95% CIs by race will be provided (with an understanding that sometimes the CI or estimate will not be computable because of scant data). |
From registration to date of death from any cause for non-randomized patients, from time of randomization until death from any cause for randomized patients, assessed up to 5 years
|
|
Estimates of OS by ethnicity
Tidsram: From registration to date of death from any cause for non-randomized patients, from time of randomization until death from any cause for randomized patients, assessed up to 5 years
|
Estimates of OS and the corresponding 95% CIs by ethnicity will be provided (with an understanding that sometimes the CI or estimate will not be computable because of scant data). |
From registration to date of death from any cause for non-randomized patients, from time of randomization until death from any cause for randomized patients, assessed up to 5 years
|
Samarbetspartners och utredare
Det är här du hittar personer och organisationer som är involverade i denna studie.
Sponsor
Utredare
- Huvudutredare: Tian Zhang, Alliance for Clinical Trials in Oncology
Publikationer och användbara länkar
Den som ansvarar för att lägga in information om studien tillhandahåller frivilligt dessa publikationer. Dessa kan handla om allt som har med studien att göra.
Allmänna publikationer
- Yang Y, Psutka SP, Parikh AB, Li M, Collier K, Miah A, Mori SV, Hinkley M, Tykodi SS, Hall E, Thompson JA, Yin M. Combining immune checkpoint inhibition plus tyrosine kinase inhibition as first and subsequent treatments for metastatic renal cell carcinoma. Cancer Med. 2022 Aug;11(16):3106-3114. doi: 10.1002/cam4.4679. Epub 2022 Mar 18.
- Labriola MK, George DJ. Setting a new standard for long-term survival in metastatic kidney cancer. Cancer. 2022 Jun 1;128(11):2058-2060. doi: 10.1002/cncr.34177. Epub 2022 Apr 5. No abstract available.
Studieavstämningsdatum
Dessa datum spårar framstegen för inlämningar av studieposter och sammanfattande resultat till ClinicalTrials.gov. Studieposter och rapporterade resultat granskas av National Library of Medicine (NLM) för att säkerställa att de uppfyller specifika kvalitetskontrollstandarder innan de publiceras på den offentliga webbplatsen.
Studera stora datum
Studiestart (Faktisk)
7 juni 2019
Primärt slutförande (Beräknad)
1 mars 2028
Avslutad studie (Beräknad)
1 mars 2028
Studieregistreringsdatum
Först inskickad
3 januari 2019
Först inskickad som uppfyllde QC-kriterierna
3 januari 2019
Första postat (Faktisk)
4 januari 2019
Uppdateringar av studier
Senaste uppdatering publicerad (Faktisk)
26 oktober 2026
Senaste inskickade uppdateringen som uppfyllde QC-kriterierna
23 oktober 2026
Senast verifierad
1 oktober 2026
Mer information
Termer relaterade till denna studie
Ytterligare relevanta MeSH-villkor
- Urogenitala sjukdomar
- Patologiska processer
- Urogenitala neoplasmer
- Neoplasmer efter plats
- Neoplasmer
- Manliga urogenitala sjukdomar
- Njursjukdomar
- Urologiska sjukdomar
- Kvinnliga urogenitala sjukdomar
- Kvinnliga urogenitala sjukdomar och graviditetskomplikationer
- Neoplasmer efter histologisk typ
- Neoplasmer, körtel och epitel
- Adenocarcinom
- Neoplastiska processer
- Urologiska neoplasmer
- Carcinom
- Neoplasmer i njurarna
- Neoplasma Metastas
- Patologiska tillstånd, tecken och symtom
- Karcinom, njurcell
- Lymfatisk metastasering
- Aminosyror, peptider och proteiner
- Proteiner
- Undersökningstekniker
- Kliniska laboratorietekniker
- Diagnostiska tekniker och procedurer
- Diagnos
- Biologiska faktorer
- Antikroppar, monoklonal, humaniserad
- Antikroppar, monoklonal
- Antikroppar
- Immunglobuliner
- Immunoproteiner
- Blodproteiner
- Serumglobuliner
- Globuliner
- Kemitekniker, analytiska
- Spektrumanalys
- Receptorer, cellytan
- Membranproteiner
- Antigen
- Antigen, yta
- Biomarkörer
- Receptorer, immunologiska
- Antigen, differentiering, T-lymfocyt
- Antigener, differentiering
- Immunkontrollproteiner
- Costimulatory och hämmande T-cellreceptorer
- Nivolumab
- Ipilimumab
- Provhantering
- Magnetresonansspektroskopi
- cabozantinib
- CTLA-4-antigen
Andra studie-ID-nummer
- NCI-2018-03694
- U10CA180821 (U.S.S. NIH-anslag/kontrakt)
- NCI-2018-03694 (Registeridentifierare: CTRP (Clinical Trial Reporting Program))
- A031704 (Annan identifierare: CTEP)
- A031704 (Annan identifierare: Alliance for Clinical Trials in Oncology)
Plan för individuella deltagardata (IPD)
Planerar du att dela individuella deltagardata (IPD)?
JA
IPD-planbeskrivning
NCI is committed to sharing data in accordance with NIH policy. For more details on how clinical trial data is shared, access the link to the NIH data sharing policy page
Läkemedels- och apparatinformation, studiedokument
Studerar en amerikansk FDA-reglerad läkemedelsprodukt
Ja
Studerar en amerikansk FDA-reglerad produktprodukt
Nej
Denna information hämtades direkt från webbplatsen clinicaltrials.gov utan några ändringar. Om du har några önskemål om att ändra, ta bort eller uppdatera dina studieuppgifter, vänligen kontakta register@clinicaltrials.gov. Så snart en ändring har implementerats på clinicaltrials.gov, kommer denna att uppdateras automatiskt även på vår webbplats .