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En studie som tester effekten av immunterapi (Ipilimumab og Nivolumab) hos pasienter med tilbakevendende glioblastom med forhøyet mutasjonsbyrde

En fase II -studie av sjekkblokkade immunterapi hos pasienter med somatisk hypermutert tilbakevendende glioblastom

Sponsorer

Hovedsponsor: National Cancer Institute (NCI)

Kilde National Cancer Institute (NCI)
Kort oppsummering

Denne fasen II -studien studerer effekten av immunterapimedisiner (ipilimumab og nivolumab) i behandling av pasienter med glioblastom som har kommet tilbake (tilbakevendende) og har et høyt antall av mutasjoner. Kreft er forårsaket av endringer (mutasjoner) i genererer som styrer våre celler funksjon. Svulster med stort antall mutasjoner kan reagere godt på immunterapi. Immunterapi med monoklonale antistoffer som ipilimumab og nivolumab kan hjelpe kroppen immunsystemet angriper kreften og kan forstyrre tumorcellers evne til å vokse og spre. Å gi ipilimumab og nivolumab kan følge sjansen for tilbakevendende glioblastom med mange mutasjoner fra å vokse eller spre seg sammenligne med vanlig pleie (kirurgi eller cellegift).

Detaljert beskrivelse

HOVEDMÅL: I. For å avgjøre om kombinasjonen av ipilimumab og nivolumab øker svulsten svarprosent rangert av modifisert responsmord i nevro-onkologi (RANO) Kriterier i pasienter med hypermutert tilbakevendende glioblastom. SEKUNDÆRE MÅL: I. Anslå den totale overlevelsesfordelingen, median overlevelse og ett års overlevelsesrate på pasienter med hypermutert, tilbakevendende glioblastom som behandles med ipilimumab og nivolumab. II. Estimere progresjonsfri overlevelsesfordeling og median progresjonsfri overlevelse av pasienter med hypermutert, tilbakevendende glioblastom som behandles med ipilimumab og nivolumab. III. Bestem bivirkningsprofilen til pasienter med hypermutert, tilbakevendende glioblastom som behandles med ipilimumab og nivolumab. UTFORSIKTIGE MÅL: I. Test om PD-L1 eller immunologisk infiltrat i tumormikromiljøet er assosiert med objektiv tumorrespons, total overlevelse, progresjonsfri overlevelse, tumor mutasjon belastning, eller satser på grad 3 eller høyere bivirkninger. II. Test om MGMT -status, microsatellitt -ustabilitet (MSI) -status, mutasjonssignaturer, eller mengde tumor mutasjonsbyrde (TMB) komponenter kimlinjeanalyse er assosiert med objektiv tumorrespons, total overlevelse, progresjonsfri overlevelse eller grad 3 eller høyere bivirkninger. III. Vurder assosiasjoner mellom eksome og transkriptome gennivåer med objektiv svulst respons, total overlevelse, progresjonsfri overlevelse, grad 3 eller høyere negative arrangementer. IV. Vurder assosiasjoner mellom tarmmikrobiomet og objektiv tumorrespons. V. Responsrate ved bruk av immunterapi (i) RANO. OUTLINE: Pasienter får nivolumab intravenøst ​​(IV) i løpet av 30 minutter og ipilimumab IV over 30 minutter på dag 1. Behandlingen gjentas hver tredje uke i 4 sykluser uten sykdom progresjon eller uakseptabel toksisitet. Pasienter får lengre nivå på 30 minutter dag 1. Sykluser gjentas hver fjerde uke i mangel av sykdomsprogresjon eller uakseptabelt gavighet. Etter fullført studiebehandling blir pasienter uten sykdomsprogresjon fulgt hver 8 uker til sykdomsprogresjon, bruker hver tredje måned i 3 år. Pasienter med sykdomsprogresjon etter avsluttet studiebehandling følges hver tredje måned jeg har 3 år.

Samlet status Rekruttering
Startdato 2020-10-30
Fullføringsdato 2023-05-31
Primær sluttdato 2023-05-31
Fase Fase 2
Studietype Intervensjonell
Primært utfall
Måle Tidsramme
Totalt svarprosent Opptil 32 måneder
Sekundært utfall
Måle Tidsramme
Overall survival (OS) From the time of treatment initiation until death from any cause, assessed up to 3 years
Progressjonsfri overlevelse (PFS) Fra behandlingsstart til sykdomsutvikling målt ved bruk av RANO -kriterier eller død, avhengig av hva som inntreffer først, vurdert opptil 3 år
Forekomst av bivirkninger Inntil 3 år
Registrering 37
Tilstand
Innblanding

Intervensjonstype: Biological

Intervensjonsnavn: Ipilimumab

Beskrivelse: Given IV

Arm Group-etikett: Treatment (nivolumab, ipilimumab)

Intervensjonstype: Biologisk

Intervensjonsnavn: Nivolumab

Beskrivelse: Gitt IV

Arm Group-etikett: Behandling (nivolumab, ipilimumab)

Kvalifisering

Kriterier:

Inklusjonskriterier: - REGISTRERING: - Histologisk bekreftet glioblastom (Verdens helseorganisasjon [WHO] klasse IV) presentere ved første eller andre tilbakefall tilgjengelig sekundært glioblastom - Tilstedeværelse av målbar sykdom, som definert av en todimensjonalt målbar lesjon på magnetisk resonansavbildning (MR) med en minimumsdiameter på 10 mm i begge dimensjoner, før reseksjon eller biopsi av tilbakevendende svulst - Tilgjengelig fra kirurgisk reseksjon eller biopsi av tilbakevendende svulst = = 18 år - Eastern Cooperative Oncology Group (ECOG) ytelsesstatus = = 1500/mm^3 - Trombocyttall> = 100 000/mm^3 - Totalt bilirubin =

Kjønn:

Alle

Minimumsalder:

18 år

Maksimal alder:

Ikke tilgjengelig

Sunne frivillige:

Nei

Samlet offisiell
Etternavn Roll Tilhørighet
Gavin P Dunn Principal Investigator Alliance for Clinical Trials in Oncology
plassering
Anlegget: Status:
Anchorage Associates in Radiation Medicine | Anchorage, Alaska, 98508, United States Suspended
Anchorage Radiation Therapy Center | Anchorage, Alaska, 99504, United States Suspended
Alaska Breast Care and Surgery LLC | Anchorage, Alaska, 99508, United States Suspended
Alaska Oncology and Hematology LLC | Anchorage, Alaska, 99508, United States Suspended
Alaska Women's Cancer Care | Anchorage, Alaska, 99508, United States Suspended
Anchorage Oncology Centre | Anchorage, Alaska, 99508, United States Suspended
Katmai Oncology Group | Anchorage, Alaska, 99508, United States Suspended
Providence Alaska Medical Center | Anchorage, Alaska, 99508, United States Suspended
Cancer Center at Saint Joseph's | Phoenix, Arizona, 85004, United States Suspended
Mayo Clinic Hospital in Arizona | Phoenix, Arizona, 85054, United States Recruiting Site Public Contact 855-776-0015 Sani H. Kizilbash Principal Investigator
Mayo Clinic in Arizona | Scottsdale, Arizona, 85259, United States Recruiting Site Public Contact 855-776-0015 Sani H. Kizilbash Principal Investigator
Mercy Hospital Fort Smith | Fort Smith, Arkansas, 72903, United States Suspended
CHI Saint Vincent Cancer Center Hot Springs | Hot Springs, Arkansas, 71913, United States Suspended
Mission Hope Medical Oncology - Arroyo Grande | Arroyo Grande, California, 93420, United States Suspended
Providence Saint Joseph Medical Center/Disney Family Cancer Center | Burbank, California, 91505, United States Suspended
UC San Diego Moores Cancer Center | La Jolla, California, 92093, United States Recruiting Site Public Contact 858-822-5354 [email protected] David E. Piccioni Principal Investigator
Cedars Sinai Medical Center | Los Angeles, California, 90048, United States Recruiting Site Public Contact 310-423-8965 Jeremy D. Rudnick Principal Investigator
Pacific Central Coast Health Center-San Luis Obispo | San Luis Obispo, California, 93401, United States Suspended
Mission Hope Medical Oncology - Santa Maria | Santa Maria, California, 93444, United States Suspended
Torrance Memorial Physician Network - Cancer Care | Torrance, California, 90505, United States Suspended
Torrance Memorial Medical Center | Torrance, California, 90509, United States Suspended
University of Colorado Hospital | Aurora, Colorado, 80045, United States Recruiting Site Public Contact 720-848-0650 Denise M. Damek Principal Investigator
Penrose-Saint Francis Healthcare | Colorado Springs, Colorado, 80907, United States Recruiting Site Public Contact 719-776-6550 [email protected] Richard L. Deming Principal Investigator
Rocky Mountain Cancer Centers-Penrose | Colorado Springs, Colorado, 80907, United States Suspended
Porter Adventist Hospital | Denver, Colorado, 80210, United States Recruiting Site Public Contact 719-776-6550 [email protected] Richard L. Deming Principal Investigator
Mercy Medical Center | Durango, Colorado, 81301, United States Suspended
Southwest Oncology PC | Durango, Colorado, 81301, United States Suspended
Saint Anthony Hospital | Lakewood, Colorado, 80228, United States Suspended
Littleton Adventist Hospital | Littleton, Colorado, 80122, United States Recruiting Site Public Contact 719-776-6550 [email protected] Richard L. Deming Principal Investigator
Longmont United Hospital | Longmont, Colorado, 80501, United States Suspended
Rocky Mountain Cancer Centers-Longmont | Longmont, Colorado, 80501, United States Suspended
Parker Adventist Hospital | Parker, Colorado, 80138, United States Recruiting Site Public Contact 719-776-6550 [email protected] Richard L. Deming Principal Investigator
Saint Mary Corwin Medical Center | Pueblo, Colorado, 81004, United States Suspended
Beebe South Coastal Health Campus | Frankford, Delaware, 19945, United States Recruiting Site Public Contact 302-645-3100 [email protected] Gregory A. Masters Principal Investigator
Beebe Medical Center | Lewes, Delaware, 19958, United States Suspended
Delaware Clinical and Laboratory Physicians PA | Newark, Delaware, 19713, United States Suspended
Helen F Graham Cancer Center | Newark, Delaware, 19713, United States Recruiting Site Public Contact 302-623-4450 [email protected] Gregory A. Masters Principal Investigator
Medical Oncology Hematology Consultants PA | Newark, Delaware, 19713, United States Recruiting Site Public Contact 302-623-4450 [email protected] Gregory A. Masters Principal Investigator
Christiana Care Health System-Christiana Hospital | Newark, Delaware, 19718, United States Suspended
Beebe Health Campus | Rehoboth Beach, Delaware, 19971, United States Recruiting Site Public Contact 302-645-3100 [email protected] Gregory A. Masters Principal Investigator
TidalHealth Nanticoke / Allen Cancer Center | Seaford, Delaware, 19973, United States Suspended
Christiana Care Health System-Wilmington Hospital | Wilmington, Delaware, 19801, United States Suspended
Holy Cross Hospital | Fort Lauderdale, Florida, 33308, United States Suspended
Mayo Clinic in Florida | Jacksonville, Florida, 32224-9980, United States Recruiting Site Public Contact 855-776-0015 Sani H. Kizilbash Principal Investigator
Low Country Cancer Care | Savannah, Georgia, 31404, United States Suspended
Memorial Health University Medical Center | Savannah, Georgia, 31404, United States Suspended
Saint Alphonsus Cancer Care Center-Boise | Boise, Idaho, 83706, United States Recruiting Site Public Contact 734-712-3671 [email protected] John M. Schallenkamp Principal Investigator
Saint Luke's Cancer Institute - Boise | Boise, Idaho, 83712, United States Recruiting Site Public Contact 208-381-2774 [email protected] Alison K. Conlin Principal Investigator
Saint Alphonsus Cancer Care Center-Caldwell | Caldwell, Idaho, 83605, United States Recruiting Site Public Contact 734-712-3671 [email protected] John M. Schallenkamp Principal Investigator
Kootenai Health - Coeur d'Alene | Coeur d'Alene, Idaho, 83814, United States Recruiting Site Public Contact 406-969-6060 [email protected] John M. Schallenkamp Principal Investigator
Walter Knox Memorial Hospital | Emmett, Idaho, 83617, United States Suspended
Saint Luke's Cancer Institute - Fruitland | Fruitland, Idaho, 83619, United States Recruiting Site Public Contact 208-381-2774 [email protected] Alison K. Conlin Principal Investigator
Idaho Urologic Institute-Meridian | Meridian, Idaho, 83642, United States Suspended
Saint Luke's Cancer Institute - Meridian | Meridian, Idaho, 83642, United States Recruiting Site Public Contact 208-381-2774 [email protected] Alison K. Conlin Principal Investigator
Saint Alphonsus Medical Center-Nampa | Nampa, Idaho, 83686, United States Recruiting Site Public Contact 406-969-6060 [email protected] John M. Schallenkamp Principal Investigator
Saint Luke's Cancer Institute - Nampa | Nampa, Idaho, 83686, United States Recruiting Site Public Contact 208-381-2774 [email protected] Alison K. Conlin Principal Investigator
Kootenai Clinic Cancer Services - Post Falls | Post Falls, Idaho, 83854, United States Recruiting Site Public Contact 406-969-6060 [email protected] John M. Schallenkamp Principal Investigator
Kootenai Cancer Clinic | Sandpoint, Idaho, 83864, United States Recruiting Site Public Contact 406-969-6060 [email protected] John M. Schallenkamp Principal Investigator
Saint Luke's Cancer Institute - Twin Falls | Twin Falls, Idaho, 83301, United States Recruiting Site Public Contact 208-381-2774 [email protected] Alison K. Conlin Principal Investigator
Saint Anthony's Health | Alton, Illinois, 62002, United States Suspended
Rush - Copley Medical Center | Aurora, Illinois, 60504, United States Recruiting Site Public Contact 630-978-6212 [email protected] Kendrith M. Rowland Principal Investigator
Illinois CancerCare-Bloomington | Bloomington, Illinois, 61704, United States Suspended
Illinois CancerCare-Canton | Canton, Illinois, 61520, United States Suspended
Memorial Hospital of Carbondale | Carbondale, Illinois, 62902, United States Suspended
SIH Cancer Institute | Carterville, Illinois, 62918, United States Suspended
Illinois CancerCare-Carthage | Carthage, Illinois, 62321, United States Suspended
Centralia Oncology Clinic | Centralia, Illinois, 62801, United States Suspended
Northwestern University | Chicago, Illinois, 60611, United States Recruiting Site Public Contact 312-695-1301 [email protected] Priya U. Kumthekar Principal Investigator
University of Illinois | Chicago, Illinois, 60612, United States Recruiting Site Public Contact 312-355-3046 Stefania Maraka Principal Investigator
Carle on Vermilion | Danville, Illinois, 61832, United States Recruiting Site Public Contact 800-446-5532 [email protected] Kendrith M. Rowland Principal Investigator
Cancer Care Specialists of Illinois - Decatur | Decatur, Illinois, 62526, United States Recruiting Site Public Contact 217-876-4762 [email protected] Bryan A. Faller Principal Investigator
Decatur Memorial Hospital | Decatur, Illinois, 62526, United States Suspended
Illinois CancerCare-Dixon | Dixon, Illinois, 61021, United States Suspended
Carle Physician Group-Effingham | Effingham, Illinois, 62401, United States Recruiting Site Public Contact 800-446-5532 [email protected] Kendrith M. Rowland Principal Investigator
Crossroads Cancer Center | Effingham, Illinois, 62401, United States Recruiting Site Public Contact 217-876-4762 [email protected] Bryan A. Faller Principal Investigator
Illinois CancerCare-Eureka | Eureka, Illinois, 61530, United States Suspended
NorthShore University HealthSystem-Evanston Hospital | Evanston, Illinois, 60201, United States Recruiting Site Public Contact 847-570-2109 Bruce E. Brockstein Principal Investigator
Illinois CancerCare-Galesburg | Galesburg, Illinois, 61401, United States Suspended
Western Illinois Cancer Treatment Center | Galesburg, Illinois, 61401, United States Suspended
NorthShore University HealthSystem-Glenbrook Hospital | Glenview, Illinois, 60026, United States Recruiting Site Public Contact 847-570-2109 Bruce E. Brockstein Principal Investigator
NorthShore University HealthSystem-Highland Park Hospital | Highland Park, Illinois, 60035, United States Recruiting Site Public Contact 847-570-2109 Bruce E. Brockstein Principal Investigator
Illinois CancerCare-Kewanee Clinic | Kewanee, Illinois, 61443, United States Suspended
Northwestern Medicine Lake Forest Hospital | Lake Forest, Illinois, 60045, United States Active, not recruiting
Illinois CancerCare-Macomb | Macomb, Illinois, 61455, United States Suspended
Carle Physician Group-Mattoon/Charleston | Mattoon, Illinois, 61938, United States Recruiting Site Public Contact 800-446-5532 [email protected] Kendrith M. Rowland Principal Investigator
Good Samaritan Regional Health Center | Mount Vernon, Illinois, 62864, United States Suspended
Cancer Care Center of O'Fallon | O'Fallon, Illinois, 62269, United States Recruiting Site Public Contact 217-876-4762 [email protected] Bryan A. Faller Principal Investigator
Illinois CancerCare-Ottawa Clinic | Ottawa, Illinois, 61350, United States Suspended
Illinois CancerCare-Pekin | Pekin, Illinois, 61554, United States Suspended
OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center | Pekin, Illinois, 61554, United States Suspended
Illinois CancerCare-Peoria | Peoria, Illinois, 61615, United States Suspended
OSF Saint Francis Radiation Oncology at Peoria Cancer Center | Peoria, Illinois, 61615, United States Suspended
Methodist Medical Center of Illinois | Peoria, Illinois, 61636, United States Suspended
OSF Saint Francis Medical Center | Peoria, Illinois, 61637, United States Suspended
Illinois CancerCare-Peru | Peru, Illinois, 61354, United States Suspended
Valley Radiation Oncology | Peru, Illinois, 61354, United States Suspended
Illinois CancerCare-Princeton | Princeton, Illinois, 61356, United States Suspended
North Shore Medical Center | Skokie, Illinois, 60076, United States Suspended
Southern Illinois University School of Medicine | Springfield, Illinois, 62702, United States Recruiting Site Public Contact 217-545-7929 Bryan A. Faller Principal Investigator
Springfield Clinic | Springfield, Illinois, 62702, United States Recruiting Site Public Contact 800-444-7541 Bryan A. Faller Principal Investigator
Memorial Medical Center | Springfield, Illinois, 62781, United States Recruiting Site Public Contact 217-788-3528 Bryan A. Faller Principal Investigator
Carle Cancer Center | Urbana, Illinois, 61801, United States Recruiting Site Public Contact 800-446-5532 [email protected] Kendrith M. Rowland Principal Investigator
The Carle Foundation Hospital | Urbana, Illinois, 61801, United States Suspended
Illinois CancerCare - Washington | Washington, Illinois, 61571, United States Suspended
Rush-Copley Healthcare Center | Yorkville, Illinois, 60560, United States Suspended
Baptist Health Floyd | New Albany, Indiana, 47150, United States Suspended
Mary Greeley Medical Center | Ames, Iowa, 50010, United States Recruiting Site Public Contact 515-956-4132 Debra M. Prow Principal Investigator
McFarland Clinic PC - Ames | Ames, Iowa, 50010, United States Recruiting Site Public Contact 515-239-4734 [email protected] Debra M. Prow Principal Investigator
McFarland Clinic PC-Boone | Boone, Iowa, 50036, United States Recruiting Site Public Contact 515-956-4132 Debra M. Prow Principal Investigator
Saint Anthony Regional Hospital | Carroll, Iowa, 51401, United States Recruiting Site Public Contact 515-689-7658 [email protected] Joshua Lukenbill Principal Investigator
Medical Oncology and Hematology Associates-West Des Moines | Clive, Iowa, 50325, United States Suspended
Mercy Cancer Center-West Lakes | Clive, Iowa, 50325, United States Suspended
Alegent Health Mercy Hospital | Council Bluffs, Iowa, 51503, United States Suspended
Greater Regional Medical Center | Creston, Iowa, 50801, United States Suspended
Iowa Methodist Medical Center | Des Moines, Iowa, 50309, United States Suspended
Medical Oncology and Hematology Associates-Des Moines | Des Moines, Iowa, 50309, United States Recruiting Site Public Contact 515-282-2921 Joshua Lukenbill Principal Investigator
Broadlawns Medical Center | Des Moines, Iowa, 50314, United States Recruiting Site Public Contact 515-282-2200 Joshua Lukenbill Principal Investigator
Medical Oncology and Hematology Associates-Laurel | Des Moines, Iowa, 50314, United States Suspended
Mercy Medical Center - Des Moines | Des Moines, Iowa, 50314, United States Suspended
Iowa Lutheran Hospital | Des Moines, Iowa, 50316, United States Suspended
McFarland Clinic PC-Trinity Cancer Center | Fort Dodge, Iowa, 50501, United States Recruiting Site Public Contact 515-956-4132 Debra M. Prow Principal Investigator
Trinity Regional Medical Center | Fort Dodge, Iowa, 50501, United States Recruiting Site Public Contact 515-574-8302 Joshua Lukenbill Principal Investigator
McFarland Clinic PC-Jefferson | Jefferson, Iowa, 50129, United States Recruiting Site Public Contact 515-956-4132 Debra M. Prow Principal Investigator
McFarland Clinic PC-Marshalltown | Marshalltown, Iowa, 50158, United States Recruiting Site Public Contact 515-956-4132 Debra M. Prow Principal Investigator
Methodist West Hospital | West Des Moines, Iowa, 50266-7700, United States Suspended
Mercy Medical Center-West Lakes | West Des Moines, Iowa, 50266, United States Suspended
Cancer Center of Kansas - Chanute | Chanute, Kansas, 66720, United States Suspended
Cancer Center of Kansas - Dodge City | Dodge City, Kansas, 67801, United States Suspended
Cancer Center of Kansas - El Dorado | El Dorado, Kansas, 67042, United States Suspended
Central Care Cancer Center - Garden City | Garden City, Kansas, 67846, United States Suspended
Central Care Cancer Center - Great Bend | Great Bend, Kansas, 67530, United States Suspended
Cancer Center of Kansas-Independence | Independence, Kansas, 67301, United States Suspended
Cancer Center of Kansas-Kingman | Kingman, Kansas, 67068, United States Suspended
Cancer Center of Kansas-Liberal | Liberal, Kansas, 67905, United States Suspended
Cancer Center of Kansas-Manhattan | Manhattan, Kansas, 66502, United States Suspended
Cancer Center of Kansas - McPherson | McPherson, Kansas, 67460, United States Suspended
Cancer Center of Kansas - Newton | Newton, Kansas, 67114, United States Suspended
Cancer Center of Kansas - Parsons | Parsons, Kansas, 67357, United States Suspended
Cancer Center of Kansas - Pratt | Pratt, Kansas, 67124, United States Suspended
Cancer Center of Kansas - Salina | Salina, Kansas, 67401, United States Suspended
Cancer Center of Kansas - Wellington | Wellington, Kansas, 67152, United States Suspended
Cancer Center of Kansas-Wichita Medical Arts Tower | Wichita, Kansas, 67208, United States Suspended
Ascension Via Christi Hospitals Wichita | Wichita, Kansas, 67214, United States Suspended
Cancer Center of Kansas - Wichita | Wichita, Kansas, 67214, United States Suspended
Cancer Center of Kansas - Winfield | Winfield, Kansas, 67156, United States Suspended
Flaget Memorial Hospital | Bardstown, Kentucky, 40004, United States Suspended
Commonwealth Cancer Center-Corbin | Corbin, Kentucky, 40701, United States Suspended
Baptist Health Lexington | Lexington, Kentucky, 40503, United States Recruiting Site Public Contact 859-260-6425 Arvinda Padmanabhan Principal Investigator
Saint Joseph Radiation Oncology Resource Center | Lexington, Kentucky, 40504, United States Suspended
Saint Joseph Hospital East | Lexington, Kentucky, 40509, United States Suspended
Saint Joseph London | London, Kentucky, 40741, United States Suspended
Jewish Hospital | Louisville, Kentucky, 40202, United States Suspended
Saints Mary and Elizabeth Hospital | Louisville, Kentucky, 40215, United States Suspended
Jewish Hospital Medical Center Northeast | Louisville, Kentucky, 40245, United States Suspended
Jewish Hospital Medical Center South | Shepherdsville, Kentucky, 40165, United States Suspended
Saint Joseph Mercy Hospital | Ann Arbor, Michigan, 48106, United States Recruiting Site Public Contact 734-712-3671 [email protected] Philip J. Stella Principal Investigator
Bronson Battle Creek | Battle Creek, Michigan, 49017, United States Recruiting Site Public Contact 616-391-1230 [email protected] Kathleen J. Yost Principal Investigator
IHA Hematology Oncology Consultants-Brighton | Brighton, Michigan, 48114, United States Recruiting Site Public Contact 734-712-3671 [email protected] Philip J. Stella Principal Investigator
Saint Joseph Mercy Brighton | Brighton, Michigan, 48114, United States Recruiting Site Public Contact 734-712-3671 [email protected] Philip J. Stella Principal Investigator
IHA Hematology Oncology Consultants-Canton | Canton, Michigan, 48188, United States Recruiting Site Public Contact 734-712-3671 [email protected] Philip J. Stella Principal Investigator
Saint Joseph Mercy Canton | Canton, Michigan, 48188, United States Recruiting Site Public Contact 734-712-3671 [email protected] Philip J. Stella Principal Investigator
Caro Cancer Center | Caro, Michigan, 48723, United States Suspended
IHA Hematology Oncology Consultants-Chelsea | Chelsea, Michigan, 48118, United States Recruiting Site Public Contact 734-712-3671 [email protected] Philip J. Stella Principal Investigator
Saint Joseph Mercy Chelsea | Chelsea, Michigan, 48118, United States Recruiting Site Public Contact 734-712-3671 [email protected] Philip J. Stella Principal Investigator
Hematology Oncology Consultants-Clarkston | Clarkston, Michigan, 48346, United States Suspended
Newland Medical Associates-Clarkston | Clarkston, Michigan, 48346, United States Suspended
Ascension Saint John Hospital | Detroit, Michigan, 48236, United States Suspended
Great Lakes Cancer Management Specialists-Doctors Park | East China Township, Michigan, 48054, United States Suspended
Genesee Cancer and Blood Disease Treatment Center | Flint, Michigan, 48503, United States Recruiting Site Public Contact 734-712-3671 [email protected] Philip J. Stella Principal Investigator
Genesee Hematology Oncology PC | Flint, Michigan, 48503, United States Recruiting Site Public Contact 734-712-3671 [email protected] Philip J. Stella Principal Investigator
Genesys Hurley Cancer Institute | Flint, Michigan, 48503, United States Recruiting Site Public Contact 734-712-3671 [email protected] Philip J. Stella Principal Investigator
Hurley Medical Center | Flint, Michigan, 48503, United States Recruiting Site Public Contact 734-712-3671 [email protected] Philip J. Stella Principal Investigator
Helen DeVos Children's Hospital at Spectrum Health | Grand Rapids, Michigan, 49503, United States Suspended
Mercy Health Saint Mary's | Grand Rapids, Michigan, 49503, United States Recruiting Site Public Contact 616-391-1230 [email protected] Kathleen J. Yost Principal Investigator
Spectrum Health at Butterworth Campus | Grand Rapids, Michigan, 49503, United States Recruiting Site Public Contact 616-391-1230 [email protected] Kathleen J. Yost Principal Investigator
Academic Hematology Oncology Specialists | Grosse Pointe Woods, Michigan, 48236, United States Suspended
Great Lakes Cancer Management Specialists-Van Elslander Cancer Center | Grosse Pointe Woods, Michigan, 48236, United States Suspended
Michigan Breast Specialists-Grosse Pointe Woods | Grosse Pointe Woods, Michigan, 48236, United States Suspended
Bronson Methodist Hospital | Kalamazoo, Michigan, 49007, United States Recruiting Site Public Contact 616-391-1230 [email protected] Kathleen J. Yost Principal Investigator
West Michigan Cancer Center | Kalamazoo, Michigan, 49007, United States Recruiting Site Public Contact 616-391-1230 [email protected] Kathleen J. Yost Principal Investigator
Borgess Medical Center | Kalamazoo, Michigan, 49048, United States Suspended
Sparrow Hospital | Lansing, Michigan, 48912, United States Suspended
Hope Cancer Clinic | Livonia, Michigan, 48154, United States Recruiting Site Public Contact 734-712-3671 [email protected] Philip J. Stella Principal Investigator
Saint Mary Mercy Hospital | Livonia, Michigan, 48154, United States Recruiting Site Public Contact 734-712-3671 [email protected] Philip J. Stella Principal Investigator
Great Lakes Cancer Management Specialists-Macomb Medical Campus | Macomb, Michigan, 48044, United States Suspended
Michigan Breast Specialists-Macomb Township | Macomb, Michigan, 48044, United States Suspended
Saint Mary's Oncology/Hematology Associates of Marlette | Marlette, Michigan, 48453, United States Suspended
Mercy Health Mercy Campus | Muskegon, Michigan, 49444, United States Recruiting Site Public Contact 616-391-1230 [email protected] Kathleen J. Yost Principal Investigator
Lakeland Hospital Niles | Niles, Michigan, 49120, United States Suspended
Cancer and Hematology Centers of Western Michigan - Norton Shores | Norton Shores, Michigan, 49444, United States Recruiting Site Public Contact 616-391-1230 [email protected] Kathleen J. Yost Principal Investigator
21st Century Oncology-Pontiac | Pontiac, Michigan, 48341, United States Suspended
Hope Cancer Center | Pontiac, Michigan, 48341, United States Suspended
Newland Medical Associates-Pontiac | Pontiac, Michigan, 48341, United States Suspended
Saint Joseph Mercy Oakland | Pontiac, Michigan, 48341, United States Suspended
Spectrum Health Reed City Hospital | Reed City, Michigan, 49677, United States Suspended
Great Lakes Cancer Management Specialists-Rochester Hills | Rochester Hills, Michigan, 48309, United States Suspended
Ascension Saint Mary's Hospital | Saginaw, Michigan, 48601, United States Recruiting Site Public Contact 734-712-3671 [email protected] Philip J. Stella Principal Investigator
Oncology Hematology Associates of Saginaw Valley PC | Saginaw, Michigan, 48604, United States Recruiting Site Public Contact 734-712-3671 [email protected] Philip J. Stella Principal Investigator
Lakeland Medical Center Saint Joseph | Saint Joseph, Michigan, 49085, United States Suspended
Marie Yeager Cancer Center | Saint Joseph, Michigan, 49085, United States Recruiting Site Public Contact 616-391-1230 [email protected] Kathleen J. Yost Principal Investigator
Bhadresh Nayak MD PC-Sterling Heights | Sterling Heights, Michigan, 48312, United States Suspended
Ascension Saint Joseph Hospital | Tawas City, Michigan, 48764, United States Recruiting Site Public Contact 734-712-3671 [email protected] Philip J. Stella Principal Investigator
Munson Medical Center | Traverse City, Michigan, 49684, United States Suspended
Advanced Breast Care Center PLLC | Warren, Michigan, 48088, United States Suspended
Great Lakes Cancer Management Specialists-Macomb Professional Building | Warren, Michigan, 48093, United States Suspended
Macomb Hematology Oncology PC | Warren, Michigan, 48093, United States Suspended
Michigan Breast Specialists-Warren | Warren, Michigan, 48093, United States Suspended
Saint John Macomb-Oakland Hospital | Warren, Michigan, 48093, United States Suspended
Saint Mary's Oncology/Hematology Associates of West Branch | West Branch, Michigan, 48661, United States Recruiting Site Public Contact 734-712-3671 [email protected] Philip J. Stella Principal Investigator
Metro Health Hospital | Wyoming, Michigan, 49519, United States Recruiting Site Public Contact 616-391-1230 [email protected] Kathleen J. Yost Principal Investigator
Huron Gastroenterology PC | Ypsilanti, Michigan, 48106, United States Recruiting Site Public Contact 734-712-3671 [email protected] Philip J. Stella Principal Investigator
IHA Hematology Oncology Consultants-Ann Arbor | Ypsilanti, Michigan, 48197, United States Recruiting Site Public Contact 734-712-3671 [email protected] Philip J. Stella Principal Investigator
Sanford Joe Lueken Cancer Center | Bemidji, Minnesota, 56601, United States Recruiting Site Public Contact 218-333-5000 [email protected] Preston D. Steen Principal Investigator
Fairview Ridges Hospital | Burnsville, Minnesota, 55337, United States Suspended
Minnesota Oncology - Burnsville | Burnsville, Minnesota, 55337, United States Suspended
Cambridge Medical Center | Cambridge, Minnesota, 55008, United States Suspended
Mercy Hospital | Coon Rapids, Minnesota, 55433, United States Suspended
Fairview Southdale Hospital | Edina, Minnesota, 55435, United States Suspended
Unity Hospital | Fridley, Minnesota, 55432, United States Suspended
Fairview Clinics and Surgery Center Maple Grove | Maple Grove, Minnesota, 55369, United States Suspended
Minnesota Oncology Hematology PA-Maplewood | Maplewood, Minnesota, 55109, United States Suspended
Saint John's Hospital - Healtheast | Maplewood, Minnesota, 55109, United States Recruiting Site Public Contact 952-993-1517 [email protected] Daniel M. Anderson Principal Investigator
Abbott-Northwestern Hospital | Minneapolis, Minnesota, 55407, United States Suspended
Hennepin County Medical Center | Minneapolis, Minnesota, 55415, United States Recruiting Site Public Contact 952-993-1517 [email protected] Daniel M. Anderson Principal Investigator
Health Partners Inc | Minneapolis, Minnesota, 55454, United States Suspended
Monticello Cancer Center | Monticello, Minnesota, 55362, United States Suspended
New Ulm Medical Center | New Ulm, Minnesota, 56073, United States Suspended
Fairview Northland Medical Center | Princeton, Minnesota, 55371, United States Suspended
North Memorial Medical Health Center | Robbinsdale, Minnesota, 55422, United States Suspended
Mayo Clinic in Rochester | Rochester, Minnesota, 55905, United States Recruiting Site Public Contact 855-776-0015 Sani H. Kizilbash Principal Investigator
Coborn Cancer Center at Saint Cloud Hospital | Saint Cloud, Minnesota, 56303, United States Recruiting Site Public Contact 877-229-4907 [email protected] Donald J. Jurgens Principal Investigator
Park Nicollet Clinic - Saint Louis Park | Saint Louis Park, Minnesota, 55416, United States Recruiting Site Public Contact 952-993-1517 [email protected] Daniel M. Anderson Principal Investigator
Regions Hospital | Saint Paul, Minnesota, 55101, United States Recruiting Site Public Contact 952-993-1517 [email protected] Daniel M. Anderson Principal Investigator
United Hospital | Saint Paul, Minnesota, 55102, United States Suspended
Saint Francis Regional Medical Center | Shakopee, Minnesota, 55379, United States Suspended
Lakeview Hospital | Stillwater, Minnesota, 55082, United States Suspended
Sanford Thief River Falls Medical Center | Thief River Falls, Minnesota, 56701, United States Suspended
Ridgeview Medical Center | Waconia, Minnesota, 55387, United States Suspended
Rice Memorial Hospital | Willmar, Minnesota, 56201, United States Suspended
Minnesota Oncology Hematology PA-Woodbury | Woodbury, Minnesota, 55125, United States Suspended
Sanford Cancer Center Worthington | Worthington, Minnesota, 56187, United States Suspended
Fairview Lakes Medical Center | Wyoming, Minnesota, 55092, United States Suspended
Saint Louis Cancer and Breast Institute-Ballwin | Ballwin, Missouri, 63011, United States Suspended
Central Care Cancer Center - Bolivar | Bolivar, Missouri, 65613, United States Suspended
Saint Francis Medical Center | Cape Girardeau, Missouri, 63703, United States Suspended
Southeast Cancer Center | Cape Girardeau, Missouri, 63703, United States Suspended
Siteman Cancer Center at West County Hospital | Creve Coeur, Missouri, 63141, United States Recruiting Site Public Contact 800-600-3606 [email protected] Tanner M. Johanns Principal Investigator
Parkland Health Center - Farmington | Farmington, Missouri, 63640, United States Active, not recruiting
Capital Region Southwest Campus | Jefferson City, Missouri, 65109, United States Suspended
Freeman Health System | Joplin, Missouri, 64804, United States Suspended
Mercy Hospital Joplin | Joplin, Missouri, 64804, United States Suspended
Delbert Day Cancer Institute at PCRMC | Rolla, Missouri, 65401, United States Suspended
Mercy Clinic-Rolla-Cancer and Hematology | Rolla, Missouri, 65401, United States Suspended
Heartland Regional Medical Center | Saint Joseph, Missouri, 64506, United States Suspended
Saint Louis Cancer and Breast Institute-South City | Saint Louis, Missouri, 63109, United States Suspended
Washington University School of Medicine | Saint Louis, Missouri, 63110, United States Recruiting Site Public Contact 800-600-3606 [email protected] Tanner M. Johanns Principal Investigator
Mercy Hospital South | Saint Louis, Missouri, 63128, United States Suspended
Missouri Baptist Medical Center | Saint Louis, Missouri, 63131, United States Suspended
Mercy Hospital Saint Louis | Saint Louis, Missouri, 63141, United States Recruiting Site Public Contact 314-251-7066 Jay W. Carlson Principal Investigator
Sainte Genevieve County Memorial Hospital | Sainte Genevieve, Missouri, 63670, United States Suspended
Mercy Hospital Springfield | Springfield, Missouri, 65804, United States Suspended
CoxHealth South Hospital | Springfield, Missouri, 65807, United States Suspended
Missouri Baptist Sullivan Hospital | Sullivan, Missouri, 63080, United States Suspended
Missouri Baptist Outpatient Center-Sunset Hills | Sunset Hills, Missouri, 63127, United States Suspended
Mercy Hospital Washington | Washington, Missouri, 63090, United States Suspended
Community Hospital of Anaconda | Anaconda, Montana, 59711, United States Recruiting Site Public Contact 406-969-6060 [email protected] John M. Schallenkamp Principal Investigator
Billings Clinic Cancer Center | Billings, Montana, 59101, United States Recruiting Site Public Contact 800-996-2663 [email protected] John M. Schallenkamp Principal Investigator
Bozeman Deaconess Hospital | Bozeman, Montana, 59715, United States Recruiting Site Public Contact 406-969-6060 [email protected] John M. Schallenkamp Principal Investigator
Benefis Healthcare- Sletten Cancer Institute | Great Falls, Montana, 59405, United States Recruiting Site Public Contact 406-969-6060 [email protected] John M. Schallenkamp Principal Investigator
Great Falls Clinic | Great Falls, Montana, 59405, United States Suspended
Kalispell Regional Medical Center | Kalispell, Montana, 59901, United States Recruiting Site Public Contact 406-969-6060 [email protected] John M. Schallenkamp Principal Investigator
Saint Patrick Hospital - Community Hospital | Missoula, Montana, 59802, United States Suspended
Community Medical Hospital | Missoula, Montana, 59804, United States Recruiting Site Public Contact 406-969-6060 [email protected] John M. Schallenkamp Principal Investigator
CHI Health Saint Francis | Grand Island, Nebraska, 68803, United States Suspended
CHI Health Good Samaritan | Kearney, Nebraska, 68847, United States Suspended
Saint Elizabeth Regional Medical Center | Lincoln, Nebraska, 68510, United States Suspended
Alegent Health Immanuel Medical Center | Omaha, Nebraska, 68122, United States Suspended
Alegent Health Bergan Mercy Medical Center | Omaha, Nebraska, 68124, United States Suspended
Alegent Health Lakeside Hospital | Omaha, Nebraska, 68130, United States Suspended
Creighton University Medical Center | Omaha, Nebraska, 68131, United States Suspended
Midlands Community Hospital | Papillion, Nebraska, 68046, United States Suspended
Dartmouth Hitchcock Medical Center | Lebanon, New Hampshire, 03756, United States Recruiting Site Public Contact 800-639-6918 [email protected] Amy M. Chan Principal Investigator
Morristown Medical Center | Morristown, New Jersey, 07960, United States Suspended
Capital Health Medical Center-Hopewell | Pennington, New Jersey, 08534, United States Recruiting Site Public Contact 609-394-4130 [email protected] Navid Redjal Principal Investigator
Overlook Hospital | Summit, New Jersey, 07902, United States Recruiting Site Public Contact 908-522-2043 Robert D. Aiken Principal Investigator
Randolph Hospital | Asheboro, North Carolina, 27203, United States Suspended
Messino Cancer Centers | Asheville, North Carolina, 28806, United States Active, not recruiting
Cone Health Cancer Center at Alamance Regional | Burlington, North Carolina, 27215, United States Recruiting Site Public Contact 336-538-7725 [email protected] Vinay K. Gudena Principal Investigator
Cone Health Cancer Center | Greensboro, North Carolina, 27403, United States Recruiting Site Public Contact 336-832-0821 [email protected] Vinay K. Gudena Principal Investigator
Vidant Medical Center | Greenville, North Carolina, 27834, United States Recruiting Site Public Contact 252-744-2391 Jasmin Jo Principal Investigator
Cone Heath Cancer Center at Mebane | Mebane, North Carolina, 27302, United States Suspended
Sanford Bismarck Medical Center | Bismarck, North Dakota, 58501, United States Recruiting Site Public Contact 701-323-5760 [email protected] Preston D. Steen Principal Investigator
Sanford South University Medical Center | Fargo, North Dakota, 58103, United States Suspended
Southpointe-Sanford Medical Center Fargo | Fargo, North Dakota, 58103, United States Suspended
Sanford Medical Center Fargo | Fargo, North Dakota, 58104, United States Suspended
Sanford Broadway Medical Center | Fargo, North Dakota, 58122, United States Recruiting Site Public Contact 701-323-5760 [email protected] Preston D. Steen Principal Investigator
Sanford Roger Maris Cancer Center | Fargo, North Dakota, 58122, United States Recruiting Site Public Contact 701-234-6161 [email protected] Preston D. Steen Principal Investigator
University of Cincinnati Cancer Center-UC Medical Center | Cincinnati, Ohio, 45219, United States Recruiting Site Public Contact 513-584-7698 [email protected] Soma Sengupta Principal Investigator
Good Samaritan Hospital - Cincinnati | Cincinnati, Ohio, 45220, United States Suspended
Bethesda North Hospital | Cincinnati, Ohio, 45242, United States Suspended
TriHealth Cancer Institute-Westside | Cincinnati, Ohio, 45247, United States Suspended
TriHealth Cancer Institute-Anderson | Cincinnati, Ohio, 45255, United States Suspended
University of Cincinnati Cancer Center-West Chester | West Chester, Ohio, 45069, United States Recruiting Site Public Contact 513-584-7698 [email protected] Soma Sengupta Principal Investigator
University of Oklahoma Health Sciences Center | Oklahoma City, Oklahoma, 73104, United States Suspended
Mercy Hospital Oklahoma City | Oklahoma City, Oklahoma, 73120, United States Suspended
Saint Alphonsus Medical Center-Baker City | Baker City, Oregon, 97814, United States Suspended
Saint Charles Health System | Bend, Oregon, 97701, United States Suspended
Clackamas Radiation Oncology Center | Clackamas, Oregon, 97015, United States Suspended
Providence Cancer Institute Clackamas Clinic | Clackamas, Oregon, 97015, United States Recruiting Site Public Contact 503-215-2614 [email protected] Alison K. Conlin Principal Investigator
Bay Area Hospital | Coos Bay, Oregon, 97420, United States Suspended
Providence Newberg Medical Center | Newberg, Oregon, 97132, United States Recruiting Site Public Contact 503-215-2614 [email protected] Alison K. Conlin Principal Investigator
Saint Alphonsus Medical Center-Ontario | Ontario, Oregon, 97914, United States Recruiting Site Public Contact 406-969-6060 [email protected] John M. Schallenkamp Principal Investigator
Providence Portland Medical Center | Portland, Oregon, 97213, United States Recruiting Site Public Contact 503-215-2614 [email protected] Alison K. Conlin Principal Investigator
Providence Saint Vincent Medical Center | Portland, Oregon, 97225, United States Recruiting Site Public Contact 503-215-2614 [email protected] Alison K. Conlin Principal Investigator
Saint Charles Health System-Redmond | Redmond, Oregon, 97756, United States Suspended
Lehigh Valley Hospital-Cedar Crest | Allentown, Pennsylvania, 18103, United States Recruiting Site Public Contact 734-712-3671 [email protected] Philip J. Stella Principal Investigator
Lehigh Valley Hospital - Muhlenberg | Bethlehem, Pennsylvania, 18017, United States Recruiting Site Public Contact 734-712-3671 [email protected] Philip J. Stella Principal Investigator
Christiana Care Health System-Concord Health Center | Chadds Ford, Pennsylvania, 19317, United States Suspended
Pocono Medical Center | East Stroudsburg, Pennsylvania, 18301, United States Suspended
Lehigh Valley Hospital-Hazleton | Hazleton, Pennsylvania, 18201, United States Suspended
University of Pittsburgh Cancer Institute (UPCI) | Pittsburgh, Pennsylvania, 15232, United States Recruiting Site Public Contact 412-647-8073 Megan Mantica Principal Investigator
Sanford Cancer Center Oncology Clinic | Sioux Falls, South Dakota, 57104, United States Recruiting Site Public Contact 605-312-3320 [email protected] Preston D. Steen Principal Investigator
Sanford USD Medical Center - Sioux Falls | Sioux Falls, South Dakota, 57117-5134, United States Recruiting Site Public Contact 605-312-3320 [email protected] Preston D. Steen Principal Investigator
Saint Joseph Regional Cancer Center | Bryan, Texas, 77802, United States Suspended
Parkland Memorial Hospital | Dallas, Texas, 75235, United States Recruiting Site Public Contact 214-590-5582 [email protected] Michael Youssef Principal Investigator
UT Southwestern/Simmons Cancer Center-Dallas | Dallas, Texas, 75390, United States Recruiting Site Public Contact 214-648-7097 [email protected] Michael Youssef Principal Investigator
Huntsman Cancer Institute/University of Utah | Salt Lake City, Utah, 84112, United States Active, not recruiting
Inova Schar Cancer Institute | Fairfax, Virginia, 22031, United States Recruiting Site Public Contact 703-720-5210 [email protected] Adam L. Cohen Principal Investigator
Inova Fairfax Hospital | Falls Church, Virginia, 22042, United States Recruiting Site Public Contact 703-208-6650 [email protected] Adam L. Cohen Principal Investigator
Providence Regional Cancer System-Aberdeen | Aberdeen, Washington, 98520, United States Suspended
PeaceHealth Saint Joseph Medical Center | Bellingham, Washington, 98225, United States Suspended
Harrison HealthPartners Hematology and Oncology-Bremerton | Bremerton, Washington, 98310, United States Recruiting Site Public Contact 308-398-6518 [email protected] Richard L. Deming Principal Investigator
Harrison Medical Center | Bremerton, Washington, 98310, United States Suspended
Highline Medical Center-Main Campus | Burien, Washington, 98166, United States Suspended
Providence Regional Cancer System-Centralia | Centralia, Washington, 98531, United States Suspended
Swedish Cancer Institute-Edmonds | Edmonds, Washington, 98026, United States Suspended
Saint Elizabeth Hospital | Enumclaw, Washington, 98022, United States Suspended
Providence Regional Cancer Partnership | Everett, Washington, 98201, United States Suspended
Saint Francis Hospital | Federal Way, Washington, 98003, United States Suspended
Swedish Cancer Institute-Issaquah | Issaquah, Washington, 98029, United States Suspended
Kadlec Clinic Hematology and Oncology | Kennewick, Washington, 99336, United States Recruiting Site Public Contact 509-783-4637 [email protected] Alison K. Conlin Principal Investigator
Providence Regional Cancer System-Lacey | Lacey, Washington, 98503, United States Suspended
Saint Clare Hospital | Lakewood, Washington, 98499, United States Suspended
PeaceHealth Saint John Medical Center | Longview, Washington, 98632, United States Suspended
Harrison HealthPartners Hematology and Oncology-Poulsbo | Poulsbo, Washington, 98370, United States Suspended
Pacific Gynecology Specialists | Seattle, Washington, 98104, United States Suspended
Swedish Medical Center-Ballard Campus | Seattle, Washington, 98107, United States Suspended
Swedish Medical Center-First Hill | Seattle, Washington, 98122-4307, United States Suspended
Swedish Medical Center-Cherry Hill | Seattle, Washington, 98122-5711, United States Suspended
PeaceHealth United General Medical Center | Sedro-Woolley, Washington, 98284, United States Suspended
Providence Regional Cancer System-Shelton | Shelton, Washington, 98584, United States Suspended
Franciscan Research Center-Northwest Medical Plaza | Tacoma, Washington, 98405, United States Suspended
Northwest Medical Specialties PLLC | Tacoma, Washington, 98405, United States Suspended
PeaceHealth Southwest Medical Center | Vancouver, Washington, 98664, United States Suspended
Providence Saint Mary Regional Cancer Center | Walla Walla, Washington, 99362, United States Suspended
Providence Regional Cancer System-Yelm | Yelm, Washington, 98597, United States Suspended
United Hospital Center | Bridgeport, West Virginia, 26330, United States Suspended
WVUH-Berkely Medical Center | Martinsburg, West Virginia, 25401, United States Suspended
West Virginia University Healthcare | Morgantown, West Virginia, 26506, United States Recruiting Site Public Contact 304-293-7374 [email protected] Sonikpreet Aulakh Principal Investigator
Camden Clark Medical Center | Parkersburg, West Virginia, 26101, United States Suspended
Mayo Clinic Health System-Eau Claire Clinic | Eau Claire, Wisconsin, 54701, United States Recruiting Site Public Contact 855-776-0015 Sani H. Kizilbash Principal Investigator
Gundersen Lutheran Medical Center | La Crosse, Wisconsin, 54601, United States Recruiting Site Public Contact 608-775-2385 [email protected] Michael O. Ojelabi Principal Investigator
Mayo Clinic Health System-Franciscan Healthcare | La Crosse, Wisconsin, 54601, United States Recruiting Site Public Contact 855-776-0015 Sani H. Kizilbash Principal Investigator
ProHealth D N Greenwald Center | Mukwonago, Wisconsin, 53149, United States Recruiting Site Public Contact [email protected] Timothy R. Wassenaar Principal Investigator
Cancer Center of Western Wisconsin | New Richmond, Wisconsin, 54017, United States Suspended
ProHealth Oconomowoc Memorial Hospital | Oconomowoc, Wisconsin, 53066, United States Recruiting Site Public Contact 262-928-7878 Timothy R. Wassenaar Principal Investigator
ProHealth Waukesha Memorial Hospital | Waukesha, Wisconsin, 53188, United States Recruiting Site Public Contact 262-928-7632 Timothy R. Wassenaar Principal Investigator
UW Cancer Center at ProHealth Care | Waukesha, Wisconsin, 53188, United States Recruiting Site Public Contact 262-928-5539 [email protected] Timothy R. Wassenaar Principal Investigator
Billings Clinic-Cody | Cody, Wyoming, 82414, United States Suspended
Welch Cancer Center | Sheridan, Wyoming, 82801, United States Suspended
Pan American Center for Oncology Trials LLC | San Juan, 00902, Puerto Rico Recruiting Site Public Contact 787-407-3333 [email protected] Marcia R. Cruz-Correa Principal Investigator
Sted Land

Puerto Rico

United States

Bekreftelsesdato

2021-09-01

Ansvarlig fest

Type: Sponsor

Har utvidet tilgang Nei
Antall våpen 1
Arm Group

Merkelapp: Behandling (nivolumab, ipilimumab)

Type: Eksperimentell

Beskrivelse: Pasienter får nivolumab IV over 30 minutter og ipilimumab IV over 30 minutter på dag 1. Behandlingen gjentas hver tredje uke i 4 sykluser i fravær av sykdomsprogresjon eller uakseptabel toksisitet. Pasienter får deretter nivolumab IV over 30 minutter på dag 1. Sykluser gjentas hver fjerde uke i fravær av sykdomsprogresjon eller uakseptabel toksisitet.

Informasjon om studiedesign

Tildeling: Ikke tilgjengelig

Intervensjonsmodell: Enkeltgruppeoppgave

Hovedformål: Behandling

Maskering: Ingen (åpen etikett)

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact [email protected]. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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