A Study Testing the Effect of Immunotherapy (Ipilimumab and Nivolumab) in Patients With Recurrent Glioblastoma With Elevated Mutational Burden

A Phase II Study of Checkpoint Blockade Immunotherapy in Patients With Somatically Hypermutated Recurrent Glioblastoma

Sponsors

Lead Sponsor: National Cancer Institute (NCI)

Source National Cancer Institute (NCI)
Brief Summary

This phase II trial studies the effect of immunotherapy drugs (ipilimumab and nivolumab) in treating patients with glioblastoma that has come back (recurrent) and carries a high number of mutations. Cancer is caused by changes (mutations) to genes that control the way cells function. Tumors with high number of mutations may respond well to immunotherapy. Immunotherapy with monoclonal antibodies such as ipilimumab and nivolumab may help the body's immune system attack the cancer and may interfere with the ability of tumor cells to grow and spread. Giving ipilimumab and nivolumab may lower the chance of recurrent glioblastoma with high number of mutations from growing or spreading compared to usual care (surgery or chemotherapy).

Detailed Description

PRIMARY OBJECTIVE: I. To determine whether the combination of ipilimumab and nivolumab increases the tumor response rate assessed by modified Response Assessment in Neuro-Oncology (RANO) Criteria in patients with hypermutated recurrent glioblastoma. SECONDARY OBJECTIVES: I. Estimate the overall survival distribution, median survival, and one-year survival rate of patients with hypermutated, recurrent glioblastoma who are treated with ipilimumab and nivolumab. II. Estimate the progression-free survival distribution and median progression-free survival of patients with hypermutated, recurrent glioblastoma who are treated with ipilimumab and nivolumab. III. Determine the adverse event profile of patients with hypermutated, recurrent glioblastoma who are treated with ipilimumab and nivolumab. EXPLORATORY OBJECTIVES: I. Test whether PD-L1 or immunologic infiltrate in the tumor microenvironment are associated with objective tumor response, overall survival, progression-free survival, tumor mutational burden, or rates of grade 3 or higher adverse events. II. Test whether MGMT status, microsatellite instability (MSI) status, mutational signatures, or amount of tumor mutational burden (TMB) including germline analysis are associated with objective tumor response, overall survival, progression-free survival, or rates of grade 3 or higher adverse events. III. Evaluate associations between exome and transcriptome gene levels with objective tumor response, overall survival, progression-free survival, rates of grade 3 or higher adverse events. IV. Evaluate associations between the gut microbiome and objective tumor response. V. Response rate using immunotherapy (i)RANO. OUTLINE: Patients receive nivolumab intravenously (IV) over 30 minutes and ipilimumab IV over 30 minutes on day 1. Treatment repeats every 3 weeks for 4 cycles in the absence of disease progression or unacceptable toxicity. Patients then receive nivolumab IV over 30 minutes on day 1. Cycles repeat every 4 weeks in the absence of disease progression or unacceptable toxicity. After completion of study treatment, patients without disease progression are followed every 8 weeks until disease progression, then every 3 months for up to 3 years. Patients with disease progression after completion of study treatment are followed every 3 months for up to 3 years.

Overall Status Recruiting
Start Date 2020-10-30
Completion Date 2023-05-31
Primary Completion Date 2023-05-31
Phase Phase 2
Study Type Interventional
Primary Outcome
Measure Time Frame
Overall response rate Up to 32 months
Secondary Outcome
Measure Time Frame
Overall survival (OS) From the time of treatment initiation until death from any cause, assessed up to 3 years
Progression-free survival (PFS) From the time of treatment initiation until disease progression as measured using RANO criteria or death, whichever occurs first, assessed up to 3 years
Incidence of adverse events (AEs) Up to 3 years
Enrollment 37
Condition
Intervention

Intervention Type: Biological

Intervention Name: Ipilimumab

Description: Given IV

Arm Group Label: Treatment (nivolumab, ipilimumab)

Intervention Type: Biological

Intervention Name: Nivolumab

Description: Given IV

Arm Group Label: Treatment (nivolumab, ipilimumab)

Eligibility

Criteria:

Inclusion Criteria: - PRE-REGISTRATION: - Histologically confirmed glioblastoma (World Health Organization [WHO] grade IV) presenting at first or second recurrence including secondary glioblastoma - Presence of measurable disease, as defined by a bidimensionally measurable lesion on magnetic resonance imaging (MRI) with a minimum diameter of 10 mm in both dimensions, prior to resection or biopsy of recurrent tumor - Tissue available from surgical resection or biopsy of recurrent tumor =< 28 days prior to pre-registration, or planned surgery or biopsy of recurrent tumor =< 28 days after pre-registration - Does not require > 4 mg dexamethasone beyond the perioperative period defined as the time =< 2 weeks after surgical procedure - No prior treatment with laser ablation at the time of recurrent tumor tissue sampling. Patients who have previously undergone laser ablation >= 4 months prior to recurrent tumor tissue sampling can be included - Age >= 18 years - Eastern Cooperative Oncology Group (ECOG) performance status =< 2 - Able to undergo brain MRI with contrast - Absolute neutrophil count >= 1500/mm^3 - Platelet count >= 100,000/mm^3 - Total bilirubin =< 1.5 x upper limit of normal (ULN) - If Gilbert syndrome, then total bilirubin =< 3 x ULN - Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 2.0 x ULN - Creatinine =< 1.5 x ULN OR creatinine clearance (CrCl) >= 50 mL/min (if using the Cockcroft-Gault formula) - History of active malignancy (outside of the patient's glioblastoma) that has required treatment within the previous 2 years. Participant with prior history of in situ cancer or basal or squamous cell skin cancer are eligible - REGISTRATION ELIGIBILITY CRITERIA: Tissue obtained from biopsy or resection at first or second recurrence exhibits TMB >= 10 on FoundationOne CDx testing Exclusion Criteria: - No active autoimmune disease or history of autoimmune disease - These include but are not limited to patients with a history of immune related neurologic disease, multiple sclerosis, autoimmune (demyelinating) neuropathy, Guillain-Barre syndrome, myasthenia gravis; systemic autoimmune disease such as systemic lupus erythematosus (SLE), connective tissue diseases, scleroderma, inflammatory bowel disease (IBD), Crohn's, ulcerative colitis, hepatitis; and patients with a history of toxic epidermal necrolysis (TEN), Stevens-Johnson syndrome, or phospholipid syndrome should be excluded because of the risk of recurrence or exacerbation of disease - Patients with vitiligo, endocrine deficiencies including thyroiditis managed with replacement hormones including physiologic corticosteroids are eligible. Patients with rheumatoid arthritis and other arthropathies, Sjogren's syndrome and psoriasis controlled with topical medication and patients with positive serology, such as antinuclear antibodies (ANA), anti-thyroid antibodies should be evaluated for the presence of target organ involvement and potential need for systemic treatment but should otherwise be eligible - No prior treatment with checkpoint blockade therapies (anti-CTLA4, anti-PD1/PD-L1) or bevacizumab

Gender:

All

Minimum Age:

18 Years

Maximum Age:

N/A

Healthy Volunteers:

No

Overall Official
Last Name Role Affiliation
Gavin P Dunn Principal Investigator Alliance for Clinical Trials in Oncology
Location
Facility: Status:
Anchorage Associates in Radiation Medicine | Anchorage, Alaska, 98508, United States Suspended
Anchorage Radiation Therapy Center | Anchorage, Alaska, 99504, United States Suspended
Alaska Breast Care and Surgery LLC | Anchorage, Alaska, 99508, United States Suspended
Alaska Oncology and Hematology LLC | Anchorage, Alaska, 99508, United States Suspended
Alaska Women's Cancer Care | Anchorage, Alaska, 99508, United States Suspended
Anchorage Oncology Centre | Anchorage, Alaska, 99508, United States Suspended
Katmai Oncology Group | Anchorage, Alaska, 99508, United States Suspended
Providence Alaska Medical Center | Anchorage, Alaska, 99508, United States Suspended
Cancer Center at Saint Joseph's | Phoenix, Arizona, 85004, United States Suspended
Mayo Clinic Hospital in Arizona | Phoenix, Arizona, 85054, United States Recruiting Site Public Contact 855-776-0015 Sani H. Kizilbash Principal Investigator
Mayo Clinic in Arizona | Scottsdale, Arizona, 85259, United States Recruiting Site Public Contact 855-776-0015 Sani H. Kizilbash Principal Investigator
Mercy Hospital Fort Smith | Fort Smith, Arkansas, 72903, United States Suspended
CHI Saint Vincent Cancer Center Hot Springs | Hot Springs, Arkansas, 71913, United States Suspended
Mission Hope Medical Oncology - Arroyo Grande | Arroyo Grande, California, 93420, United States Suspended
Providence Saint Joseph Medical Center/Disney Family Cancer Center | Burbank, California, 91505, United States Suspended
UC San Diego Moores Cancer Center | La Jolla, California, 92093, United States Recruiting Site Public Contact 858-822-5354 [email protected] David E. Piccioni Principal Investigator
Cedars Sinai Medical Center | Los Angeles, California, 90048, United States Recruiting Site Public Contact 310-423-8965 Jeremy D. Rudnick Principal Investigator
University of California Davis Comprehensive Cancer Center | Sacramento, California, 95817, United States Recruiting Site Public Contact 916-734-3089 Orin Bloch Principal Investigator
Pacific Central Coast Health Center-San Luis Obispo | San Luis Obispo, California, 93401, United States Suspended
Mission Hope Medical Oncology - Santa Maria | Santa Maria, California, 93444, United States Suspended
Torrance Memorial Physician Network - Cancer Care | Torrance, California, 90505, United States Suspended
Torrance Memorial Medical Center | Torrance, California, 90509, United States Suspended
University of Colorado Hospital | Aurora, Colorado, 80045, United States Recruiting Site Public Contact 720-848-0650 Denise M. Damek Principal Investigator
Penrose-Saint Francis Healthcare | Colorado Springs, Colorado, 80907, United States Recruiting Site Public Contact 719-776-6550 [email protected] Richard L. Deming Principal Investigator
Rocky Mountain Cancer Centers-Penrose | Colorado Springs, Colorado, 80907, United States Suspended
Porter Adventist Hospital | Denver, Colorado, 80210, United States Recruiting Site Public Contact 719-776-6550 [email protected] Richard L. Deming Principal Investigator
Mercy Medical Center | Durango, Colorado, 81301, United States Suspended
Southwest Oncology PC | Durango, Colorado, 81301, United States Suspended
Saint Anthony Hospital | Lakewood, Colorado, 80228, United States Suspended
Littleton Adventist Hospital | Littleton, Colorado, 80122, United States Recruiting Site Public Contact 719-776-6550 [email protected] Richard L. Deming Principal Investigator
Longmont United Hospital | Longmont, Colorado, 80501, United States Suspended
Rocky Mountain Cancer Centers-Longmont | Longmont, Colorado, 80501, United States Suspended
Parker Adventist Hospital | Parker, Colorado, 80138, United States Recruiting Site Public Contact 719-776-6550 [email protected] Richard L. Deming Principal Investigator
Saint Mary Corwin Medical Center | Pueblo, Colorado, 81004, United States Suspended
Beebe South Coastal Health Campus | Frankford, Delaware, 19945, United States Recruiting Site Public Contact 302-645-3100 [email protected] Gregory A. Masters Principal Investigator
Beebe Medical Center | Lewes, Delaware, 19958, United States Suspended
Delaware Clinical and Laboratory Physicians PA | Newark, Delaware, 19713, United States Suspended
Helen F Graham Cancer Center | Newark, Delaware, 19713, United States Recruiting Site Public Contact 302-623-4450 [email protected]are.org Gregory A. Masters Principal Investigator
Medical Oncology Hematology Consultants PA | Newark, Delaware, 19713, United States Recruiting Site Public Contact 302-623-4450 [email protected] Gregory A. Masters Principal Investigator
Christiana Care Health System-Christiana Hospital | Newark, Delaware, 19718, United States Suspended
Beebe Health Campus | Rehoboth Beach, Delaware, 19971, United States Recruiting Site Public Contact 302-645-3100 [email protected] Gregory A. Masters Principal Investigator
TidalHealth Nanticoke / Allen Cancer Center | Seaford, Delaware, 19973, United States Suspended
Christiana Care Health System-Wilmington Hospital | Wilmington, Delaware, 19801, United States Suspended
Holy Cross Hospital | Fort Lauderdale, Florida, 33308, United States Suspended
Mayo Clinic in Florida | Jacksonville, Florida, 32224-9980, United States Suspended
Emory University Hospital/Winship Cancer Institute | Atlanta, Georgia, 30322, United States Recruiting Site Public Contact 404-778-1868 Jeffrey J. Olson Principal Investigator
Low Country Cancer Care | Savannah, Georgia, 31404, United States Suspended
Memorial Health University Medical Center | Savannah, Georgia, 31404, United States Suspended
Saint Alphonsus Cancer Care Center-Boise | Boise, Idaho, 83706, United States Recruiting Site Public Contact 734-712-3671 [email protected] John M. Schallenkamp Principal Investigator
Saint Luke's Cancer Institute - Boise | Boise, Idaho, 83712, United States Recruiting Site Public Contact 208-381-2774 [email protected] Alison K. Conlin Principal Investigator
Saint Alphonsus Cancer Care Center-Caldwell | Caldwell, Idaho, 83605, United States Recruiting Site Public Contact 734-712-3671 [email protected] John M. Schallenkamp Principal Investigator
Kootenai Health - Coeur d'Alene | Coeur d'Alene, Idaho, 83814, United States Recruiting Site Public Contact 406-969-6060 [email protected] John M. Schallenkamp Principal Investigator
Walter Knox Memorial Hospital | Emmett, Idaho, 83617, United States Suspended
Saint Luke's Cancer Institute - Fruitland | Fruitland, Idaho, 83619, United States Recruiting Site Public Contact 208-381-2774 [email protected] Alison K. Conlin Principal Investigator
Idaho Urologic Institute-Meridian | Meridian, Idaho, 83642, United States Suspended
Saint Luke's Cancer Institute - Meridian | Meridian, Idaho, 83642, United States Recruiting Site Public Contact 208-381-2774 [email protected] Alison K. Conlin Principal Investigator
Saint Alphonsus Medical Center-Nampa | Nampa, Idaho, 83686, United States Recruiting Site Public Contact 406-969-6060 [email protected] John M. Schallenkamp Principal Investigator
Saint Luke's Cancer Institute - Nampa | Nampa, Idaho, 83686, United States Recruiting Site Public Contact 208-381-2774 [email protected] Alison K. Conlin Principal Investigator
Kootenai Clinic Cancer Services - Post Falls | Post Falls, Idaho, 83854, United States Recruiting Site Public Contact 406-969-6060 [email protected] John M. Schallenkamp Principal Investigator
Kootenai Cancer Clinic | Sandpoint, Idaho, 83864, United States Recruiting Site Public Contact 406-969-6060 [email protected] John M. Schallenkamp Principal Investigator
Saint Luke's Cancer Institute - Twin Falls | Twin Falls, Idaho, 83301, United States Recruiting Site Public Contact 208-381-2774 [email protected] Alison K. Conlin Principal Investigator
Saint Anthony's Health | Alton, Illinois, 62002, United States Suspended
Rush - Copley Medical Center | Aurora, Illinois, 60504, United States Recruiting Site Public Contact 630-978-6212 [email protected] Kendrith M. Rowland Principal Investigator
Illinois CancerCare-Bloomington | Bloomington, Illinois, 61704, United States Suspended
Illinois CancerCare-Canton | Canton, Illinois, 61520, United States Suspended
Memorial Hospital of Carbondale | Carbondale, Illinois, 62902, United States Suspended
SIH Cancer Institute | Carterville, Illinois, 62918, United States Suspended
Illinois CancerCare-Carthage | Carthage, Illinois, 62321, United States Suspended
Centralia Oncology Clinic | Centralia, Illinois, 62801, United States Suspended
Northwestern University | Chicago, Illinois, 60611, United States Recruiting Site Public Contact 312-695-1301 [email protected] Priya U. Kumthekar Principal Investigator
University of Illinois | Chicago, Illinois, 60612, United States Recruiting Site Public Contact 312-355-3046 Stefania Maraka Principal Investigator
Carle on Vermilion | Danville, Illinois, 61832, United States Recruiting Site Public Contact 800-446-5532 [email protected] Kendrith M. Rowland Principal Investigator
Cancer Care Specialists of Illinois - Decatur | Decatur, Illinois, 62526, United States Recruiting Site Public Contact 217-876-4762 [email protected] Bryan A. Faller Principal Investigator
Decatur Memorial Hospital | Decatur, Illinois, 62526, United States Suspended
Illinois CancerCare-Dixon | Dixon, Illinois, 61021, United States Suspended
Carle Physician Group-Effingham | Effingham, Illinois, 62401, United States Recruiting Site Public Contact 800-446-5532 [email protected] Kendrith M. Rowland Principal Investigator
Crossroads Cancer Center | Effingham, Illinois, 62401, United States Recruiting Site Public Contact 217-876-4762 [email protected] Bryan A. Faller Principal Investigator
Illinois CancerCare-Eureka | Eureka, Illinois, 61530, United States Suspended
NorthShore University HealthSystem-Evanston Hospital | Evanston, Illinois, 60201, United States Recruiting Site Public Contact 847-570-2109 Bruce E. Brockstein Principal Investigator
Illinois CancerCare-Galesburg | Galesburg, Illinois, 61401, United States Suspended
Western Illinois Cancer Treatment Center | Galesburg, Illinois, 61401, United States Suspended
NorthShore University HealthSystem-Glenbrook Hospital | Glenview, Illinois, 60026, United States Recruiting Site Public Contact 847-570-2109 Bruce E. Brockstein Principal Investigator
NorthShore University HealthSystem-Highland Park Hospital | Highland Park, Illinois, 60035, United States Recruiting Site Public Contact 847-570-2109 Bruce E. Brockstein Principal Investigator
Illinois CancerCare-Kewanee Clinic | Kewanee, Illinois, 61443, United States Suspended
Northwestern Medicine Lake Forest Hospital | Lake Forest, Illinois, 60045, United States Active, not recruiting
Illinois CancerCare-Macomb | Macomb, Illinois, 61455, United States Suspended
Carle Physician Group-Mattoon/Charleston | Mattoon, Illinois, 61938, United States Recruiting Site Public Contact 800-446-5532 [email protected] Kendrith M. Rowland Principal Investigator
Good Samaritan Regional Health Center | Mount Vernon, Illinois, 62864, United States Suspended
Cancer Care Center of O'Fallon | O'Fallon, Illinois, 62269, United States Recruiting Site Public Contact 217-876-4762 [email protected] Bryan A. Faller Principal Investigator
Illinois CancerCare-Ottawa Clinic | Ottawa, Illinois, 61350, United States Suspended
Illinois CancerCare-Pekin | Pekin, Illinois, 61554, United States Suspended
OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center | Pekin, Illinois, 61554, United States Suspended
Illinois CancerCare-Peoria | Peoria, Illinois, 61615, United States Suspended
OSF Saint Francis Radiation Oncology at Peoria Cancer Center | Peoria, Illinois, 61615, United States Suspended
Methodist Medical Center of Illinois | Peoria, Illinois, 61636, United States Suspended
OSF Saint Francis Medical Center | Peoria, Illinois, 61637, United States Suspended
Illinois CancerCare-Peru | Peru, Illinois, 61354, United States Suspended
Valley Radiation Oncology | Peru, Illinois, 61354, United States Suspended
Illinois CancerCare-Princeton | Princeton, Illinois, 61356, United States Suspended
North Shore Medical Center | Skokie, Illinois, 60076, United States Suspended
Southern Illinois University School of Medicine | Springfield, Illinois, 62702, United States Recruiting Site Public Contact 217-545-7929 Bryan A. Faller Principal Investigator
Springfield Clinic | Springfield, Illinois, 62702, United States Recruiting Site Public Contact 800-444-7541 Bryan A. Faller Principal Investigator
Memorial Medical Center | Springfield, Illinois, 62781, United States Recruiting Site Public Contact 217-528-7541 [email protected] Bryan A. Faller Principal Investigator
Carle Cancer Center | Urbana, Illinois, 61801, United States Recruiting Site Public Contact 800-446-5532 [email protected] Kendrith M. Rowland Principal Investigator
The Carle Foundation Hospital | Urbana, Illinois, 61801, United States Suspended
Illinois CancerCare - Washington | Washington, Illinois, 61571, United States Suspended
Rush-Copley Healthcare Center | Yorkville, Illinois, 60560, United States Suspended
Baptist Health Floyd | New Albany, Indiana, 47150, United States Suspended
Mary Greeley Medical Center | Ames, Iowa, 50010, United States Recruiting Site Public Contact 515-956-4132 Debra M. Prow Principal Investigator
McFarland Clinic PC - Ames | Ames, Iowa, 50010, United States Recruiting Site Public Contact 515-239-4734 [email protected] Debra M. Prow Principal Investigator
McFarland Clinic PC-Boone | Boone, Iowa, 50036, United States Recruiting Site Public Contact 515-956-4132 Debra M. Prow Principal Investigator
Saint Anthony Regional Hospital | Carroll, Iowa, 51401, United States Active, not recruiting
Medical Oncology and Hematology Associates-West Des Moines | Clive, Iowa, 50325, United States Suspended
Mercy Cancer Center-West Lakes | Clive, Iowa, 50325, United States Suspended
Alegent Health Mercy Hospital | Council Bluffs, Iowa, 51503, United States Suspended
Greater Regional Medical Center | Creston, Iowa, 50801, United States Suspended
Iowa Methodist Medical Center | Des Moines, Iowa, 50309, United States Active, not recruiting
Medical Oncology and Hematology Associates-Des Moines | Des Moines, Iowa, 50309, United States Active, not recruiting
Broadlawns Medical Center | Des Moines, Iowa, 50314, United States Active, not recruiting
Medical Oncology and Hematology Associates-Laurel | Des Moines, Iowa, 50314, United States Suspended
Mercy Medical Center - Des Moines | Des Moines, Iowa, 50314, United States Recruiting Site Public Contact 515-643-2196 [email protected] Richard L. Deming Principal Investigator
Iowa Lutheran Hospital | Des Moines, Iowa, 50316, United States Active, not recruiting
McFarland Clinic PC-Trinity Cancer Center | Fort Dodge, Iowa, 50501, United States Recruiting Site Public Contact 515-956-4132 Debra M. Prow Principal Investigator
Trinity Regional Medical Center | Fort Dodge, Iowa, 50501, United States Active, not recruiting
McFarland Clinic PC-Jefferson | Jefferson, Iowa, 50129, United States Recruiting Site Public Contact 515-956-4132 Debra M. Prow Principal Investigator
McFarland Clinic PC-Marshalltown | Marshalltown, Iowa, 50158, United States Recruiting Site Public Contact 515-956-4132 Debra M. Prow Principal Investigator
Methodist West Hospital | West Des Moines, Iowa, 50266-7700, United States Active, not recruiting
Mercy Medical Center-West Lakes | West Des Moines, Iowa, 50266, United States Suspended
Cancer Center of Kansas - Chanute | Chanute, Kansas, 66720, United States Suspended
Cancer Center of Kansas - Dodge City | Dodge City, Kansas, 67801, United States Suspended
Cancer Center of Kansas - El Dorado | El Dorado, Kansas, 67042, United States Suspended
Central Care Cancer Center - Garden City | Garden City, Kansas, 67846, United States Suspended
Central Care Cancer Center - Great Bend | Great Bend, Kansas, 67530, United States Suspended
Cancer Center of Kansas-Independence | Independence, Kansas, 67301, United States Suspended
Cancer Center of Kansas-Kingman | Kingman, Kansas, 67068, United States Suspended
Cancer Center of Kansas-Liberal | Liberal, Kansas, 67905, United States Suspended
Cancer Center of Kansas-Manhattan | Manhattan, Kansas, 66502, United States Suspended
Cancer Center of Kansas - McPherson | McPherson, Kansas, 67460, United States Suspended
Cancer Center of Kansas - Newton | Newton, Kansas, 67114, United States Suspended
Cancer Center of Kansas - Parsons | Parsons, Kansas, 67357, United States Suspended
Cancer Center of Kansas - Pratt | Pratt, Kansas, 67124, United States Suspended
Cancer Center of Kansas - Salina | Salina, Kansas, 67401, United States Suspended
Cancer Center of Kansas - Wellington | Wellington, Kansas, 67152, United States Suspended
Cancer Center of Kansas-Wichita Medical Arts Tower | Wichita, Kansas, 67208, United States Suspended
Ascension Via Christi Hospitals Wichita | Wichita, Kansas, 67214, United States Suspended
Cancer Center of Kansas - Wichita | Wichita, Kansas, 67214, United States Suspended
Cancer Center of Kansas - Winfield | Winfield, Kansas, 67156, United States Suspended
Flaget Memorial Hospital | Bardstown, Kentucky, 40004, United States Suspended
Commonwealth Cancer Center-Corbin | Corbin, Kentucky, 40701, United States Suspended
Baptist Health Lexington | Lexington, Kentucky, 40503, United States Recruiting Site Public Contact 859-260-6425 Arvinda Padmanabhan Principal Investigator
Saint Joseph Radiation Oncology Resource Center | Lexington, Kentucky, 40504, United States Suspended
Saint Joseph Hospital East | Lexington, Kentucky, 40509, United States Suspended
Saint Joseph London | London, Kentucky, 40741, United States Suspended
Jewish Hospital | Louisville, Kentucky, 40202, United States Suspended
Saints Mary and Elizabeth Hospital | Louisville, Kentucky, 40215, United States Suspended
Jewish Hospital Medical Center Northeast | Louisville, Kentucky, 40245, United States Suspended
Jewish Hospital Medical Center South | Shepherdsville, Kentucky, 40165, United States Suspended
Saint Joseph Mercy Hospital | Ann Arbor, Michigan, 48106, United States Recruiting Site Public Contact 734-712-7251 [email protected] Philip J. Stella Principal Investigator
Bronson Battle Creek | Battle Creek, Michigan, 49017, United States Recruiting Site Public Contact 616-391-1230 [email protected] Kathleen J. Yost Principal Investigator
IHA Hematology Oncology Consultants-Brighton | Brighton, Michigan, 48114, United States Recruiting Site Public Contact 734-712-7251 [email protected] Philip J. Stella Principal Investigator
Saint Joseph Mercy Brighton | Brighton, Michigan, 48114, United States Recruiting Site Public Contact 734-712-7251 [email protected] Philip J. Stella Principal Investigator
IHA Hematology Oncology Consultants-Canton | Canton, Michigan, 48188, United States Recruiting Site Public Contact 734-712-7251 [email protected] Philip J. Stella Principal Investigator
Saint Joseph Mercy Canton | Canton, Michigan, 48188, United States Recruiting Site Public Contact 734-712-7251 [email protected] Philip J. Stella Principal Investigator
Caro Cancer Center | Caro, Michigan, 48723, United States Suspended
IHA Hematology Oncology Consultants-Chelsea | Chelsea, Michigan, 48118, United States Recruiting Site Public Contact 734-712-7251 [email protected] Philip J. Stella Principal Investigator
Saint Joseph Mercy Chelsea | Chelsea, Michigan, 48118, United States Recruiting Site Public Contact 734-712-7251 [email protected] Philip J. Stella Principal Investigator
Hematology Oncology Consultants-Clarkston | Clarkston, Michigan, 48346, United States Suspended
Newland Medical Associates-Clarkston | Clarkston, Michigan, 48346, United States Suspended
Ascension Saint John Hospital | Detroit, Michigan, 48236, United States Suspended
Great Lakes Cancer Management Specialists-Doctors Park | East China Township, Michigan, 48054, United States Suspended
Genesee Cancer and Blood Disease Treatment Center | Flint, Michigan, 48503, United States Recruiting Site Public Contact 810-762-8038 [email protected] Philip J. Stella Principal Investigator
Genesee Hematology Oncology PC | Flint, Michigan, 48503, United States Recruiting Site Public Contact 810-762-8038 [email protected] Philip J. Stella Principal Investigator
Genesys Hurley Cancer Institute | Flint, Michigan, 48503, United States Recruiting Site Public Contact 810-762-8038 [email protected] Philip J. Stella Principal Investigator
Hurley Medical Center | Flint, Michigan, 48503, United States Recruiting Site Public Contact 810-762-8038 [email protected] Philip J. Stella Principal Investigator
Helen DeVos Children's Hospital at Spectrum Health | Grand Rapids, Michigan, 49503, United States Suspended
Mercy Health Saint Mary's | Grand Rapids, Michigan, 49503, United States Recruiting Site Public Contact 616-391-1230 [email protected] Kathleen J. Yost Principal Investigator
Spectrum Health at Butterworth Campus | Grand Rapids, Michigan, 49503, United States Recruiting Site Public Contact 616-391-1230 [email protected] Kathleen J. Yost Principal Investigator
Academic Hematology Oncology Specialists | Grosse Pointe Woods, Michigan, 48236, United States Suspended
Great Lakes Cancer Management Specialists-Van Elslander Cancer Center | Grosse Pointe Woods, Michigan, 48236, United States Suspended
Michigan Breast Specialists-Grosse Pointe Woods | Grosse Pointe Woods, Michigan, 48236, United States Suspended
Bronson Methodist Hospital | Kalamazoo, Michigan, 49007, United States Recruiting Site Public Contact 616-391-1230 [email protected] Kathleen J. Yost Principal Investigator
West Michigan Cancer Center | Kalamazoo, Michigan, 49007, United States Recruiting Site Public Contact 616-391-1230 [email protected] Kathleen J. Yost Principal Investigator
Ascension Borgess Cancer Center | Kalamazoo, Michigan, 49009, United States Recruiting Site Public Contact 616-391-1230 [email protected] Kathleen J. Yost Principal Investigator
Borgess Medical Center | Kalamazoo, Michigan, 49048, United States Suspended
Sparrow Hospital | Lansing, Michigan, 48912, United States Suspended
Hope Cancer Clinic | Livonia, Michigan, 48154, United States Suspended
Saint Mary Mercy Hospital | Livonia, Michigan, 48154, United States Recruiting Site Public Contact 734-712-7251 [email protected] Philip J. Stella Principal Investigator
Great Lakes Cancer Management Specialists-Macomb Medical Campus | Macomb, Michigan, 48044, United States Suspended
Michigan Breast Specialists-Macomb Township | Macomb, Michigan, 48044, United States Suspended
Saint Mary's Oncology/Hematology Associates of Marlette | Marlette, Michigan, 48453, United States Suspended
Mercy Health Mercy Campus | Muskegon, Michigan, 49444, United States Recruiting Site Public Contact 616-391-1230 [email protected] Kathleen J. Yost Principal Investigator
Lakeland Hospital Niles | Niles, Michigan, 49120, United States Suspended
Cancer and Hematology Centers of Western Michigan - Norton Shores | Norton Shores, Michigan, 49444, United States Recruiting Site Public Contact 616-391-1230 [email protected] Kathleen J. Yost Principal Investigator
21st Century Oncology-Pontiac | Pontiac, Michigan, 48341, United States Suspended
Hope Cancer Center | Pontiac, Michigan, 48341, United States Suspended
Newland Medical Associates-Pontiac | Pontiac, Michigan, 48341, United States Suspended
Saint Joseph Mercy Oakland | Pontiac, Michigan, 48341, United States Suspended
Spectrum Health Reed City Hospital | Reed City, Michigan, 49677, United States Suspended
Great Lakes Cancer Management Specialists-Rochester Hills | Rochester Hills, Michigan, 48309, United States Suspended
Ascension Saint Mary's Hospital | Saginaw, Michigan, 48601, United States Recruiting Site Public Contact 989-907-8411 [email protected] Philip J. Stella Principal Investigator
Oncology Hematology Associates of Saginaw Valley PC | Saginaw, Michigan, 48604, United States Recruiting Site Public Contact 989-907-8411 [email protected] Philip J. Stella Principal Investigator
Lakeland Medical Center Saint Joseph | Saint Joseph, Michigan, 49085, United States Suspended
Marie Yeager Cancer Center | Saint Joseph, Michigan, 49085, United States Recruiting Site Public Contact 616-391-1230 [email protected] Kathleen J. Yost Principal Investigator
Bhadresh Nayak MD PC-Sterling Heights | Sterling Heights, Michigan, 48312, United States Suspended
Ascension Saint Joseph Hospital | Tawas City, Michigan, 48764, United States Recruiting Site Public Contact 989-907-8411 [email protected] Philip J. Stella Principal Investigator
Munson Medical Center | Traverse City, Michigan, 49684, United States Suspended
Advanced Breast Care Center PLLC | Warren, Michigan, 48088, United States Suspended
Great Lakes Cancer Management Specialists-Macomb Professional Building | Warren, Michigan, 48093, United States Suspended
Macomb Hematology Oncology PC | Warren, Michigan, 48093, United States Suspended
Michigan Breast Specialists-Warren | Warren, Michigan, 48093, United States Suspended
Saint John Macomb-Oakland Hospital | Warren, Michigan, 48093, United States Suspended
Saint Mary's Oncology/Hematology Associates of West Branch | West Branch, Michigan, 48661, United States Recruiting Site Public Contact 989-907-8411 [email protected] Philip J. Stella Principal Investigator
Metro Health Hospital | Wyoming, Michigan, 49519, United States Recruiting Site Public Contact 616-391-1230 [email protected] Kathleen J. Yost Principal Investigator
Huron Gastroenterology PC | Ypsilanti, Michigan, 48106, United States Recruiting Site Public Contact 734-712-7251 [email protected] Philip J. Stella Principal Investigator
IHA Hematology Oncology Consultants-Ann Arbor | Ypsilanti, Michigan, 48197, United States Recruiting Site Public Contact 734-712-7251 [email protected] Philip J. Stella Principal Investigator
Sanford Joe Lueken Cancer Center | Bemidji, Minnesota, 56601, United States Recruiting Site Public Contact 218-333-5000 [email protected] Preston D. Steen Principal Investigator
Fairview Ridges Hospital | Burnsville, Minnesota, 55337, United States Suspended
Minnesota Oncology - Burnsville | Burnsville, Minnesota, 55337, United States Suspended
Cambridge Medical Center | Cambridge, Minnesota, 55008, United States Suspended
Mercy Hospital | Coon Rapids, Minnesota, 55433, United States Suspended
Fairview Southdale Hospital | Edina, Minnesota, 55435, United States Suspended
Unity Hospital | Fridley, Minnesota, 55432, United States Suspended
Fairview Clinics and Surgery Center Maple Grove | Maple Grove, Minnesota, 55369, United States Suspended
Minnesota Oncology Hematology PA-Maplewood | Maplewood, Minnesota, 55109, United States Suspended
Saint John's Hospital - Healtheast | Maplewood, Minnesota, 55109, United States Recruiting Site Public Contact 952-993-1517 [email protected] Daniel M. Anderson Principal Investigator
Abbott-Northwestern Hospital | Minneapolis, Minnesota, 55407, United States Suspended
Hennepin County Medical Center | Minneapolis, Minnesota, 55415, United States Recruiting Site Public Contact 952-993-1517 [email protected] Daniel M. Anderson Principal Investigator
Health Partners Inc | Minneapolis, Minnesota, 55454, United States Suspended
Monticello Cancer Center | Monticello, Minnesota, 55362, United States Suspended
New Ulm Medical Center | New Ulm, Minnesota, 56073, United States Suspended
Fairview Northland Medical Center | Princeton, Minnesota, 55371, United States Suspended
North Memorial Medical Health Center | Robbinsdale, Minnesota, 55422, United States Suspended
Mayo Clinic in Rochester | Rochester, Minnesota, 55905, United States Recruiting Site Public Contact 855-776-0015 Sani H. Kizilbash Principal Investigator
Coborn Cancer Center at Saint Cloud Hospital | Saint Cloud, Minnesota, 56303, United States Recruiting Site Public Contact 877-229-4907 [email protected] Donald J. Jurgens Principal Investigator
Park Nicollet Clinic - Saint Louis Park | Saint Louis Park, Minnesota, 55416, United States Recruiting Site Public Contact 952-993-1517 [email protected] Daniel M. Anderson Principal Investigator
Regions Hospital | Saint Paul, Minnesota, 55101, United States Recruiting Site Public Contact 952-993-1517 [email protected] Daniel M. Anderson Principal Investigator
United Hospital | Saint Paul, Minnesota, 55102, United States Suspended
Saint Francis Regional Medical Center | Shakopee, Minnesota, 55379, United States Suspended
Lakeview Hospital | Stillwater, Minnesota, 55082, United States Suspended
Sanford Thief River Falls Medical Center | Thief River Falls, Minnesota, 56701, United States Suspended
Ridgeview Medical Center | Waconia, Minnesota, 55387, United States Suspended
Rice Memorial Hospital | Willmar, Minnesota, 56201, United States Suspended
Minnesota Oncology Hematology PA-Woodbury | Woodbury, Minnesota, 55125, United States Suspended
Sanford Cancer Center Worthington | Worthington, Minnesota, 56187, United States Suspended
Fairview Lakes Medical Center | Wyoming, Minnesota, 55092, United States Suspended
Saint Louis Cancer and Breast Institute-Ballwin | Ballwin, Missouri, 63011, United States Suspended
Central Care Cancer Center - Bolivar | Bolivar, Missouri, 65613, United States Suspended
Saint Francis Medical Center | Cape Girardeau, Missouri, 63703, United States Suspended
Southeast Cancer Center | Cape Girardeau, Missouri, 63703, United States Suspended
Siteman Cancer Center at West County Hospital | Creve Coeur, Missouri, 63141, United States Recruiting Site Public Contact 800-600-3606 [email protected] Tanner M. Johanns Principal Investigator
Parkland Health Center - Farmington | Farmington, Missouri, 63640, United States Active, not recruiting
Capital Region Southwest Campus | Jefferson City, Missouri, 65109, United States Suspended
Freeman Health System | Joplin, Missouri, 64804, United States Suspended
Mercy Hospital Joplin | Joplin, Missouri, 64804, United States Suspended
Delbert Day Cancer Institute at PCRMC | Rolla, Missouri, 65401, United States Suspended
Mercy Clinic-Rolla-Cancer and Hematology | Rolla, Missouri, 65401, United States Suspended
Heartland Regional Medical Center | Saint Joseph, Missouri, 64506, United States Suspended
Saint Louis Cancer and Breast Institute-South City | Saint Louis, Missouri, 63109, United States Suspended
Washington University School of Medicine | Saint Louis, Missouri, 63110, United States Recruiting Site Public Contact 800-600-3606 [email protected] Tanner M. Johanns Principal Investigator
Mercy Hospital South | Saint Louis, Missouri, 63128, United States Suspended
Missouri Baptist Medical Center | Saint Louis, Missouri, 63131, United States Suspended
Mercy Hospital Saint Louis | Saint Louis, Missouri, 63141, United States Recruiting Site Public Contact 314-251-7066 Jay W. Carlson Principal Investigator
Sainte Genevieve County Memorial Hospital | Sainte Genevieve, Missouri, 63670, United States Suspended
Mercy Hospital Springfield | Springfield, Missouri, 65804, United States Suspended
CoxHealth South Hospital | Springfield, Missouri, 65807, United States Recruiting Site Public Contact 417-269-4520 Jay W. Carlson Principal Investigator
Missouri Baptist Sullivan Hospital | Sullivan, Missouri, 63080, United States Suspended
Missouri Baptist Outpatient Center-Sunset Hills | Sunset Hills, Missouri, 63127, United States Suspended
Mercy Hospital Washington | Washington, Missouri, 63090, United States Suspended
Community Hospital of Anaconda | Anaconda, Montana, 59711, United States Recruiting Site Public Contact 406-969-6060 [email protected] John M. Schallenkamp Principal Investigator
Billings Clinic Cancer Center | Billings, Montana, 59101, United States Recruiting Site Public Contact 800-996-2663 [email protected] John M. Schallenkamp Principal Investigator
Bozeman Deaconess Hospital | Bozeman, Montana, 59715, United States Recruiting Site Public Contact 406-969-6060 [email protected] John M. Schallenkamp Principal Investigator
Benefis Healthcare- Sletten Cancer Institute | Great Falls, Montana, 59405, United States Recruiting Site Public Contact 406-969-6060 [email protected] John M. Schallenkamp Principal Investigator
Great Falls Clinic | Great Falls, Montana, 59405, United States Suspended
Kalispell Regional Medical Center | Kalispell, Montana, 59901, United States Recruiting Site Public Contact 406-969-6060 [email protected] John M. Schallenkamp Principal Investigator
Saint Patrick Hospital - Community Hospital | Missoula, Montana, 59802, United States Suspended
Community Medical Hospital | Missoula, Montana, 59804, United States Recruiting Site Public Contact 406-969-6060 [email protected] John M. Schallenkamp Principal Investigator
CHI Health Saint Francis | Grand Island, Nebraska, 68803, United States Suspended
CHI Health Good Samaritan | Kearney, Nebraska, 68847, United States Suspended
Saint Elizabeth Regional Medical Center | Lincoln, Nebraska, 68510, United States Suspended
Cancer Partners of Nebraska - Pine Lake | Lincoln, Nebraska, 68516, United States Recruiting Site Public Contact 402-327-7363 [email protected] Joni A. Tilford Principal Investigator
Southeast Nebraska Cancer Center - 68th Street Place | Lincoln, Nebraska, 68516, United States Recruiting Site Public Contact 402-327-7363 [email protected] Joni A. Tilford Principal Investigator
Alegent Health Immanuel Medical Center | Omaha, Nebraska, 68122, United States Suspended
Alegent Health Bergan Mercy Medical Center | Omaha, Nebraska, 68124, United States Suspended
Alegent Health Lakeside Hospital | Omaha, Nebraska, 68130, United States Suspended
Creighton University Medical Center | Omaha, Nebraska, 68131, United States Suspended
Midlands Community Hospital | Papillion, Nebraska, 68046, United States Suspended
Dartmouth Hitchcock Medical Center | Lebanon, New Hampshire, 03756, United States Recruiting Site Public Contact 800-639-6918 [email protected] Amy M. Chan Principal Investigator
Morristown Medical Center | Morristown, New Jersey, 07960, United States Suspended
Capital Health Medical Center-Hopewell | Pennington, New Jersey, 08534, United States Recruiting Site Public Contact 609-394-4130 [email protected] Navid Redjal Principal Investigator
Overlook Hospital | Summit, New Jersey, 07902, United States Recruiting Site Public Contact 908-522-2043 Robert D. Aiken Principal Investigator
Randolph Hospital | Asheboro, North Carolina, 27203, United States Suspended
Messino Cancer Centers | Asheville, North Carolina, 28806, United States Active, not recruiting
Cone Health Cancer Center at Alamance Regional | Burlington, North Carolina, 27215, United States Recruiting Site Public Contact 336-538-7725 [email protected] Vinay K. Gudena Principal Investigator
Cone Health Cancer Center | Greensboro, North Carolina, 27403, United States Recruiting Site Public Contact 336-832-0821 [email protected] Vinay K. Gudena Principal Investigator
Vidant Medical Center | Greenville, North Carolina, 27834, United States Recruiting Site Public Contact 252-744-2391 Jasmin Jo Principal Investigator
Cone Heath Cancer Center at Mebane | Mebane, North Carolina, 27302, United States Suspended
Sanford Bismarck Medical Center | Bismarck, North Dakota, 58501, United States Recruiting Site Public Contact 701-323-5760 [email protected] Preston D. Steen Principal Investigator
Sanford South University Medical Center | Fargo, North Dakota, 58103, United States Suspended
Southpointe-Sanford Medical Center Fargo | Fargo, North Dakota, 58103, United States Suspended
Sanford Medical Center Fargo | Fargo, North Dakota, 58104, United States Suspended
Sanford Broadway Medical Center | Fargo, North Dakota, 58122, United States Recruiting Site Public Contact 701-323-5760 [email protected] Preston D. Steen Principal Investigator
Sanford Roger Maris Cancer Center | Fargo, North Dakota, 58122, United States Recruiting Site Public Contact 701-234-6161 [email protected] Preston D. Steen Principal Investigator
University of Cincinnati Cancer Center-UC Medical Center | Cincinnati, Ohio, 45219, United States Recruiting Site Public Contact 513-584-7698 [email protected] Soma Sengupta Principal Investigator
Good Samaritan Hospital - Cincinnati | Cincinnati, Ohio, 45220, United States Suspended
Bethesda North Hospital | Cincinnati, Ohio, 45242, United States Suspended
TriHealth Cancer Institute-Westside | Cincinnati, Ohio, 45247, United States Suspended
TriHealth Cancer Institute-Anderson | Cincinnati, Ohio, 45255, United States Suspended
University of Cincinnati Cancer Center-West Chester | West Chester, Ohio, 45069, United States Recruiting Site Public Contact 513-584-7698 [email protected] Soma Sengupta Principal Investigator
University of Oklahoma Health Sciences Center | Oklahoma City, Oklahoma, 73104, United States Suspended
Mercy Hospital Oklahoma City | Oklahoma City, Oklahoma, 73120, United States Suspended
Saint Alphonsus Medical Center-Baker City | Baker City, Oregon, 97814, United States Suspended
Saint Charles Health System | Bend, Oregon, 97701, United States Suspended
Clackamas Radiation Oncology Center | Clackamas, Oregon, 97015, United States Suspended
Providence Cancer Institute Clackamas Clinic | Clackamas, Oregon, 97015, United States Recruiting Site Public Contact 503-215-2614 [email protected] Alison K. Conlin Principal Investigator
Bay Area Hospital | Coos Bay, Oregon, 97420, United States Suspended
Providence Newberg Medical Center | Newberg, Oregon, 97132, United States Recruiting Site Public Contact 503-215-2614 [email protected] Alison K. Conlin Principal Investigator
Saint Alphonsus Medical Center-Ontario | Ontario, Oregon, 97914, United States Recruiting Site Public Contact 406-969-6060 [email protected] John M. Schallenkamp Principal Investigator
Providence Portland Medical Center | Portland, Oregon, 97213, United States Recruiting Site Public Contact 503-215-2614 [email protected] Alison K. Conlin Principal Investigator
Providence Saint Vincent Medical Center | Portland, Oregon, 97225, United States Recruiting Site Public Contact 503-215-2614 [email protected] Alison K. Conlin Principal Investigator
Saint Charles Health System-Redmond | Redmond, Oregon, 97756, United States Suspended
Lehigh Valley Hospital-Cedar Crest | Allentown, Pennsylvania, 18103, United States Recruiting Site Public Contact 610-402-9543 [email protected] Philip J. Stella Principal Investigator
Lehigh Valley Hospital - Muhlenberg | Bethlehem, Pennsylvania, 18017, United States Recruiting Site Public Contact 610-402-9543 [email protected] Philip J. Stella Principal Investigator
Christiana Care Health System-Concord Health Center | Chadds Ford, Pennsylvania, 19317, United States Suspended
Pocono Medical Center | East Stroudsburg, Pennsylvania, 18301, United States Suspended
Lehigh Valley Hospital-Hazleton | Hazleton, Pennsylvania, 18201, United States Suspended
University of Pittsburgh Cancer Institute (UPCI) | Pittsburgh, Pennsylvania, 15232, United States Recruiting Site Public Contact 412-647-8073 Megan Mantica Principal Investigator
Sanford Cancer Center Oncology Clinic | Sioux Falls, South Dakota, 57104, United States Recruiting Site Public Contact 605-312-3320 [email protected] Preston D. Steen Principal Investigator
Sanford USD Medical Center - Sioux Falls | Sioux Falls, South Dakota, 57117-5134, United States Recruiting Site Public Contact 605-312-3320 [email protected] Preston D. Steen Principal Investigator
Saint Joseph Regional Cancer Center | Bryan, Texas, 77802, United States Suspended
Parkland Memorial Hospital | Dallas, Texas, 75235, United States Recruiting Site Public Contact 214-590-5582 [email protected] Michael Youssef Principal Investigator
UT Southwestern/Simmons Cancer Center-Dallas | Dallas, Texas, 75390, United States Recruiting Site Public Contact 214-648-7097 [email protected] Michael Youssef Principal Investigator
Huntsman Cancer Institute/University of Utah | Salt Lake City, Utah, 84112, United States Active, not recruiting
Inova Schar Cancer Institute | Fairfax, Virginia, 22031, United States Recruiting Site Public Contact 703-720-5210 [email protected] Adam L. Cohen Principal Investigator
Inova Fairfax Hospital | Falls Church, Virginia, 22042, United States Recruiting Site Public Contact 703-208-6650 [email protected] Adam L. Cohen Principal Investigator
Providence Regional Cancer System-Aberdeen | Aberdeen, Washington, 98520, United States Suspended
PeaceHealth Saint Joseph Medical Center | Bellingham, Washington, 98225, United States Suspended
Harrison HealthPartners Hematology and Oncology-Bremerton | Bremerton, Washington, 98310, United States Recruiting Site Public Contact 308-398-6518 [email protected] Richard L. Deming Principal Investigator
Harrison Medical Center | Bremerton, Washington, 98310, United States Suspended
Highline Medical Center-Main Campus | Burien, Washington, 98166, United States Suspended
Providence Regional Cancer System-Centralia | Centralia, Washington, 98531, United States Suspended
Swedish Cancer Institute-Edmonds | Edmonds, Washington, 98026, United States Suspended
Saint Elizabeth Hospital | Enumclaw, Washington, 98022, United States Suspended
Providence Regional Cancer Partnership | Everett, Washington, 98201, United States Suspended
Saint Francis Hospital | Federal Way, Washington, 98003, United States Suspended
Swedish Cancer Institute-Issaquah | Issaquah, Washington, 98029, United States Suspended
Kadlec Clinic Hematology and Oncology | Kennewick, Washington, 99336, United States Recruiting Site Public Contact 509-783-4637 [email protected] Alison K. Conlin Principal Investigator
Providence Regional Cancer System-Lacey | Lacey, Washington, 98503, United States Suspended
Saint Clare Hospital | Lakewood, Washington, 98499, United States Suspended
PeaceHealth Saint John Medical Center | Longview, Washington, 98632, United States Suspended
Harrison HealthPartners Hematology and Oncology-Poulsbo | Poulsbo, Washington, 98370, United States Suspended
Pacific Gynecology Specialists | Seattle, Washington, 98104, United States Suspended
Swedish Medical Center-Ballard Campus | Seattle, Washington, 98107, United States Suspended
Swedish Medical Center-First Hill | Seattle, Washington, 98122-4307, United States Suspended
Swedish Medical Center-Cherry Hill | Seattle, Washington, 98122-5711, United States Suspended
PeaceHealth United General Medical Center | Sedro-Woolley, Washington, 98284, United States Suspended
Providence Regional Cancer System-Shelton | Shelton, Washington, 98584, United States Suspended
Franciscan Research Center-Northwest Medical Plaza | Tacoma, Washington, 98405, United States Suspended
Northwest Medical Specialties PLLC | Tacoma, Washington, 98405, United States Suspended
PeaceHealth Southwest Medical Center | Vancouver, Washington, 98664, United States Recruiting Site Public Contact 360-514-3940 [email protected] Alison K. Conlin Principal Investigator
Providence Saint Mary Regional Cancer Center | Walla Walla, Washington, 99362, United States Suspended
Providence Regional Cancer System-Yelm | Yelm, Washington, 98597, United States Suspended
United Hospital Center | Bridgeport, West Virginia, 26330, United States Suspended
WVUH-Berkely Medical Center | Martinsburg, West Virginia, 25401, United States Suspended
West Virginia University Healthcare | Morgantown, West Virginia, 26506, United States Recruiting Site Public Contact 304-293-7374 [email protected] Sonikpreet Aulakh Principal Investigator
Camden Clark Medical Center | Parkersburg, West Virginia, 26101, United States Suspended
Mayo Clinic Health System-Eau Claire Clinic | Eau Claire, Wisconsin, 54701, United States Recruiting Site Public Contact 855-776-0015 Sani H. Kizilbash Principal Investigator
Gundersen Lutheran Medical Center | La Crosse, Wisconsin, 54601, United States Recruiting Site Public Contact 608-775-2385 [email protected] Michael O. Ojelabi Principal Investigator
Mayo Clinic Health System-Franciscan Healthcare | La Crosse, Wisconsin, 54601, United States Recruiting Site Public Contact 855-776-0015 Sani H. Kizilbash Principal Investigator
ProHealth D N Greenwald Center | Mukwonago, Wisconsin, 53149, United States Recruiting Site Public Contact [email protected] Timothy R. Wassenaar Principal Investigator
Cancer Center of Western Wisconsin | New Richmond, Wisconsin, 54017, United States Suspended
ProHealth Oconomowoc Memorial Hospital | Oconomowoc, Wisconsin, 53066, United States Recruiting Site Public Contact 262-928-7878 Timothy R. Wassenaar Principal Investigator
ProHealth Waukesha Memorial Hospital | Waukesha, Wisconsin, 53188, United States Recruiting Site Public Contact 262-928-7632 Timothy R. Wassenaar Principal Investigator
UW Cancer Center at ProHealth Care | Waukesha, Wisconsin, 53188, United States Recruiting Site Public Contact 262-928-5539 [email protected] Timothy R. Wassenaar Principal Investigator
Billings Clinic-Cody | Cody, Wyoming, 82414, United States Suspended
Welch Cancer Center | Sheridan, Wyoming, 82801, United States Suspended
Pan American Center for Oncology Trials LLC | San Juan, 00902, Puerto Rico Recruiting Site Public Contact 787-407-3333 [email protected] Marcia R. Cruz-Correa Principal Investigator
Location Countries

Puerto Rico

United States

Verification Date

2021-12-01

Responsible Party

Type: Sponsor

Has Expanded Access No
Condition Browse
Number Of Arms 1
Arm Group

Label: Treatment (nivolumab, ipilimumab)

Type: Experimental

Description: Patients receive nivolumab IV over 30 minutes and ipilimumab IV over 30 minutes on day 1. Treatment repeats every 3 weeks for 4 cycles in the absence of disease progression or unacceptable toxicity. Patients then receive nivolumab IV over 30 minutes on day 1. Cycles repeat every 4 weeks in the absence of disease progression or unacceptable toxicity.

Patient Data Yes
Study Design Info

Allocation: N/A

Intervention Model: Single Group Assignment

Primary Purpose: Treatment

Masking: None (Open Label)

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact [email protected]. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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