- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT04314232
Mechanisms for Covid-19 Disease Complications (COVID MECH)
June 24, 2020 updated by: Torbjorn Omland, University Hospital, Akershus
Changes in Organ Specific Biomarkers, Virus Expression and Prognosis of Covid-19
Covid-19 is associated with a wide range of symptoms and clinical trajectories, and early identification of patients at risk for developing severe disease is desirable.
Several risk markers and comorbidity profiles have been proposed but their relative importance in unselected patients admitted to hospital with Covid-19 remains unclear.
This study aims to assess the prognostic value organ specific biomarkers, viral dynamics and immune response markers in patients infected with SARS-CoV2.
Study Overview
Status
Unknown
Conditions
Study Type
Observational
Enrollment (Anticipated)
200
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Contact
- Name: Torbjørn Omland, MD, PhD
- Phone Number: 67960000
- Email: torbjorn.omland@medisin.uio.no
Study Locations
-
-
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Lørenskog, Norway
- Recruiting
- Akershus University Hospital
-
Contact:
- Peder Myhre, MD, PhD
- Phone Number: 6790000
- Email: p.l.myhre@medisin.uio.no
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-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years and older (Adult, Older Adult)
Accepts Healthy Volunteers
Yes
Genders Eligible for Study
All
Sampling Method
Non-Probability Sample
Study Population
All patients with a positive test for SARS-CoV2 admitted to Akershus University Hospital.
Description
Inclusion Criteria:
- All patients >18 years of age with a positive test for SARS-CoV2 are eligble for inclusion.
- Healty age-matched volunteers will be included as a control group
Exclusion Criteria:
- None
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Number of participants with ICU admission or death
Time Frame: From hospital admission (baseline) until the date of either admission to the ICU or death during the index hospitalization (up to 52 weeks)
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Combined outcome measure of either ICU admission or death
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From hospital admission (baseline) until the date of either admission to the ICU or death during the index hospitalization (up to 52 weeks)
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Number of participants with ICU admission
Time Frame: From hospital admission (baseline) until the date of admission to the ICU during the index hospitalization (up to 52 weeks)
|
ICU admission
|
From hospital admission (baseline) until the date of admission to the ICU during the index hospitalization (up to 52 weeks)
|
Number of participants with death from all causes
Time Frame: From hospital admission (baseline) unitl the date of death during the index hospitalization (up to 52 weeks)
|
Hospital mortality
|
From hospital admission (baseline) unitl the date of death during the index hospitalization (up to 52 weeks)
|
Total duration of ICU stay
Time Frame: From admission to the ICU until transfer to another ward, discharge from the hospital or death during the index hospitalization (up to 52 weeks)
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Total time admitted to the ICU
|
From admission to the ICU until transfer to another ward, discharge from the hospital or death during the index hospitalization (up to 52 weeks)
|
Total duration of hospital stay
Time Frame: From hospital admission (baseline) until hospital discharge or death during the index hospitalization (up to 52 weeks)
|
From hospital admission (baseline) until hospital discharge or death during the index hospitalization (up to 52 weeks)
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Publications and helpful links
The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.
General Publications
- Omland T, Prebensen C, Jonassen C, Svensson M, Berdal JE, Seljeflot I, Myhre PL. Soluble ST2 concentrations associate with in-hospital mortality and need for mechanical ventilation in unselected patients with COVID-19. Open Heart. 2021 Dec;8(2):e001884. doi: 10.1136/openhrt-2021-001884.
- Myhre PL, Heck SL, Skranes JB, Prebensen C, Jonassen CM, Berge T, Mecinaj A, Melles W, Einvik G, Ingul CB, Tveit A, Berdal JE, Rosjo H, Lyngbakken MN, Omland T. Cardiac pathology 6 months after hospitalization for COVID-19 and association with the acute disease severity. Am Heart J. 2021 Dec;242:61-70. doi: 10.1016/j.ahj.2021.08.001. Epub 2021 Aug 13.
- Myhre PL, Prebensen C, Jonassen CM, Berdal JE, Omland T. SARS-CoV-2 Viremia is Associated With Inflammatory, But Not Cardiovascular Biomarkers, in Patients Hospitalized for COVID-19. J Am Heart Assoc. 2021 May 4;10(9):e019756. doi: 10.1161/JAHA.120.019756. Epub 2021 Feb 18.
- Myhre PL, Prebensen C, Strand H, Roysland R, Jonassen CM, Rangberg A, Sorensen V, Sovik S, Rosjo H, Svensson M, Berdal JE, Omland T. Growth Differentiation Factor 15 Provides Prognostic Information Superior to Established Cardiovascular and Inflammatory Biomarkers in Unselected Patients Hospitalized With COVID-19. Circulation. 2020 Dec;142(22):2128-2137. doi: 10.1161/CIRCULATIONAHA.120.050360. Epub 2020 Oct 15.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
March 18, 2020
Primary Completion (Anticipated)
December 31, 2021
Study Completion (Anticipated)
December 31, 2021
Study Registration Dates
First Submitted
March 17, 2020
First Submitted That Met QC Criteria
March 17, 2020
First Posted (Actual)
March 19, 2020
Study Record Updates
Last Update Posted (Actual)
June 26, 2020
Last Update Submitted That Met QC Criteria
June 24, 2020
Last Verified
June 1, 2020
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 117589
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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