FTO Gene Variants and Diet in Obesity

Impact of FTO Gene Variants and Lifestyle Factors on Obesity Traits in a Turkish Population

Studies have shown that the effect of fat mass and obesity-associated (FTO) gene on obesity is modulated by lifestyle factors. Hence, we aimed to determine whether two single nucleotide polymorphisms (SNPs) in the FTO gene are associated with obesity and to assess whether these associations were modified by lifestyle factors. The study included 200 obese and 200 non-obese individuals from Turkey. Our study suggests that the effect of the SNPs on obesity traits is likely to be influenced by lifestyle factors in this Turkish population.

Study Overview

• Status: Completed
• Conditions: Obesity; Diet Habit; Genetic Predisposition

• Study Type: Observational
• Enrollment (Actual): 400

Contacts and Locations

Study Locations

• Turkey
  • Ankara, Turkey, 06100
    • Zehra Buyuktuncer

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 24 years to 50 years (Adult)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

400 unrelated individuals, aged 24-50 years

Description

Inclusion Criteria:

1. attending routine outpatient visits,
2. aged 24 to 50 years,
3. having a BMI ≥ 18.50 kg/m2

Study Plan

How is the study designed?

Number of groups / cohorts

2

Cohorts and Interventions

Group / Cohort
study; obese (BMI ≥25.00 kg/m2, n=200)
control; non-obese (BMI= 18.50-24.99 kg/m2, n=200)

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Genetic analysis of two SNPs at FTO gene	FTO SNPs rs9939609 and rs10163409	up to 36 weeks
Anthropometric measurements	Body mass index, waist circumference, hip circumference, body composition	up to 36 weeks
Biochemical measurements	lipid profile, glucose, insulin, adiponectin	up to 36 weeks

Collaborators and Investigators

• Sponsor: Hacettepe University
• Collaborators: The Scientific and Technological Research Council of Turkey; University of Reading
• Investigators: Principal Investigator: Zehra Buyuktuncer, Hacettepe University, Department of Nutrition and Dietetics, Ankara, TURKEY; Principal Investigator: Vimales Karani Santhanakrishnan, Department of Food and Nutritional Sciences, University of Reading, UK

Study record dates

Study Major Dates

• Study Start (Actual): March 1, 2017
• Primary Completion (Actual): February 1, 2018
• Study Completion (Actual): December 31, 2018

Study Registration Dates

• First Submitted: July 21, 2019
• First Submitted That Met QC Criteria: December 17, 2019
• First Posted (Actual): December 19, 2019

Study Record Updates

• Last Update Posted (Actual): December 19, 2019
• Last Update Submitted That Met QC Criteria: December 17, 2019
• Last Verified: August 1, 2019

More Information

Terms related to this study

• Keywords: obesity; gene-diet interaction; FTO gene variant
• Additional Relevant MeSH Terms: Pathologic Processes; Disease Attributes; Overnutrition; Nutrition Disorders; Overweight; Body Weight; Obesity; Disease Susceptibility; Genetic Predisposition to Disease
• Other Study ID Numbers: GO15/612-11

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No