Inmunoterapia con nivolumab e ipilimumab seguida de nivolumab o nivolumab con cabozantinib para pacientes con cáncer de riñón avanzado, estudio PDIGREE
23 de octubre de 2026 actualizado por: National Cancer Institute (NCI)
Inhibidor de la PD (nivolumab) e ipilimumab seguidos de nivolumab frente a VEGF TKI Cabozantinib con nivolumab: un ensayo de fase III en cáncer de células renales metastásico no tratado [PDIGREE]
This phase III trial compares the usual treatment (treatment with ipilimumab and nivolumab followed by nivolumab alone) to treatment with ipilimumab and nivolumab, followed by nivolumab with cabozantinib in patients with untreated renal cell carcinoma that has spread to other parts of the body. The addition of cabozantinib to the usual treatment may make it work better. Immunotherapy with monoclonal antibodies, such as nivolumab and ipilimumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Cabozantinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. It is not yet known how well the combination of cabozantinib and nivolumab after initial treatment with ipilimumab and nivolumab works in treating patients with renal cell cancer that has spread to other parts of the body.
Descripción general del estudio
Estado
Activo, no reclutando
Condiciones
- Carcinoma de células renales de células claras
- Cáncer de células renales en estadio III AJCC v8
- Cáncer de células renales en estadio IV AJCC v8
- Neoplasia maligna metastásica en el hueso
- Neoplasia maligna metastásica en los ganglios linfáticos
- Neoplasia maligna metastásica en las vísceras
- Carcinoma de células renales sarcomatoide
- Tumor rabdoide del riñón
- Neoplasia maligna metastásica en el tejido blando
Descripción detallada
PRIMARY OBJECTIVE:
I. To compare the overall survival (OS) in patients with metastatic renal cell cancer (RCC) treated with ipilimumab-nivolumab followed by either nivolumab versus cabozantinib-nivolumab.
SECONDARY OBJECTIVES:
I. To determine progression free survival (PFS) of patients treated with nivolumab versus nivolumab-cabozantinib.
II. To evaluate the 12-month complete response rate in patients treated with ipilimumab-nivolumab followed by cabozantinib-nivolumab versus ipilimumab-nivolumab followed by nivolumab (patients who have complete response [CR] and relapse before 12 months will not be counted as a CR at 12-months).
III. To evaluate the rates of discontinuing therapy at 1 year. IV. To compare objective response rates (ORR, assessed by Response Evaluation Criteria in Solid Tumors [RECIST] 1.1 and Immune Response Evaluation Criteria in Solid Tumors [iRECIST] criteria) for patients treated with ipilimumab-nivolumab followed by cabozantinib-nivolumab versus ipilimumab-nivolumab followed by nivolumab.
V. To document the adverse event profile of ipilimumab-nivolumab followed by cabozantinib-nivolumab.
BIOMARKER OBJECTIVES:
I. To evaluate biomarkers associated with exceptional responses in both arms (exceptional responses defined as CRs with treatment discontinuation at 12 months or 24 months).
II. To evaluate whether baseline IL-6 is predictive of outcome in patients treated with cabozantinib-containing regimen.
QUALITY OF LIFE (QOL) OBJECTIVES:
I. To compare health-related quality of life at 18 months post-registration as assessed by the Functional Assessment of Cancer Therapy (FACT)-Kidney Symptom Index 19 (FKSI-19) between patients randomized to nivolumab (nivo) versus (vs) cabozantinib (cabo)/nivo.
II. To compare health-related quality of life as assessed by the FKSI-19 between patients randomized to nivo vs cabo/nivo at other time points.
III. To compare patient-reported fatigue using Patient-Reported Outcomes Measurement Information System (PROMIS)-Fatigue between patients randomized to nivo vs cabo/nivo.
IV. To compare quality-adjusted survival (overall survival x utility score assessed by EuroQol five-dimensional questionnaire [EQ5D-5L]) between patients randomized to nivo vs cabo/nivo.
OUTLINE:
INDUCTION: Patients receive nivolumab intravenously (IV) over 30 minutes and ipilimumab IV over 30 minutes on day 1. Treatment repeats every 21 days for up to 4 cycles in the absence of disease progression or unacceptable toxicity.
TREATMENT:
Patients with unconfirmed but clinical progression of disease (iuPD) with clinical instability receive cabozantinib orally (PO) daily on days 1-28. Treatment repeats every 28 days until further disease progression or unacceptable toxicity.
Patients with unconfirmed CR (iCR) receive nivolumab IV between 30-60 minutes on day 1. Treatment repeats every 28 days in the absence of disease progression or unacceptable toxicity.
Patients with non-CR/non-PD or iuPD with clinical stability are randomized to 1 of 2 arms.
ARM A: Patients receive nivolumab IV between 30-60 minutes on day 1. Treatment repeats every 28 days in the absence of disease progression or unacceptable toxicity.
ARM B: Patients receive nivolumab IV between 30-60 minutes on day 1 and cabozantinib PO daily on days 1-28. Treatment repeats every 28 days in the absence of disease progression or unacceptable toxicity.
Patients undergo computed tomography (CT) scan, magnetic resonance imaging (MRI) and blood and urine sample collection, and may also undergo a bone scan as clinically indicated throughout the study.
Tipo de estudio
Intervencionista
Inscripción (Estimado)
1175
Fase
- Fase 3
Contactos y Ubicaciones
Esta sección proporciona los datos de contacto de quienes realizan el estudio e información sobre dónde se lleva a cabo este estudio.
Ubicaciones de estudio
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Alabama
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Mobile, Alabama, Estados Unidos, 36688
- University of South Alabama Mitchell Cancer Institute
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Alaska
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Anchorage, Alaska, Estados Unidos, 98508
- Anchorage Associates in Radiation Medicine
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Anchorage, Alaska, Estados Unidos, 99508
- Alaska Breast Care and Surgery LLC
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Anchorage, Alaska, Estados Unidos, 99508
- Alaska Oncology and Hematology LLC
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Anchorage, Alaska, Estados Unidos, 99508
- Alaska Women's Cancer Care
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Anchorage, Alaska, Estados Unidos, 99508
- Anchorage Oncology Centre
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Anchorage, Alaska, Estados Unidos, 99508
- Katmai Oncology Group
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Anchorage, Alaska, Estados Unidos, 99508
- Providence Alaska Medical Center
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Anchorage, Alaska, Estados Unidos, 99504
- Anchorage Radiation Therapy Center
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Fairbanks, Alaska, Estados Unidos, 99701
- Fairbanks Memorial Hospital
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Arizona
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Kingman, Arizona, Estados Unidos, 86401
- Kingman Regional Medical Center
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Phoenix, Arizona, Estados Unidos, 85004
- Cancer Center at Saint Joseph's
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Arkansas
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Fayetteville, Arkansas, Estados Unidos, 72703
- Highlands Oncology Group - Fayetteville
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Fort Smith, Arkansas, Estados Unidos, 72903
- Mercy Hospital Fort Smith
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Hot Springs, Arkansas, Estados Unidos, 71913
- CHI Saint Vincent Cancer Center Hot Springs
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Rogers, Arkansas, Estados Unidos, 72758
- Highlands Oncology Group - Rogers
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Springdale, Arkansas, Estados Unidos, 72762
- Highlands Oncology Group
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California
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Anaheim, California, Estados Unidos, 92806
- Kaiser Permanente-Anaheim
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Arroyo Grande, California, Estados Unidos, 93420
- PCR Oncology
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Arroyo Grande, California, Estados Unidos, 93420
- Mission Hope Medical Oncology - Arroyo Grande
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Baldwin Park, California, Estados Unidos, 91706
- Kaiser Permanente-Baldwin Park
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Bellflower, California, Estados Unidos, 90706
- Kaiser Permanente-Bellflower
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Burbank, California, Estados Unidos, 91505
- Providence Saint Joseph Medical Center/Disney Family Cancer Center
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Clovis, California, Estados Unidos, 93611
- Community Cancer Institute
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Clovis, California, Estados Unidos, 93611
- University Oncology Associates
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Fontana, California, Estados Unidos, 92335
- Kaiser Permanente-Fontana
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Harbor City, California, Estados Unidos, 90710
- Kaiser Permanente South Bay
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Irvine, California, Estados Unidos, 92618
- Kaiser Permanente-Irvine
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La Jolla, California, Estados Unidos, 92093
- UC San Diego Moores Cancer Center
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Los Angeles, California, Estados Unidos, 90027
- Kaiser Permanente Los Angeles Medical Center
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Los Angeles, California, Estados Unidos, 90034
- Kaiser Permanente West Los Angeles
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Ontario, California, Estados Unidos, 91761
- Kaiser Permanente-Ontario
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Panorama City, California, Estados Unidos, 91402
- Kaiser Permanente - Panorama City
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Riverside, California, Estados Unidos, 92505
- Kaiser Permanente-Riverside
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Sacramento, California, Estados Unidos, 95817
- University of California Davis Comprehensive Cancer Center
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San Diego, California, Estados Unidos, 92120
- Kaiser Permanente-San Diego Zion
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San Diego, California, Estados Unidos, 92134
- Naval Medical Center -San Diego
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San Diego, California, Estados Unidos, 92123
- Sharp Memorial Hospital
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San Diego, California, Estados Unidos, 92108
- Kaiser Permanente-Rio San Diego
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San Francisco, California, Estados Unidos, 94158
- UCSF Medical Center-Mission Bay
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San Luis Obispo, California, Estados Unidos, 93401
- Pacific Central Coast Health Center-San Luis Obispo
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San Marcos, California, Estados Unidos, 92078
- Kaiser Permanente-San Marcos
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Santa Maria, California, Estados Unidos, 93444
- Mission Hope Medical Oncology - Santa Maria
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Woodland Hills, California, Estados Unidos, 91367
- Kaiser Permanente-Woodland Hills
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Colorado
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Aurora, Colorado, Estados Unidos, 80012
- Rocky Mountain Cancer Centers-Aurora
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Aurora, Colorado, Estados Unidos, 80012
- The Medical Center of Aurora
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Aurora, Colorado, Estados Unidos, 80045
- UCHealth University of Colorado Hospital
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Boulder, Colorado, Estados Unidos, 80303
- Boulder Community Foothills Hospital
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Boulder, Colorado, Estados Unidos, 80304
- Rocky Mountain Cancer Centers-Boulder
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Centennial, Colorado, Estados Unidos, 80112
- Rocky Mountain Cancer Centers - Centennial
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Colorado Springs, Colorado, Estados Unidos, 80907
- Penrose-Saint Francis Healthcare
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Colorado Springs, Colorado, Estados Unidos, 80909
- UCHealth Memorial Hospital Central
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Colorado Springs, Colorado, Estados Unidos, 80907
- Rocky Mountain Cancer Centers-Penrose
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Colorado Springs, Colorado, Estados Unidos, 80920
- Memorial Hospital North
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Denver, Colorado, Estados Unidos, 80205
- Kaiser Permanente-Franklin
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Denver, Colorado, Estados Unidos, 80218
- Presbyterian - Saint Lukes Medical Center - Health One
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Denver, Colorado, Estados Unidos, 80220
- Rose Medical Center
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Denver, Colorado, Estados Unidos, 80218
- Rocky Mountain Cancer Centers-Midtown
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Denver, Colorado, Estados Unidos, 80220
- Rocky Mountain Cancer Centers-Rose
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Denver, Colorado, Estados Unidos, 80218
- Colorado Blood Cancer Institute
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Denver, Colorado, Estados Unidos, 80204
- Cancer Center of Colorado at Sloan's Lake
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Denver, Colorado, Estados Unidos, 80209
- The Women's Imaging Center
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Denver, Colorado, Estados Unidos, 80206
- National Jewish Health-Main Campus
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Denver, Colorado, Estados Unidos, 80220
- Western Surgical Care
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Denver, Colorado, Estados Unidos, 80206
- UCHealth - Cherry Creek
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Denver, Colorado, Estados Unidos, 80218
- Saint Joseph Hospital - Cancer Centers of Colorado
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Denver, Colorado, Estados Unidos, 80210
- AdventHealth Porter
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Durango, Colorado, Estados Unidos, 81301
- Mercy Medical Center
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Durango, Colorado, Estados Unidos, 81301
- CommonSpirit Cancer Center Mercy
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Englewood, Colorado, Estados Unidos, 80113
- Mountain Blue Cancer Care Center - Swedish
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Englewood, Colorado, Estados Unidos, 80113
- Swedish Medical Center
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Englewood, Colorado, Estados Unidos, 80113
- Rocky Mountain Cancer Centers - Swedish
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Englewood, Colorado, Estados Unidos, 80113
- The Melanoma and Skin Cancer Institute
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Fort Collins, Colorado, Estados Unidos, 80524
- Poudre Valley Hospital
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Fort Collins, Colorado, Estados Unidos, 80528
- Cancer Care and Hematology-Fort Collins
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Golden, Colorado, Estados Unidos, 80401
- National Jewish Health-Western Hematology Oncology
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Grand Junction, Colorado, Estados Unidos, 81501
- Saint Mary's Hospital and Regional Medical Center
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Greeley, Colorado, Estados Unidos, 80631
- UCHealth Greeley Hospital
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Greeley, Colorado, Estados Unidos, 80631
- Banner North Colorado Medical Center
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Highlands Ranch, Colorado, Estados Unidos, 80129
- UCHealth Highlands Ranch Hospital
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Lafayette, Colorado, Estados Unidos, 80026
- Kaiser Permanente-Rock Creek
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Lafayette, Colorado, Estados Unidos, 80026
- Good Samaritan Hospital - Cancer Centers of Colorado
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Lakewood, Colorado, Estados Unidos, 80228
- Rocky Mountain Cancer Centers-Lakewood
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Lakewood, Colorado, Estados Unidos, 80228
- CommonSpirit Saint Anthony Hospital Cancer Center
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Littleton, Colorado, Estados Unidos, 80120
- Rocky Mountain Cancer Centers-Littleton
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Littleton, Colorado, Estados Unidos, 80122
- AdventHealth Littleton
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Lone Tree, Colorado, Estados Unidos, 80124
- Kaiser Permanente-Lone Tree
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Lone Tree, Colorado, Estados Unidos, 80124
- Sky Ridge Medical Center
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Lone Tree, Colorado, Estados Unidos, 80124
- Rocky Mountain Cancer Centers-Sky Ridge
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Lone Tree, Colorado, Estados Unidos, 80124
- UCHealth Lone Tree Health Center
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Longmont, Colorado, Estados Unidos, 80501
- Longmont United Hospital
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Longmont, Colorado, Estados Unidos, 80501
- Rocky Mountain Cancer Centers-Longmont
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Loveland, Colorado, Estados Unidos, 80538
- Medical Center of the Rockies
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Loveland, Colorado, Estados Unidos, 80539
- Banner North Colorado Medical Center - Loveland Campus
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Parker, Colorado, Estados Unidos, 80138
- AdventHealth Parker
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Pueblo, Colorado, Estados Unidos, 81004
- Saint Mary Corwin Medical Center
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Thornton, Colorado, Estados Unidos, 80260
- Rocky Mountain Cancer Centers-Thornton
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Thornton, Colorado, Estados Unidos, 80260
- National Jewish Health-Northern Hematology Oncology
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Wheat Ridge, Colorado, Estados Unidos, 80401
- Intermountain Health Lutheran Hospital
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Connecticut
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Stamford, Connecticut, Estados Unidos, 06904
- Stamford Hospital/Bennett Cancer Center
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Delaware
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Lewes, Delaware, Estados Unidos, 19958
- Beebe Medical Center
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Millville, Delaware, Estados Unidos, 19967
- Beebe South Coastal Health Campus
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Newark, Delaware, Estados Unidos, 19713
- Helen F Graham Cancer Center
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Newark, Delaware, Estados Unidos, 19713
- Delaware Clinical and Laboratory Physicians PA
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Newark, Delaware, Estados Unidos, 19713
- Medical Oncology Hematology Consultants PA
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Newark, Delaware, Estados Unidos, 19718
- Christiana Care Health System-Christiana Hospital
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Rehoboth Beach, Delaware, Estados Unidos, 19971
- Beebe Health Campus
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Seaford, Delaware, Estados Unidos, 19973
- TidalHealth Nanticoke / Allen Cancer Center
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Wilmington, Delaware, Estados Unidos, 19801
- Christiana Care Health System-Wilmington Hospital
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District of Columbia
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Washington D.C., District of Columbia, Estados Unidos, 20037
- George Washington University Medical Center
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Washington D.C., District of Columbia, Estados Unidos, 20010
- MedStar Washington Hospital Center
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Washington D.C., District of Columbia, Estados Unidos, 20007
- MedStar Georgetown University Hospital
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Florida
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Coral Gables, Florida, Estados Unidos, 33146
- UM Sylvester Comprehensive Cancer Center at Coral Gables
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Deerfield Beach, Florida, Estados Unidos, 33442
- UM Sylvester Comprehensive Cancer Center at Deerfield Beach
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Fort Lauderdale, Florida, Estados Unidos, 33308
- Holy Cross Hospital
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Gainesville, Florida, Estados Unidos, 32610
- UF Health Cancer Institute - Gainesville
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Miami, Florida, Estados Unidos, 33136
- University of Miami Miller School of Medicine-Sylvester Cancer Center
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Miami, Florida, Estados Unidos, 33176
- UM Sylvester Comprehensive Cancer Center at Kendall
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Orlando, Florida, Estados Unidos, 32806
- Orlando Health Cancer Institute
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Plantation, Florida, Estados Unidos, 33324
- UM Sylvester Comprehensive Cancer Center at Plantation
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Georgia
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Atlanta, Georgia, Estados Unidos, 30342
- Northside Hospital
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Duluth, Georgia, Estados Unidos, 30096
- Northside Hospital - Duluth
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Lawrenceville, Georgia, Estados Unidos, 30046
- Northside Hospital - Gwinnett
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Savannah, Georgia, Estados Unidos, 31405
- Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
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Snellville, Georgia, Estados Unidos, 30078
- Suburban Hematology Oncology Associates - Snellville
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Hawaii
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Honolulu, Hawaii, Estados Unidos, 96813
- Queen's Medical Center
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Honolulu, Hawaii, Estados Unidos, 96817
- The Cancer Center of Hawaii-Liliha
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Honolulu, Hawaii, Estados Unidos, 96813
- Hawaii Cancer Care Inc - Waterfront Plaza
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Honolulu, Hawaii, Estados Unidos, 96813
- Queen's Cancer Cenrer - POB I
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Honolulu, Hawaii, Estados Unidos, 96813
- Straub Clinic and Hospital
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Honolulu, Hawaii, Estados Unidos, 96813
- University of Hawaii Cancer Center
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Honolulu, Hawaii, Estados Unidos, 96817
- Queen's Cancer Center - Kuakini
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Honolulu, Hawaii, Estados Unidos, 96826
- Kapiolani Medical Center for Women and Children
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Honolulu, Hawaii, Estados Unidos, 96813
- Island Urology
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Lihue, Hawaii, Estados Unidos, 96766
- Wilcox Memorial Hospital and Kauai Medical Clinic
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‘Aiea, Hawaii, Estados Unidos, 96701
- Hawaii Cancer Care - Westridge
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‘Aiea, Hawaii, Estados Unidos, 96701
- Pali Momi Medical Center
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‘Aiea, Hawaii, Estados Unidos, 96701
- Queen's Cancer Center - Pearlridge
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‘Aiea, Hawaii, Estados Unidos, 96701
- The Cancer Center of Hawaii-Pali Momi
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Idaho
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Boise, Idaho, Estados Unidos, 83706
- Saint Alphonsus Cancer Care Center-Boise
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Boise, Idaho, Estados Unidos, 83712
- Saint Luke's Cancer Institute - Boise
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Caldwell, Idaho, Estados Unidos, 83605
- Saint Alphonsus Cancer Care Center-Caldwell
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Coeur d'Alene, Idaho, Estados Unidos, 83814
- Kootenai Health - Coeur d'Alene
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Emmett, Idaho, Estados Unidos, 83617
- Walter Knox Memorial Hospital
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Fruitland, Idaho, Estados Unidos, 83619
- Saint Luke's Cancer Institute - Fruitland
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Meridian, Idaho, Estados Unidos, 83642
- Idaho Urologic Institute-Meridian
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Meridian, Idaho, Estados Unidos, 83642
- Saint Luke's Cancer Institute - Meridian
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Nampa, Idaho, Estados Unidos, 83687
- Saint Alphonsus Cancer Care Center-Nampa
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Nampa, Idaho, Estados Unidos, 83687
- Saint Luke's Cancer Institute - Nampa
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Post Falls, Idaho, Estados Unidos, 83854
- Kootenai Clinic Cancer Services - Post Falls
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Sandpoint, Idaho, Estados Unidos, 83864
- Kootenai Clinic Cancer Services - Sandpoint
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Twin Falls, Idaho, Estados Unidos, 83301
- Saint Luke's Cancer Institute - Twin Falls
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Illinois
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Alton, Illinois, Estados Unidos, 62002
- OSF Saint Anthony's Health Center
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Aurora, Illinois, Estados Unidos, 60504
- Rush-Copley Medical Center
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Bloomington, Illinois, Estados Unidos, 61704
- Illinois CancerCare-Bloomington
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Burr Ridge, Illinois, Estados Unidos, 60527
- Loyola Center for Health at Burr Ridge
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Canton, Illinois, Estados Unidos, 61520
- Illinois CancerCare-Canton
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Carbondale, Illinois, Estados Unidos, 62902
- Memorial Hospital of Carbondale
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Carterville, Illinois, Estados Unidos, 62918
- SIH Cancer Institute
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Carthage, Illinois, Estados Unidos, 62321
- Illinois CancerCare-Carthage
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Centralia, Illinois, Estados Unidos, 62801
- Centralia Oncology Clinic
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Chicago, Illinois, Estados Unidos, 60611
- Northwestern University
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Chicago, Illinois, Estados Unidos, 60637
- University of Chicago Comprehensive Cancer Center
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Chicago, Illinois, Estados Unidos, 60612
- John H Stroger Jr Hospital of Cook County
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Chicago, Illinois, Estados Unidos, 60612
- Rush MD Anderson Cancer Center
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Danville, Illinois, Estados Unidos, 61832
- Carle at The Riverfront
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DeKalb, Illinois, Estados Unidos, 60115
- Northwestern Medicine Cancer Center Kishwaukee
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Decatur, Illinois, Estados Unidos, 62526
- Decatur Memorial Hospital
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Decatur, Illinois, Estados Unidos, 62526
- Cancer Care Specialists of Illinois - Decatur
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Dixon, Illinois, Estados Unidos, 61021
- Illinois CancerCare-Dixon
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Effingham, Illinois, Estados Unidos, 62401
- Crossroads Cancer Center
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Effingham, Illinois, Estados Unidos, 62401
- Carle Physician Group-Effingham
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Elmhurst, Illinois, Estados Unidos, 60126
- Elmhurst Memorial Hospital
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Eureka, Illinois, Estados Unidos, 61530
- Illinois CancerCare-Eureka
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Galesburg, Illinois, Estados Unidos, 61401
- Western Illinois Cancer Treatment Center
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Galesburg, Illinois, Estados Unidos, 61401
- Illinois CancerCare-Galesburg
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Geneva, Illinois, Estados Unidos, 60134
- Northwestern Medicine Cancer Center Delnor
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Harvey, Illinois, Estados Unidos, 60426
- Ingalls Memorial Hospital
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Homer Glen, Illinois, Estados Unidos, 60491
- Loyola Medicine Homer Glen
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Joliet, Illinois, Estados Unidos, 60435
- Duly Health and Care Joliet
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Kewanee, Illinois, Estados Unidos, 61443
- Illinois CancerCare-Kewanee Clinic
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Lake Forest, Illinois, Estados Unidos, 60045
- Northwestern Medicine Lake Forest Hospital
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Macomb, Illinois, Estados Unidos, 61455
- Illinois CancerCare-Macomb
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Mattoon, Illinois, Estados Unidos, 61938
- Carle Physician Group-Mattoon/Charleston
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Maywood, Illinois, Estados Unidos, 60153
- Loyola University Medical Center
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Melrose Park, Illinois, Estados Unidos, 60160
- Marjorie Weinberg Cancer Center at Loyola-Gottlieb
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Mount Vernon, Illinois, Estados Unidos, 62864
- SSM Health Good Samaritan
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Naperville, Illinois, Estados Unidos, 60540
- Edward Hospital/Cancer Center
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New Lenox, Illinois, Estados Unidos, 60451
- UC Comprehensive Cancer Center at Silver Cross
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O'Fallon, Illinois, Estados Unidos, 62269
- Cancer Care Center of O'Fallon
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Orland Park, Illinois, Estados Unidos, 60462
- University of Chicago Medicine-Orland Park
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Orland Park, Illinois, Estados Unidos, 60462
- Northwestern Medicine Orland Park
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Ottawa, Illinois, Estados Unidos, 61350
- Illinois CancerCare-Ottawa Clinic
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Pekin, Illinois, Estados Unidos, 61554
- Illinois CancerCare-Pekin
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Peoria, Illinois, Estados Unidos, 61636
- Methodist Medical Center of Illinois
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Peoria, Illinois, Estados Unidos, 61615
- Illinois CancerCare-Peoria
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Peru, Illinois, Estados Unidos, 61354
- Illinois CancerCare-Peru
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Peru, Illinois, Estados Unidos, 61354
- Valley Radiation Oncology
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Plainfield, Illinois, Estados Unidos, 60585
- Edward Hospital/Cancer Center?Plainfield
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Princeton, Illinois, Estados Unidos, 61356
- Illinois CancerCare-Princeton
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Rockford, Illinois, Estados Unidos, 61114
- UW Health Carbone Cancer Center Rockford
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Shiloh, Illinois, Estados Unidos, 62269
- Memorial Hospital East
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Springfield, Illinois, Estados Unidos, 62702
- Southern Illinois University School of Medicine
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Springfield, Illinois, Estados Unidos, 62702
- Springfield Clinic
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Springfield, Illinois, Estados Unidos, 62781
- Springfield Memorial Hospital
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Swansea, Illinois, Estados Unidos, 62226
- Southwest Illinois Health Services LLP
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Urbana, Illinois, Estados Unidos, 61801
- Carle Cancer Center
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Urbana, Illinois, Estados Unidos, 61801
- The Carle Foundation Hospital
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Warrenville, Illinois, Estados Unidos, 60555
- Northwestern Medicine Cancer Center Warrenville
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Washington, Illinois, Estados Unidos, 61571
- Illinois CancerCare - Washington
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Yorkville, Illinois, Estados Unidos, 60560
- Rush-Copley Healthcare Center
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Indiana
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Indianapolis, Indiana, Estados Unidos, 46237
- Franciscan Health Indianapolis
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Indianapolis, Indiana, Estados Unidos, 46202
- Indiana University/Melvin and Bren Simon Cancer Center
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Indianapolis, Indiana, Estados Unidos, 46202
- Sidney and Lois Eskenazi Hospital
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Michigan City, Indiana, Estados Unidos, 46360
- Woodland Cancer Care Center
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Mooresville, Indiana, Estados Unidos, 46158
- Franciscan Health Mooresville
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Richmond, Indiana, Estados Unidos, 47374
- Reid Health
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Iowa
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Ames, Iowa, Estados Unidos, 50010
- Mary Greeley Medical Center
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Ames, Iowa, Estados Unidos, 50010
- McFarland Clinic - Ames
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Ankeny, Iowa, Estados Unidos, 50023
- UI Health Care Mission Cancer and Blood - Ankeny Clinic
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Boone, Iowa, Estados Unidos, 50036
- McFarland Clinic - Boone
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Carroll, Iowa, Estados Unidos, 51401
- Saint Anthony Regional Hospital
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Clive, Iowa, Estados Unidos, 50325
- Mercy Cancer Center-West Lakes
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Clive, Iowa, Estados Unidos, 50325
- UI Health Care Mission Cancer and Blood - West Des Moines Clinic
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Council Bluffs, Iowa, Estados Unidos, 51503
- Alegent Health Mercy Hospital
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Creston, Iowa, Estados Unidos, 50801
- Greater Regional Medical Center
-
Des Moines, Iowa, Estados Unidos, 50309
- Iowa Methodist Medical Center
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Des Moines, Iowa, Estados Unidos, 50314
- Mercy Medical Center - Des Moines
-
Des Moines, Iowa, Estados Unidos, 50314
- Broadlawns Medical Center
-
Des Moines, Iowa, Estados Unidos, 50316
- Iowa Lutheran Hospital
-
Des Moines, Iowa, Estados Unidos, 50309
- UI Health Care Mission Cancer and Blood - Des Moines Clinic
-
Des Moines, Iowa, Estados Unidos, 50314
- UI Health Care Mission Cancer and Blood - Laurel Clinic
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Fort Dodge, Iowa, Estados Unidos, 50501
- McFarland Clinic - Trinity Cancer Center
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Fort Dodge, Iowa, Estados Unidos, 50501
- UI Healthcare Mission Cancer and Blood - Fort Dodge
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Jefferson, Iowa, Estados Unidos, 50129
- McFarland Clinic - Jefferson
-
Marshalltown, Iowa, Estados Unidos, 50158
- McFarland Clinic - Marshalltown
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Sioux City, Iowa, Estados Unidos, 51101
- Siouxland Regional Cancer Center
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West Des Moines, Iowa, Estados Unidos, 50266-7700
- Methodist West Hospital
-
West Des Moines, Iowa, Estados Unidos, 50266
- Mercy Medical Center-West Lakes
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Kansas
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Fairway, Kansas, Estados Unidos, 66205
- University of Kansas Clinical Research Center
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Garden City, Kansas, Estados Unidos, 67846
- Central Care Cancer Center - Garden City
-
Great Bend, Kansas, Estados Unidos, 67530
- Central Care Cancer Center - Great Bend
-
Hays, Kansas, Estados Unidos, 67601
- HaysMed
-
Lawrence, Kansas, Estados Unidos, 66044
- Lawrence Memorial Hospital
-
Lenexa, Kansas, Estados Unidos, 66219
- Kansas Institute of Medicine Cancer and Blood Center
-
Lenexa, Kansas, Estados Unidos, 66219
- Minimally Invasive Surgery Hospital
-
Olathe, Kansas, Estados Unidos, 66061
- The University of Kansas Cancer Center - Olathe
-
Overland Park, Kansas, Estados Unidos, 66210
- University of Kansas Cancer Center-Overland Park
-
Overland Park, Kansas, Estados Unidos, 66209
- Menorah Medical Center
-
Parsons, Kansas, Estados Unidos, 67357
- Cancer Center of Kansas - Parsons
-
Pittsburg, Kansas, Estados Unidos, 66762
- Freeman Physician Group of Pittsburg
-
Pittsburg, Kansas, Estados Unidos, 66762
- Mercy Hospital Pittsburg
-
Salina, Kansas, Estados Unidos, 67401
- Salina Regional Health Center
-
Topeka, Kansas, Estados Unidos, 66606
- University of Kansas Health System Saint Francis Campus
-
Westwood, Kansas, Estados Unidos, 66205
- University of Kansas Hospital-Westwood Cancer Center
-
Wichita, Kansas, Estados Unidos, 67214
- Ascension Via Christi Hospitals Wichita
-
Wichita, Kansas, Estados Unidos, 67208
- Cancer Center of Kansas-Wichita Medical Arts Tower
-
Wichita, Kansas, Estados Unidos, 67214
- Cancer Center of Kansas - Wichita
-
-
Kentucky
-
Bardstown, Kentucky, Estados Unidos, 40004
- CommonSpirit Saint Joseph Hospital - Bardstown
-
Corbin, Kentucky, Estados Unidos, 40701
- Commonwealth Cancer Center-Corbin
-
Lexington, Kentucky, Estados Unidos, 40536
- University of Kentucky/Markey Cancer Center
-
Lexington, Kentucky, Estados Unidos, 40504
- Saint Joseph Radiation Oncology Resource Center
-
Lexington, Kentucky, Estados Unidos, 40509
- CommonSpirit Saint Joseph Medical Center - East Lexington
-
London, Kentucky, Estados Unidos, 40741
- CommonSpirit Saint Joseph Hospital London
-
Louisville, Kentucky, Estados Unidos, 40202
- Jewish Hospital
-
Louisville, Kentucky, Estados Unidos, 40245
- UofL Health Medical Center Northeast
-
Louisville, Kentucky, Estados Unidos, 40207
- Baptist Health Louisville
-
Louisville, Kentucky, Estados Unidos, 40215
- Saints Mary and Elizabeth Hospital
-
Shepherdsville, Kentucky, Estados Unidos, 40165
- Jewish Hospital Medical Center South
-
-
Louisiana
-
Baton Rouge, Louisiana, Estados Unidos, 70805
- LSU Health Baton Rouge-North Clinic
-
Baton Rouge, Louisiana, Estados Unidos, 70809
- Louisiana Hematology Oncology Associates LLC
-
Baton Rouge, Louisiana, Estados Unidos, 70809
- Mary Bird Perkins Cancer Center
-
Baton Rouge, Louisiana, Estados Unidos, 70836
- Ochsner High Grove
-
Baton Rouge, Louisiana, Estados Unidos, 70809
- Hematology/Oncology Clinic PLLC
-
Baton Rouge, Louisiana, Estados Unidos, 70808
- Our Lady of The Lake
-
Baton Rouge, Louisiana, Estados Unidos, 70808
- Our Lady of the Lake Physician Group
-
Covington, Louisiana, Estados Unidos, 70433
- Northshore Oncology Associates-Covington
-
Covington, Louisiana, Estados Unidos, 70433
- Ochsner Hematology Oncology North Shore - Covington (West Region)
-
Houma, Louisiana, Estados Unidos, 70360
- Terrebonne General Medical Center
-
Houma, Louisiana, Estados Unidos, 70360
- Oncology Center of The South Incorporated
-
Metairie, Louisiana, Estados Unidos, 70006
- East Jefferson General Hospital
-
Metairie, Louisiana, Estados Unidos, 70006
- LSU Healthcare Network / Metairie Multi-Specialty Clinic
-
Monroe, Louisiana, Estados Unidos, 71202
- Ochsner LSU Health Monroe Medical Center
-
New Orleans, Louisiana, Estados Unidos, 70112
- Tulane University School of Medicine
-
New Orleans, Louisiana, Estados Unidos, 70121
- Ochsner Medical Center Jefferson
-
New Orleans, Louisiana, Estados Unidos, 70112
- University Medical Center New Orleans
-
New Orleans, Louisiana, Estados Unidos, 70112
- Louisiana State University Health Science Center
-
New Orleans, Louisiana, Estados Unidos, 70115
- Touro Infirmary
-
Shreveport, Louisiana, Estados Unidos, 71103
- LSU Health Sciences Center at Shreveport
-
-
Maine
-
Augusta, Maine, Estados Unidos, 04330
- Harold Alfond Center for Cancer Care
-
Belfast, Maine, Estados Unidos, 04915
- MaineHealth Waldo Hospital
-
Biddeford, Maine, Estados Unidos, 04005
- MaineHealth Maine Medical Center - Biddeford
-
Brewer, Maine, Estados Unidos, 04412
- Lafayette Family Cancer Center-EMMC
-
Norway, Maine, Estados Unidos, 04268
- MaineHealth Stephens Hospital
-
Rockport, Maine, Estados Unidos, 04856
- Penobscot Bay Medical Center
-
Sanford, Maine, Estados Unidos, 04073
- MaineHealth Cancer Care and IV Therapy - Sanford
-
South Portland, Maine, Estados Unidos, 04106
- MaineHealth Cancer Care and IV Therapy - South Portland
-
-
Maryland
-
Baltimore, Maryland, Estados Unidos, 21204
- Greater Baltimore Medical Center
-
-
Massachusetts
-
Boston, Massachusetts, Estados Unidos, 02215
- Dana-Farber Cancer Institute
-
Newton, Massachusetts, Estados Unidos, 02467
- Dana-Farber Cancer Institute - Chestnut Hill
-
Springfield, Massachusetts, Estados Unidos, 01104
- Mercy Medical Center
-
-
Michigan
-
Adrian, Michigan, Estados Unidos, 49221
- Hickman Cancer Center
-
Ann Arbor, Michigan, Estados Unidos, 48106
- Trinity Health Saint Joseph Mercy Hospital Ann Arbor
-
Battle Creek, Michigan, Estados Unidos, 49017
- Bronson Battle Creek
-
Brighton, Michigan, Estados Unidos, 48114
- Trinity Health IHA Medical Group Hematology Oncology - Brighton
-
Brighton, Michigan, Estados Unidos, 48114
- Trinity Health Medical Center - Brighton
-
Brownstown, Michigan, Estados Unidos, 48183
- Henry Ford Cancer Institute-Downriver
-
Canton, Michigan, Estados Unidos, 48188
- Trinity Health IHA Medical Group Hematology Oncology - Canton
-
Canton, Michigan, Estados Unidos, 48188
- Trinity Health Medical Center - Canton
-
Caro, Michigan, Estados Unidos, 48723
- Caro Cancer Center
-
Chelsea, Michigan, Estados Unidos, 48118
- Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
-
Chelsea, Michigan, Estados Unidos, 48118
- Chelsea Hospital
-
Clarkston, Michigan, Estados Unidos, 48346
- Hematology Oncology Consultants-Clarkston
-
Clarkston, Michigan, Estados Unidos, 48346
- Newland Medical Associates-Clarkston
-
Clinton Township, Michigan, Estados Unidos, 48038
- Henry Ford Macomb Hospital-Clinton Township
-
Dearborn, Michigan, Estados Unidos, 48126
- Henry Ford Medical Center-Fairlane
-
Detroit, Michigan, Estados Unidos, 48202
- Henry Ford Hospital
-
Detroit, Michigan, Estados Unidos, 48236
- Henry Ford Health Saint John Hospital
-
East China Township, Michigan, Estados Unidos, 48054
- Henry Ford River District Hospital
-
Escanaba, Michigan, Estados Unidos, 49829
- OSF Saint Francis Hospital and Medical Group
-
Flint, Michigan, Estados Unidos, 48503
- Hurley Medical Center
-
Flint, Michigan, Estados Unidos, 48503
- Genesee Hematology Oncology PC
-
Flint, Michigan, Estados Unidos, 48503
- Genesys Hurley Cancer Institute
-
Flint, Michigan, Estados Unidos, 48503
- Cancer Hematology Centers - Flint
-
Grand Rapids, Michigan, Estados Unidos, 49503
- Trinity Health Grand Rapids Hospital
-
Grand Rapids, Michigan, Estados Unidos, 49503
- Corewell Health Grand Rapids Hospitals - Butterworth Hospital
-
Grand Rapids, Michigan, Estados Unidos, 49503
- Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital
-
Grosse Pointe Woods, Michigan, Estados Unidos, 48236
- Henry Ford Saint John Hospital - Academic
-
Grosse Pointe Woods, Michigan, Estados Unidos, 48236
- Henry Ford Saint John Hospital - Breast
-
Grosse Pointe Woods, Michigan, Estados Unidos, 48236
- Henry Ford Saint John Hospital - Van Elslander
-
Jackson, Michigan, Estados Unidos, 49201
- Allegiance Health
-
Kalamazoo, Michigan, Estados Unidos, 49007
- West Michigan Cancer Center
-
Kalamazoo, Michigan, Estados Unidos, 49007
- Bronson Methodist Hospital
-
Kalamazoo, Michigan, Estados Unidos, 49009
- Beacon Kalamazoo Cancer Center
-
Kalamazoo, Michigan, Estados Unidos, 49048
- Beacon Kalamazoo
-
Lansing, Michigan, Estados Unidos, 48912
- University of Michigan Health - Sparrow Lansing
-
Livonia, Michigan, Estados Unidos, 48154
- Trinity Health Saint Mary Mercy Livonia Hospital
-
Livonia, Michigan, Estados Unidos, 48154
- Hope Cancer Clinic
-
Macomb, Michigan, Estados Unidos, 48044
- Henry Ford Warren Hospital - Breast Macomb
-
Macomb, Michigan, Estados Unidos, 48044
- Henry Ford Saint John Hospital - Macomb Medical
-
Marlette, Michigan, Estados Unidos, 48453
- Saint Mary's Oncology/Hematology Associates of Marlette
-
Monroe, Michigan, Estados Unidos, 48162
- Toledo Clinic Cancer Centers-Monroe
-
Muskegon, Michigan, Estados Unidos, 49444
- Trinity Health Muskegon Hospital
-
Niles, Michigan, Estados Unidos, 49120
- Corewell Health Lakeland Hospitals - Niles Hospital
-
Norton Shores, Michigan, Estados Unidos, 49444
- Cancer and Hematology Centers of Western Michigan - Norton Shores
-
Novi, Michigan, Estados Unidos, 48377
- Henry Ford Medical Center-Columbus
-
Novi, Michigan, Estados Unidos, 48374
- Henry Ford Health Providence Novi Hospital
-
Pontiac, Michigan, Estados Unidos, 48341
- Hope Cancer Center
-
Pontiac, Michigan, Estados Unidos, 48341
- Trinity Health Saint Joseph Mercy Oakland Hospital
-
Pontiac, Michigan, Estados Unidos, 48341
- Michigan Healthcare Professionals Pontiac
-
Pontiac, Michigan, Estados Unidos, 48341
- Trinity Health IHA Medical Group-Alice Gustafson Center
-
Port Huron, Michigan, Estados Unidos, 48060
- Lake Huron Medical Center
-
Port Huron, Michigan, Estados Unidos, 48060
- Huron Medical Center PC
-
Reed City, Michigan, Estados Unidos, 49677
- Corewell Health Reed City Hospital
-
Rochester Hills, Michigan, Estados Unidos, 48309
- Henry Ford Rochester Hospital
-
Saginaw, Michigan, Estados Unidos, 48604
- Oncology Hematology Associates of Saginaw Valley PC
-
Saginaw, Michigan, Estados Unidos, 48601
- MyMichigan Medical Center Saginaw
-
Saint Joseph, Michigan, Estados Unidos, 49085
- Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center
-
Saint Joseph, Michigan, Estados Unidos, 49085
- Corewell Health Lakeland Hospitals - Saint Joseph Hospital
-
Shelby, Michigan, Estados Unidos, 48315
- Henry Ford Macomb Health Center - Shelby Township
-
Southfield, Michigan, Estados Unidos, 48075
- Henry Ford Health Providence Southfield Hospital
-
Sterling Heights, Michigan, Estados Unidos, 48312
- Bhadresh Nayak MD PC-Sterling Heights
-
Tawas City, Michigan, Estados Unidos, 48764
- MyMichigan Medical Center Tawas
-
Traverse City, Michigan, Estados Unidos, 49684
- Munson Medical Center
-
Warren, Michigan, Estados Unidos, 48088
- Advanced Breast Care Center PLLC
-
Warren, Michigan, Estados Unidos, 48093
- Macomb Hematology Oncology PC
-
Warren, Michigan, Estados Unidos, 48093
- Henry Ford Madison Heights Hospital - Breast
-
Warren, Michigan, Estados Unidos, 48093
- Henry Ford Health Warren Hospital
-
Warren, Michigan, Estados Unidos, 48093
- Henry Ford Warren Hospital - GLCMS
-
West Bloomfield, Michigan, Estados Unidos, 48322
- Henry Ford West Bloomfield Hospital
-
West Branch, Michigan, Estados Unidos, 48661
- Saint Mary's Oncology/Hematology Associates of West Branch
-
Wyoming, Michigan, Estados Unidos, 49519
- University of Michigan Health - West
-
Ypsilanti, Michigan, Estados Unidos, 48197
- Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
-
Ypsilanti, Michigan, Estados Unidos, 48106
- Huron Gastroenterology PC
-
-
Minnesota
-
Aitkin, Minnesota, Estados Unidos, 56431
- Riverwood Healthcare Center
-
Bemidji, Minnesota, Estados Unidos, 56601
- Sanford Joe Lueken Cancer Center
-
Brainerd, Minnesota, Estados Unidos, 56401
- Essentia Health Saint Joseph's Medical Center
-
Burnsville, Minnesota, Estados Unidos, 55337
- Fairview Ridges Hospital
-
Burnsville, Minnesota, Estados Unidos, 55337
- Minnesota Oncology - Burnsville
-
Cambridge, Minnesota, Estados Unidos, 55008
- Cambridge Medical Center
-
Coon Rapids, Minnesota, Estados Unidos, 55433
- Mercy Hospital
-
Deer River, Minnesota, Estados Unidos, 56636
- Essentia Health - Deer River Clinic
-
Detroit Lakes, Minnesota, Estados Unidos, 56501
- Essentia Health Saint Mary's - Detroit Lakes Clinic
-
Duluth, Minnesota, Estados Unidos, 55805
- Essentia Health Cancer Center
-
Duluth, Minnesota, Estados Unidos, 55805
- Essentia Health Saint Mary's Medical Center
-
Duluth, Minnesota, Estados Unidos, 55805
- Miller-Dwan Hospital
-
Edina, Minnesota, Estados Unidos, 55435
- Fairview Southdale Hospital
-
Fergus Falls, Minnesota, Estados Unidos, 56537
- Lake Region Healthcare Corporation-Cancer Care
-
Fosston, Minnesota, Estados Unidos, 56542
- Essentia Health - Fosston
-
Fridley, Minnesota, Estados Unidos, 55432
- Unity Hospital
-
Hibbing, Minnesota, Estados Unidos, 55746
- Essentia Health Hibbing Clinic
-
Maple Grove, Minnesota, Estados Unidos, 55369
- Fairview Clinics and Surgery Center Maple Grove
-
Maplewood, Minnesota, Estados Unidos, 55109
- Saint John's Hospital - Healtheast
-
Maplewood, Minnesota, Estados Unidos, 55109
- Minnesota Oncology Hematology PA-Maplewood
-
Minneapolis, Minnesota, Estados Unidos, 55415
- Hennepin County Medical Center
-
Minneapolis, Minnesota, Estados Unidos, 55407
- Abbott-Northwestern Hospital
-
Minneapolis, Minnesota, Estados Unidos, 55454
- Health Partners Inc
-
Minneapolis, Minnesota, Estados Unidos, 55417
- Minneapolis VA Medical Center
-
Monticello, Minnesota, Estados Unidos, 55362
- Monticello Cancer Center
-
New Ulm, Minnesota, Estados Unidos, 56073
- New Ulm Medical Center
-
Park Rapids, Minnesota, Estados Unidos, 56470
- Essentia Health - Park Rapids
-
Princeton, Minnesota, Estados Unidos, 55371
- Fairview Northland Medical Center
-
Robbinsdale, Minnesota, Estados Unidos, 55422
- North Memorial Medical Health Center
-
Saint Cloud, Minnesota, Estados Unidos, 56303
- Coborn Cancer Center at Saint Cloud Hospital
-
Saint Louis Park, Minnesota, Estados Unidos, 55416
- Park Nicollet Clinic - Saint Louis Park
-
Saint Paul, Minnesota, Estados Unidos, 55101
- Regions Hospital
-
Saint Paul, Minnesota, Estados Unidos, 55102
- United Hospital
-
Sandstone, Minnesota, Estados Unidos, 55072
- Essentia Health Sandstone
-
Shakopee, Minnesota, Estados Unidos, 55379
- Saint Francis Regional Medical Center
-
Stillwater, Minnesota, Estados Unidos, 55082
- Lakeview Hospital
-
Thief River Falls, Minnesota, Estados Unidos, 56701
- Sanford Thief River Falls Medical Center
-
Virginia, Minnesota, Estados Unidos, 55792
- Essentia Health Virginia Clinic
-
Waconia, Minnesota, Estados Unidos, 55387
- Ridgeview Medical Center
-
Willmar, Minnesota, Estados Unidos, 56201
- Rice Memorial Hospital
-
Woodbury, Minnesota, Estados Unidos, 55125
- Minnesota Oncology Hematology PA-Woodbury
-
Worthington, Minnesota, Estados Unidos, 56187
- Sanford Cancer Center Worthington
-
Wyoming, Minnesota, Estados Unidos, 55092
- Fairview Lakes Medical Center
-
-
Mississippi
-
Columbus, Mississippi, Estados Unidos, 39705
- Baptist Memorial Hospital and Cancer Center-Golden Triangle
-
Grenada, Mississippi, Estados Unidos, 38901
- Baptist Cancer Center-Grenada
-
Gulfport, Mississippi, Estados Unidos, 39502
- Gulfport Memorial Hospital
-
Jackson, Mississippi, Estados Unidos, 39216
- University of Mississippi Medical Center
-
New Albany, Mississippi, Estados Unidos, 38652
- Baptist Memorial Hospital and Cancer Center-Union County
-
Oxford, Mississippi, Estados Unidos, 38655
- Baptist Memorial Hospital and Cancer Center-Oxford
-
Southhaven, Mississippi, Estados Unidos, 38671
- Baptist Memorial Hospital and Cancer Center-Desoto
-
-
Missouri
-
Ballwin, Missouri, Estados Unidos, 63011
- Mercy Oncology and Hematology - Clayton-Clarkson
-
Bolivar, Missouri, Estados Unidos, 65613
- Central Care Cancer Center - Bolivar
-
Bonne Terre, Missouri, Estados Unidos, 63628
- Parkland Health Center-Bonne Terre
-
Branson, Missouri, Estados Unidos, 65616
- Cox Cancer Center Branson
-
Cape Girardeau, Missouri, Estados Unidos, 63703
- Saint Francis Medical Center
-
Cape Girardeau, Missouri, Estados Unidos, 63703
- Mercy Cancer Center - Cape Girardeau
-
Chesterfield, Missouri, Estados Unidos, 63017
- Saint Luke's Hospital
-
City of Saint Peters, Missouri, Estados Unidos, 63376
- Siteman Cancer Center at Saint Peters Hospital
-
Columbia, Missouri, Estados Unidos, 65212
- MU Health - University Hospital/Ellis Fischel Cancer Center
-
Creve Coeur, Missouri, Estados Unidos, 63141
- Siteman Cancer Center at West County Hospital
-
Farmington, Missouri, Estados Unidos, 63640
- Parkland Health Center - Farmington
-
Independence, Missouri, Estados Unidos, 64057
- Centerpoint Medical Center LLC
-
Jefferson City, Missouri, Estados Unidos, 65109
- MU Health Care Goldschmidt Cancer Center
-
Joplin, Missouri, Estados Unidos, 64804
- Freeman Health System
-
Joplin, Missouri, Estados Unidos, 64804
- Mercy Hospital Joplin
-
Kansas City, Missouri, Estados Unidos, 64154
- University of Kansas Cancer Center - North
-
Kansas City, Missouri, Estados Unidos, 64132
- Research Medical Center
-
Kansas City, Missouri, Estados Unidos, 64108
- University Health Truman Medical Center
-
Lee's Summit, Missouri, Estados Unidos, 64064
- University of Kansas Cancer Center - Lee's Summit
-
North Kansas City, Missouri, Estados Unidos, 64116
- University of Kansas Cancer Center at North Kansas City Hospital
-
Rolla, Missouri, Estados Unidos, 65401
- Mercy Clinic-Rolla-Cancer and Hematology
-
Rolla, Missouri, Estados Unidos, 65401
- Phelps Health Delbert Day Cancer Institute
-
Saint Joseph, Missouri, Estados Unidos, 64506
- Heartland Regional Medical Center
-
Sainte Genevieve, Missouri, Estados Unidos, 63670
- Sainte Genevieve County Memorial Hospital
-
Springfield, Missouri, Estados Unidos, 65807
- CoxHealth South Hospital
-
Springfield, Missouri, Estados Unidos, 65804
- Mercy Hospital Springfield
-
St Louis, Missouri, Estados Unidos, 63110
- Washington University School of Medicine
-
St Louis, Missouri, Estados Unidos, 63129
- Siteman Cancer Center-South County
-
St Louis, Missouri, Estados Unidos, 63136
- Siteman Cancer Center at Christian Hospital
-
St Louis, Missouri, Estados Unidos, 63131
- Missouri Baptist Medical Center
-
St Louis, Missouri, Estados Unidos, 63109
- Mercy Infusion Center - Chippewa
-
St Louis, Missouri, Estados Unidos, 63141
- Mercy Hospital Saint Louis
-
St Louis, Missouri, Estados Unidos, 63128
- Mercy Hospital South
-
Sullivan, Missouri, Estados Unidos, 63080
- Missouri Baptist Sullivan Hospital
-
Washington, Missouri, Estados Unidos, 63090
- Mercy Hospital Washington
-
-
Montana
-
Anaconda, Montana, Estados Unidos, 59711
- Community Hospital of Anaconda
-
Billings, Montana, Estados Unidos, 59101
- Billings Clinic Cancer Center
-
Billings, Montana, Estados Unidos, 59101
- Saint Vincent Healthcare
-
Billings, Montana, Estados Unidos, 59102
- Saint Vincent Frontier Cancer Center
-
Bozeman, Montana, Estados Unidos, 59715
- Bozeman Health Deaconess Hospital
-
Butte, Montana, Estados Unidos, 59701
- Saint James Community Hospital and Cancer Treatment Center
-
Great Falls, Montana, Estados Unidos, 59405
- Great Falls Clinic
-
Great Falls, Montana, Estados Unidos, 59405
- Benefis Sletten Cancer Institute
-
Helena, Montana, Estados Unidos, 59601
- Saint Peter's Community Hospital
-
Kalispell, Montana, Estados Unidos, 59901
- Logan Health Medical Center
-
Missoula, Montana, Estados Unidos, 59802
- Saint Patrick Hospital - Community Hospital
-
Missoula, Montana, Estados Unidos, 59804
- Community Medical Center
-
-
Nebraska
-
Bellevue, Nebraska, Estados Unidos, 68123
- Nebraska Medicine-Bellevue
-
Grand Island, Nebraska, Estados Unidos, 68803
- Nebraska Cancer Specialists/Oncology Hematology West PC
-
Kearney, Nebraska, Estados Unidos, 68847
- CHI Health Good Samaritan
-
Lincoln, Nebraska, Estados Unidos, 68510
- Saint Elizabeth Regional Medical Center
-
Lincoln, Nebraska, Estados Unidos, 68516
- Cancer Partners of Nebraska
-
Omaha, Nebraska, Estados Unidos, 68114
- Nebraska Methodist Hospital
-
Omaha, Nebraska, Estados Unidos, 68198
- University of Nebraska Medical Center
-
Omaha, Nebraska, Estados Unidos, 68124
- Alegent Health Bergan Mercy Medical Center
-
Omaha, Nebraska, Estados Unidos, 68118
- Nebraska Medicine-Village Pointe
-
Omaha, Nebraska, Estados Unidos, 68122
- Alegent Health Immanuel Medical Center
-
Omaha, Nebraska, Estados Unidos, 68130
- Alegent Health Lakeside Hospital
-
Omaha, Nebraska, Estados Unidos, 68114
- Oncology Associates PC
-
Omaha, Nebraska, Estados Unidos, 68114
- Nebraska Cancer Specialists/Oncology Hematology West PC - MECC
-
Papillion, Nebraska, Estados Unidos, 68046
- Midlands Community Hospital
-
-
Nevada
-
Carson City, Nevada, Estados Unidos, 89703
- Carson Tahoe Regional Medical Center
-
Henderson, Nevada, Estados Unidos, 89052
- Comprehensive Cancer Centers of Nevada - Henderson
-
Henderson, Nevada, Estados Unidos, 89052
- Cancer and Blood Specialists-Henderson
-
Henderson, Nevada, Estados Unidos, 89052
- Las Vegas Cancer Center-Henderson
-
Henderson, Nevada, Estados Unidos, 89074
- Comprehensive Cancer Centers of Nevada-Southeast Henderson
-
Henderson, Nevada, Estados Unidos, 89052
- Comprehensive Cancer Centers of Nevada-Horizon Ridge
-
Henderson, Nevada, Estados Unidos, 89074
- Las Vegas Urology - Green Valley
-
Henderson, Nevada, Estados Unidos, 89074
- Las Vegas Urology - Pebble
-
Henderson, Nevada, Estados Unidos, 89074
- Urology Specialists of Nevada - Green Valley
-
Henderson, Nevada, Estados Unidos, 89074
- Oncology Las Vegas - Henderson
-
Las Vegas, Nevada, Estados Unidos, 89144
- Summerlin Hospital Medical Center
-
Las Vegas, Nevada, Estados Unidos, 89109
- Sunrise Hospital and Medical Center
-
Las Vegas, Nevada, Estados Unidos, 89102
- OptumCare Cancer Care at Charleston
-
Las Vegas, Nevada, Estados Unidos, 89106
- Radiation Oncology Centers of Nevada Central
-
Las Vegas, Nevada, Estados Unidos, 89119
- Radiation Oncology Centers of Nevada Southeast
-
Las Vegas, Nevada, Estados Unidos, 89128
- Comprehensive Cancer Centers of Nevada - Northwest
-
Las Vegas, Nevada, Estados Unidos, 89128
- OptumCare Cancer Care at MountainView
-
Las Vegas, Nevada, Estados Unidos, 89135
- Alliance for Childhood Diseases/Cure 4 the Kids Foundation
-
Las Vegas, Nevada, Estados Unidos, 89144
- Comprehensive Cancer Centers of Nevada - Town Center
-
Las Vegas, Nevada, Estados Unidos, 89144
- Comprehensive Cancer Centers of Nevada-Summerlin
-
Las Vegas, Nevada, Estados Unidos, 89148
- Comprehensive Cancer Centers of Nevada
-
Las Vegas, Nevada, Estados Unidos, 89169
- Comprehensive Cancer Centers of Nevada - Central Valley
-
Las Vegas, Nevada, Estados Unidos, 89102
- University Medical Center of Southern Nevada
-
Las Vegas, Nevada, Estados Unidos, 89106
- Cancer and Blood Specialists-Shadow
-
Las Vegas, Nevada, Estados Unidos, 89109
- HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway
-
Las Vegas, Nevada, Estados Unidos, 89113
- HealthCare Partners Medical Group Oncology/Hematology-San Martin
-
Las Vegas, Nevada, Estados Unidos, 89128
- Cancer and Blood Specialists-Tenaya
-
Las Vegas, Nevada, Estados Unidos, 89128
- HealthCare Partners Medical Group Oncology/Hematology-Tenaya
-
Las Vegas, Nevada, Estados Unidos, 89148-2405
- Las Vegas Cancer Center-Medical Center
-
Las Vegas, Nevada, Estados Unidos, 89149
- HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills
-
Las Vegas, Nevada, Estados Unidos, 89128
- Ann M Wierman MD LTD
-
Las Vegas, Nevada, Estados Unidos, 89074
- Las Vegas Urology - Pecos
-
Las Vegas, Nevada, Estados Unidos, 89102
- Desert West Surgery
-
Las Vegas, Nevada, Estados Unidos, 89103
- Hope Cancer Care of Nevada
-
Las Vegas, Nevada, Estados Unidos, 89106
- Urology Specialists of Nevada - Central
-
Las Vegas, Nevada, Estados Unidos, 89113
- Las Vegas Prostate Cancer Center
-
Las Vegas, Nevada, Estados Unidos, 89113
- Las Vegas Urology - Sunset
-
Las Vegas, Nevada, Estados Unidos, 89128
- Las Vegas Urology - Cathedral Rock
-
Las Vegas, Nevada, Estados Unidos, 89128
- Las Vegas Urology - Smoke Ranch
-
Las Vegas, Nevada, Estados Unidos, 89128
- Urology Specialists of Nevada - Northwest
-
Las Vegas, Nevada, Estados Unidos, 89169
- University Cancer Center
-
Las Vegas, Nevada, Estados Unidos, 89113
- Urology Specialists of Nevada - Southwest
-
Las Vegas, Nevada, Estados Unidos, 89128
- Oncology Las Vegas - Tenaya
-
Las Vegas, Nevada, Estados Unidos, 89183
- OptumCare Cancer Care at Fort Apache
-
Pahrump, Nevada, Estados Unidos, 89048
- Hope Cancer Care of Nevada-Pahrump
-
Reno, Nevada, Estados Unidos, 89502
- Renown Regional Medical Center
-
Reno, Nevada, Estados Unidos, 89503
- Saint Mary's Regional Medical Center
-
Reno, Nevada, Estados Unidos, 89509
- Radiation Oncology Associates
-
-
New Hampshire
-
Concord, New Hampshire, Estados Unidos, 03301
- New Hampshire Oncology Hematology PA-Concord
-
Manchester, New Hampshire, Estados Unidos, 03103
- Solinsky Center for Cancer Care
-
Manchester, New Hampshire, Estados Unidos, 03103
- Elliot Hospital
-
-
New Jersey
-
Brick, New Jersey, Estados Unidos, 08724
- Ocean University Medical Center
-
Cape May Court House, New Jersey, Estados Unidos, 08210
- AtlantiCare Health Park-Cape May Court House
-
Egg Harbor, New Jersey, Estados Unidos, 08234
- AtlantiCare Surgery Center
-
Hackensack, New Jersey, Estados Unidos, 07601
- Hackensack University Medical Center
-
Livingston, New Jersey, Estados Unidos, 07039
- Cooperman Barnabas Medical Center
-
Manahawkin, New Jersey, Estados Unidos, 08050
- Southern Ocean County Medical Center
-
Mullica Hill, New Jersey, Estados Unidos, 08062
- Inspira Medical Center Mullica Hill
-
Neptune City, New Jersey, Estados Unidos, 07753
- Jersey Shore Medical Center
-
New Brunswick, New Jersey, Estados Unidos, 08903
- Rutgers Cancer Institute of New Jersey
-
Red Bank, New Jersey, Estados Unidos, 07701
- Riverview Medical Center/Booker Cancer Center
-
-
New Mexico
-
Albuquerque, New Mexico, Estados Unidos, 87106
- University of New Mexico Cancer Center
-
-
New York
-
Auburn, New York, Estados Unidos, 13021
- Hematology Oncology Associates of Central New York-Auburn
-
Camillus, New York, Estados Unidos, 13031
- Hematology Oncology Associates of CNY at Camillus
-
Cooperstown, New York, Estados Unidos, 13326
- Mary Imogene Bassett Hospital
-
East Syracuse, New York, Estados Unidos, 13057
- Hematology Oncology Associates of Central New York-East Syracuse
-
Glens Falls, New York, Estados Unidos, 12801
- Glens Falls Hospital
-
Lake Success, New York, Estados Unidos, 11042
- Northwell Health/Center for Advanced Medicine
-
New York, New York, Estados Unidos, 10065
- NYP/Weill Cornell Medical Center
-
Rochester, New York, Estados Unidos, 14642
- University of Rochester
-
Stony Brook, New York, Estados Unidos, 11794
- Stony Brook University Medical Center
-
The Bronx, New York, Estados Unidos, 10461
- Montefiore Medical Center-Einstein Campus
-
The Bronx, New York, Estados Unidos, 10467
- Montefiore Medical Center - Moses Campus
-
The Bronx, New York, Estados Unidos, 10461
- Montefiore Medical Center-Weiler Hospital
-
-
North Carolina
-
Asheville, North Carolina, Estados Unidos, 28803
- AdventHealth Infusion Center Asheville
-
Chapel Hill, North Carolina, Estados Unidos, 27599
- UNC Lineberger Comprehensive Cancer Center
-
Charlotte, North Carolina, Estados Unidos, 28204
- Novant Health Presbyterian Medical Center
-
Clemmons, North Carolina, Estados Unidos, 27012
- Wake Forest University at Clemmons
-
Clinton, North Carolina, Estados Unidos, 28328
- Southeastern Medical Oncology Center-Clinton
-
Clyde, North Carolina, Estados Unidos, 28721
- AdventHealth Infusion Center Haywood
-
Durham, North Carolina, Estados Unidos, 27710
- Duke University Medical Center
-
Durham, North Carolina, Estados Unidos, 27705
- Durham VA Medical Center
-
Goldsboro, North Carolina, Estados Unidos, 27534
- Southeastern Medical Oncology Center-Goldsboro
-
Greenville, North Carolina, Estados Unidos, 27834
- ECU Health Medical Center
-
Hendersonville, North Carolina, Estados Unidos, 28791
- Margaret R Pardee Memorial Hospital
-
Hendersonville, North Carolina, Estados Unidos, 28792
- AdventHealth Hendersonville
-
Huntersville, North Carolina, Estados Unidos, 28078
- Novant Health Cancer Institute - Huntersville
-
Huntersville, North Carolina, Estados Unidos, 28078
- Novant Health Presbyterian Medical Center Huntersville
-
Jacksonville, North Carolina, Estados Unidos, 28546
- Southeastern Medical Oncology Center-Jacksonville
-
Kenansville, North Carolina, Estados Unidos, 28349
- ECU Health Oncology Kenansville
-
Kernersville, North Carolina, Estados Unidos, 27284
- Novant Health Cancer Institute - Kernersville
-
Kinston, North Carolina, Estados Unidos, 28501
- ECU Health Oncology Kinston
-
Matthews, North Carolina, Estados Unidos, 28105
- Novant Health Cancer Institute - Matthews
-
Mooresville, North Carolina, Estados Unidos, 28117
- Novant Health Cancer Institute - Mooresville
-
Mount Airy, North Carolina, Estados Unidos, 27030
- Novant Health Cancer Institute - Mount Airy
-
North Wilkesboro, North Carolina, Estados Unidos, 28659
- Novant Health Cancer Institute - Wilkesboro
-
Richlands, North Carolina, Estados Unidos, 28574
- ECU Health Oncology Richlands
-
Statesville, North Carolina, Estados Unidos, 28625
- Novant Health Cancer Institute - Statesville
-
Statesville, North Carolina, Estados Unidos, 28677
- Wake Forest Baptist Health - Hematology Oncology - Statesville
-
Thomasville, North Carolina, Estados Unidos, 27360
- Novant Health Cancer Institute - Thomasville
-
Weaverville, North Carolina, Estados Unidos, 28787
- AdventHealth Infusion Center Weaverville
-
Wilkesboro, North Carolina, Estados Unidos, 28659
- Wake Forest Baptist Health - Wilkes Medical Center
-
Winston-Salem, North Carolina, Estados Unidos, 27157
- Wake Forest University Health Sciences
-
Winston-Salem, North Carolina, Estados Unidos, 27103
- Novant Health Forsyth Medical Center
-
-
North Dakota
-
Bismarck, North Dakota, Estados Unidos, 58501
- Sanford Bismarck Medical Center
-
Fargo, North Dakota, Estados Unidos, 58122
- Sanford Roger Maris Cancer Center
-
Fargo, North Dakota, Estados Unidos, 58103
- Essentia Health Cancer Center-South University Clinic
-
Fargo, North Dakota, Estados Unidos, 58122
- Sanford Broadway Medical Center
-
Fargo, North Dakota, Estados Unidos, 58103
- Sanford South University Medical Center
-
Fargo, North Dakota, Estados Unidos, 58103
- Southpointe-Sanford Medical Center Fargo
-
Fargo, North Dakota, Estados Unidos, 58104
- Sanford Medical Center Fargo
-
Grand Forks, North Dakota, Estados Unidos, 58201
- Altru Cancer Center
-
Jamestown, North Dakota, Estados Unidos, 58401
- Essentia Health - Jamestown Clinic
-
Minot, North Dakota, Estados Unidos, 58701
- Trinity Cancer Care Center
-
-
Ohio
-
Beavercreek, Ohio, Estados Unidos, 45431
- Indu and Raj Soin Medical Center
-
Belpre, Ohio, Estados Unidos, 45714
- Strecker Cancer Center-Belpre
-
Boardman, Ohio, Estados Unidos, 44512
- Saint Elizabeth Boardman Hospital
-
Centerville, Ohio, Estados Unidos, 45459
- Miami Valley Hospital South
-
Centerville, Ohio, Estados Unidos, 45459
- Dayton Physicians LLC-Miami Valley South
-
Chillicothe, Ohio, Estados Unidos, 45601
- Adena Regional Medical Center
-
Cincinnati, Ohio, Estados Unidos, 45219
- University of Cincinnati Cancer Center-UC Medical Center
-
Cincinnati, Ohio, Estados Unidos, 45220
- Good Samaritan Hospital - Cincinnati
-
Cincinnati, Ohio, Estados Unidos, 45242
- Bethesda North Hospital
-
Cincinnati, Ohio, Estados Unidos, 45236
- Oncology Hematology Care Inc-Kenwood
-
Cincinnati, Ohio, Estados Unidos, 45247
- TriHealth Cancer Institute-Westside
-
Cincinnati, Ohio, Estados Unidos, 45255
- TriHealth Cancer Institute-Anderson
-
Cleveland, Ohio, Estados Unidos, 44109
- MetroHealth Medical Center
-
Columbus, Ohio, Estados Unidos, 43214
- Riverside Methodist Hospital
-
Columbus, Ohio, Estados Unidos, 43210
- Ohio State University Comprehensive Cancer Center
-
Columbus, Ohio, Estados Unidos, 43219
- The Mark H Zangmeister Center
-
Columbus, Ohio, Estados Unidos, 43214
- Columbus Oncology and Hematology Associates Inc
-
Columbus, Ohio, Estados Unidos, 43228
- Doctors Hospital
-
Columbus, Ohio, Estados Unidos, 43213
- Mount Carmel East Hospital
-
Columbus, Ohio, Estados Unidos, 43215
- Grant Medical Center
-
Columbus, Ohio, Estados Unidos, 43222
- Mount Carmel Health Center West
-
Dayton, Ohio, Estados Unidos, 45406
- Good Samaritan Hospital - Dayton
-
Dayton, Ohio, Estados Unidos, 45409
- Miami Valley Hospital
-
Dayton, Ohio, Estados Unidos, 45415
- Miami Valley Hospital North
-
Dayton, Ohio, Estados Unidos, 45415
- Dayton Physician LLC - Englewood
-
Dayton, Ohio, Estados Unidos, 45409
- Premier Blood and Cancer Center
-
Delaware, Ohio, Estados Unidos, 43015
- Delaware Health Center-Grady Cancer Center
-
Delaware, Ohio, Estados Unidos, 43015
- Grady Memorial Hospital
-
Dublin, Ohio, Estados Unidos, 43016
- Dublin Methodist Hospital
-
Dublin, Ohio, Estados Unidos, 43016
- Columbus Oncology and Hematology Associates
-
Findlay, Ohio, Estados Unidos, 45840
- Blanchard Valley Hospital
-
Findlay, Ohio, Estados Unidos, 45840
- Armes Family Cancer Center
-
Findlay, Ohio, Estados Unidos, 45840
- Orion Cancer Care
-
Franklin, Ohio, Estados Unidos, 45005-1066
- Atrium Medical Center-Middletown Regional Hospital
-
Franklin, Ohio, Estados Unidos, 45005
- Dayton Physicians LLC-Atrium
-
Gahanna, Ohio, Estados Unidos, 43230
- Central Ohio Breast and Endocrine Surgery
-
Greenville, Ohio, Estados Unidos, 45331
- Wayne Hospital
-
Greenville, Ohio, Estados Unidos, 45331
- Dayton Physicians LLC-Wayne
-
Greenville, Ohio, Estados Unidos, 45331
- Miami Valley Cancer Care and Infusion
-
Grove City, Ohio, Estados Unidos, 43123
- Mount Carmel Grove City Hospital
-
Kettering, Ohio, Estados Unidos, 45429
- Kettering Medical Center
-
Kettering, Ohio, Estados Unidos, 45409
- Greater Dayton Cancer Center
-
Kettering, Ohio, Estados Unidos, 45420
- First Dayton Cancer Care
-
Lancaster, Ohio, Estados Unidos, 43130
- Fairfield Medical Center
-
Lima, Ohio, Estados Unidos, 45801
- Saint Rita's Medical Center
-
Mansfield, Ohio, Estados Unidos, 44903
- OhioHealth Mansfield Hospital
-
Marietta, Ohio, Estados Unidos, 45750
- Marietta Memorial Hospital
-
Marion, Ohio, Estados Unidos, 43302
- OhioHealth Marion General Hospital
-
Marysville, Ohio, Estados Unidos, 43040
- Memorial Hospital
-
Mount Vernon, Ohio, Estados Unidos, 43050
- Knox Community Hospital
-
Newark, Ohio, Estados Unidos, 43055
- Licking Memorial Hospital
-
Newark, Ohio, Estados Unidos, 43055
- Newark Radiation Oncology
-
Perrysburg, Ohio, Estados Unidos, 43551
- Mercy Health - Perrysburg Hospital
-
Portsmouth, Ohio, Estados Unidos, 45662
- Southern Ohio Medical Center
-
Springfield, Ohio, Estados Unidos, 45504
- Springfield Regional Cancer Center
-
Springfield, Ohio, Estados Unidos, 45504
- Springfield Regional Medical Center
-
Toledo, Ohio, Estados Unidos, 43623
- Mercy Health - Saint Anne Hospital
-
Toledo, Ohio, Estados Unidos, 43623
- Toledo Clinic Cancer Centers-Toledo
-
Toledo, Ohio, Estados Unidos, 43608
- Mercy Health - Saint Vincent Hospital
-
Troy, Ohio, Estados Unidos, 45373
- Upper Valley Medical Center
-
Troy, Ohio, Estados Unidos, 45373
- Dayton Physicians LLC - Troy
-
Warren, Ohio, Estados Unidos, 44484
- Saint Joseph Warren Hospital
-
West Chester, Ohio, Estados Unidos, 45069
- University of Cincinnati Cancer Center-West Chester
-
Westerville, Ohio, Estados Unidos, 43081
- Saint Ann's Hospital
-
Youngstown, Ohio, Estados Unidos, 44501
- Saint Elizabeth Youngstown Hospital
-
Zanesville, Ohio, Estados Unidos, 43701
- Genesis Healthcare System Cancer Care Center
-
-
Oklahoma
-
Lawton, Oklahoma, Estados Unidos, 73505
- Cancer Centers of Southwest Oklahoma Research
-
Oklahoma City, Oklahoma, Estados Unidos, 73104
- University of Oklahoma Health Sciences Center
-
Oklahoma City, Oklahoma, Estados Unidos, 73120
- Mercy Hospital Oklahoma City
-
Tulsa, Oklahoma, Estados Unidos, 74146
- Oklahoma Cancer Specialists and Research Institute-Tulsa
-
-
Oregon
-
Baker City, Oregon, Estados Unidos, 97814
- Saint Alphonsus Cancer Care Center-Baker City
-
Bend, Oregon, Estados Unidos, 97701
- Saint Charles Health System
-
Clackamas, Oregon, Estados Unidos, 97015
- Clackamas Radiation Oncology Center
-
Clackamas, Oregon, Estados Unidos, 97015
- Providence Cancer Institute Clackamas Clinic
-
Coos Bay, Oregon, Estados Unidos, 97420
- Bay Area Hospital
-
Gresham, Oregon, Estados Unidos, 97030
- Legacy Mount Hood Medical Center
-
Newberg, Oregon, Estados Unidos, 97132
- Providence Newberg Medical Center
-
Ontario, Oregon, Estados Unidos, 97914
- Saint Alphonsus Cancer Care Center-Ontario
-
Oregon City, Oregon, Estados Unidos, 97045
- Providence Willamette Falls Medical Center
-
Portland, Oregon, Estados Unidos, 97239
- Oregon Health and Science University
-
Portland, Oregon, Estados Unidos, 97210
- Legacy Good Samaritan Hospital and Medical Center
-
Portland, Oregon, Estados Unidos, 97213
- Providence Portland Medical Center
-
Portland, Oregon, Estados Unidos, 97225
- Providence Saint Vincent Medical Center
-
Redmond, Oregon, Estados Unidos, 97756
- Saint Charles Health System-Redmond
-
Tualatin, Oregon, Estados Unidos, 97062
- Legacy Meridian Park Hospital
-
-
Pennsylvania
-
Allentown, Pennsylvania, Estados Unidos, 18103
- Lehigh Valley Hospital-Cedar Crest
-
Bethlehem, Pennsylvania, Estados Unidos, 18017
- Lehigh Valley Hospital - Muhlenberg
-
Bryn Mawr, Pennsylvania, Estados Unidos, 19010
- Bryn Mawr Hospital
-
Chadds Ford, Pennsylvania, Estados Unidos, 19317
- Christiana Care Health System-Concord Health Center
-
Collegeville, Pennsylvania, Estados Unidos, 19426
- Main Line Health Center-Collegeville
-
Danville, Pennsylvania, Estados Unidos, 17822
- Geisinger Medical Center
-
East Stroudsburg, Pennsylvania, Estados Unidos, 18301
- Pocono Medical Center
-
Exton, Pennsylvania, Estados Unidos, 19341
- Main Line Health Center-Exton
-
Hazleton, Pennsylvania, Estados Unidos, 18201
- Geisinger Medical Center-Cancer Center Hazleton
-
Hazleton, Pennsylvania, Estados Unidos, 18201
- Lehigh Valley Hospital-Hazleton
-
Hershey, Pennsylvania, Estados Unidos, 17033-0850
- Penn State Milton S Hershey Medical Center
-
Lewisburg, Pennsylvania, Estados Unidos, 17837
- Geisinger Medical Oncology-Lewisburg
-
Lewistown, Pennsylvania, Estados Unidos, 17044
- Lewistown Hospital
-
Media, Pennsylvania, Estados Unidos, 19063
- Riddle Memorial Hospital
-
Newtown Square, Pennsylvania, Estados Unidos, 19073
- Bryn Mawr Health Center
-
Paoli, Pennsylvania, Estados Unidos, 19301
- Paoli Memorial Hospital
-
Philadelphia, Pennsylvania, Estados Unidos, 19107
- Thomas Jefferson University Hospital
-
Philadelphia, Pennsylvania, Estados Unidos, 19148
- Jefferson Methodist Hospital
-
Pottsville, Pennsylvania, Estados Unidos, 17901
- Geisinger Cancer Services-Pottsville
-
Sayre, Pennsylvania, Estados Unidos, 18840
- Guthrie Medical Group PC-Robert Packer Hospital
-
Scranton, Pennsylvania, Estados Unidos, 18510
- Community Medical Center
-
Selinsgrove, Pennsylvania, Estados Unidos, 17870
- Geisinger Medical Oncology-Selinsgrove
-
State College, Pennsylvania, Estados Unidos, 16801
- Geisinger Medical Group
-
Wilkes-Barre, Pennsylvania, Estados Unidos, 18711
- Geisinger Wyoming Valley/Henry Cancer Center
-
Wynnewood, Pennsylvania, Estados Unidos, 19096
- Lankenau Medical Center
-
-
South Carolina
-
Boiling Springs, South Carolina, Estados Unidos, 29316
- Prisma Health Cancer Institute - Spartanburg
-
Charleston, South Carolina, Estados Unidos, 29425
- Medical University of South Carolina
-
Easley, South Carolina, Estados Unidos, 29640
- Prisma Health Cancer Institute - Easley
-
Gaffney, South Carolina, Estados Unidos, 29341
- Gibbs Cancer Center-Gaffney
-
Greenville, South Carolina, Estados Unidos, 29605
- Prisma Health Cancer Institute - Faris
-
Greenville, South Carolina, Estados Unidos, 29607
- Saint Francis Cancer Center
-
Greenville, South Carolina, Estados Unidos, 29615
- Prisma Health Cancer Institute - Eastside
-
Greenville, South Carolina, Estados Unidos, 29605
- Prisma Health Cancer Institute - Butternut
-
Greenville, South Carolina, Estados Unidos, 29601
- Saint Francis Hospital
-
Greenville, South Carolina, Estados Unidos, 29605
- Prisma Health Greenville Memorial Hospital
-
Greer, South Carolina, Estados Unidos, 29650
- Prisma Health Cancer Institute - Greer
-
Greer, South Carolina, Estados Unidos, 29651
- Gibbs Cancer Center-Pelham
-
Seneca, South Carolina, Estados Unidos, 29672
- Prisma Health Cancer Institute - Seneca
-
Spartanburg, South Carolina, Estados Unidos, 29303
- Spartanburg Medical Center
-
Spartanburg, South Carolina, Estados Unidos, 29307
- Spartanburg Medical Center - Mary Black Campus
-
Spartanburg, South Carolina, Estados Unidos, 29303
- North Grove Medical Park
-
Union, South Carolina, Estados Unidos, 29379
- SMC Center for Hematology Oncology Union
-
-
South Dakota
-
Aberdeen, South Dakota, Estados Unidos, 57401
- Avera Cancer Institute-Aberdeen
-
Rapid City, South Dakota, Estados Unidos, 57701
- Rapid City Regional Hospital
-
Sioux Falls, South Dakota, Estados Unidos, 57105
- Avera Cancer Institute
-
Sioux Falls, South Dakota, Estados Unidos, 57117-5134
- Sanford USD Medical Center - Sioux Falls
-
Sioux Falls, South Dakota, Estados Unidos, 57104
- Sanford Cancer Center Oncology Clinic
-
-
Tennessee
-
Alcoa, Tennessee, Estados Unidos, 37701
- University Cancer Specialists - Alcoa
-
Bristol, Tennessee, Estados Unidos, 37620
- Bristol Regional Medical Center
-
Collierville, Tennessee, Estados Unidos, 38017
- Baptist Memorial Hospital and Cancer Center-Collierville
-
Cookeville, Tennessee, Estados Unidos, 38501
- Cookeville Regional Medical Center
-
Kingsport, Tennessee, Estados Unidos, 37660
- Ballad Health Cancer Care - Kingsport
-
Kingsport, Tennessee, Estados Unidos, 37660
- Wellmont Holston Valley Hospital and Medical Center
-
Knoxville, Tennessee, Estados Unidos, 37920
- University of Tennessee - Knoxville
-
Memphis, Tennessee, Estados Unidos, 38120
- Baptist Memorial Hospital and Cancer Center-Memphis
-
-
Texas
-
Austin, Texas, Estados Unidos, 78701
- Dell Seton Medical Center at The University of Texas
-
Bryan, Texas, Estados Unidos, 77802
- Saint Joseph Regional Cancer Center
-
Dallas, Texas, Estados Unidos, 75235
- Parkland Memorial Hospital
-
Dallas, Texas, Estados Unidos, 75390
- UT Southwestern/Simmons Cancer Center-Dallas
-
Dallas, Texas, Estados Unidos, 75237
- UT Southwestern Simmons Cancer Center - RedBird
-
Fort Worth, Texas, Estados Unidos, 76104
- UT Southwestern/Simmons Cancer Center-Fort Worth
-
Galveston, Texas, Estados Unidos, 77555-0565
- University of Texas Medical Branch
-
Houston, Texas, Estados Unidos, 77030
- Memorial Hermann Texas Medical Center
-
Laredo, Texas, Estados Unidos, 78041
- Doctor's Hospital of Laredo
-
Richardson, Texas, Estados Unidos, 75080
- UT Southwestern Clinical Center at Richardson/Plano
-
-
Utah
-
American Fork, Utah, Estados Unidos, 84003
- American Fork Hospital / Huntsman Intermountain Cancer Center
-
Cedar City, Utah, Estados Unidos, 84720
- Sandra L Maxwell Cancer Center
-
Logan, Utah, Estados Unidos, 84321
- Logan Regional Hospital
-
Murray, Utah, Estados Unidos, 84107
- Intermountain Medical Center
-
Ogden, Utah, Estados Unidos, 84403
- McKay-Dee Hospital Center
-
Provo, Utah, Estados Unidos, 84604
- Utah Valley Regional Medical Center
-
Riverton, Utah, Estados Unidos, 84065
- Riverton Hospital
-
Salt Lake City, Utah, Estados Unidos, 84106
- Utah Cancer Specialists-Salt Lake City
-
Salt Lake City, Utah, Estados Unidos, 84143
- LDS Hospital
-
St. George, Utah, Estados Unidos, 84770
- Saint George Regional Medical Center
-
-
Vermont
-
Berlin Corners, Vermont, Estados Unidos, 05602
- Central Vermont Medical Center/National Life Cancer Treatment
-
Burlington, Vermont, Estados Unidos, 05401
- University of Vermont Medical Center
-
Burlington, Vermont, Estados Unidos, 05405
- University of Vermont and State Agricultural College
-
-
Virginia
-
Bristol, Virginia, Estados Unidos, 24201
- Ballad Health Cancer Care - Bristol
-
Fishersville, Virginia, Estados Unidos, 22939
- Augusta Health Center for Cancer and Blood Disorders
-
Lynchburg, Virginia, Estados Unidos, 24501
- Centra Alan B Pearson Regional Cancer Center
-
Mechanicsville, Virginia, Estados Unidos, 23116
- Bon Secours Memorial Regional Medical Center
-
Midlothian, Virginia, Estados Unidos, 23114
- Bon Secours Saint Francis Medical Center
-
Midlothian, Virginia, Estados Unidos, 23113
- Bon Secours Westchester Emergency Center
-
Norfolk, Virginia, Estados Unidos, 23505
- Bon Secours DePaul Medical Center
-
Norton, Virginia, Estados Unidos, 24273
- Ballad Health Cancer Care - Norton
-
Portsmouth, Virginia, Estados Unidos, 23707
- Bon Secours Maryview Medical Center
-
Richmond, Virginia, Estados Unidos, 23226
- Bon Secours Saint Mary's Hospital
-
Richmond, Virginia, Estados Unidos, 23230
- Bon Secours Cancer Institute at Reynolds Crossing
-
Richmond, Virginia, Estados Unidos, 23298
- VCU Massey Comprehensive Cancer Center
-
South Hill, Virginia, Estados Unidos, 23970
- VCU Community Memorial Health Center
-
Suffolk, Virginia, Estados Unidos, 23435
- Bon Secours Health Center at Harbour View
-
-
Washington
-
Aberdeen, Washington, Estados Unidos, 98520
- Providence Regional Cancer System-Aberdeen
-
Auburn, Washington, Estados Unidos, 98001
- MultiCare Auburn Medical Center
-
Bellevue, Washington, Estados Unidos, 98004
- Overlake Medical Center
-
Bellingham, Washington, Estados Unidos, 98225
- PeaceHealth Saint Joseph Medical Center
-
Burien, Washington, Estados Unidos, 98166
- Saint Anne Hospital
-
Centralia, Washington, Estados Unidos, 98531
- Providence Regional Cancer System-Centralia
-
Edmonds, Washington, Estados Unidos, 98026
- Swedish Cancer Institute-Edmonds
-
Enumclaw, Washington, Estados Unidos, 98022
- Saint Elizabeth Hospital
-
Everett, Washington, Estados Unidos, 98201
- Providence Regional Cancer Partnership
-
Federal Way, Washington, Estados Unidos, 98003
- Saint Francis Hospital
-
Gig Harbor, Washington, Estados Unidos, 98335
- MultiCare Gig Harbor Medical Park
-
Issaquah, Washington, Estados Unidos, 98029
- Swedish Cancer Institute-Issaquah
-
Kennewick, Washington, Estados Unidos, 99336
- Kadlec Clinic Hematology and Oncology
-
Lacey, Washington, Estados Unidos, 98503
- Providence Regional Cancer System-Lacey
-
Lakewood, Washington, Estados Unidos, 98499
- Saint Clare Hospital
-
Longview, Washington, Estados Unidos, 98632
- PeaceHealth Saint John Medical Center
-
Port Townsend, Washington, Estados Unidos, 98368
- Jefferson Healthcare
-
Poulsbo, Washington, Estados Unidos, 98370
- Harrison HealthPartners Hematology and Oncology-Poulsbo
-
Puyallup, Washington, Estados Unidos, 98372
- MultiCare Good Samaritan Hospital
-
Renton, Washington, Estados Unidos, 98055
- Valley Medical Center
-
Seattle, Washington, Estados Unidos, 98107
- Swedish Medical Center-Ballard Campus
-
Seattle, Washington, Estados Unidos, 98122
- Swedish Medical Center-First Hill
-
Seattle, Washington, Estados Unidos, 98104
- Pacific Gynecology Specialists
-
Seattle, Washington, Estados Unidos, 98122-5711
- Swedish Medical Center-Cherry Hill
-
Sedro-Woolley, Washington, Estados Unidos, 98284
- PeaceHealth United General Medical Center
-
Shelton, Washington, Estados Unidos, 98584
- Providence Regional Cancer System-Shelton
-
Silverdale, Washington, Estados Unidos, 98383
- Saint Joseph Medical Center Hematology and Oncology - Silverdale
-
Spokane, Washington, Estados Unidos, 99204
- MultiCare Deaconess Cancer and Blood Specialty Center - Downtown
-
Spokane, Washington, Estados Unidos, 99218
- MultiCare Deaconess Cancer and Blood Specialty Center - North
-
Spokane Valley, Washington, Estados Unidos, 99216
- MultiCare Deaconess Cancer and Blood Specialty Center - Valley
-
Tacoma, Washington, Estados Unidos, 98405
- Mary Bridge Children's Hospital and Health Center
-
Tacoma, Washington, Estados Unidos, 98405
- Northwest Medical Specialties PLLC
-
Tacoma, Washington, Estados Unidos, 98405
- MultiCare Tacoma General Hospital
-
Tacoma, Washington, Estados Unidos, 98405
- Franciscan Research Center-Northwest Medical Plaza
-
Vancouver, Washington, Estados Unidos, 98686
- Legacy Salmon Creek Hospital
-
Vancouver, Washington, Estados Unidos, 98664
- PeaceHealth Southwest Medical Center
-
Vancouver, Washington, Estados Unidos, 98684
- Legacy Cancer Institute Medical Oncology and Day Treatment
-
Walla Walla, Washington, Estados Unidos, 99362
- Providence Saint Mary Regional Cancer Center
-
Yakima, Washington, Estados Unidos, 98902
- North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
-
Yelm, Washington, Estados Unidos, 98597
- Providence Regional Cancer System-Yelm
-
-
West Virginia
-
Bridgeport, West Virginia, Estados Unidos, 26330
- United Hospital Center
-
Charleston, West Virginia, Estados Unidos, 25304
- Vandalia Health/CAMC Institute for Academic Medicine
-
Huntington, West Virginia, Estados Unidos, 25701
- Edwards Comprehensive Cancer Center
-
Martinsburg, West Virginia, Estados Unidos, 25401
- WVUH-Berkely Medical Center
-
Morgantown, West Virginia, Estados Unidos, 26506
- West Virginia University Healthcare
-
Parkersburg, West Virginia, Estados Unidos, 26101
- Camden Clark Medical Center
-
-
Wisconsin
-
Antigo, Wisconsin, Estados Unidos, 54409
- Aspirus Cancer Care-Antigo-Volm Cancer Center
-
Appleton, Wisconsin, Estados Unidos, 54911
- ThedaCare Regional Cancer Center
-
Ashland, Wisconsin, Estados Unidos, 54806
- Duluth Clinic Ashland
-
Ashland, Wisconsin, Estados Unidos, 54806
- Northwest Wisconsin Cancer Center
-
Eau Claire, Wisconsin, Estados Unidos, 54701
- Marshfield Medical Center-EC Cancer Center
-
Eau Claire, Wisconsin, Estados Unidos, 54701
- HSHS Sacred Heart Hospital
-
Green Bay, Wisconsin, Estados Unidos, 54301
- Saint Vincent Hospital Cancer Center Green Bay
-
Green Bay, Wisconsin, Estados Unidos, 54303
- Saint Vincent Hospital Cancer Center at Saint Mary's
-
Green Bay, Wisconsin, Estados Unidos, 54301
- Bellin Memorial Hospital
-
Madison, Wisconsin, Estados Unidos, 53792
- University of Wisconsin Carbone Cancer Center - University Hospital
-
Madison, Wisconsin, Estados Unidos, 53715
- SSM Health Dean Medical Group - South Madison Campus
-
Manitowoc, Wisconsin, Estados Unidos, 54221
- Holy Family Memorial Hospital
-
Marshfield, Wisconsin, Estados Unidos, 54449
- Marshfield Medical Center-Marshfield
-
Medford, Wisconsin, Estados Unidos, 54451
- Aspirus Medford Hospital
-
Menomonee Falls, Wisconsin, Estados Unidos, 53051
- Froedtert Menomonee Falls Hospital
-
Milwaukee, Wisconsin, Estados Unidos, 53226
- Medical College of Wisconsin
-
Minocqua, Wisconsin, Estados Unidos, 54548
- Marshfield Medical Center - Minocqua
-
Mukwonago, Wisconsin, Estados Unidos, 53149
- ProHealth D N Greenwald Center
-
New Richmond, Wisconsin, Estados Unidos, 54017
- Cancer Center of Western Wisconsin
-
Oconomowoc, Wisconsin, Estados Unidos, 53066
- ProHealth Oconomowoc Memorial Hospital
-
Oconto Falls, Wisconsin, Estados Unidos, 54154
- Saint Vincent Hospital Cancer Center at Oconto Falls
-
Rhinelander, Wisconsin, Estados Unidos, 54501
- Aspirus Cancer Care-Rhinelander-James Beck Cancer Center
-
Rice Lake, Wisconsin, Estados Unidos, 54868
- Marshfield Medical Center-Rice Lake
-
Sheboygan, Wisconsin, Estados Unidos, 53081
- HSHS Saint Nicholas Hospital
-
Stevens Point, Wisconsin, Estados Unidos, 54482
- Marshfield Medical Center-River Region at Stevens Point
-
Stevens Point, Wisconsin, Estados Unidos, 54481
- Aspirus Cancer Care - Stevens Point
-
Sturgeon Bay, Wisconsin, Estados Unidos, 54235-1495
- Saint Vincent Hospital Cancer Center at Sturgeon Bay
-
Waukesha, Wisconsin, Estados Unidos, 53188
- UW Cancer Center at ProHealth Care
-
Waukesha, Wisconsin, Estados Unidos, 53188
- ProHealth Waukesha Memorial Hospital
-
Wausau, Wisconsin, Estados Unidos, 54401
- Aspirus Cancer Care-Wausau
-
West Bend, Wisconsin, Estados Unidos, 53095
- Froedtert West Bend Hospital/Kraemer Cancer Center
-
Weston, Wisconsin, Estados Unidos, 54476
- Marshfield Medical Center - Weston
-
Wisconsin Rapids, Wisconsin, Estados Unidos, 54494
- Aspirus Cancer Care - Wisconsin Rapids
-
-
Wyoming
-
Cheyenne, Wyoming, Estados Unidos, 82001
- Cheyenne Regional Medical Center-West
-
Cody, Wyoming, Estados Unidos, 82414
- Billings Clinic-Cody
-
Sheridan, Wyoming, Estados Unidos, 82801
- Welch Cancer Center
-
-
-
-
-
San Juan, Puerto Rico, 00902
- Pan American Center for Oncology Trials LLC
-
-
Criterios de participación
Los investigadores buscan personas que se ajusten a una determinada descripción, denominada criterio de elegibilidad. Algunos ejemplos de estos criterios son el estado de salud general de una persona o tratamientos previos.
Criterio de elegibilidad
Edades elegibles para estudiar
18 años y mayores (Adulto, Adulto Mayor)
Acepta Voluntarios Saludables
No
Géneros elegibles para el estudio
Todos
Descripción
Inclusion Criteria:
-
STEP I REGISTRATION CRITERIA
-
Histologically documented renal cell carcinoma with clear cell component, including patients who have sarcomatoid or rhabdoid features
-
Any metastatic disease, including visceral, lymph node, other soft tissue and bone, measurable per RECIST 1.1
-
Measurable disease as defined in the protocol
-
Must be intermediate or poor risk patient per International Metastatic Renal Cell Carcinoma Database (IMDC) criteria (1 or more of the following): Karnofsky performance status [KPS] < 80, < 1 year from diagnosis [including initial nephrectomy] to systemic treatment for metastatic disease, hemoglobin less than lower limit of normal [LLN], corrected calcium concentration greater than upper limit of normal [ULN], absolute neutrophil count greater than ULN, platelet count > ULN)
-
Central nervous system (CNS) disease permitted, if stable and not otherwise causing symptoms or needing active treatment
-
Karnofsky performance status >= 70%
-
No prior treatment with PD-1, PD-L1, or CTLA-4 targeting agents (including but not limited to nivolumab, pembrolizumab, pidilizumab, durvalumab, atezolizumab, tremelimumab, and ipilimumab), or any other drug or antibody specifically targeting T-cell co-stimulation or checkpoint pathways. The only exception is for prior treatment with nivolumab or other PD-1/PD-L1/CTLA-4 targeting therapy on pre- or post-operative trials, as long as > 1 year since completion of systemic therapy
-
No prior previous systemic therapy for renal cell carcinoma (prior HD IL-2 [>28 days]. Prior adjuvant sunitinib >180 days since completion and prior immunotherapy as above are allowed).
-
No systemic cancer therapy less than 28 days prior to registration; no radiation therapy less than 14 days prior to registration. There must be a complete recovery and no ongoing complications from radiotherapy
-
Not pregnant and not nursing, because this study involves an agent that has known genotoxic, mutagenic and teratogenic effects. Therefore, for women of childbearing potential only, a negative serum or urine pregnancy test done =< 14 days prior to registration is required
-
Age >= 18 years
-
None of the following:
- Active autoimmune disease requiring ongoing therapy
- Ongoing acute toxicity > grade 2 from previous treatment
- History of severe allergic, anaphylactic or other hypersensitivity reactions to chimeric or humanized antibodies
- Active hepatitis B/C, or active tuberculosis (purified protein derivative [PPD] response without active tuberculosis [TB] is allowed)
- HIV-infected patients with detectable viral load within 6 months prior to registration. Patients on effective anti-retroviral therapy with undetectable viral load within 6 months prior to registration are eligible
- Concurrent use of immunosuppressive medication including prednisone above 10 mg daily
- Uncontrolled adrenal insufficiency
- Uncontrolled hypertension (systolic blood pressure [BP] > 150mmHg or diastolic BP > 90mmHg)
- Major surgery less than 28 days prior to registration
- Any serious non-healing wound, ulcer, or bone fracture within 28 days prior to registration
- Any arterial thrombotic events within 180 days prior to registration
- Clinically significant hematuria, hematemesis, or hemoptysis within 12 weeks prior to registration
- Cavitating pulmonary lesions or known endotracheal or endobronchial disease manifestations
- Lesions encasing or invading any major blood vessels (this does not include tumor thrombus extending into/through renal vein/inferior vena cava [IVC]). Patients with tumor thrombus extending into/through renal vein are considered eligible
- Moderate of severe hepatic impairment (child-Pugh B or C)
- Any history of untreated pulmonary embolism or deep venous thrombosis (DVT) in the 180 days prior to registration. (Any asymptomatic, treated pulmonary embolism or asymptomatic, treated deep venous thrombosis > 30 days prior to registration allowed)
- Corrected QT interval calculated by the Fridericia formula (QTcF) > 500 ms
- Unstable cardiac arrhythmia within 6 months prior to registration
- Any gastrointestinal (GI) bleeding =< 180 days, hemoptysis, or other signs of pulmonary hemorrhage =< 90 days prior to registration
- History of abdominal fistula, gastrointestinal perforation, intra-abdominal abscess, bowel obstruction, or gastric outlet obstruction within 180 days prior to registration
- Active peptic ulcer disease, inflammatory bowel disease, or malabsorption syndrome within 28 days prior to registration
- Untreated hypothyroidism (treated hypothyroidism on thyroid replacement therapy is allowed. Abnormal thyroid-stimulating hormone [TSH] is acceptable with normal T3/free T4 if treated on thyroid replacement therapy)
- Evidence of pancreatitis, history of organ transplant, or history of congenital QT syndrome
- Active treatment with coumarin agents (e.g., warfarin), direct thrombin inhibitors (e.g., dabigatran), direct Xa inhibitor betrixaban or platelet inhibitors (e.g., clopidogrel) within 5 days of registration Allowed anticoagulants include: prophylactic use of low-dose aspirin for cardio-protection (per local applicable guidelines) and low-dose low molecular weight heparins (LMWH), therapeutic doses of LMWH or anticoagulation with direct factor Xa inhibitors rivaroxaban, edoxaban, apixaban. Allowed also in patients with known brain metastases who are on a stable dose of the anticoagulant for at least 1 week prior to registration without clinically significant hemorrhagic complications from the anticoagulation regimen or the tumor
- Significant cardiac ischemia events (ST elevation myocardial infarction [STEMI] or non-ST-elevation myocardial infarction [NSTEMI]) within 6 months or active New York (NY) Heart Association class 3-4 heart failure symptoms
-
Absolute neutrophil count (ANC) >= 1,500/mm^3
-
Platelet count >= 100,000/mm^3
-
Hemoglobin >= 8 g/dL
-
Calculated (Calc.) creatinine clearance >= 30 mL/min
-
Urine protein =< 1+ or urine protein to creatinine (UPC) ratio < 1
-
Total bilirubin =< 1.5 x upper limit of normal (ULN) (except for patients with known or likely Gilbert's syndrome, for whom total bilirubin up to 3 mg/dL is allowed with direct bilirubin =< 20% total bilirubin)
-
Aspartate aminotransferase/alanine aminotransferase (AST/ALT) =< 2.5 x upper limit of normal (ULN) or < 5 x ULN if hepatic metastases present
-
STEP 2 REGISTRATION ELIGIBILITY CRITERIA
-
Successful completion of at least 1 cycle of ipilimumab/nivolumab
-
Resolution of any treatment-related adverse events to grade 1 or less per dose modification section (this criteria does not include any adverse events [AEs] not attributable to treatment which are present due to disease), with prednisone-equivalent dosing at 10 mg daily or less. Exceptions for this criteria include patients receiving replacement hormone treatments (such as levothyroxine for treatment-related hypothyroidism or glucocorticoid replacement for adrenal insufficiency). Please contact study chair if further discussion is needed
-
No more than 80 days from last dose of ipilimumab/nivolumab
Plan de estudios
Esta sección proporciona detalles del plan de estudio, incluido cómo está diseñado el estudio y qué mide el estudio.
¿Cómo está diseñado el estudio?
Detalles de diseño
- Propósito principal: Tratamiento
- Asignación: Aleatorizado
- Modelo Intervencionista: Asignación paralela
- Enmascaramiento: Ninguno (etiqueta abierta)
Armas e Intervenciones
Grupo de participantes/brazo |
Intervención / Tratamiento |
|---|---|
|
Comparador activo: Arm A (nivolumab)
INDUCTION: Patients receive nivolumab IV over 30 minutes and ipilimumab IV over 30 minutes on day 1. Treatment repeats every 21 days for up to 4 cycles in the absence of disease progression or unacceptable toxicity. TREATMENT: Patients with iuPD with clinical instability receive cabozantinib PO daily on days 1-28. Treatment repeats every 28 days until further disease progression or unacceptable toxicity Patients with iCR receive nivolumab IV over 30 minutes on day 1. Treatment repeats every 28 days in the absence of disease progression or unacceptable toxicity. Patients with non-CR/non-PD with clinical stability receive nivolumab IV over 30 minutes on day 1. Treatment repeats every 28 days in the absence of disease progression or unacceptable toxicity. Patients undergo CT scan, MRI and blood and urine sample collection, and may also undergo a bone scan as clinically indicated throughout the study. |
Ancillary studies
Otros nombres:
Given IV
Otros nombres:
Undergo MRI
Otros nombres:
Ancillary studies Given IV
Otros nombres:
Undergo CT scan
Otros nombres:
Undergo bone scan
Otros nombres:
Undergo blood and urine sample collection
Otros nombres:
|
|
Experimental: Arm B (nivolumab, cabozantinib)
INDUCTION: Patients receive nivolumab IV over 30 minutes and ipilimumab IV over 30 minutes on day 1. Treatment repeats every 21 days for up to 4 cycles in the absence of disease progression or unacceptable toxicity. TREATMENT: Patients with iuPD with clinical instability receive cabozantinib PO daily on days 1-28. Treatment repeats every 28 days until further disease progression or unacceptable toxicity. Patients with iCR receive nivolumab IV over 30 minutes on day 1. Treatment repeats every 28 days in the absence of disease progression or unacceptable toxicity. Patients with non-CR/non-PD rwith clinical stability eceive nivolumab IV over 30 minutes on day 1 and cabozantinib PO daily on days 1-28. Treatment repeats every 28 days in the absence of disease progression or unacceptable toxicity. Patients undergo CT scan, MRI and blood and urine sample collection, and may also undergo a bone scan as clinically indicated throughout the study. |
Ancillary studies
Otros nombres:
Given IV
Otros nombres:
Undergo MRI
Otros nombres:
Ancillary studies Given IV
Otros nombres:
Undergo CT scan
Otros nombres:
Undergo blood and urine sample collection
Otros nombres:
Given PO |
¿Qué mide el estudio?
Medidas de resultado primarias
Medida de resultado |
Medida Descripción |
Periodo de tiempo |
|---|---|---|
|
Overall survival (OS)
Periodo de tiempo: From registration to date of death from any cause for non-randomized patients, from time of randomization until death from any cause for randomized patients, assessed up to 5 years
|
OS of patients who achieve complete response (CR) and progressive disease (PD) from ipilimumab-nivolumab induction phase will be summarized. The stratified log-rank statistic will be the primary analysis to compare the hypothesis on OS with the stratification factors (presence of bone metastases and IMDC risk criteria). The Kaplan-Meier product-limit estimator will be used to estimate the OS. A stratified proportional hazards model will be used to generate estimates for the OS hazard ratio. For the randomized patients, OS will be calculated and compared from the time of randomization until the time of an OS event or time of last-follow-up, whatever occurs first. For the patients who were initially CR or PD, OS will be measured from the time of study registration. A comparison of OS will be made across the patient groups (randomized patients, patients initially CR, and patients initially PD). |
From registration to date of death from any cause for non-randomized patients, from time of randomization until death from any cause for randomized patients, assessed up to 5 years
|
Medidas de resultado secundarias
Medida de resultado |
Medida Descripción |
Periodo de tiempo |
|---|---|---|
|
Progression-free survival (PFS)
Periodo de tiempo: From date of registration to date of progression (or disease recurrence) or death due to any cause, whichever occurs first, assessed up to 5 years
|
Progression will be defined using the Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 criteria. PFS of patients who achieve CR and PD from ipilimumab-nivolumab induction phase will be summarized (secondary analysis). The Kaplan-Meier product-limit estimator will be used to estimate the PFS distribution. A stratified proportional hazards model will be used to generate estimates for the PFS hazard ratio. For the randomized patients, PFS will be calculated and compared from the time of randomization until the time of a PFS event or time of last-follow-up, whatever occurs first. For the patients who were initially CR or PD, PFS will be measured from the time of study registration. A comparison of PFS will be made across the patient groups (randomized patients, patients initially CR, and patients initially PD). For this comparison, PFS will be measured from time of study registration all the patients, regardless of whether they were randomized or not. |
From date of registration to date of progression (or disease recurrence) or death due to any cause, whichever occurs first, assessed up to 5 years
|
|
Complete response (CR) (randomized patients)
Periodo de tiempo: At 12 months from date of randomization
|
Patients who had a CR prior to 12 months but have experienced a disease recurrence prior to 12 months, will not be considered to be a CR at 12 months. The Cochran-Mantel-Haenszel test will be used to compare the two arms on the proportion of patients who have a 12-month CR adjusting on the stratification factors. |
At 12 months from date of randomization
|
|
Objective response
Periodo de tiempo: Up to 5 years
|
Defined as the best response observed that has been confirmed by a scan performed 4 or more weeks after the observation of the initial response. The objective response will be confirmed using RECIST 1.1. In addition, objective responses will also be confirmed using Immune Response Evaluation Criteria in Solid Tumors (iRECIST). |
Up to 5 years
|
|
Proportion of patients who discontinue protocol-directed treatment prior to 1 year from date of study registration
Periodo de tiempo: Up to 5 years
|
Patients who stop their protocol directed treatment for any reason prior to one year from study registration will be considered to have discontinued their treatment. The Cochran-Mantel-Haenszel test will also be used to compare the proportion of patients who discontinue their treatment prior to one-year after study registration. |
Up to 5 years
|
|
Incidence of adverse events
Periodo de tiempo: Up to 5 years
|
Assessed with National Cancer Institute Common Terminology Criteria for Adverse Events version 5.0. A Fisher's exact test will be used to compare the two treatment arms on the proportion of patient with a grade 3 or higher adverse event. |
Up to 5 years
|
Otras medidas de resultado
Medida de resultado |
Medida Descripción |
Periodo de tiempo |
|---|---|---|
|
Estimates of OS by sex
Periodo de tiempo: From registration to date of death from any cause for non-randomized patients, from time of randomization until death from any cause for randomized patients, assessed up to 5 years
|
Estimates of OS and the corresponding 95% confidence intervals (CIs) by sex will be provided (with an understanding that sometimes the CI or estimate will not be computable because of scant data). |
From registration to date of death from any cause for non-randomized patients, from time of randomization until death from any cause for randomized patients, assessed up to 5 years
|
|
Estimates of OS by race
Periodo de tiempo: From registration to date of death from any cause for non-randomized patients, from time of randomization until death from any cause for randomized patients, assessed up to 5 years
|
Estimates of OS and the corresponding 95% CIs by race will be provided (with an understanding that sometimes the CI or estimate will not be computable because of scant data). |
From registration to date of death from any cause for non-randomized patients, from time of randomization until death from any cause for randomized patients, assessed up to 5 years
|
|
Estimates of OS by ethnicity
Periodo de tiempo: From registration to date of death from any cause for non-randomized patients, from time of randomization until death from any cause for randomized patients, assessed up to 5 years
|
Estimates of OS and the corresponding 95% CIs by ethnicity will be provided (with an understanding that sometimes the CI or estimate will not be computable because of scant data). |
From registration to date of death from any cause for non-randomized patients, from time of randomization until death from any cause for randomized patients, assessed up to 5 years
|
Colaboradores e Investigadores
Aquí es donde encontrará personas y organizaciones involucradas en este estudio.
Patrocinador
Investigadores
- Investigador principal: Tian Zhang, Alliance for Clinical Trials in Oncology
Publicaciones y enlaces útiles
La persona responsable de ingresar información sobre el estudio proporciona voluntariamente estas publicaciones. Estos pueden ser sobre cualquier cosa relacionada con el estudio.
Publicaciones Generales
- Yang Y, Psutka SP, Parikh AB, Li M, Collier K, Miah A, Mori SV, Hinkley M, Tykodi SS, Hall E, Thompson JA, Yin M. Combining immune checkpoint inhibition plus tyrosine kinase inhibition as first and subsequent treatments for metastatic renal cell carcinoma. Cancer Med. 2022 Aug;11(16):3106-3114. doi: 10.1002/cam4.4679. Epub 2022 Mar 18.
- Labriola MK, George DJ. Setting a new standard for long-term survival in metastatic kidney cancer. Cancer. 2022 Jun 1;128(11):2058-2060. doi: 10.1002/cncr.34177. Epub 2022 Apr 5. No abstract available.
Fechas de registro del estudio
Estas fechas rastrean el progreso del registro del estudio y los envíos de resultados resumidos a ClinicalTrials.gov. Los registros del estudio y los resultados informados son revisados por la Biblioteca Nacional de Medicina (NLM) para asegurarse de que cumplan con los estándares de control de calidad específicos antes de publicarlos en el sitio web público.
Fechas importantes del estudio
Inicio del estudio (Actual)
7 de junio de 2019
Finalización primaria (Estimado)
1 de marzo de 2028
Finalización del estudio (Estimado)
1 de marzo de 2028
Fechas de registro del estudio
Enviado por primera vez
3 de enero de 2019
Primero enviado que cumplió con los criterios de control de calidad
3 de enero de 2019
Publicado por primera vez (Actual)
4 de enero de 2019
Actualizaciones de registros de estudio
Última actualización publicada (Actual)
26 de octubre de 2026
Última actualización enviada que cumplió con los criterios de control de calidad
23 de octubre de 2026
Última verificación
1 de octubre de 2026
Más información
Términos relacionados con este estudio
Términos MeSH relevantes adicionales
- Enfermedades urogenitales
- Procesos Patológicos
- Neoplasias urogenitales
- Neoplasias por sitio
- Neoplasias
- Enfermedades urogenitales masculinas
- Enfermedades Renales
- Enfermedades urológicas
- Enfermedades urogenitales femeninas
- Enfermedades urogenitales femeninas y complicaciones del embarazo
- Neoplasias por tipo histológico
- Neoplasias Glandulares y Epiteliales
- Adenocarcinoma
- Procesos Neoplásicos
- Neoplasias Urológicas
- Carcinoma
- Neoplasias Renales
- Metástasis de neoplasias
- Condiciones Patológicas, Signos y Síntomas
- Carcinoma De Célula Renal
- Metástasis linfática
- Aminoácidos, péptidos y proteínas
- Proteínas
- Técnicas de investigación
- Técnicas de laboratorio clínico
- Técnicas y procedimientos de diagnóstico
- Diagnóstico
- Factores biológicos
- Anticuerpos, monoclonales, humanizados
- Anticuerpos, monoclonal
- Anticuerpos
- Inmunoglobulinas
- Inmunoproteínas
- Proteínas de la sangre
- Globulinas séricas
- Globulinas
- Técnicas de química, analítica
- Análisis de espectro
- Receptores, superficie celular
- Proteínas de membrana
- Antígenos
- Antígenos, superficie
- Biomarcadores
- Receptores, inmunológico
- Antígenos, diferenciación, linfocito T
- Antígenos, diferenciación
- Proteínas de punto de control inmunes
- Receptores de células T costimulador e inhibidor
- Nivolumab
- Ipilimumab
- Manejo de muestras
- Espectroscopía de resonancia magnética
- taza de taxis
- Antígeno CTLA-4
Otros números de identificación del estudio
- NCI-2018-03694
- U10CA180821 (Subvención/contrato del NIH de EE. UU.)
- NCI-2018-03694 (Identificador de registro: CTRP (Clinical Trial Reporting Program))
- A031704 (Otro identificador: CTEP)
- A031704 (Otro identificador: Alliance for Clinical Trials in Oncology)
Plan de datos de participantes individuales (IPD)
¿Planea compartir datos de participantes individuales (IPD)?
SÍ
Descripción del plan IPD
NCI is committed to sharing data in accordance with NIH policy. For more details on how clinical trial data is shared, access the link to the NIH data sharing policy page
Información sobre medicamentos y dispositivos, documentos del estudio
Estudia un producto farmacéutico regulado por la FDA de EE. UU.
Sí
Estudia un producto de dispositivo regulado por la FDA de EE. UU.
No
Esta información se obtuvo directamente del sitio web clinicaltrials.gov sin cambios. Si tiene alguna solicitud para cambiar, eliminar o actualizar los detalles de su estudio, comuníquese con register@clinicaltrials.gov. Tan pronto como se implemente un cambio en clinicaltrials.gov, también se actualizará automáticamente en nuestro sitio web. .